Search Results - "Pickett, Eleanor"

Region-specific depletion of synaptic mitochondria in the brains of patients with Alzheimer’s disease by Pickett, Eleanor K., Rose, Jamie, McCrory, Caoimhe, McKenzie, Chris-Anne, King, Declan, Smith, Colin, Gillingwater, Thomas H., Henstridge, Christopher M., Spires-Jones, Tara L.

“…Of all of the neuropathological changes observed in Alzheimer’s disease (AD), the loss of synapses correlates most strongly with cognitive decline. The precise…”
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Synaptic pathology: a shared mechanism in neurological disease by Henstridge, Christopher M, Pickett, Eleanor, Spires-Jones, Tara L

“…Graphical abstract…”
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Amyloid Beta and Tau Cooperate to Cause Reversible Behavioral and Transcriptional Deficits in a Model of Alzheimer’s Disease by Pickett, Eleanor K., Herrmann, Abigail G., McQueen, Jamie, Abt, Kimberly, Dando, Owen, Tulloch, Jane, Jain, Pooja, Dunnett, Sophie, Sohrabi, Sadaf, Fjeldstad, Maria P., Calkin, Will, Murison, Leo, Jackson, Rosemary J., Tzioras, Makis, Stevenson, Anna, d’Orange, Marie, Hooley, Monique, Davies, Caitlin, Colom-Cadena, Marti, Anton-Fernandez, Alejandro, King, Declan, Oren, Iris, Rose, Jamie, McKenzie, Chris-Anne, Allison, Elizabeth, Smith, Colin, Hardt, Oliver, Henstridge, Christopher M., Hardingham, Giles E., Spires-Jones, Tara L.

“…A key knowledge gap blocking development of effective therapeutics for Alzheimer’s disease (AD) is the lack of understanding of how amyloid beta (Aβ) peptide…”
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Spread of tau down neural circuits precedes synapse and neuronal loss in the rTgTauEC mouse model of early Alzheimer's disease by Pickett, Eleanor K., Henstridge, Christopher M., Allison, Elizabeth, Pitstick, Rose, Pooler, Amy, Wegmann, Susanne, Carlson, George, Hyman, Bradley T., Spires‐Jones, Tara L.

“…Synaptic dysfunction and loss is the strongest pathological correlate of cognitive decline in Alzheimer's disease (AD) with increasing evidence implicating…”
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Non-Fibrillar Oligomeric Amyloid-β within Synapses by Pickett, Eleanor K, Koffie, Robert M, Wegmann, Susanne, Henstridge, Christopher M, Herrmann, Abigail G, Colom-Cadena, Marti, Lleo, Alberto, Kay, Kevin R, Vaught, Melissa, Soberman, Roy, Walsh, Dominic M, Hyman, Bradley T, Spires-Jones, Tara L

“…Alzheimer's disease (AD) is characterized by memory loss, insidious cognitive decline, profound neurodegeneration, and the extracellular accumulation of…”
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Maintained memory and long‐term potentiation in a mouse model of Alzheimer's disease with both amyloid pathology and human tau by Tulloch, Jane, Netsyk, Olga, Pickett, Eleanor K., Herrmann, Abigail G., Jain, Pooja, Stevenson, Anna J., Oren, Iris, Hardt, Oliver, Spires‐Jones, Tara L.

“…One of the key knowledge gaps in the field of Alzheimer's disease research is the lack of understanding of how amyloid beta and tau cooperate to cause…”
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Does feature binding account for functional decline in patients with mild cognitive impairment? Evidence from the Details of Function of Everyday Life Questionnaire (DoFEL) by Calia, Clara, O'Donal, Freddie, Pickett, Eleanor, Parra, Mario A.

“…Background Available functional scales used to discriminate normal and abnormal ageing are informative of basic abilities (e.g., bathing, grooming, feeding,…”
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Functional assessment of cognitively impaired older adults: Are we asking the right questions? by Calia, Clara, Pickett, Eleanor, O'Donal, Freddie, Parra, Mario A.

“…Background Recent attention has turned to the development of preventative treatments for Alzheimer’s disease (AD) by targeting the early stages of impairment…”
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Does feature binding account for functional decline in patients with mild cognitive impairment? Evidence from the Details of Function of Everyday Life Questionnaire (DoFEL): Neuropsychology/Early detection of cognitive decline with neuropsychological tests by Calia, Clara, O'Donal, Freddie, Pickett, Eleanor, Parra, Mario A.

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Functional assessment of cognitively impaired older adults: Are we asking the right questions?: Neuropsychology/Early detection of cognitive decline with neuropsychological tests by Calia, Clara, Pickett, Eleanor, O'Donal, Freddie, Parra, Mario A.

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Antidiabetic Polypill Improves Central Pathology and Cognitive Impairment in a Mixed Model of Alzheimer’s Disease and Type 2 Diabetes by Infante-Garcia, Carmen, Ramos-Rodriguez, Juan Jose, Hierro-Bujalance, Carmen, Ortegon, Esperanza, Pickett, Eleanor, Jackson, Rosemary, Hernandez-Pacho, Fernando, Spires-Jones, Tara, Garcia-Alloza, Monica

“…Type 2 diabetes (T2D) is an important risk factor to suffer dementia, being Alzheimer’s disease (AD) as the most common form. Both AD and T2D are closely…”
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Spread of tau down neural circuits precedes synapse and neuronal loss in the rTgTauEC mouse model of early A lzheimer's disease by Pickett, Eleanor K., Henstridge, Christopher M., Allison, Elizabeth, Pitstick, Rose, Pooler, Amy, Wegmann, Susanne, Carlson, George, Hyman, Bradley T., Spires‐Jones, Tara L.

“…Synaptic dysfunction and loss is the strongest pathological correlate of cognitive decline in Alzheimer's disease (AD) with increasing evidence implicating…”
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Synapse dysfunction in alzheimer's disease: contributions of amyloid-beta and tau by Pickett, Eleanor Kay

“…Alzheimer's disease (AD) is characterised by memory loss, insidious cognitive decline, profound neurodegeneration, and the extracellular accumulation of…”
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EC‐03‐03: Tau Spreading and Toxicity by Pickett, Eleanor, Henstridge, Christopher, Jackson, Rosemary J., Herrmann, Abigail G., Wegmann, Susanne, Hyman, Bradley T., Carlson, George A., Spires-Jones, Tara L.

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TAU SPREADING AND TOXICITY by Pickett, Eleanor, Henstridge, Christopher, Jackson, Rosemary J, Herrmann, Abigail G, Wegmann, Susanne, Hyman, Bradley T, Carlson, George A, Spires-Jones, Tara L

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