Search Results - "Piekorz, Roland P."

Impact of the 3D microenvironment on phenotype, gene expression, and EGFR inhibition of colorectal cancer cell lines by Luca, Anna C, Mersch, Sabrina, Deenen, René, Schmidt, Stephan, Messner, Isabelle, Schäfer, Karl-Ludwig, Baldus, Stephan E, Huckenbeck, Wolfgang, Piekorz, Roland P, Knoefel, Wolfram T, Krieg, Andreas, Stoecklein, Nikolas H

“…Three-dimensional (3D) tumor cell cultures grown in laminin-rich-extracellular matrix (lrECM) are considered to reflect human tumors more realistic as compared…”
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IL‐6 Trans‐signaling Controls Liver Regeneration After Partial Hepatectomy by Fazel Modares, Nastaran, Polz, Robin, Haghighi, Fereshteh, Lamertz, Larissa, Behnke, Kristina, Zhuang, Yuan, Kordes, Claus, Häussinger, Dieter, Sorg, Ursula R., Pfeffer, Klaus, Floss, Doreen M., Moll, Jens M., Piekorz, Roland P., Ahmadian, M. Reza, Lang, Philipp A., Scheller, Jürgen

“…Interleukin‐6 (IL‐6) is critically involved in liver regeneration after partial hepatectomy (PHX). Previous reports suggest that IL‐6 trans‐signaling through…”
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Novel FMRP interaction networks linked to cellular stress by Taha, Mohamed S., Haghighi, Fereshteh, Stefanski, Anja, Nakhaei‐Rad, Saeideh, Kazemein Jasemi, Neda S., Al Kabbani, Mohamed Aghyad, Görg, Boris, Fujii, Masahiro, Lang, Phillip A., Häussinger, Dieter, Piekorz, Roland P., Stühler, Kai, Ahmadian, Mohammad R.

“…Silencing of the fragile X mental retardation 1 (FMR1) gene and consequently lack of synthesis of FMR protein (FMRP) are associated with fragile X syndrome,…”
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Rho-kinase: regulation, (dys)function, and inhibition by Amin, Ehsan, Dubey, Badri Nath, Zhang, Si-Cai, Gremer, Lothar, Dvorsky, Radovan, Moll, Jens M, Taha, Mohamed S, Nagel-Steger, Luitgard, Piekorz, Roland P, Somlyo, Avril V, Ahmadian, Mohammad R

“…In a variety of normal and pathological cell types, Rho-kinases I and II (ROCKI/II) play a pivotal role in the organization of the nonmuscle and smooth muscle…”
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Ammonia inhibits energy metabolism in astrocytes in a rapid and glutamate dehydrogenase 2-dependent manner by Drews, Leonie, Zimmermann, Marcel, Westhoff, Philipp, Brilhaus, Dominik, Poss, Rebecca E, Bergmann, Laura, Wiek, Constanze, Brenneisen, Peter, Piekorz, Roland P, Mettler-Altmann, Tabea, Weber, Andreas P M, Reichert, Andreas S

“…Astrocyte dysfunction is a primary factor in hepatic encephalopathy (HE) impairing neuronal activity under hyperammonemia. In particular, the early events…”
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Combined inhibition of class 1-PI3K-alpha and delta isoforms causes senolysis by inducing p21WAF1/CIP1 proteasomal degradation in senescent cells by Neuwahl, Judith, Neumann, Chantal A., Fitz, Annika C., Biermann, Anica D., Magel, Maja, Friedrich, Annabelle, Sellin, Lorenz, Stork, Björn, Piekorz, Roland P., Proksch, Peter, Budach, Wilfried, Jänicke, Reiner U., Sohn, Dennis

“…The targeted elimination of radio- or chemotherapy-induced senescent cells by so-called senolytic substances represents a promising approach to reduce tumor…”
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Subcellular fractionation and localization studies reveal a direct interaction of the fragile X mental retardation protein (FMRP) with nucleolin by Taha, Mohamed S, Nouri, Kazem, Milroy, Lech G, Moll, Jens M, Herrmann, Christian, Brunsveld, Luc, Piekorz, Roland P, Ahmadian, Mohammad R

“…Fragile X mental Retardation Protein (FMRP) is a well-known regulator of local translation of its mRNA targets in neurons. However, despite its ubiquitous…”
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bFGF-mediated pluripotency maintenance in human induced pluripotent stem cells is associated with NRAS-MAPK signaling by Haghighi, Fereshteh, Dahlmann, Julia, Nakhaei-Rad, Saeideh, Lang, Alexander, Kutschka, Ingo, Zenker, Martin, Kensah, George, Piekorz, Roland P, Ahmadian, Mohammad Reza

“…Human pluripotent stem cells (PSCs) open new windows for basic research and regenerative medicine due to their remarkable properties, i.e. their ability to…”
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Platelet Gᵢ protein Gαᵢ₂ is an essential mediator of thrombo-inflammatory organ damage in mice by Devanathan, Vasudharani, Hagedorn, Ina, Köhler, David, Pexa, Katja, Cherpokova, Deya, Kraft, Peter, Singh, Madhurendra, Rosenberger, Peter, Stoll, Guido, Birnbaumer, Lutz, Piekorz, Roland P, Beer-Hammer, Sandra, Nieswandt, Bernhard, Nürnberg, Bernd

“…Platelets are crucial for hemostasis and thrombosis and exacerbate tissue injury following ischemia and reperfusion. Important regulators of platelet function…”
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Gαi Proteins are Indispensable for Hearing by Beer-Hammer, Sandra, Lee, Sze Chim, Mauriac, Stephanie A., Leiss, Veronika, Groh, Isabel A. M., Novakovic, Ana, Piekorz, Roland P., Bucher, Kirsten, Chen, Chengfang, Ni, Kun, Singer, Wibke, Harasztosi, Csaba, Schimmang, Thomas, Zimmermann, Ulrike, Pfeffer, Klaus, Birnbaumer, Lutz, Forge, Andrew, Montcouquiol, Mireille, Knipper, Marlies, Nürnberg, Bernd, Rüttiger, Lukas

“…Background/Aims: From invertebrates to mammals, Gα i proteins act together with their common binding partner Gpsm2 to govern cell polarization and planar…”
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The Role of Embryonic Stem Cell-expressed RAS (ERAS) in the Maintenance of Quiescent Hepatic Stellate Cells by Nakhaei-Rad, Saeideh, Nakhaeizadeh, Hossein, Götze, Silke, Kordes, Claus, Sawitza, Iris, Hoffmann, Michèle J, Franke, Manuel, Schulz, Wolfgang A., Scheller, Jürgen, Piekorz, Roland P., Häussinger, Dieter, Ahmadian, Mohammad R.

“…Hepatic stellate cells (HSCs) were recently identified as liver-resident mesenchymal stem cells. HSCs are activated after liver injury and involved in pivotal…”
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CoCl2‐triggered pseudohypoxic stress induces proteasomal degradation of SIRT4 via polyubiquitination of lysines K78 and K299 by Hampel, Nils, Georgy, Jacqueline, Mehrabipour, Mehrnaz, Lang, Alexander, Lehmkuhl, Isabell, Scheller, Jürgen, Ahmadian, Mohammad R., Floss, Doreen M., Piekorz, Roland P.

“…SIRT4, together with SIRT3 and SIRT5, comprises the mitochondrially localized subgroup of sirtuins. SIRT4 regulates mitochondrial bioenergetics, dynamics…”
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New model for gastroenteropancreatic large-cell neuroendocrine carcinoma: establishment of two clinically relevant cell lines by Krieg, Andreas, Mersch, Sabrina, Boeck, Inga, Dizdar, Levent, Weihe, Eberhard, Hilal, Zena, Krausch, Markus, Möhlendick, Birte, Topp, Stefan A, Piekorz, Roland P, Huckenbeck, Wolfgang, Stoecklein, Nikolas H, Anlauf, Martin, Knoefel, Wolfram T

“…Recently, a novel WHO-classification has been introduced that divided gastroenteropancreatic neuroendocrine neoplasms (GEP-NEN) according to their…”
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The Centrosomal Adaptor TACC3 and the Microtubule Polymerase chTOG Interact via Defined C-terminal Subdomains in an Aurora-A Kinase-independent Manner by Thakur, Harish C., Singh, Madhurendra, Nagel-Steger, Luitgard, Kremer, Jana, Prumbaum, Daniel, Fansa, Eyad Kalawy, Ezzahoini, Hakima, Nouri, Kazem, Gremer, Lothar, Abts, André, Schmitt, Lutz, Raunser, Stefan, Ahmadian, Mohammad R., Piekorz, Roland P.

“…The cancer-associated, centrosomal adaptor protein TACC3 (transforming acidic coiled-coil 3) and its direct effector, the microtubule polymerase chTOG (colonic…”
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Data on common carotid artery occlusion inducing focalized stroke lesions after Pertussis toxin injection by Leiss, Veronika, Piekorz, Roland P., Vega, Salvador Castaneda, Jacoby, Christoph, Flögel, Ulrich, Pexa, Katja, Schrader, Jürgen, Pichler, Bernd J., Beer-Hammer, Sandra, Nürnberg, Bernd

“…This article contains raw and processed data related to research published by Vega et al. (2022). This complementary dataset provides further insight into the…”
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Novel role of the SIRT4-OPA1 axis in mitochondrial quality control by Lang, Alexander, Piekorz, Roland P

“…Mammalian sirtuins are fundamental regulators of a plethora of cellular functions, including gene expression, proliferation, metabolism, and ultimatively…”
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p110γ/δ Double-Deficiency Induces Eosinophilia and IgE Production but Protects from OVA-Induced Airway Inflammation by Mothes, Benedikt, Bucher, Kirsten, Ammon-Treiber, Susanne, Schwab, Matthias, Piekorz, Roland P, Hirsch, Emilio, Nürnberg, Bernd, Beer-Hammer, Sandra

“…The catalytical isoforms p110γ and p110δ of phosphatidylinositide 3-kinase γ (PI3Kγ) and PI3Kδ play an important role in the pathogenesis of asthma. Two key…”
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Subcellular Localization and Mitotic Interactome Analyses Identify SIRT4 as a Centrosomally Localized and Microtubule Associated Protein by Bergmann, Laura, Lang, Alexander, Bross, Christoph, Altinoluk-Hambüchen, Simone, Fey, Iris, Overbeck, Nina, Stefanski, Anja, Wiek, Constanze, Kefalas, Andreas, Verhülsdonk, Patrick, Mielke, Christian, Sohn, Dennis, Stühler, Kai, Hanenberg, Helmut, Jänicke, Reiner U, Scheller, Jürgen, Reichert, Andreas S, Ahmadian, Mohammad Reza, Piekorz, Roland P

“…The stress-inducible and senescence-associated tumor suppressor SIRT4, a member of the family of mitochondrial sirtuins (SIRT3, SIRT4, and SIRT5), regulates…”
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PI3Kδ is essential for tumor clearance mediated by cytotoxic T lymphocytes by Putz, Eva Maria, Prchal-Murphy, Michaela, Simma, Olivia Annabella, Forster, Florian, Koenig, Xaver, Stockinger, Hannes, Piekorz, Roland P, Freissmuth, Michael, Müller, Mathias, Sexl, Veronika, Zebedin-Brandl, Eva

“…PI3Kδ is a lipid kinase of the phosphoinositide 3-kinase class 1A family and involved in early signaling events of leukocytes regulating proliferation,…”
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obligatory requirement for the heterotrimeric G protein Gi₃ in the antiautophagic action of insulin in the liver by Gohla, Antje, Klement, Karinna, Piekorz, Roland P, Pexa, Katja, vom Dahl, Stephan, Spicher, Karsten, Dreval, Vladyslav, Häussinger, Dieter, Birnbaumer, Lutz, Nrnberg, Bernd

“…Heterotrimeric G proteins of the Gi class have been implicated in signaling pathways regulating growth and metabolism under physiological and…”
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