Search Results - "Pickhardt, M."

Stepwise proteolysis liberates tau fragments that nucleate the Alzheimer-like aggregation of full-length tau in a neuronal cell model by Wang, Y.P, Biernat, J, Pickhardt, M, Mandelkow, E, Mandelkow, E.-M

“…Tau is a highly soluble protein, yet it aggregates abnormally in Alzheimer's disease. Here, we address the question of proteolytic processing of tau and the…”
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On the way to precision formulation additives: 2D-screening to select solubilizers with tailored host and release capabilities by Remmler, D., Schwaar, T., Pickhardt, M., Donth, C., Mandelkow, E., Weller, M.G., Börner, H.G.

“…A 2-dimensional high-throughput screening method is presented to select peptide sequences from large peptide libraries for precision formulation additives,…”
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N-phenylamine derivatives as aggregation inhibitors in cell models of tauopathy by Pickhardt, M, Biernat, J, Khlistunova, I, Wang, Y-P, Gazova, Z, Mandelkow, E-M, Mandelkow, E

“…Cell models of tauopathy were generated in order to study mechanisms of neurodegeneration involving abnormal changes of tau. They are based on neuroblastoma…”
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Inducible expression of Tau repeat domain in cell models of tauopathy: aggregation is toxic to cells but can be reversed by inhibitor drugs by Khlistunova, Inna, Biernat, Jacek, Wang, Yipeng, Pickhardt, Marcus, von Bergen, Martin, Gazova, Zuzana, Mandelkow, Eckhard, Mandelkow, Eva-Maria

“…We generated several cell models of tauopathy in order to study the mechanisms of neurodegeneration in diseases involving abnormal changes of tau protein. N2a…”
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Anthraquinones Inhibit Tau Aggregation and Dissolve Alzheimer's Paired Helical Filaments in Vitro and in Cells by Pickhardt, Marcus, Gazova, Zuzana, von Bergen, Martin, Khlistunova, Inna, Wang, Yipeng, Hascher, Antje, Mandelkow, Eva-Maria, Biernat, Jacek, Mandelkow, Eckhard

“…The abnormal aggregation of tau protein into paired helical filaments (PHFs) is one of the hallmarks of Alzheimer's disease. Aggregation takes place in the…”
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Phenylthiazolyl-Hydrazide and Its Derivatives Are Potent Inhibitors of τ Aggregation and Toxicity in Vitro and in Cells by Pickhardt, Marcus, Larbig, Gregor, Khlistunova, Inna, Coksezen, Atilla, Meyer, Bernd, Mandelkow, Eva-Maria, Schmidt, Boris, Mandelkow, Eckhard

“…One of the key pathological features of Alzheimer's disease is the aggregation of tau protein. We are therefore searching for compounds capable of inhibiting…”
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The Core of Tau-Paired Helical Filaments Studied by Scanning Transmission Electron Microscopy and Limited Proteolysis by von Bergen, Martin, Barghorn, Stefan, Müller, Shirley A, Pickhardt, Marcus, Biernat, Jacek, Mandelkow, Eva-Maria, Davies, Peter, Aebi, Ueli, Mandelkow, Eckhard

“…In Alzheimer's disease and frontotemporal dementias the microtubule-associated protein tau forms intracellular paired helical filaments (PHFs). The filaments…”
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Vaginal birth after cesarean delivery: are there useful and valid predictors of success or failure? by Pickhardt, M G, Martin, Jr, J N, Meydrech, E F, Blake, P G, Martin, R W, Perry, Jr, K G, Morrison, J C

“…Before parturition are there useful and valid predictors of successful or unsuccessful vaginal birth after previous cesarean birth that could be used to…”
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Size and scope of the underground economy in Germany by Pickhardt, Michael, Sardà Pons, Jordi

“…The objective of this paper is to improve estimations of the size and scope of the underground economy by introducing a new approach that combines the…”
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Teaching public goods theory with a classroom game by Pickhardt, Michael

“…The author extends the work of Holt and Laury (1997) on a simple noncomputerized card game for teaching the essential aspects of public goods theory. He…”
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Cellular and humoral immune response in progressive multifocal leukoencephalopathy by Weber, Frank, Goldmann, Claudia, Krämer, Marcus, Kaup, Franz Josef, Pickhardt, Marcus, Young, Peter, Petry, Harald, Weber, Thomas, Lüke, Wolfgang

“…Progressive multifocal leukoencephalopathy (PML) is a fatal, demyelinating disease caused by JC virus (JCV) in patients with severe immunosuppression. We…”
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Analysis of the transcriptional control region in progressive multifocal leukoencephalopathy by Vaz, B, Cinque, P, Pickhardt, M, Weber, T

“…Progressive multifocal leukoencephalopathy (PML) is a fatal demyelinating disease caused by the human polyomavirus JCV. The hypervariable noncoding…”
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On the role of backauditing for tax evasion in an agent-based Econophysics model by Seibold, G, Pickhardt, M

“…We investigate an inhomogeneous Ising model in the context of tax evasion dynamics where different types of agents are parametrized via local temperatures and…”
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Complications of Immunosuppressive Therapy in Solid Organ Transplantation by Katabathina, Venkata, MD, Menias, Christine O., MD, Pickhardt, Perry, MD, Lubner, Meghan, MD, Prasad, Srinivasa R., MD

“…Availability of novel immunosuppressive drugs is the most important factor responsible for significant improvement in long-term graft survival rates after…”
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Automated Stone Volume Measurement Using Reduced-Dose (RD) CT Is Comparable Standard-Dose CT: A Prospective Clinical Trial by Bell, John R., MD, Lim, Amy, MD, Pickhardt, Perry, MD, Nakada, Stephen Y., MD, FACS

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ACR Colon Cancer Committee White Paper: Status of CT Colonography 2009 by McFarland, Elizabeth G., MD, Fletcher, Joel G., MD, Pickhardt, Perry, MD, Dachman, Abraham, MD, Yee, Judy, MD, McCollough, Cynthia H., PhD, Macari, Michael, MD, Knechtges, Paul, MD, Zalis, Michael, MD, Barish, Matthew, MD, Kim, David H., MD, Keysor, Kathryn J., BS, Johnson, C. Daniel, MD

“…Purpose To review the current status and rationale of the updated ACR practice guidelines for CT colonography (CTC). Methods Clinical validation trials in both…”
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Computed Tomography Colonography by Kim, David H., MD, Moreno, Courtney C., MD, Pickhardt, Perry J., MD

“…This article serves as a practical reference to optimize the performance of computed tomography colonography in the detection of colorectal neoplasia. A…”
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MR Evaluation of the Nontraumatic Acute Abdomen with CT Correlation by Bannas, Peter, MD, Pickhardt, Perry J., MD

“…Cross-sectional imaging plays a crucial role in the triage of patients with acute abdominal pain. Ionizing radiation exposure is a recognized drawback of…”
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Cost-Effectiveness of CT Colonography by Hassan, Cesare, MD, Pickhardt, Perry J., MD

“…Simulation modeling is extensively applied to CT colonography (CTC) to define its long-term efficacy and cost-effectiveness for colorectal cancer (CRC)…”
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Opportunistic Osteoporosis Screening: Addition of Quantitative CT Bone Mineral Density Evaluation to CT Colonography by Ziemlewicz, Timothy J., MD, Binkley, Neil, MD, Pickhardt, Perry J., MD

“…Abstract Purpose For patients undergoing CT colonography (CTC), the screening presents an opportunity for concurrent osteoporosis screening, without increasing…”
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