Search Results - "Pickworth, Josephine"

Altered Macrophage Polarization Induces Experimental Pulmonary Hypertension and Is Observed in Patients With Pulmonary Arterial Hypertension by Zawia, Amira, Arnold, Nadine D., West, Laura, Pickworth, Josephine A., Turton, Helena, Iremonger, James, Braithwaite, Adam T., Cañedo, Jaime, Johnston, Simon A., Thompson, A.A. Roger, Miller, Gaynor, Lawrie, Allan

“…OBJECTIVE:To determine whether global reduction of CD68 macrophages impacts the development of experimental pulmonary arterial hypertension (PAH) and whether…”
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MicroRNA-140-5p and SMURF1 regulate pulmonary arterial hypertension by Rothman, Alexander M K, Arnold, Nadine D, Pickworth, Josephine A, Iremonger, James, Ciuclan, Loredana, Allen, Robert M H, Guth-Gundel, Sabine, Southwood, Mark, Morrell, Nicholas W, Thomas, Matthew, Francis, Sheila E, Rowlands, David J, Lawrie, Allan

“…Loss of the growth-suppressive effects of bone morphogenetic protein (BMP) signaling has been demonstrated to promote pulmonary arterial endothelial cell…”
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A diagnostic miRNA signature for pulmonary arterial hypertension using a consensus machine learning approach by Errington, Niamh, Iremonger, James, Pickworth, Josephine A., Kariotis, Sokratis, Rhodes, Christopher J., Rothman, Alexander MK, Condliffe, Robin, Elliot, Charles A., Kiely, David G., Howard, Luke S., Wharton, John, Thompson, A. A. Roger, Morrell, Nicholas W, Wilkins, Martin R., Wang, Dennis, Lawrie, Allan

“…Pulmonary arterial hypertension (PAH) is a rare but life shortening disease, the diagnosis of which is often delayed, and requires an invasive right heart…”
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A therapeutic antibody targeting osteoprotegerin attenuates severe experimental pulmonary arterial hypertension by Arnold, Nadine D., Pickworth, Josephine A., West, Laura E., Dawson, Sarah, Carvalho, Joana A., Casbolt, Helen, Braithwaite, Adam T., Iremonger, James, Renshall, Lewis, Germaschewski, Volker, McCourt, Matthew, Bland-Ward, Philip, Kowash, Hager, Hameed, Abdul G., Rothman, Alexander M. K., Frid, Maria G., Roger Thompson, A. A., Evans, Holly R., Southwood, Mark, Morrell, Nicholas W., Crossman, David C., Whyte, Moira K. B., Stenmark, Kurt R., Newman, Christopher M., Kiely, David G., Francis, Sheila E., Lawrie, Allan

“…Pulmonary arterial hypertension (PAH) is a rare but fatal disease. Current treatments increase life expectancy but have limited impact on the progressive…”
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Inhibition of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) reverses experimental pulmonary hypertension by Hameed, Abdul G, Arnold, Nadine D, Chamberlain, Janet, Pickworth, Josephine A, Paiva, Claudia, Dawson, Sarah, Cross, Simon, Long, Lu, Zhao, Lan, Morrell, Nicholas W, Crossman, David C, Newman, Christopher M H, Kiely, David G, Francis, Sheila E, Lawrie, Allan

“…Pulmonary arterial hypertension (PAH) is a life-threatening disease characterized by the progressive narrowing and occlusion of small pulmonary arteries…”
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Eplerenone attenuates pathological pulmonary vascular rather than right ventricular remodeling in pulmonary arterial hypertension by Boehm, Mario, Arnold, Nadine, Braithwaite, Adam, Pickworth, Josephine, Lu, Changwu, Novoyatleva, Tatyana, Kiely, David G, Grimminger, Friedrich, Ghofrani, Hossein A, Weissmann, Norbert, Seeger, Werner, Lawrie, Allan, Schermuly, Ralph T, Kojonazarov, Baktybek

“…Aldosterone is a mineralocorticoid hormone critically involved in arterial blood pressure regulation. Although pharmacological aldosterone antagonism reduces…”
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Soluble P-Selectin and von Willebrand Factor Rise in Healthy Volunteers Following Non-exertional Ascent to High Altitude by Turton, Helena A, Pickworth, Josephine, Paterson, Gordon G, Lawrie, Allan, Baillie, J Kenneth, Thompson, A A Roger

“…Reduced oxygen tensions experienced at high altitudes are thought to predispose to thrombosis, yet there are few studies linking hypoxia, platelet activation,…”
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Correction to: Eplerenone attenuates pathological pulmonary vascular rather than right ventricular remodeling in pulmonary arterial hypertension by Boehm, Mario, Arnold, Nadine, Braithwaite, Adam, Pickworth, Josephine, Lu, Changwu, Novoyatleva, Tatyana, Kiely, David G, Grimminger, Friedrich, Ghofrani, Hossein A, Weissmann, Norbert, Seeger, Werner, Lawrie, Allan, Schermuly, Ralph T, Kojonazarov, Baktybek

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Differential IL-1 signaling induced by BMPR2 deficiency drives pulmonary vascular remodeling by Pickworth, Josephine, Rothman, Alexander, Iremonger, James, Casbolt, Helen, Hopkinson, Kay, Hickey, Peter M., Gladson, Santhi, Shay, Sheila, Morrell, Nicholas W., Francis, Sheila E., West, James D., Lawrie, Allan

“…Bone morphogenetic protein receptor type 2 (BMPR2) mutations are present in patients with heritable and idiopathic pulmonary arterial hypertension (PAH)…”
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Selective improvement of pulmonary arterial hypertension with a dual ETA/ETB receptors antagonist in the apolipoprotein E−/− model of PAH and atherosclerosis by Renshall, Lewis, Arnold, Nadine, West, Laura, Braithwaite, Adam, Pickworth, Josephine, Walker, Rachel, Alfaidi, Mabruka, Chamberlain, Janet, Casbolt, Helen, Thompson, A.A. Roger, Holt, Cathy, Iglarz, Marc, Francis, Sheila, Lawrie, Allan

“…Idiopathic pulmonary arterial hypertension (IPAH) is increasingly diagnosed in elderly patients who also have an increased risk of co-morbid atherosclerosis…”
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TRAIL Deficient Mice Are Protected from Sugen/Hypoxia Induced Pulmonary Arterial Hypertension by Dawson, Sarah H, Arnold, Nadine D, Pickworth, Josephine A, Francis, Sheila E, Lawrie, Allan

“…Pulmonary arterial hypertension (PAH) is a progressive lung disease diagnosed by an increase in pulmonary arterial blood pressure that is driven by a…”
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Serum osteoprotegerin is increased and predicts survival in idiopathic pulmonary arterial hypertension by Condliffe, Robin, Pickworth, Josephine A., Hopkinson, Kay, Walker, Sara J., Hameed, Abdul G., Suntharaligam, Jay, Soon, Elaine, Treacy, Carmen, Pepke-Zaba, Joanna, Francis, Sheila E., Crossman, David C., Newman, Christopher M. H., Elliot, Charles A., Morton, Allison C., Morrell, Nicholas W., Kiely, David G., Lawrie, Allan

“…We previously reported that osteoprotegerin (OPG) is regulated by pathways associated with pulmonary arterial hypertension (PAH), and is present at elevated…”
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Author Correction: Biological heterogeneity in idiopathic pulmonary arterial hypertension identified through unsupervised transcriptomic profiling of whole blood by Kariotis, Sokratis, Jammeh, Emmanuel, Swietlik, Emilia M., Pickworth, Josephine A., Rhodes, Christopher J., Otero, Pablo, Wharton, John, Iremonger, James, Dunning, Mark J., Pandya, Divya, Mascarenhas, Thomas S., Errington, Niamh, Thompson, A. A. Roger, Romanoski, Casey E., Rischard, Franz, Garcia, Joe G. N., Yuan, Jason X.-J., An, Tae-Hwi Schwantes, Desai, Ankit A., Coghlan, Gerry, Lordan, Jim, Corris, Paul A., Howard, Luke S., Condliffe, Robin, Kiely, David G., Church, Colin, Pepke-Zaba, Joanna, Toshner, Mark, Wort, Stephen, Gräf, Stefan, Morrell, Nicholas W., Wilkins, Martin R., Lawrie, Allan, Wang, Dennis

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Paigen Diet–Fed Apolipoprotein E Knockout Mice Develop Severe Pulmonary Hypertension in an Interleukin-1–Dependent Manner by Lawrie, Allan, Hameed, Abdul G, Chamberlain, Janet, Arnold, Nadine, Kennerley, Aneurin, Hopkinson, Kay, Pickworth, Josephine, Kiely, David G, Crossman, David C, Francis, Sheila E

“…Inflammatory mechanisms are proposed to play a significant role in the pathogenesis of pulmonary arterial hypertension (PAH). Previous studies have described…”
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Links Between Dysfunctional Bone Morphogenetic Protein Signalling and Interleukin-1ß Mediated Inflammation in Pulmonary Arterial Hypertension by Pickworth, Josephine

“…Rationale: Bone morphogenetic protein receptor type 2 (BMPR2) mutations are present in up to 70% of patients with heritable and up to 25% with idiopathic…”
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Abstract 13921: Dysfunctional Bone Morphogenetic Protein Signaling Interlinks With Interleukin-1ß Mediated Inflammation in Pulmonary Arterial Hypertension by Pickworth, Josephine A, Shay, Sheila, Gladson, Santhi, Iremonger, James, Rothman, Alex M, Francis, Sheila, West, James, Lawrie, Allan

“…RationaleBone morphogenetic protein receptor type 2 (BMPR2) mutations are found in heritable and idiopathic pulmonary arterial hypertension but disease…”
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Abstract 11498: MicroRNA 140 Regulates Disease Phenotype in Experimental Pulmonary Arterial Hypertension And Identifies Smurf1 as a Novel Therapeutic Target by Rothman, Alexander M, Arnold, Nadine D, Pickworth, Josephine A, Iremonger, James, Ciuclan, Loredana, Allen, Robert, Guth-Gundel, Sabine, Southwood, Mark, Morrell, Nicholas W, Francis, Sheila E, Rowlands, David, Lawrie, Allan

“…RationaleClinical therapies for the treatment of pulmonary arterial hypertension (PAH) target vasoconstriction. However, the proliferative pulmonary vascular…”
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Tumour necrosis factor-related apoptosis-inducing ligand is a novel therapeutic target in pulmonary arterial hypertension by Hameed, Abdul G, Dr, Arnold, Nadine D, Chamberlain, Janet, Pickworth, Josephine A, Paiva, Claudia, Dawson, Sarah, Cross, Simon, Long, Lu, Zhao, Lan, Morrell, Nicholas W, Crossman, David C, Newman, Christopher MH, Kiely, David G, Francis, Sheila E, Lawrie, Allan

“…Abstract Background Pulmonary arterial hypertension is a fatal disease characterised by progressive narrowing of pulmonary arterioles, driven by aberrant…”
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Selective improvement of pulmonary arterial hypertension with a dual ET A /ET B receptors antagonist in the apolipoprotein E −/− model of PAH and atherosclerosis by Renshall, Lewis, Arnold, Nadine, West, Laura, Braithwaite, Adam, Pickworth, Josephine, Walker, Rachel, Alfaidi, Mabruka, Chamberlain, Janet, Casbolt, Helen, Thompson, A.A. Roger, Holt, Cathy, Iglarz, Marc, Francis, Sheila, Lawrie, Allan

“…Idiopathic pulmonary arterial hypertension (IPAH) is increasingly diagnosed in elderly patients who also have an increased risk of co‐morbid atherosclerosis…”
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Selective improvement of pulmonary arterial hypertension with a dual ET/ET receptors antagonist in the apolipoprotein E model of PAH and atherosclerosis by Lewis Renshall, Nadine Arnold, Laura West, Adam Braithwaite, Josephine Pickworth, Rachel Walker, Mabruka Alfaidi, Janet Chamberlain, Helen Casbolt, A.A. Roger Thompson, Cathy Holt, Marc Iglarz, Sheila Francis, Allan Lawrie

“…Idiopathic pulmonary arterial hypertension (IPAH) is increasingly diagnosed in elderly patients who also have an increased risk of co-morbid atherosclerosis…”
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