Search Results - "Pien, Gary C"

NATURAL KILLER CELLS IN ANTIVIRAL DEFENSE: Function and Regulation by Innate Cytokines by Biron, Christine A, Nguyen, Khuong B, Pien, Gary C, Cousens, Leslie P, Salazar-Mather, Thais P

“…Natural killer (NK) cells are populations of lymphocytes that can be activated to mediate significant levels of cytotoxic activity and produce high levels of…”
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AAV capsid CD8+ T-cell epitopes are highly conserved across AAV serotypes by Hui, Daniel J, Edmonson, Shyrie C, Podsakoff, Gregory M, Pien, Gary C, Ivanciu, Lacramioara, Camire, Rodney M, Ertl, Hildegund, Mingozzi, Federico, High, Katherine A, Basner-Tschakarjan, Etiena

“…Adeno-associated virus (AAV) has become one of the most promising vectors in gene transfer in the last 10 years with successful translation to clinical trials…”
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Evaluation and clinical interpretation of hypergammaglobulinemia E: differentiating atopy from immunodeficiency by Pien, Gary C., MD, PhD, Orange, Jordan S., MD, PhD

“…Increases in total serum IgE levels can be observed in many diverse conditions, from infection to atopy to primary immunodeficiency. The differentiation of…”
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Capsid antigen presentation flags human hepatocytes for destruction after transduction by adeno-associated viral vectors by Pien, Gary C, Basner-Tschakarjan, Etiena, Hui, Daniel J, Mentlik, Ashley N, Finn, Jonathan D, Hasbrouck, Nicole C, Zhou, Shangzhen, Murphy, Samuel L, Maus, Marcela V, Mingozzi, Federico, Orange, Jordan S, High, Katherine A

“…Adeno-associated virus (AAV) vectors are effective gene delivery vehicles mediating long-lasting transgene expression. Data from a clinical trial of…”
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Proteasome Inhibitors Decrease AAV2 Capsid derived Peptide Epitope Presentation on MHC Class I Following Transduction by Finn, Jonathan D, Hui, Daniel, Downey, Harre D, Dunn, Danielle, Pien, Gary C, Mingozzi, Federico, Zhou, Shangzhen, High, Katherine A

“…Adeno-associated viral (AAV) vectors are an extensively studied and highly used vector platform for gene therapy applications. We hypothesize that in the first…”
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neuronal chemokine CX3CL1/fractalkine selectively recruits NK cells that modify experimental autoimmune encephalomyelitis within the central nervous system by Huang, DeRen, Shi, Fu-Dong, Jung, Steffen, Pien, Gary C, Wang, Jintang, Salazar-Mather, Thais P, He, Toby T, Weaver, Jennifer T, Ljunggren, Hans-Gustaf, Biron, Christine A, Littman, Dan R, Ransohoff, Richard M

“…Leukocyte trafficking to the central nervous system (CNS), regulated in part by chemokines, determines severity of the demyelinating diseases multiple…”
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Critical Role for STAT4 Activation by Type 1 Interferons in the Interferon-γ Response to Viral Infection by Nguyen, Khuong B., Watford, Wendy T., Salomon, Rachelle, Hofmann, Sigrun R., Pien, Gary C., Morinobu, Akio, Gadina, Massimo, O'Shea, John J., Biron, Christine A.

“…Interferons (IFNs) are essential for host defense. Although the antiviral effects of the type 1 IFNs IFN-α and IFN-β (IFN-α/β) have been established, their…”
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Modulation of CD8+ T cell responses to AAV vectors with IgG-derived MHC class II epitopes by Hui, Daniel J, Basner-Tschakarjan, Etiena, Chen, Yifeng, Davidson, Robert J, Buchlis, George, Yazicioglu, Mustafa, Pien, Gary C, Finn, Jonathan D, Haurigot, Virginia, Tai, Alex, Scott, David W, Cousens, Leslie P, Zhou, Shangzhen, De Groot, Anne S, Mingozzi, Federico

“…Immune responses directed against viral capsid proteins constitute a main safety concern in the use of adeno-associated virus (AAV) as gene transfer vectors in…”
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Interferon α/β-mediated inhibition and promotion of interferon γ: STAT1 resolves a paradox by Biron, Christine A, Nguyen, Khuong B, Cousens, Leslie P, Doughty, Lesley A, Pien, Gary C, Durbin, Joan E

“…Induction of high systemic levels of type 1 interferons (IFNs) IFN-alpha and IFN-beta is a hallmark of many viral infections. In addition to their potent…”
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SAP controls T cell responses to virus and terminal differentiation of TH2 cells by Wu, C, Nguyen, K B, Pien, G C, Wang, N, Gullo, C, Howie, D, Sosa, M R, Edwards, M J, Borrow, P, Satoskar, A R, Sharpe, A H, Biron, C A, Terhorst, C

“…SH2D1A, which encodes signaling lymphocyte activation molecule (SLAM)-associated protein (SAP), is altered in patients with X-linked lymphoproliferative…”
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A Unique Mechanism for Innate Cytokine Promotion of T Cell Responses to Viral Infections by Pien, Gary C, Nguyen, Khuong B, Malmgaard, Lene, Satoskar, Abhay R, Biron, Christine A

“…The kinetics of CD8 T cell IFN-gamma responses as they occur in situ are defined here during lymphocytic choriomeningitis virus (LCMV) infections, and a unique…”
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Coordination of multidisciplinary resources for vaccination of egg-allergic individuals during an H1N1 (novel) influenza pandemic by Pien, Gary C, LeBenger, Kerry S, Carotenuto, Danielle R, Difilippi, Michele, Scolpino, Denise, Simmons, Jane M, Barrett, Cindy, Brenner, Robert W

“…Egg allergy is a contraindication for influenza vaccination because of the presence of trace egg protein. Although recent reports suggest that egg-allergic…”
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Compartmental Differences in NK Cell Responsiveness to IL-12 During Lymphocytic Choriomeningitis Virus Infection by Pien, Gary C, Biron, Christine A

“…Some, but not all, viral infections induce endogenous IL-12 to drive NK cell IFN-gamma production and downstream antiviral defenses during innate immune…”
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Atopic Dermatitis: An Evidence-Based Management Approach by Pien, Gary C, Spergel, Jonathan M

“…Atopic dermatitis (AD) is a chronic, relapsing inflammatory skin disorder that affects 10% to 30% of children and 1% to 3% of adults, and its incidence appears…”
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Modulation of CD8 super(+) T cell responses to AAV vectors with IgG-derived MHC class II epitopes by Hui, Daniel J, Basner-Tschakarjan, Etiena, Chen, Yifeng, Davidson, Robert J, Buchlis, George, Yazicioglu, Mustafa, Pien, Gary C, Finn, Jonathan D, Haurigot, Virginia, Tai, Alex, Scott, David W, Cousens, Leslie P, Zhou, Shangzhen, De Groot, Anne S, Mingozzi, Federico

“…Immune responses directed against viral capsid proteins constitute a main safety concern in the use of adeno-associated virus (AAV) as gene transfer vectors in…”
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Peptide-Induced Antigen-Specific CD4+CD25+FoxP3+ T Cells Suppress Cytotoxicity T Cell Responses Directed Against the AAV Capsid by Hui, Daniel J., Basner-Tschakarjan, Etiena, Pien, Gary C., Martin, William D., DeGroot, Annie S., High, Katherine A., Mingozzi, Federico

“…Abstract 3769 Recent advances in adeno-associated viral (AAV) vector-mediated gene transfer continue to offer hope for the correction of monogenic disorders…”
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Cutting edge: selective IL-18 requirements for induction of compartmental IFN-gamma responses during viral infection by Pien, G C, Satoskar, A R, Takeda, K, Akira, S, Biron, C A

“…Optimal protective effects for defense against infection require orchestration of immune responses spanning multiple host compartments and divergent local…”
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Suppression of CTL Responses against AAV-Capsid Epitopes by Peptide-Induced Regulatory T Cells by Hui, Daniel J, Pien, Gary C, Basner-Tschakarjan, Etiena, Mingozzi, Federico, Finn, Jonathan D, Zhou, Shangzhen, Martin, William, Groot, Anne S. De, High, Katherine A.

“…Abstract 377 Hemophilia B represents a promising model for the development of adeno-associated viral (AAV) vectors-based gene therapeutics. In the first…”
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Quantifying Capsid Peptide:MHC I Complexes Following Adeno-Associated Virus (AAV) Transduction by Pien, Gary C., Hasbrouck, Nicole C., Maus, Marcela V., Mingozzi, Federico, High, Katherine A.

“…Recent data from a clinical trial of adeno-associated virus (AAV) 2-mediated hepatic gene transfer of factor IX into hemophilia B subjects demonstrated the…”
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Critical role for STAT4 activation by type 1 interferons in the interferon-[gamma] response to viral infection by Nguyen, Khuong B, Watford, Wendy T, Salomon, Rachelle, Hofmann, Sigrun R, Pien, Gary C, Morinobu, Akio, Gadina, Massimo, O'Shea, John J, Biron, Christine A

“…Interferons (IFNs) are essential for host defense. Although the antiviral effects of the type 1 IFNs IFN-[alpha] and IFN-[beta] (IFN-[alpha]/[beta]) have been…”
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