Search Results - "Piddlesden, Sara J"

Pilot phase III immunotherapy study in early-stage breast cancer patients using oxidized mannan-MUC1 [ISRCTN71711835] by Apostolopoulos, Vasso, Pietersz, Geoffrey A, Tsibanis, Anastasios, Tsikkinis, Annivas, Drakaki, Heleni, Loveland, Bruce E, Piddlesden, Sara J, Plebanski, Magdalena, Pouniotis, Dodie S, Alexis, Michael N, McKenzie, Ian F, Vassilaros, Stamatis

“…Mucin 1 (MUC1) is a high molecular weight glycoprotein overexpressed on adenocarcinoma cells and is a target for immunotherapy protocols. To date, clinical…”
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Epitope specificity of demyelinating monoclonal autoantibodies directed against the human myelin oligodendrocyte glycoprotein (MOG) by Brehm, Uschi, Piddlesden, Sara J, Gardinier, Minnetta V, Linington, Christopher

“…We describe the epitope specificity of a panel of ten demyelinating monoclonal antibodies (mAb) that recognise the extracellular immunoglobulin-like domain of…”
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Pathological and regulatory effects of anti-myelin antibodies in experimental allergic encephalomyelitis in mice by Morris-Downes, Margaret M, Smith, Paul A, Rundle, Jon L, Piddlesden, Sara J, Baker, David, Pham-Dinh, Danielle, Heijmans, Nicole, Amor, Sandra

“…Neurological deficit in experimental allergic encephalomyelitis (EAE) and multiple sclerosis (MS) is probably a consequence of synergy between T and B cell…”
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The effects of functional suppression of a membrane-bound complement regulatory protein, CD59, in the synovial tissue in rats by Mizuno, M, Nishikawa, K, Goodfellow, R M, Piddlesden, S J, Morgan, B P, Matsuo, S

“…To investigate the roles of CD59 in the synovial tissue by functional suppression of CD59. Rats treated with cobra venom factor to deplete complement or…”
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Soluble complement receptor 1 (sCR1) protects against experimental autoimmune myasthenia gravis by Piddlesden, Sara J., Jiang, Shisong, Levin, James L., Vincent, Angela, Morgan, B.Paul

“…The loss of muscle function seen in myasthenia gravis and in the animal model of the disease, experimental autoimmune myasthenia gravis (EAMG) is in part due…”
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Tubulointerstitial injury induced in rats by a monoclonal antibody that inhibits function of a membrane inhibitor of complement by Nomura, A, Nishikawa, K, Yuzawa, Y, Okada, H, Okada, N, Morgan, B P, Piddlesden, S J, Nadai, M, Hasegawa, T, Matsuo, S

“…The kidney widely expresses membrane-associated complement regulatory proteins (membrane inhibitors of complement). The aim of this work was to evaluate the…”
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Demyelinating Antibodies to Myelin Oligodendrocyte Glycoprotein and Galactocerebroside Induce Degradation of Myelin Basic Protein in Isolated Human Myelin by Menon, Krishna Kumar, Piddlesden, Sara J., Bernard, Claude C. A.

“…: Although the specificity of multiple sclerosis (MS) brain immunoglobulins (lgs) remains unknown, the incubation of these lgs with human myelin can lead to…”
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Killing of rat glial cells by complement: deficiency of the rat analogue of CD59 is the cause of oligodendrocyte susceptibility to lysis by Piddlesden, S J, Morgan, B P

“…In an effort to understand the mechanisms of complement-mediated injury of the myelin/oligodendrocyte complex in demyelinating disease, we have examined the…”
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Role of CD59 in experimental glomerulonephritis in rats by Matsuo, Seiichi, Nishikage, Hirofumi, Yoshida, Futoshi, Nomura, Atsushi, Piddlesden, Sara J., Morgan, B. Paul

“…Role of CD59 in experimental glomerulonephritis in rats. CD59 is a molecule which is present on the host cell membranes and inhibits formation of membrane…”
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The role of complement in disorders of the nervous system by Paul Morgan, B., Gasque, Philippe, Singhrao, Sim, Piddlesden, Sara J.

“…The complement (C) system plays important roles in host defense but activation at inappropriate sites or to an excessive degree can cause host tissue damage. C…”
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CD59 homologue regulates complement-dependent cytolysis of rat Schwann cells by Sawant-Mane, Suneeti, Piddlesden, Sara J., Morgan, B.Paul, Holers, V.Michael, Lee Koski, Carol

“…Antibody (Ab) sensitized sciatic nerve Schwann cells (SchC) of 2-day-old rats (SchC/2d) were significantly more susceptible to cytolysis by both heterologous,…”
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Role of complement in inflammation and injury in the nervous system by Morgan, B P, Gasque, P, Singhrao, S K, Piddlesden, S J

“…The complement (C) system plays important roles in host defence but activation at inappropriate sites or to an excessive degree can cause host tissue damage. C…”
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