Search Results - "Pidot, Sacha"

Genome mining for ribosomally synthesized and post-translationally modified peptides (RiPPs) in anaerobic bacteria by Letzel, Anne-Catrin, Pidot, Sacha J, Hertweck, Christian

“…Ribosomally synthesized and post-translationally modified peptides (RiPPs) are a diverse group of biologically active bacterial molecules. Due to the conserved…”
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Genomics‐Driven Discovery of NO‐Donating Diazeniumdiolate Siderophores in Diverse Plant‐Associated Bacteria by Hermenau, Ron, Mehl, Jule L., Ishida, Keishi, Dose, Benjamin, Pidot, Sacha J., Stinear, Timothy P., Hertweck, Christian

“…Siderophores are key players in bacteria–host interactions, with the main function to provide soluble iron for their producers. Gramibactin from rhizosphere…”
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Antibiotics from neglected bacterial sources by Pidot, Sacha J, Coyne, Sébastien, Kloss, Florian, Hertweck, Christian

“…Abstract The current crop of antibiotics in clinical use are either natural products or their derivatives. However, the rise of a multitude of different…”
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Bacterial endosymbionts protect beneficial soil fungus from nematode attack by Büttner, Hannah, Niehs, Sarah P., Vandelannoote, Koen, Cseresnyés, Zoltán, Dose, Benjamin, Richter, Ingrid, Gerst, Ruman, Figge, Marc Thilo, Stinear, Timothy P., Pidot, Sacha J., Hertweck, Christian

“…Fungi of the genus Mortierella occur ubiquitously in soils where they play pivotal roles in carbon cycling, xenobiont degradation, and promoting plant growth…”
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Endofungal bacteria boost anthelminthic host protection with the biosurfactant symbiosin by Büttner, Hannah, Pidot, Sacha J, Scherlach, Kirstin, Hertweck, Christian

“…Effective protection of soil fungi from predators is crucial for their survival in the niche. Thus, fungi have developed efficient defence strategies. We…”
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Predicting nitroimidazole antibiotic resistance mutations in Mycobacterium tuberculosis with protein engineering by Lee, Brendon M, Harold, Liam K, Almeida, Deepak V, Afriat-Jurnou, Livnat, Aung, Htin Lin, Forde, Brian M, Hards, Kiel, Pidot, Sacha J, Ahmed, F Hafna, Mohamed, A Elaaf, Taylor, Matthew C, West, Nicholas P, Stinear, Timothy P, Greening, Chris, Beatson, Scott A, Nuermberger, Eric L, Cook, Gregory M, Jackson, Colin J

“…Our inability to predict which mutations could result in antibiotic resistance has made it difficult to rapidly identify the emergence of resistance, identify…”
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The Nargenicin Family of Oxa‐Bridged Macrolide Antibiotics by Pidot, Sacha J., Rizzacasa, Mark A.

“…The nargenicin family of antibiotic macrolides comprise a group of bacterial natural products with a rare ether bridged cis‐decalin moiety and a narrow…”
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In vitro activity of SPR719 against Mycobacterium ulcerans, Mycobacterium marinum and Mycobacterium chimaera by Pidot, Sacha J, Porter, Jessica L, Lister, Troy, Stinear, Timothy P

“…Nontuberculosis mycobacterial (NTM) infections are increasing in prevalence across the world. In many cases, treatment options for these infections are…”
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Mycobacterium ulcerans low infectious dose and mechanical transmission support insect bites and puncturing injuries in the spread of Buruli ulcer by Wallace, John R, Mangas, Kirstie M, Porter, Jessica L, Marcsisin, Renee, Pidot, Sacha J, Howden, Brian, Omansen, Till F, Zeng, Weiguang, Axford, Jason K, Johnson, Paul D R, Stinear, Timothy P

“…Addressing the transmission enigma of the neglected disease Buruli ulcer (BU) is a World Health Organization priority. In Australia, we have observed an…”
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Discovery of Clostrubin, an Exceptional Polyphenolic Polyketide Antibiotic from a Strictly Anaerobic Bacterium by Pidot, Sacha, Ishida, Keishi, Cyrulies, Michael, Hertweck, Christian

“…Genome mining of the strictly anaerobic bacterium Clostridium beijerinckii, an industrial producer of solvents, revealed the presence of several cryptic gene…”
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Natural product discovery through microbial genome mining by Kenshole, Emma, Herisse, Marion, Michael, Michael, Pidot, Sacha J.

“…The advent of the genomic era has opened up enormous possibilities for the discovery of new natural products. Also known as specialized metabolites, these…”
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Marine sponge microbe provides insights into evolution and virulence of the tubercle bacillus by Pidot, Sacha J, Klatt, Stephan, Ates, Louis S, Frigui, Wafa, Sayes, Fadel, Majlessi, Laleh, Izumi, Hiroshi, Monk, Ian R, Porter, Jessica L, Bennett-Wood, Vicki, Seemann, Torsten, Otter, Ashley, Taiaroa, George, Cook, Gregory M, West, Nicholas, Tobias, Nicholas J, Fuerst, John A, Stutz, Michael D, Pellegrini, Marc, McConville, Malcolm, Brosch, Roland, Stinear, Timothy P

“…Reconstructing the evolutionary origins of Mycobacterium tuberculosis, the causative agent of human tuberculosis, has helped identify bacterial factors that…”
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Bacterial membrane vesicles transport their DNA cargo into host cells by Bitto, Natalie J., Chapman, Ross, Pidot, Sacha, Costin, Adam, Lo, Camden, Choi, Jasmine, D’Cruze, Tanya, Reynolds, Eric C., Dashper, Stuart G., Turnbull, Lynne, Whitchurch, Cynthia B., Stinear, Timothy P., Stacey, Katryn J., Ferrero, Richard L.

“…Bacterial outer membrane vesicles (OMVs) are extracellular sacs containing biologically active products, such as proteins, cell wall components and toxins…”
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Genomic exploration of coral-associated bacteria: identifying probiotic candidates to increase coral bleaching resilience in Galaxea fascicularis by Doering, Talisa, Tandon, Kshitij, Topa, Sanjida H., Pidot, Sacha J., Blackall, Linda L., van Oppen, Madeleine J. H.

“…Abstract Background Reef-building corals are acutely threatened by ocean warming, calling for active interventions to reduce coral bleaching and mortality…”
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Global analysis of biosynthetic gene clusters reveals conserved and unique natural products in entomopathogenic nematode-symbiotic bacteria by Shi, Yi-Ming, Hirschmann, Merle, Shi, Yan-Ni, Ahmed, Shabbir, Abebew, Desalegne, Tobias, Nicholas J., Grün, Peter, Crames, Jan J., Pöschel, Laura, Kuttenlochner, Wolfgang, Richter, Christian, Herrmann, Jennifer, Müller, Rolf, Thanwisai, Aunchalee, Pidot, Sacha J., Stinear, Timothy P., Groll, Michael, Kim, Yonggyun, Bode, Helge B.

“…Microorganisms contribute to the biology and physiology of eukaryotic hosts and affect other organisms through natural products. Xenorhabdus and Photorhabdus (…”
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A genomic approach to the cryptic secondary metabolome of the anaerobic world by Letzel, Anne-Catrin, Pidot, Sacha J, Hertweck, Christian

“…A total of 211 complete and published genomes from anaerobic bacteria are analysed for the presence of secondary metabolite biosynthesis gene clusters, in…”
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Plant pathogenic anaerobic bacteria use aromatic polyketides to access aerobic territory by Shabuer, Gulimila, Ishida, Keishi, Pidot, Sacha J., Roth, Martin, Dahse, Hans-Martin, Hertweck, Christian

“…Around 25% of vegetable food is lost worldwide because of infectious plant diseases, including microbe-induced decay of harvested crops. In wet seasons and…”
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Mining Symbionts of a Spider‐Transmitted Fungus Illuminates Uncharted Biosynthetic Pathways to Cytotoxic Benzolactones by Niehs, Sarah P., Dose, Benjamin, Richter, Sophie, Pidot, Sacha J., Dahse, Hans‐Martin, Stinear, Timothy P., Hertweck, Christian

“…A spider‐transmitted fungus (Rhizopus microsporus) that was isolated from necrotic human tissue was found to harbor endofungal bacteria (Burkholderia sp.)…”
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Frontispiece: The Nargenicin Family of Oxa‐Bridged Macrolide Antibiotics by Pidot, Sacha J., Rizzacasa, Mark A.

“…The history of the nargenicin family, including synthetic approaches as well as investigations on the structure–activity relationships among them, is reviewed…”
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Analysis of Rhizonin Biosynthesis Reveals Origin of Pharmacophoric Furylalanine Moieties in Diverse Cyclopeptides by Ehinger, Friedrich J., Niehs, Sarah P., Dose, Benjamin, Dell, Maria, Krabbe, Jana, Pidot, Sacha J., Stinear, Timothy P., Scherlach, Kirstin, Ross, Claudia, Lackner, Gerald, Hertweck, Christian

“…Abstract Rhizonin A and B are hepatotoxic cyclopeptides produced by bacterial endosymbionts ( Mycetohabitans endofungorum ) of the fungus Rhizopus microsporus…”
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