Search Results - "Piemonti, Lorenzo"

Felix dies natalis, insulin… ceterum autem censeo “beta is better” by Piemonti, Lorenzo

“…One hundred years after its discovery, insulin remains the life-saving therapy for many patients with diabetes. It has been a 100-years-old success story…”
Get full text

Neutralizing antibody responses to SARS-CoV-2 in symptomatic COVID-19 is persistent and critical for survival by Dispinseri, Stefania, Secchi, Massimiliano, Pirillo, Maria Franca, Tolazzi, Monica, Borghi, Martina, Brigatti, Cristina, De Angelis, Maria Laura, Baratella, Marco, Bazzigaluppi, Elena, Venturi, Giulietta, Sironi, Francesca, Canitano, Andrea, Marzinotto, Ilaria, Tresoldi, Cristina, Ciceri, Fabio, Piemonti, Lorenzo, Negri, Donatella, Cara, Andrea, Lampasona, Vito, Scarlatti, Gabriella

“…Understanding how antibody responses to SARS-CoV-2 evolve during infection may provide important insight into therapeutic approaches and vaccination for…”
Get full text

Low-Carb and Ketogenic Diets in Type 1 and Type 2 Diabetes by Bolla, Andrea Mario, Caretto, Amelia, Laurenzi, Andrea, Scavini, Marina, Piemonti, Lorenzo

“…Low-carb and ketogenic diets are popular among clinicians and patients, but the appropriateness of reducing carbohydrates intake in obese patients and in…”
Get full text

Targeting GLP-1 receptor trafficking to improve agonist efficacy by Jones, Ben, Buenaventura, Teresa, Kanda, Nisha, Chabosseau, Pauline, Owen, Bryn M., Scott, Rebecca, Goldin, Robert, Angkathunyakul, Napat, Corrêa Jr, Ivan R., Bosco, Domenico, Johnson, Paul R., Piemonti, Lorenzo, Marchetti, Piero, Shapiro, A. M. James, Cochran, Blake J., Hanyaloglu, Aylin C., Inoue, Asuka, Tan, Tricia, Rutter, Guy A., Tomas, Alejandra, Bloom, Stephen R.

“…Glucagon-like peptide-1 receptor (GLP-1R) activation promotes insulin secretion from pancreatic beta cells, causes weight loss, and is an important…”
Get full text

Molecular mechanisms of perineural invasion, a forgotten pathway of dissemination and metastasis by Marchesi, Federica, Piemonti, Lorenzo, Mantovani, Alberto, Allavena, Paola

“…Abstract Invasion and metastasis are key components of cancer progression. Inflammatory mediators, including cytokines and chemokines, can facilitate tumor…”
Get full text

Cautious Optimism Warranted for Stem Cell-Derived Islet Transplantation in Type 2 Diabetes by Scholz, Hanne, Sordi, Valeria, Piemonti, Lorenzo

Get full text

Beta Cell Hubs Dictate Pancreatic Islet Responses to Glucose by Johnston, Natalie R., Mitchell, Ryan K., Haythorne, Elizabeth, Pessoa, Maria Paiva, Semplici, Francesca, Ferrer, Jorge, Piemonti, Lorenzo, Marchetti, Piero, Bugliani, Marco, Bosco, Domenico, Berishvili, Ekaterine, Duncanson, Philip, Watkinson, Michael, Broichhagen, Johannes, Trauner, Dirk, Rutter, Guy A., Hodson, David J.

“…The arrangement of β cells within islets of Langerhans is critical for insulin release through the generation of rhythmic activity. A privileged role for…”
Get full text

Alternative Transplantation Sites for Pancreatic Islet Grafts by Cantarelli, Elisa, Piemonti, Lorenzo

“…The liver is the current site of choice for pancreatic islet transplantation, even though it is far from being an ideal site because of immunologic, anatomic,…”
Get full text

Pig Xenotransplantation in Beta Cell Replacement: Addressing Challenges and Harnessing Potential for Type 1 Diabetes Therapy by Piemonti, Lorenzo, Citro, Antonio, Tomajer, Valentina, Partelli, Stefano, Caldara, Rossana

“…This opinion paper evaluates the potential of porcine islets as a promising alternative in beta cell replacement therapy for Type 1 Diabetes (T1D), juxtaposed…”
Get full text

Antibody response to multiple antigens of SARS-CoV-2 in patients with diabetes: an observational cohort study by Lampasona, Vito, Secchi, Massimiliano, Scavini, Marina, Bazzigaluppi, Elena, Brigatti, Cristina, Marzinotto, Ilaria, Davalli, Alberto, Caretto, Amelia, Laurenzi, Andrea, Martinenghi, Sabina, Molinari, Chiara, Vitali, Giordano, Di Filippo, Luigi, Mercalli, Alessia, Melzi, Raffaella, Tresoldi, Cristina, Rovere-Querini, Patrizia, Landoni, Giovanni, Ciceri, Fabio, Bosi, Emanuele, Piemonti, Lorenzo

“…Aims/hypothesis The aim of the study was to characterise the humoral response against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in patients…”
Get full text

Pharmacological Targeting of GLUT1 to Control Autoreactive T Cell Responses by Di Dedda, Carla, Vignali, Debora, Piemonti, Lorenzo, Monti, Paolo

“…An increasing body of evidence indicates that bio-energetic metabolism of T cells can be manipulated to control T cell responses. This potentially finds a…”
Get full text

Innate Immunity Mediated Inflammation and Beta Cell Function: Neighbors or Enemies? by Citro, Antonio, Campo, Francesco, Dugnani, Erica, Piemonti, Lorenzo

“…Type 1 diabetes (T1D) is still considered a huge burden because the available treatments are not effective in preventing the onset or progression of the…”
Get full text

Robust Neutralizing Antibodies to SARS-CoV-2 Develop and Persist in Subjects with Diabetes and COVID-19 Pneumonia by Dispinseri, Stefania, Lampasona, Vito, Secchi, Massimiliano, Cara, Andrea, Bazzigaluppi, Elena, Negri, Donatella, Brigatti, Cristina, Pirillo, Maria Franca, Marzinotto, Ilaria, Borghi, Martina, Rovere-Querini, Patrizia, Tresoldi, Cristina, Ciceri, Fabio, Scavini, Marina, Scarlatti, Gabriella, Piemonti, Lorenzo

“…Abstract Context Demonstrating the ability to mount a neutralizing antibody response to SARS-CoV-2 in the presence of diabetes is crucial to understand…”
Get full text

Pancreatic Endocrine Tumors: Expression Profiling Evidences a Role for AKT-mTOR Pathway by MISSIAGLIA, Edoardo, DALAI, Irene, PEDERZOLI, Paolo, CROCE, Carlo M, SCARPA, Aldo, BARBI, Stefano, BEGHELLI, Stefania, FALCONI, Massimo, DELLA PERUTA, Marco, PIEMONTI, Lorenzo, CAPURSO, Gabriele, DI FLORIO, Alessia, DELLE FAVE, Gianfranco

“…We investigated the global gene expression in a large panel of pancreatic endocrine tumors (PETs) aimed at identifying new potential targets for therapy and…”
Get full text

A/H1N1 hemagglutinin antibodies show comparable affinity in vaccine-related Narcolepsy type 1 and control and are unlikely to contribute to pathogenesis by Lind, Alexander, Marzinotto, Ilaria, Brigatti, Cristina, Ramelius, Anita, Piemonti, Lorenzo, Lampasona, Vito

“…An increased incidence of narcolepsy type 1 (NT1) was observed in Scandinavia following the 2009–2010 influenza Pandemrix vaccination. The association between…”
Get full text

The effect of reparixin on survival in patients at high risk for in-hospital mortality: a meta-analysis of randomized trials by Landoni, Giovanni, Zangrillo, Alberto, Piersanti, Gioia, Scquizzato, Tommaso, Piemonti, Lorenzo

“…A great number of anti-inflammatory drugs have been suggested in the treatment of SARS-CoV-2 infection. Reparixin, a non-competitive allosteric inhibitor of…”
Get full text

Biofabrication of a vascularized islet organ for type 1 diabetes by Citro, Antonio, Moser, Philipp T., Dugnani, Erica, Rajab, Taufiek K., Ren, Xi, Evangelista-Leite, Daniele, Charest, Jonathan M., Peloso, Andrea, Podesser, Bruno K., Manenti, Fabio, Pellegrini, Silvia, Piemonti, Lorenzo, Ott, Harald C.

“…Islet transplantation is superior to extrinsic insulin supplementation in the treating severe Type 1 diabetes. However, its efficiency and longevity are…”
Get full text

Identification of Tetraspanin-7 as a Target of Autoantibodies in Type 1 Diabetes by McLaughlin, Kerry A, Richardson, Carolyn C, Ravishankar, Aarthi, Brigatti, Cristina, Liberati, Daniela, Lampasona, Vito, Piemonti, Lorenzo, Morgan, Diana, Feltbower, Richard G, Christie, Michael R

“…The presence of autoantibodies to multiple-islet autoantigens confers high risk for the development of type 1 diabetes. Four major autoantigens are established…”
Get full text

CCL2/MCP‐1 and CXCL12/SDF‐1 blockade by L‐aptamers improve pancreatic islet engraftment and survival in mouse by Citro, Antonio, Pellegrini, Silvia, Dugnani, Erica, Eulberg, Dirk, Klussmann, Sven, Piemonti, Lorenzo

“…The blockade of pro‐inflammatory mediators is a successful approach to improve the engraftment after islet transplantation. L‐aptamers are chemically…”
Get full text

Circulating CXCL10 and IL-6 in solid organ donors after brain death predict graft outcomes by Piemonti, Lorenzo, Sordi, Valeria, Pellegrini, Silvia, Scotti, Giulia Maria, Scavini, Marina, Sioli, Viviana, Gianelli Castiglione, Andrea, Cardillo, Massimo

“…We tested the hypothesis that circulating CXCL10 and IL-6 in donor after brain death provide independent additional predictors of graft outcome. From January…”
Get full text