Search Results - "Pickersgill, Richard W"

De novo targeting to the cytoplasmic and luminal side of bacterial microcompartments by Lee, Matthew J., Mantell, Judith, Brown, Ian R., Fletcher, Jordan M., Verkade, Paul, Pickersgill, Richard W., Woolfson, Derek N., Frank, Stefanie, Warren, Martin J.

“…Bacterial microcompartments, BMCs, are proteinaceous organelles that encase a specific metabolic pathway within a semi-permeable protein shell. Short…”
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Structural basis of pyrrole polymerization in human porphobilinogen deaminase by Pluta, Paula, Roversi, Pietro, Bernardo-Seisdedos, Ganeko, Rojas, Adriana L., Cooper, Jonathan B., Gu, Shuang, Pickersgill, Richard W., Millet, Oscar

“…Human porphobilinogen deaminase (PBGD), the third enzyme in the heme pathway, catalyzes four times a single reaction to convert porphobilinogen into…”
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Kinetochores attached to microtubule-ends are stabilised by Astrin bound PP1 to ensure proper chromosome segregation by Conti, Duccio, Gul, Parveen, Islam, Asifa, Martín-Durán, José M, Pickersgill, Richard W, Draviam, Viji M

“…Microtubules segregate chromosomes by attaching to macromolecular kinetochores. Only microtubule-end attached kinetochores can be pulled apart; how these…”
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Scaffolding Protein GspB/OutB Facilitates Assembly of the Dickeya dadantii Type 2 Secretion System by Anchoring the Outer Membrane Secretin Pore to the Inner Membrane and to the Peptidoglycan Cell Wall by Zhang, Shiheng, Gu, Shuang, Rycroft, Piers, Ruaudel, Florence, Delolme, Frederic, Robert, Xavier, Ballut, Lionel, Pickersgill, Richard W, Shevchik, Vladimir E

“…The phytopathogenic proteobacterium Dickeya dadantii secretes an array of plant cell wall-degrading enzymes and other virulence factors via the type 2…”
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An enzyme-trap approach allows isolation of intermediates in cobalamin biosynthesis by Deery, Evelyne, Schroeder, Susanne, Lawrence, Andrew D, Taylor, Samantha L, Seyedarabi, Arefeh, Waterman, Jitka, Wilson, Keith S, Brown, David, Geeves, Michael A, Howard, Mark J, Pickersgill, Richard W, Warren, Martin J

“…The use of abbreviated pathway constructs leads to trapping of a series of cobalamin intermediates, allowing assignment of the full biosynthetic pathway and…”
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Structure of a trimeric bacterial microcompartment shell protein, EtuB, associated with ethanol utilization in Clostridium kluyveri by Heldt, Dana, Frank, Stefanie, Seyedarabi, Arefeh, Ladikis, Dimitrios, Parsons, Joshua B, Warren, Martin J, Pickersgill, Richard W

“…It has been suggested that ethanol metabolism in the strict anaerobe Clostridium kluyveri occurs within a metabolosome, a subcellular proteinaceous bacterial…”
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A disulfide driven domain swap switches off the activity of Shigella IpaH9.8 E3 ligase by Seyedarabi, Arefeh, Sullivan, James A., Sasakawa, Chihiro, Pickersgill, Richard W.

“…We show that the monomeric form of Shigella IpaH9.8 E3 ligase catalyses the ubiquitination of human U2AF35 in vitro, providing a molecular mechanism for the…”
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Structural and functional insights into the pilotin-secretin complex of the type II secretion system by Gu, Shuang, Rehman, Saima, Wang, Xiaohui, Shevchik, Vladimir E, Pickersgill, Richard W

“…Gram-negative bacteria secrete virulence factors and assemble fibre structures on their cell surface using specialized secretion systems. Three of these, T2SS,…”
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Evolution in a family of chelatases facilitated by the introduction of active site asymmetry and protein oligomerization by Romão, Célia V, Ladakis, Dimitrios, Lobo, Susana A.L, Carrondo, Maria A, Brindley, Amanda A, Deery, Evelyne, Matias, Pedro M, Pickersgill, Richard W, Saraiva, Lígia M, Warren, Martin J

“…The class II chelatases associated with heme, siroheme, and cobalamin biosynthesis are structurally related enzymes that insert a specific metal ion (Fe²⁺ or…”
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A Generic Self‐Assembly Process in Microcompartments and Synthetic Protein Nanotubes by Uddin, Ismail, Frank, Stefanie, Warren, Martin J., Pickersgill, Richard W.

“…Bacterial microcompartments enclose a biochemical pathway and reactive intermediate within a protein envelope formed by the shell proteins. Herein, the…”
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Enzyme-cargo encapsulation peptides bind between tessellating tiles of the bacterial microcompartment shell by Gu, Shuang, Bradley-Clarke, Jack, Rose, Ruth-Sarah, Warren, Martin J., Pickersgill, Richard W.

“…Bacterial microcompartments are prokaryotic organelles comprising encapsulated enzymes within a thin protein shell. They facilitate metabolic processing…”
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Enzyme sequence and its relationship to hyperbaric stability of artificial and natural fish lactate dehydrogenases by Brindley, Amanda A, Pickersgill, Richard W, Partridge, Julian C, Dunstan, David J, Hunt, David M, Warren, Martin J

“…The cDNAs of lactate dehydrogenase b (LDH-b) from both deep-sea and shallow living fish species, Corphaenoides armatus and Gadus morhua respectively, have been…”
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FAD binding, cobinamide binding and active site communication in the corrin reductase (CobR) by Lawrence, Andrew D, Taylor, Samantha L, Scott, Alan, Rowe, Michelle L, Johnson, Christopher M, Rigby, Stephen E J, Geeves, Michael A, Pickersgill, Richard W, Howard, Mark J, Warren, Martin J

“…Adenosylcobalamin, the coenzyme form of vitamin B12, is one Nature's most complex coenzyme whose de novo biogenesis proceeds along either an anaerobic or…”
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Structural and Spectroscopic Studies Shed Light on the Mechanism of Oxalate Oxidase by Opaleye, Olaniyi, Rose, Ruth-Sarah, Whittaker, Mei M., Woo, Eui-Jeon, Whittaker, James W., Pickersgill, Richard W.

“…Oxalate oxidase (EC 1.2.3.4) catalyzes the conversion of oxalate and dioxygen to hydrogen peroxide and carbon dioxide. In this study, glycolate was used as a…”
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The Crystal Structure of Pectate Lyase Pel9A from Erwinia chrysanthemi by Jenkins, John, Shevchik, Vladimir E., Hugouvieux-Cotte-Pattat, Nicole, Pickersgill, Richard W.

“…The “family 9 polysaccharide lyase” pectate lyase L (Pel9A) from Erwinia chrysanthemi comprises a 10-coil parallel β-helix domain with distinct structural…”
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Structural Insights into Higher Order Assembly and Function of the Bacterial Microcompartment Protein PduA by Pang, Allan, Frank, Stefanie, Brown, Ian, Warren, Martin J., Pickersgill, Richard W.

“…Bacterial microcompartments are large proteinaceous assemblies that are found in the cytoplasm of some bacteria. These structures consist of proteins…”
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Characterization of retinaldehyde dehydrogenase 3 by Graham, Caroline E, Brocklehurst, Keith, Pickersgill, Richard W, Warren, Martin J

“…RALDH3 (retinal dehydrogenase 3) was characterized by kinetic and binding studies, protein engineering, homology modelling, ligand docking and…”
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Identification, Characterization, and Structure/Function Analysis of a Corrin Reductase Involved in Adenosylcobalamin Biosynthesis by Lawrence, Andrew D., Deery, Evelyne, McLean, Kirsty J., Munro, Andrew W., Pickersgill, Richard W., Rigby, Stephen E.J., Warren, Martin J.

“…Vitamin B12, the antipernicious anemia factor, is the cyano derivative of adenosylcobalamin, which is one of nature's most complex coenzymes. Adenosylcobalamin…”
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Substrate channels revealed in the trimeric Lactobacillus reuteri bacterial microcompartment shell protein PduB by Pang, Allan, Liang, Mingzhi, Prentice, Michael B., Pickersgill, Richard W.

“…Lactobacillus reuteri metabolizes two similar three‐carbon molecules, 1,2‐propanediol and glycerol, within closed polyhedral subcellular bacterial organelles…”
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Synthetic Protein Nanotubes: A Generic Self‐Assembly Process in Microcompartments and Synthetic Protein Nanotubes (Small 19/2018) by Uddin, Ismail, Frank, Stefanie, Warren, Martin J., Pickersgill, Richard W.

“…In article number 1704020, Richard W. Pickersgill and co‐workers uncover the orientation of shell proteins within synthetic protein nanotubes and bacterial…”
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