Search Results - "Pickkers, Peter"

Acute kidney injury in the critically ill: an updated review on pathophysiology and management by Pickkers, Peter, Darmon, Michael, Hoste, Eric, Joannidis, Michael, Legrand, Matthieu, Ostermann, Marlies, Prowle, John R., Schneider, Antoine, Schetz, Miet

“…Acute kidney injury (AKI) is now recognized as a heterogeneous syndrome that not only affects acute morbidity and mortality, but also a patient’s long-term…”
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Obesity in the critically ill: a narrative review by Schetz, Miet, De Jong, Audrey, Deane, Adam M., Druml, Wilfried, Hemelaar, Pleun, Pelosi, Paolo, Pickkers, Peter, Reintam-Blaser, Annika, Roberts, Jason, Sakr, Yasser, Jaber, Samir

“…The World Health Organization defines overweight and obesity as the condition where excess or abnormal fat accumulation increases risks to health. The…”
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Letter to the Editor: Vitamin D deficiency in COVID-19: Mixing up cause and consequence by Smolders, Joost, van den Ouweland, Jody, Geven, Christopher, Pickkers, Peter, Kox, Matthijs

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The mechanism of action of the adrenomedullin-binding antibody adrecizumab by Geven, Christopher, Pickkers, Peter

“…While adrecizumab only partially inhibits ADM signaling, the strong concentration increase of ADM (complexed with adrecizumab) in the circulation is thought to…”
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Adrenomedullin in heart failure: pathophysiology and therapeutic application by Voors, Adriaan A., Kremer, Daan, Geven, Christopher, ter Maaten, Jozine M., Struck, Joachim, Bergmann, Andreas, Pickkers, Peter, Metra, Marco, Mebazaa, Alexandre, Düngen, Hans‐Dirk, Butler, Javed

“…Adrenomedullin (ADM) is a peptide hormone first discovered in 1993 in pheochromocytoma. It is synthesized by endothelial and vascular smooth muscle cells and…”
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Multicentric experience with interferon gamma therapy in sepsis induced immunosuppression. A case series by Payen, Didier, Faivre, Valerie, Miatello, Jordi, Leentjens, Jenneke, Brumpt, Caren, Tissières, Pierre, Dupuis, Claire, Pickkers, Peter, Lukaszewicz, Anne Claire

“…The sepsis-induced immunodepression contributes to impaired clinical outcomes of various stress conditions. This syndrome is well documented and characterized…”
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Immunotherapy for the Adjunctive Treatment of Sepsis: From Immunosuppression to Immunostimulation: Time for a Paradigm Change? by LEENTJENS, Jenneke, KOX, Matthijs, VAN DER HOEVEN, Johannes G, NETEA, Mihai G, PICKKERS, Peter

“…Sepsis is the leading cause of death in the intensive care unit and ranks in the top 10 causes of death in general worldwide. Proinflammatory mediators are…”
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A worldwide multicentre evaluation of the influence of deterioration or improvement of acute kidney injury on clinical outcome in critically ill patients with and without sepsis at ICU admission: results from The Intensive Care Over Nations audit by Peters, Esther, Antonelli, Massimo, Wittebole, Xavier, Nanchal, Rahul, François, Bruno, Sakr, Yasser, Vincent, Jean-Louis, Pickkers, Peter

“…Acute kidney injury (AKI) is a common complication of critical illness and is associated with worse outcomes. However, the influence of deterioration or…”
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Precision Immunotherapy for Sepsis by Peters van Ton, Annemieke M, Kox, Matthijs, Abdo, Wilson F, Pickkers, Peter

“…Decades of sepsis research into a specific immune system-targeting adjunctive therapy have not resulted in the discovery of an effective compound. Apart from…”
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Monocytic HLA-DR expression kinetics in septic shock patients with different pathogens, sites of infection and adverse outcomes by Leijte, Guus P, Rimmelé, Thomas, Kox, Matthijs, Bruse, Niklas, Monard, Céline, Gossez, Morgane, Monneret, Guillaume, Pickkers, Peter, Venet, Fabienne

“…Decreased monocytic (m)HLA-DR expression is the most studied biomarker of sepsis-induced immunosuppression. To date, little is known about the relationship…”
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Broad defects in the energy metabolism of leukocytes underlie immunoparalysis in sepsis by Cheng, Shih-Chin, Scicluna, Brendon P, Arts, Rob J W, Gresnigt, Mark S, Lachmandas, Ekta, Giamarellos-Bourboulis, Evangelos J, Kox, Matthijs, Manjeri, Ganesh R, Wagenaars, Jori A L, Cremer, Olaf L, Leentjens, Jenneke, van der Meer, Anne J, van de Veerdonk, Frank L, Bonten, Marc J, Schultz, Marcus J, Willems, Peter H G M, Pickkers, Peter, Joosten, Leo A B, van der Poll, Tom, Netea, Mihai G

“…Sepsis is poorly understood, largely untreatable and frequently fatal. Netea and colleagues assess both mouse sepsis and human sepsis to demonstrate that its…”
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CytoSorb hemoperfusion markedly attenuates circulating cytokine concentrations during systemic inflammation in humans in vivo by Jansen, Aron, Waalders, Nicole J B, van Lier, Dirk P T, Kox, Matthijs, Pickkers, Peter

“…The CytoSorb hemoadsorption device has been demonstrated to be capable of clearing inflammatory cytokines, but has not yet been shown to attenuate plasma…”
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Cleaved N-terminal histone tails distinguish between NADPH oxidase (NOX)-dependent and NOX-independent pathways of neutrophil extracellular trap formation by Pieterse, Elmar, Rother, Nils, Yanginlar, Cansu, Gerretsen, Jelle, Boeltz, Sebastian, Munoz, Luis Enrique, Herrmann, Martin, Pickkers, Peter, Hilbrands, Luuk B, van der Vlag, Johan

“…Neutrophil extracellular traps (NETs) act in various rheumatic diseases. Although NET formation was originally described as a nicotinamide adenine dinucleotide…”
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Body Mass Index and Mortality in Coronavirus Disease 2019 and Other Diseases: A Cohort Study in 35,506 ICU Patients by Kooistra, Emma J., Brinkman, Sylvia, van der Voort, Peter H. J., de Keizer, Nicolette F., Dongelmans, Dave A., Kox, Matthijs, Pickkers, Peter

“…Obesity is a risk factor for severe coronavirus disease 2019 and might play a role in its pathophysiology. It is unknown whether body mass index is related to…”
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Dexamethasone and tocilizumab treatment considerably reduces the value of C-reactive protein and procalcitonin to detect secondary bacterial infections in COVID-19 patients by Kooistra, Emma J, van Berkel, Miranda, van Kempen, Noortje F, van Latum, Celine R. M, Bruse, Niklas, Frenzel, Tim, van den Berg, Maarten J. W, Schouten, Jeroen A, Kox, Matthijs, Pickkers, Peter

“…Abstract Background Procalcitonin (PCT) and C-reactive protein (CRP) were previously shown to have value for the detection of secondary infections in…”
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Voluntary activation of the sympathetic nervous system and attenuation of the innate immune response in humans by Kox, Matthijs, van Eijk, Lucas T., Zwaag, Jelle, van den Wildenberg, Joanne, Sweep, Fred C. G. J., van der Hoeven, Johannes G., Pickkers, Peter

“…Excessive or persistent proinflammatory cytokine production plays a central role in autoimmune diseases. Acute activation of the sympathetic nervous system…”
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IFN-γ-stimulated neutrophils suppress lymphocyte proliferation through expression of PD-L1 by de Kleijn, Stan, Langereis, Jeroen D, Leentjens, Jenneke, Kox, Matthijs, Netea, Mihai G, Koenderman, Leo, Ferwerda, Gerben, Pickkers, Peter, Hermans, Peter W M

“…During systemic inflammation different neutrophil subsets are mobilized to the peripheral blood. These neutrophil subsets can be distinguished from normal…”
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Cardiac and Vascular Surgery–Associated Acute Kidney Injury: The 20th International Consensus Conference of the ADQI (Acute Disease Quality Initiative) Group by Nadim, Mitra K., Forni, Lui G., Bihorac, Azra, Hobson, Charles, Koyner, Jay L., Shaw, Andrew, Arnaoutakis, George J., Ding, Xiaoqiang, Engelman, Daniel T., Gasparovic, Hrvoje, Gasparovic, Vladimir, Herzog, Charles A., Kashani, Kianoush, Katz, Nevin, Liu, Kathleen D., Mehta, Ravindra L., Ostermann, Marlies, Pannu, Neesh, Pickkers, Peter, Price, Susanna, Ricci, Zaccaria, Rich, Jeffrey B., Sajja, Lokeswara R., Weaver, Fred A., Zarbock, Alexander, Ronco, Claudio, Kellum, John A.

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Proenkephalin A 119–159 predicts early and successful liberation from renal replacement therapy in critically ill patients with acute kidney injury: a post hoc analysis of the ELAIN trial by von Groote, Thilo, Albert, Felix, Meersch, Melanie, Koch, Raphael, Porschen, Christian, Hartmann, Oliver, Bergmann, Deborah, Pickkers, Peter, Zarbock, Alexander

“…Abstract Background Renal replacement therapy (RRT) remains the key rescue therapy for critically ill patients with severe acute kidney injury (AKI). However,…”
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Human CD62Ldim neutrophils identified as a separate subset by proteome profiling and in vivo pulse-chase labeling by Tak, Tamar, Wijten, Patrick, Heeres, Marjolein, Pickkers, Peter, Scholten, Arjen, Heck, Albert J.R., Vrisekoop, Nienke, Leenen, Luke P., Borghans, José A.M., Tesselaar, Kiki, Koenderman, Leo

“…During acute inflammation, 3 neutrophil subsets are found in the blood: neutrophils with a conventional segmented nucleus, neutrophils with a banded nucleus,…”
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