Search Results - "Pieper, J A"

Effects of erythromycin or rifampin on losartan pharmacokinetics in healthy volunteers by Williamson, Kristin M., Patterson, J. Herbert, McQueen, Robert H., Adams, Kirkwood F., Pieper, John A.

“…Background Losartan is metabolized by CYP2C9 and CYP3A4 to an active metabolite, E3174, which has greater antihypertensive activity than the parent compound…”
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Lack of Gender Differences and Large Intrasubject Variability in Cytochrome P450 Activity Measured by Phenotyping with Dextromethorphan by McCune, Jeannine S., Lindley, Celeste, Decker, Jodi L., Williamson, Kristin M., Meadowcroft, Amy M., Graff, Donald, Sawyer, William T., Blough, David K., Pieper, John A.

“…Gender‐based differences in cytochrome P450 (CYP) activity may occur due to endogenous hormonal fluctuations with the menstrual cycle, which are altered by…”
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Pharmacologic interventions for coronary artery disease and risk factors. Introduction by Pieper, J A

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Management of Coronary Heart Disease Risk Factors and Progression with Calcium Channel Blockers by Pieper, John A.

“…The death rate from coronary heart disease (CHD) declined by 25% in the United States during 1987–1997, but the actual number of deaths fell by only 9%…”
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The Effects of Fluvastatin, a CYP2C9 Inhibitor, on Losartan Pharmacokinetics in Healthy Volunteers by Meadowcroft, Amy M., Williamson, Kristin M., Patterson, J. Herbert, Hinderliter, Alan L., Pieper, John A.

“…Losartan is an angiotensin II receptor antagonist that is metabolized by CYP2C9 and CYP3A4 to a more potent antihypertensive metabolite, E3174. Interaction…”
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Clinical pharmacokinetics of fluvastatin by SCRIPTURE, Charity D, PIEPER, John A

“…Fluvastatin, the first fully synthetic HMG-CoA reductase inhibitor, has been shown to reduce cholesterol in patients with hyperlipidaemia, to prevent…”
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Calcium Channel Blockers: The Present and the Future by Pieper, John A.

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Inhaled verapamil-induced bronchoconstriction in mild asthma by Harman, E, Hill, M, Pieper, J A, Hendeles, L

“…Methacholine challenges were performed in ten subjects with mild asthma at 2 h before and 20 min after placebo or 5, 10, 20, 40, 80, and 160 mg of inhaled…”
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Altered protein binding of etoposide in patients with cancer by Stewart, C F, Pieper, J A, Arbuck, S G, Evans, W E

“…Etoposide plasma protein binding (PB) is reported to be 94% based on in vitro studies using normal human serum albumin (SA). Etoposide PB in 17 patients with…”
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Pharmacogenetics and Heart Failure: A Convergence with Carvedilol by Meadowcroft, Amy M., Williamson, Kristin M., Patterson, J. Herbert, Pieper, John A.

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Effects of chronic phenobarbital on verapamil disposition in humans by Rutledge, D R, Pieper, J A, Mirvis, D M

“…Very little is known about the effects of hepatic enzyme induction with phenobarbital on the disposition of high clearance drugs in humans. Our study was…”
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Optimal Management of Amiodarone Therapy: Efficacy and Side Effects by Hilleman, Daniel, Miller, Mary Ann, Parker, Robert, Doering, Paul, Pieper, John A.

“…Objectives. To review management and dosing guidelines for amiodarone therapy, and discuss the drug's adverse event profile. Methods. Review of relevant…”
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Gallopamil binding to human serum proteins by RUTLEDGE, D. R, PIEPER, J. A

“…We have determined the extent and variability in the binding of gallopamil to human serum proteins. Binding was determined by equilibrium dialysis in healthy…”
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Propranolol pharmacokinetics and pharmacodynamics after single doses and at steady-state by LALONDE, R. L, PIEPER, J. A, STRAKA, R. J, BOTTORFF, M. B, MIRVIS, D. M

“…The duration and extent of cardiac beta-blockade and their relationship to propranolol pharmacokinetics were assessed in nine healthy volunteers. Each subject…”
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Liquid chromatography and fluorescence polarization immunoassay methods compared for measuring flecainide acetate in serum by Straka, R J, Hoon, T J, Lalonde, R L, Pieper, J A, Bottorff, M B

“…We analyzed 99 patients' serum samples for concentrations of a new antiarrhythmic agent, flecainide acetate, by fluorescence polarization immunoassay (FPIA)…”
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Absorption pharmacokinetics of atenolol in patients with the Marfan syndrome by Phelps, S J, Alpert, B S, Ward, J L, Pieper, J A, Lima, J J

“…The negative inotropic and chronotropic effects of beta-blocker therapy have been reported to reduce morbidity and mortality in patients with Marfan syndrome;…”
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Hepatic drug clearance in children: studies with indocyanine green as a model substrate by Evans, W E, Relling, M V, de Graaf, S, Rodman, J H, Pieper, J A, Christensen, M L, Crom, W R

“…For several drugs metabolized by the liver, higher dosages (mg/kg body weight) are required in children to attain serum concentrations comparable to those in…”
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Determination of verapamil and its primary metabolites in serum by ion-pair adsorption high-performance liquid chromatography by Pieper, J A, Rutledge, D R

“…A high-performance liquid chromatographic (HPLC) method for the simultaneous quantitation of verapamil, norverapamil, N-dealkylverapamil (D617) and…”
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Lorazepam pharmacodynamics and pharmacokinetics in children by Relling, M V, Mulhern, R K, Dodge, R K, Johnson, D, Pieper, J A, Rivera, G K, Evans, W E

“…We evaluated the effects of low doses of lorazepam on episodic versus long-term memory, attention, and somatic and affective symptoms, as well as its…”
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The effect of ranitidine and cimetidine on imipramine disposition by WELLS, B. G, PIEPER, J. A, SELF, T. H, STEWART, C. F, WALDON, S. L, BOBO, L, WARNER, C

“…The pharmacokinetic characteristics of imipramine were studied after a single, oral, 100 mg dose was taken by 12 healthy male subjects following 3 days of…”
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