Search Results - "Pierce, G F"

Biochemical and functional characterization of a recombinant monomeric factor VIII–Fc fusion protein by PETERS, R. T., TOBY, G., LU, Q., LIU, T., KULMAN, J. D., LOW, S. C., BITONTI, A. J., PIERCE, G. F.

“…Background: Hemophilia A results from a deficiency in factor VIII activity. Current treatment regimens require frequent dosing, owing to the short half‐life of…”
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Comparative field study evaluating the activity of recombinant factor VIII Fc fusion protein in plasma samples at clinical haemostasis laboratories by Sommer, J. M., Moore, N., McGuffie-Valentine, B., Bardan, S., Buyue, Y., Kamphaus, G. D., Konkle, B. A., Pierce, G. F.

“…Summary Discrepancies exist for some of the modified coagulation factors when assayed with different one‐stage clotting and chromogenic substrate assay…”
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Validation of the manufacturing process used to produce long-acting recombinant factor IX Fc fusion protein by McCue, J., Osborne, D., Dumont, J., Peters, R., Mei, B., Pierce, G. F., Kobayashi, K., Euwart, D.

“…Summary Recombinant factor IX Fc (rFIXFc) fusion protein is the first of a new class of bioengineered long‐acting factors approved for the treatment and…”
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Past, present and future of haemophilia gene therapy: From vectors and transgenes to known and unknown outcomes by Pierce, G. F., Iorio, A.

“…Since the 1960s, the pace of innovation in haemophilia treatment has been fast and furious and occasionally with unintended consequences. As newer technologies…”
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Inflammation in Nonhealing Diabetic Wounds: The Space-Time Continuum Does Matter by Pierce, Glenn F.

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Recombinant factor VIII Fc fusion protein for the prevention and treatment of bleeding in children with severe hemophilia A by Young, G., Mahlangu, J., Kulkarni, R., Nolan, B., Liesner, R., Pasi, J., Barnes, C., Neelakantan, S., Gambino, G., Cristiano, L. M., Pierce, G. F., Allen, G.

“…Summary Background Prophylactic factor replacement, which prevents hemarthroses and thereby reduces the musculoskeletal disease burden in children with…”
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Keratinocyte growth factor is a growth factor for type II pneumocytes in vivo by ULICH, T R, YI, E. S, LONGMUIR, K, SONGMEI YIN, BILTZ, R, MORRIS, C. F, HOUSLEY, R. M, PIERCE, G. F

“…Keratinocyte growth factor (KGF) administered as a single intratracheal injection causes a prominent dose-dependent proliferation of type II alveolar…”
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Keratinocyte growth factor is an important endogenous mediator of hair follicle growth, development, and differentiation. Normalization of the nu/nu follicular differentiation defect and amelioration of chemotherapy-induced alopecia by Danilenko, DM, Ring, BD, Yanagihara, D, Benson, W, Wiemann, B, Starnes, CO, Pierce, GF

“…The growth and development of hair follicles is influenced by a number of different growth factors and cytokines, particularly members of the fibroblast growth…”
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Genotypes, phenotypes and whole genome sequence: Approaches from the My Life Our Future haemophilia project by Konkle, B. A., Johnsen, J. M., Wheeler, M., Watson, C., Skinner, M., Pierce, G. F.

“…Introduction Information from the genes encoding factor VIII (F8) and IX (F9) is used in reproductive planning and to inform inhibitor formation, bleeding…”
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Core outcome set for gene therapy in haemophilia: Results of the coreHEM multistakeholder project by Iorio, A., Skinner, M. W., Clearfield, E., Messner, D., Pierce, G. F., Witkop, M., Tunis, S., Akehurst, Ronald, Jain, Mohit, Pezalla, Edmund, Valentino, Leonard, Altemark, Andreas, Belinson, Suzanne, Booth, Jason, Dahm, Philipp, Dolan, Gerard, Facey, Karen, Gouw, Samantha, Hart, Daniel, Hilger, Anneliese, Hooper, Craig, Hoots, Keith, Jorgenson, James, Keene, Daniel, Kim, Joanne, Krassova, Snejana, LeCleir, Gregory, Lillicrap, David, Lopes, Maria, Marks, Peter, Monahan, Paul, Moscou‐Jackson, Gyasi, Murray, Jennifer, Mujoomdar, Michelle, Neufeld, Ellis, O'Hara, Jamie, O'Mahony, Brian, Österberg, Marie, Petrie, Charles, Pindolia, Vanita, Pipe, Steven, Pleil, Andreas, Reilly, Philip, Reiss, Ulrike, Rice, Michelle, Ruiz, Sol, Sandy, Lew, Sawyer, Eileen, Sharp, Michael, Sood, Amy, Spiegler, Clive, Tugwell, Peter, Weill, Alain, Werkö, Sophie, Wong, Wing Yen, Zelenkofske, Steven, Al Naber, Jennifer, King, Janelle, Simmons, Julie

“…Background Gene therapy trial results show potential to cure haemophilia A and haemophilia B. Securing broad access to a cure for a lifelong chronic disease is…”
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Keratinocyte growth factor protects mice from chemotherapy and radiation-induced gastrointestinal injury and mortality by FARRELL, C. L, BREADY, J. V, HAVILL, A. M, LU, Z.-N, AUKERMAN, S. L, PIERCE, G. F, THOMASON, A, POTTEN, C. S, ULICH, T. R, LACEY, D. L, REX, K. L, CHEN, J. N, DIPALMA, C. R, WHITCOMB, K. L, SONGMEI YIN, HILL, D. C, WIEMANN, B, STARNES, C. O

“…Keratinocyte growth factor (KGF) stimulates the proliferation and differentiation of epithelial cells including those of the gastrointestinal tract. Although…”
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Long-term safety and efficacy of recombinant factor VIII Fc fusion protein (rFVIIIFc) in subjects with haemophilia A by Nolan, B., Mahlangu, J., Perry, D., Young, G., Liesner, R., Konkle, B., Rangarajan, S., Brown, S., Hanabusa, H., Pasi, K. J., Pabinger, I., Jackson, S., Cristiano, L. M., Li, X., Pierce, G. F., Allen, G.

“…Introduction The safety, efficacy and prolonged half‐life of recombinant factor VIII Fc fusion protein (rFVIIIFc) in previously treated patients with severe…”
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First‐year results of an expanded humanitarian aid programme for haemophilia in resource‐constrained countries by Pierce, G. F., Haffar, A., Ampartzidis, G., Peyvandi, F., Diop, S., El‐Ekiaby, M., Berg, H. M.

“…Introduction The gaps in haemophilia treatment around the world are enormous; approximately 60% of an estimated 475 000 individuals are not identified. Of the…”
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Basic fibroblast growth factor enhancement of adenovirus-mediated delivery of the herpes simplex virus thymidine kinase gene results in augmented therapeutic benefit in a murine model of ovarian cancer by RANCOURT, C, ROGERS, B. E, SOSNOWSKI, B. A, WANG, M, PICHE, A, PIERCE, G. F, ALVAREZ, R. D, SIEGAL, G. P, DOUGLAS, J. T, CURIEL, D. T

“…A number of preclinical and human clinical gene therapy trials using adenoviral vectors have shown that the number of viral particles necessary to give…”
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Changes in health-related quality of life with treatment of longer-acting clotting factors: results in the A-LONG and B-LONG clinical studies by Wyrwich, K. W., Krishnan, S., Auguste, P., Poon, J.-L., von Maltzahn, R., Yu, R., Pierce, G. F., Mei, B., Mahlangu, J., von Mackensen, S.

“…Introduction In haemophilia, prophylactic infusion of replacement factor can result in improvements in health‐related quality of life (HRQoL) when compared…”
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Platelet-derived growth factor BB for the treatment of chronic pressure ulcers by Robson, M C, Phillips, L G, Thomason, A, Robson, L E, Pierce, G F

“…A randomised, phase I/II, double-blind, placebo-controlled study was designed to assess the effect of topically applied recombinant human BB homodimeric…”
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Recombinant factor VIII Fc fusion protein: extended‐interval dosing maintains low bleeding rates and correlates with von Willebrand factor levels by Shapiro, A. D., Ragni, M. V., Kulkarni, R., Oldenberg, J., Srivastava, A., Quon, D. V., Pasi, K. J., Hanabusa, H., Pabinger, I., Mahlangu, J., Fogarty, P., Lillicrap, D., Kulke, S., Potts, J., Neelakantan, S., Nestorov, I., Li, S., Dumont, J. A., Jiang, H., Brennan, A., Pierce, G. F.

“…Summary Background Routine prophylaxis with replacement factor VIII (FVIII) – the standard of care for severe hemophilia A – often requires frequent…”
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Platelet-Derived Growth Factor and Transforming Growth Factor-β Enhance Tissue Repair Activities by Unique Mechanisms by Pierce, Glenn F., Mustoe, Thomas A., Lingelbach, Jane, Masakowski, Victoria R., Griffin, Gail L., Senior, Robert M., Deuel, Thomas F.

“…Platelet-derived growth factor (PDGF) and transforming growth factor-β (TGF-β) markedly potentiate tissue repair in vivo. In the present experiments, both in…”
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Stimulation of all epithelial elements during skin regeneration by keratinocyte growth factor by PIERCE, G. F, YANAGIHARA, D, KLOPCHIN, K, DANILENKO, D. M, HSU, E, KENNEY, W. C, MORRIS, C. F

“…Keratinocyte growth factor (KGF), a recently discovered 18.9 kD member of the fibroblast growth factor family has been shown to selectively induce keratinocyte…”
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Growth factor-induced acceleration of tissue repair through direct and inductive activities in a rabbit dermal ulcer model by MUSTOE, T. A, PIERCE, G. F, MORISHIMA, C, DEUEL, T. F

“…The roles of polypeptide growth factors in promoting wound healing and in directing the specificity and sequence of responses of different tissues in wounds…”
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