Search Results - "Pieńko, Tomasz"

Computational Methods Used to Explore Transport Events in Biological Systems by Pieńko, Tomasz, Trylska, Joanna

“…Transport of various molecules facilitated with membrane proteins is necessary for maintaining homeostasis in living cells. In humans, dysfunction of these…”
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Extracellular loops of BtuB facilitate transport of vitamin B12 through the outer membrane of E. coli by Pieńko, Tomasz, Trylska, Joanna

“…Vitamin B12 (or cobalamin) is an enzymatic cofactor essential both for mammals and bacteria. However, cobalamin can be synthesized only by few microorganisms…”
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Balancing Nonsense Mutation Readthrough and Toxicity of Designer Aminoglycosides for Treatment of Genetic Diseases by Guchhait, Sandip, Khononov, Alina, Pieńko, Tomasz, Belakhov, Valery, Baasov, Timor

“…New derivatives of aminoglycosides with a side chain 1,2-aminoalcohol at the 5” position of ring III were designed, synthesized, and biologically evaluated…”
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Dynamic Intramolecular Cap for Preserving Metallodrug IntegrityA Case of Catalytic Fluoroquinolones by Goldmeier, Moshe N., Khononov, Alina, Belakhov, Valery, Pieńko, Tomasz, Orbach, Noam, Gilad Barzilay, Yuval, Baasov, Timor

“…A library of eight new fluoroquinolone–nuclease conjugates containing a guanidinoethyl or aminoethyl auxiliary pendant on the cyclen moiety was designed and…”
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The protein phosphorylation landscape in photosystem I of the desert algae Chlorella sp by Levin, Guy, Yasmin, Michael, Pieńko, Tomasz, Yehishalom, Nitsan, Hanna, Rawad, Kleifeld, Oded, Glaser, Fabian, Schuster, Gadi

“…Summary The phosphorylation of photosystem II (PSII) and its antenna (LHCII) proteins has been studied, and its involvement in state transitions and PSII…”
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Artificial Activation of Escherichia coli mazEF and hipBA Toxin-Antitoxin Systems by Antisense Peptide Nucleic Acids as an Antibacterial Strategy by Równicki, Marcin, Pieńko, Tomasz, Czarnecki, Jakub, Kolanowska, Monika, Bartosik, Dariusz, Trylska, Joanna

“…The search for new, non-standard targets is currently a high priority in the design of new antibacterial compounds. Bacterial toxin-antitoxin systems (TAs) are…”
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Conformational Dynamics of Cyanocobalamin and Its Conjugates with Peptide Nucleic Acids by Pieńko, Tomasz, Wierzba, Aleksandra J, Wojciechowska, Monika, Gryko, Dorota, Trylska, Joanna

“…Vitamin B12 also called cobalamin (Cbl) is an important enzymatic cofactor taken up by mammalian and also by many bacterial cells. Peptide nucleic acid (PNA)…”
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Vitamin B12-peptide nucleic acids use the BtuB receptor to pass through the Escherichia coli outer membrane by Pieńko, Tomasz, Czarnecki, Jakub, Równicki, Marcin, Wojciechowska, Monika, Wierzba, Aleksandra J., Gryko, Dorota, Bartosik, Dariusz, Trylska, Joanna

“…Short modified oligonucleotides that bind in a sequence-specific way to messenger RNA essential for bacterial growth could be useful to fight bacterial…”
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Towards catalytic aminoglycoside: Probing the modification of kanamycin B at the 3′- and 4′-positions by Fung, Ka-Shu, Abragam Joseph, A., Khononov, Alina, Pieńko, Tomasz, Belakhov, Valery, Baasov, Timor

“…The chemistry of selective modification of kanamycin B at the 3′- and 4′-positions of ring I and the evaluation of the resulting derivatives in cell-free…”
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Towards Catalytic Antibiotics: Redesign of Aminoglycosides To Catalytically Disable Bacterial Ribosomes by Smolkin, Boris, Khononov, Alina, Pieńko, Tomasz, Shavit, Michal, Belakhov, Valery, Trylska, Joanna, Baasov, Timor

“…The emergence of multidrug‐resistant pathogens that are resistant to the majority of currently available antibiotics is a significant clinical problem. The…”
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Fullerene Derivatives of Nucleoside HIV Reverse Transcriptase Inhibitors-In Silico Activity Prediction by Dąbrowska, Aleksandra, Pieńko, Tomasz, Taciak, Przemysław, Wiktorska, Katarzyna, Chilmonczyk, Zdzisław, Mazurek, Aleksander P, Stasiulewicz, Adam

“…Here we present new derivatives of nucleoside reverse transcriptase inhibitors with a C fullerene. The computational chemistry methods used in this study…”
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Cytisine basicity, solvation, log P , and log D theoretical determination as tool for bioavailability prediction by Pieko, Tomasz, Grudzie, Monika, Taciak, Przemysaw Pawe, Mazurek, Aleksander Pawe

“…Cytisine, an alpha 4 beta 2 nicotinic receptor partial agonist, is a plant alkaloid widely used as a smoking cessation agent. Despite long history of use,…”
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Exploring eukaryotic versus prokaryotic ribosomal RNA recognition with aminoglycoside derivatives by Sabbavarapu, Narayana Murthy, Pieńko, Tomasz, Zalman, Bat-Hen, Trylska, Joanna, Baasov, Timor

“…New derivatives of aminoglycosides containing 6'-carboxylic acid or 6'-amide on their ring I were designed, synthesized and their ability to readthrough…”
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Adsorption of Antifungal Drugs Inside Pristine and Functionalized Fullerenes and Nanotubes: DFT Investigation by Pieńko, Tomasz, Grudzień, Monika, Taciak, Przemysław Paweł, Mazurek, Aleksander P

“…Econazole, sulconazole and tioconazole usage as antifungal agents is limited due to poor pharmacokinetic properties. Pristine and hydroxylated structures of…”
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Correction: Extracellular loops of BtuB facilitate transport of vitamin B12 through the outer membrane of E. coli by Pieńko, Tomasz, Trylska, Joanna

“…[This corrects the article DOI: 10.1371/journal.pcbi.1008024.]…”
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Transport of Vitamin B12 and its Conjugate with Peptide Nucleic Acid Through the E. Coli BtuB Outer Membrane Protein Explored with Steered Molecular Dynamics by Pieńko, Tomasz, Trylska, Joanna

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Cytisine basicity, solvation, logP, and logD theoretical determination as tool for bioavailability prediction by Pieńko, Tomasz, Grudzień, Monika, Taciak, Przemysław Paweł, Mazurek, Aleksander Paweł

“…[Display omitted] •Boltzmann populations of cytisine conformations in water were computed.•Theoretical pKa of cytisine is in accordance with experiment.•The…”
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Correction: Extracellular loops of BtuB facilitate transport of vitamin B.sub.12 through the outer membrane of E. coli by Pienko, Tomasz, Trylska, Joanna

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Exploring eukaryotic versus prokaryotic ribosomal RNA recognition with aminoglycoside derivatives† †Electronic supplementary information (ESI) available: Simulation methods, biochemical assays, synthetic procedures, and copies of NMR spectra (PDF). See DOI: 10.1039/c8md00001h by Sabbavarapu, Narayana Murthy, Pieńko, Tomasz, Zalman, Bat-Hen, Trylska, Joanna, Baasov, Timor

“…New aminoglycosides containing 6′-carboxylic acid or 6′-amide were designed, synthesized and their ability to readthrough nonsense mutations was examined. New…”
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Extracellular loops of BtuB facilitate transport of vitamin B.sub.12 through the outer membrane of E. coli by Pienko, Tomasz, Trylska, Joanna

“…Vitamin B.sub.12 (or cobalamin) is an enzymatic cofactor essential both for mammals and bacteria. However, cobalamin can be synthesized only by few…”
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