Search Results - "Picksley, M."

Human hair follicles contain two forms of ATP-sensitive potassium channels, only one of which is sensitive to minoxidil by Shorter, Katie, Farjo, Nilofer P, Picksley, Steven M, Randall, Valerie A

“…Hair disorders cause psychological distress but are generally poorly controlled; more effective treatments are required. Despite the long-standing use of…”
Get full text

Characterising the cleaning mechanisms of yeast and the implications for Cleaning In Place (CIP) by Goode, K.R., Asteriadou, K., Fryer, P.J., Picksley, M., Robbins, P.T.

“…▶ Model yeast soils relevant to fermenter operation have been developed. ▶ Water and chemical rinsing of these deposits on a lab scale flow cell revealed three…”
Get full text

Mammalian Prohibitin Proteins Respond to Mitochondrial Stress and Decrease during Cellular Senescence by Coates, P.J., Nenutil, R., McGregor, A., Picksley, S.M., Crouch, D.H., Hall, P.A., Wright, E.G.

“…The two prohibitin proteins, Phb1p and Phb2pBAP37, have been ascribed various functions, including cell cycle regulation, apoptosis, assembly of mitochondrial…”
Get full text

Characterization of p53 oligomerization domain mutations isolated from Li-Fraumeni and Li-Fraumeni like family members by LOMAX, M. E, BARNES, D. M, HUPP, T. R, PICKSLEY, S. M, CAMPLEJOHN, R. S

“…p53 is a tumour suppressor gene which functions as a transcription factor to upregulate genes for growth arrest and apoptosis following DNA damage. p53…”
Get full text

Immunochemical analysis of the interaction of p53 with MDM2;--fine mapping of the MDM2 binding site on p53 using synthetic peptides by Picksley, S M, Vojtesek, B, Sparks, A, Lane, D P

“…The function of p53 is modulated by binding to a number of cellular and viral proteins, such as MDM2 and SV40 large T antigen. An initial immunochemical…”
Get more information

Molecular characterization of the hdm2-p53 interaction by Böttger, A, Böttger, V, Garcia-Echeverria, C, Chène, P, Hochkeppel, H K, Sampson, W, Ang, K, Howard, S F, Picksley, S M, Lane, D P

“…A number of viral oncogenes target the tumour suppressor protein p53 and inactivate its function. This is an important step in tumourogenesis. The cellular…”
Get full text

The p53-mdm2 autoregulatory feedback loop: a paradigm for the regulation of growth control by p53? by Picksley, S M, Lane, D P

Get more information

The prostamide‐related glaucoma therapy, bimatoprost, offers a novel approach for treating scalp alopecias by Khidhir, Karzan G., Woodward, David F., Farjo, Nilofer P., Farjo, Bessam K., Tang, Elaine S., Wang, Jenny W., Picksley, Steven M., Randall, Valerie A.

“…Balding causes widespread psychological distress but is poorly controlled. The commonest treatment, minoxidil, was originally an antihypertensive drug that…”
Get full text

Two functional assays employed to detect an unusual mutation in the oligomerisation domain of p53 in a Li-Fraumeni like family by LOMAX, M. E, BARNES, D. M, GILCHRIST, R, PICKSLEY, S. M, VARLEY, J. M, CAMPLEJOHN, R. S

“…Previous investigations of a Li - Fraumeni like family (Barnes et al., 1992) demonstrated that both the proband and her mother had elevated p53 protein levels…”
Get full text

Identification of novel mdm2 binding peptides by phage display by Böttger, V, Böttger, A, Howard, S F, Picksley, S M, Chène, P, Garcia-Echeverria, C, Hochkeppel, H K, Lane, D P

“…The oncogene mdm2 and its human homologue hdm2 bind to the tumour suppressor protein p53 and inactivate its function as a transcription factor. This has been…”
Get more information

Anticancer Activity of Electron‐Deficient Metal Complexes against Colorectal Cancer in vitro Models by Azmanova, Maria, Soldevila‐Barreda, Joan, Bani Hani, Hira, Lord, Rianne M., Pitto‐Barry, Anaïs, Picksley, Steven M., Barry, Nicolas P. E.

“…An evaluation of the in vitro cytotoxicity of nine electron‐deficient half‐sandwich metal complexes towards two colorectal cancer cell lines (HCT116 p53+/+,…”
Get full text

The role of p53 in the chemotherapeutic responses to cisplatin, doxorubicin and 5-fluorouracil treatment by Dart, D Alwyn, Picksley, Steven M, Cooper, Patricia A, Double, John A, Bibby, Michael C

“…A panel of tumour models used extensively for in vivo evaluation of new drugs was characterised for their p53 status. Basal p53 protein levels were measured by…”
Get more information

Increased epidermal functioning wild-type p53 expression in vitiligo by Schallreuter, Karin U., Behrens-Williams, Stefanie, Khaliq, Tahira P., Picksley, Steven M., Peters, Eva M. J., Marles, Lee K., Westerhof, Wiete, Miehe, Bärbel, Fanghänel, Jochen

“…:  Despite the lack of protective melanin and increased oxidative stress due to mM concentrations of epidermal H2O2 in vitiligo, there is no significantly…”
Get full text

p53 and Rb: their cellular roles by Picksley, S M, Lane, D P

“…Within the past year considerable new insights have been gained into the roles the p53 and retinoblastoma tumour suppressors play in determining the fate of…”
Get more information

Cells expressing HPV16 E7 continue cell cycle progression following DNA damage induced p53 activation by Hickman, E S, Picksley, S M, Vousden, K H

“…Stabilisation and activation of p53 contributes to the G1 arrest exhibited by many cells in response to DNA damage. One function of p53 is the transcriptional…”
Get more information

Abnormal expression of wild type p53 protein in normal cells of a cancer family patient by Barnes, D M, Hanby, A M, Gillett, C E, Mohammed, S, Hodgson, S, Bobrow, L G, Leigh, I M, Purkis, T, MacGeoch, C, Spurr, N K

“…Mutations in the p53 gene are the commonest specific genetic change in human cancer. In normal tissues, p53 protein is present in such low quantities that it…”
Get more information

On the Regulation of the p53 Tumour Suppressor, and Its Role in the Cellular Response to DNA Damage by Lane, David P., Midgley, Carol A., Hupp, Ted R., Lu, Xin, Vojtesek, Borivoj, Picksley, Steven M.

“…The p53 gene is required for the normal apoptotic response of mammalian cells to DNA damage caused by ionizing radiation and DNA damaging drugs. DNA damage…”
Get full text

Analysis of the K-ras and p53 Pathways in X-Ray-Induced Lung Tumors in the Rat by Belinsky, Steven A., Middleton, Susan K., Picksley, Steven M., Hahn, Fletcher F., Nikula, Kristen J.

“…The risk from exposure to low-dose radiation in conjunction with cigarette smoking has not been estimated due in part to limited knowledge surrounding the…”
Get full text

The p53-MDM2 interaction in a cancer-prone family, and the identification of a novel therapeutic target by Picksley, S M, Spicer, J F, Barnes, D M, Lane, D P

“…One approach to developing novel anti-cancer agents is to identify and characterise targets that directly regulate cell growth and are dysfunctional in the…”
Get more information

Epitope analysis of the murine p53 tumour suppressor protein by Lane, D P, Stephen, C W, Midgley, C A, Sparks, A, Hupp, T R, Daniels, D A, Greaves, R, Reid, A, Vojtesek, B, Picksley, S M

“…The identification and characterisation of the p53 tumour suppressor has relied extensively on the use of immunological reagents. To facilitate further…”
Get more information