Search Results - "Pickkers, P."

Promotion of vascular integrity in sepsis through modulation of bioactive adrenomedullin and dipeptidyl peptidase 3 by Lier, D., Kox, M., Pickkers, P.

“…Sepsis represents one of the major medical challenges of the 21st century. Despite substantial improvements in the knowledge on pathophysiological mechanisms,…”
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Sepsis-induced immunoparalysis: mechanisms, markers, and treatment options by Hamers, L, Kox, M, Pickkers, P

“…Sepsis remains the leading cause of death in the ICU. Considering the key role of the immune system in sepsis, immunomodulation represents an attractive target…”
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An add-on training program involving breathing exercises, cold exposure, and meditation attenuates inflammation and disease activity in axial spondyloarthritis - A proof of concept trial by Buijze, G A, De Jong, H M Y, Kox, M, van de Sande, M G, Van Schaardenburg, D, Van Vugt, R M, Popa, C D, Pickkers, P, Baeten, D L P

“…The primary objective of this trial was to assess safety and anti-inflammatory effects of an add-on training program involving breathing exercises, cold…”
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Development and validation of PRE-DELIRIC (PREdiction of DELIRium in ICu patients) delirium prediction model for intensive care patients: observational multicentre study by Boogaard, M van den, Pickkers, P, Slooter, A J C, Kuiper, M A, Spronk, P E, Voort, P H J van der, Hoeven, J G van der, Donders, R, Achterberg, T van, Schoonhoven, L

“…Objectives To develop and validate a delirium prediction model for adult intensive care patients and determine its additional value compared with prediction by…”
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Hypoxemia in the presence or absence of systemic inflammation does not increase blood lactate levels in healthy volunteers by Kiers, H.D., Pickkers, P., Kox, M.

“…Elevated lactate levels are a sign of critical illness and may result from insufficient oxygen delivery. We investigated whether hypoxemia and/or systemic…”
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Recalibration of the delirium prediction model for ICU patients (PRE-DELIRIC): a multinational observational study by van den Boogaard, M., Schoonhoven, L., Maseda, E., Plowright, C., Jones, C., Luetz, A., Sackey, P. V., Jorens, P. G., Aitken, L. M., van Haren, F. M. P., Donders, R., van der Hoeven, J. G., Pickkers, P.

“…Purpose Recalibration and determining discriminative power, internationally, of the existing delirium prediction model (PRE-DELIRIC) for intensive care…”
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Alkaline phosphatase protects against renal inflammation through dephosphorylation of lipopolysaccharide and adenosine triphosphate by Peters, E, Geraci, S, Heemskerk, S, Wilmer, M J, Bilos, A, Kraenzlin, B, Gretz, N, Pickkers, P, Masereeuw, R

“…Background and Purpose Recently, two phase‐II trials demonstrated improved renal function in critically ill patients with sepsis‐associated acute kidney injury…”
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Systemic inflammation relates to neuroaxonal damage associated with long-term cognitive dysfunction in COVID-19 patients by Duindam, H.B., Mengel, D., Kox, M., Göpfert, J.C., Kessels, R.P.C., Synofzik, M., Pickkers, P., Abdo, W.F.

“…•Long-term cognitive impairments are common in patients that suffered from severe COVID-19.•In critically ill COVID-19 patients, NfL increases significantly…”
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Downregulation of synapse-associated protein expression and loss of homeostatic microglial control in cerebrospinal fluid of infectious patients with delirium and patients with Alzheimer’s disease by Peters van Ton, A.M., Verbeek, M.M., Alkema, W., Pickkers, P., Abdo, W.F.

“…•Given the association between delirium and dementia, a shared origin is suspected.•CSF protein expression shows similarities in infectious delirium and…”
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Multinational development and validation of an early prediction model for delirium in ICU patients by Wassenaar, A., van den Boogaard, M., van Achterberg, T., Slooter, A. J. C., Kuiper, M. A., Hoogendoorn, M. E., Simons, K. S., Maseda, E., Pinto, N., Jones, C., Luetz, A., Schandl, A., Verbrugghe, W., Aitken, L. M., van Haren, F. M. P., Donders, A. R. T., Schoonhoven, L., Pickkers, P.

“…Rationale Delirium incidence in intensive care unit (ICU) patients is high and associated with poor outcome. Identification of high-risk patients may…”
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Corrigendum to “Systemic inflammation relates to neuroaxonal damage associated with long-term cognitive dysfunction in COVID-19 patients” [Brain Behav. Immun. 117 (2024) 510–520] by Duindam, H.B., Mengel, D., Kox, M., Göpfert, J.C., Kessels, R.P.C., Synofzik, M., Pickkers, P., Abdo, W.F.

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Fatigue during acute systemic inflammation is associated with reduced mental effort expenditure while task accuracy is preserved by Lambregts, B.I.H.M., Vassena, E., Jansen, A., Stremmelaar, D.E., Pickkers, P., Kox, M., Aarts, E., van der Schaaf, M.E.

“…•Inflammation alters mental effort-allocation, despite preserved mental abilities.•These motivational changes depend on effort and not reward…”
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Dynamic indices do not predict volume responsiveness in routine clinical practice by Lansdorp, B., Lemson, J., van Putten, M.J.A.M., de Keijzer, A., van der Hoeven, J.G., Pickkers, P.

“…Dynamic indices, including pulse pressure, systolic pressure, and stroke volume variation (PPV, SPV, and SVV), are accurate predictors of fluid responsiveness…”
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A comparison of the renal function biomarkers serum creatinine, pro-enkephalin and cystatin C to predict clearance of pemetrexed by de Rouw, N., Beunders, R., Hartmann, O., Schulte, J., Boosman, R. J., Derijks, H. J., Burger, D. M., van den Heuvel, M. M., Hilbrands, L. B., Pickkers, P., ter Heine, R.

“…Introduction For drugs with a narrow therapeutic window, there is a delicate balance between efficacy and toxicity, thus it is pivotal to administer the right…”
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Crew Resource Management in the Intensive Care Unit: a prospective 3-year cohort study by Haerkens, M. H. T. M., Kox, M., Lemson, J., Houterman, S., van der Hoeven, J. G., Pickkers, P.

“…Background Human factors account for the majority of adverse events in both aviation and medicine. Human factors awareness training entitled “Crew Resource…”
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Remote ischaemic preconditioning does not modulate the systemic inflammatory response or renal tubular stress biomarkers after endotoxaemia in healthy human volunteers: a single-centre, mechanistic, randomised controlled trial by Zwaag, J, Beunders, R, Warlé, M C, Kellum, J A, Riksen, N P, Pickkers, P, Kox, M

“…Remote ischaemic preconditioning (RIPC) consists of repeated cycles of limb ischaemia and reperfusion, which may reduce perioperative myocardial ischaemic…”
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Pharmacokinetics of caspofungin in ICU patients by Muilwijk, E W, Schouten, J A, van Leeuwen, H J, van Zanten, A R H, de Lange, D W, Colbers, A, Verweij, P E, Burger, D M, Pickkers, P, Brüggemann, R J M

“…Caspofungin is used for treatment of invasive fungal infections. As the pharmacokinetics (PK) of antimicrobial agents in critically ill patients can be highly…”
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Pharmacokinetics of Anidulafungin in Critically Ill Intensive Care Unit Patients with Suspected or Proven Invasive Fungal Infections by Brüggemann, R J M, Middel-Baars, V, de Lange, D W, Colbers, A, Girbes, A R J, Pickkers, P, Swart, E L

“…Echinocandins, such as anidulafungin, are the first-line treatment for candidemia or invasive candidiasis in critically ill patients. There are conflicting…”
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Characterization of a model of systemic inflammation in humans in vivo elicited by continuous infusion of endotoxin by Kiers, D., Koch, R. M., Hamers, L., Gerretsen, J., Thijs, E. J. M., van Ede, L., Riksen, N. P., Kox, M., Pickkers, P.

“…Investigating the systemic inflammatory response in patients with critical illness such as sepsis, trauma and burns is complicated due to uncertainties about…”
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The value of D-dimer to predict pulmonary embolism in critically ill COVID-19 patients by van den Berg, M.J.W., Waanders, D., Kooistra, E.J., Kox, M., Pickkers, P.

“…[...]conflicting suggestions for serial D-dimer determinations were published [4,5]. Because a significant part of our COVID-19 cohort was not scanned, PE may…”
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