Search Results - "Pickering‐Brown, S."

The role of lysosomes and autophagosomes in frontotemporal lobar degeneration by Bain, H. D. C., Davidson, Y. S., Robinson, A. C., Ryan, S., Rollinson, S., Richardson, A., Jones, M., Snowden, J. S., Pickering‐Brown, S., Mann, D. M. A.

“…Introduction Cell biological and genetic evidence implicate failures in degrading aggregating proteins, such as tau and TDP‐43, through the autophagy or…”
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Neurodegeneration in frontotemporal lobar degeneration and motor neurone disease associated with expansions in C9orf72 is linked to TDP-43 pathology and not associated with aggregated forms of dipeptide repeat proteins by Davidson, Y., Robinson, A. C., Liu, X., Wu, D., Troakes, C., Rollinson, S., Masuda-Suzukake, M., Suzuki, G., Nonaka, T., Shi, J., Tian, J., Hamdalla, H., Ealing, J., Richardson, A., Jones, M., Pickering-Brown, S., Snowden, J. S., Hasegawa, M., Mann, D. M. A.

“…Aims A hexanucleotide expansion in C9orf72 is the major genetic cause of inherited behavioural variant Frontotemporal dementia (bvFTD) and motor neurone…”
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Progranulin gene mutations associated with frontotemporal dementia and progressive non-fluent aphasia by Snowden, J. S., Pickering-Brown, S. M., Mackenzie, I. R., Richardson, A. M. T., Varma, A., Neary, D., Mann, D. M. A.

“…Frontotemporal lobar degeneration (FTLD) refers to a focal, non-Alzheimer form of cerebral degeneration that encompasses the distinct clinical syndromes of…”
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The neuropathology of frontotemporal lobar degeneration caused by mutations in the progranulin gene by Mackenzie, Ian R. A., Baker, Matt, Pickering-Brown, Stuart, Hsiung, Ging-Yuek R., Lindholm, Caroline, Dwosh, Emily, Gass, Jennifer, Cannon, Ashley, Rademakers, Rosa, Hutton, Mike, Feldman, Howard H.

“…The most common pathology in frontotemporal dementia (FTD) is tau-negative, ubiquitin-immunoreactive (ub-ir) neuronal inclusions (FTLD-U). Recently, we…”
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Corticobasal degeneration and progressive supranuclear palsy share a common tau haplotype by HOULDEN, H, BAKER, M, KHAN, M. N, HARDY, J, LANTOS, P. L, GEORGE-HYSLOP, P. St, MUNOZ, D. G, MANN, D, LANG, A. E, BERGERON, C, BIGIO, E. H, LITVAN, I, MORRIS, H. R, BHATIA, K. P, DICKSON, D, WOOD, N. W, HUTTON, M, MACDONALD, N, PICKERING-BROWN, S, ADAMSON, J, LEES, A. J, ROSSOR, M. N, QUINN, N. P, KERTESZ, A

“…To analyze the association of polymorphisms in the tau gene with pathologically confirmed corticobasal degeneration (CBD). The authors previously described an…”
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Review: Recent progress in frontotemporal lobar degeneration by Pickering-Brown, S. M.

“…S. M. Pickering‐Brown (2010) Neuropathology and Applied Neurobiology36, 4–16
Recent progress in frontotemporal lobar degeneration Frontotemporal lobar…”
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Frontotemporal dementia with Pick‐type histology associated with Q336R mutation in the tau gene by Pickering‐Brown, S. M., Baker, M., Nonaka, T., Ikeda, K., Sharma, S., Mackenzie, J., Simpson, S. A., Moore, J. W., Snowden, J. S., de Silva, R., Revesz, T., Hasegawa, M., Hutton, M., Mann, D. M. A.

“…In this report, we describe the clinical and neuropathological features of a case of familial frontotemporal dementia (FTD), with onset at 58 years of age and…”
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Inherited frontotemporal dementia in nine british families associated with intronic mutations in the tau gene by PICKERING-BROWN, S. M, RICHARDSON, A. M. T, HUTTON, M, DAVIES, Y, ALLSOP, D, CRAUFURD, D, NEARY, D, MANN, D. M. A, SNOWDEN, J. S, MCDONAGH, A. M, BURNS, A, BRAUDE, W, BAKER, M, LIU, W.-K, YEN, S.-H, HARDY, J

“…Genetic screening of 171 patients with frontotemporal lobar degeneration disclosed 14 patients, across nine pedigrees, with mutations in the intron to exon 10…”
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The neuropathology of frontotemporal lobar degeneration with respect to the cytological and biochemical characteristics of tau protein by Taniguchi, S., McDonagh, A. M., Pickering-Brown, S. M., Umeda, Y., Iwatsubo, T., Hasegawa, M., Mann, D. M. A.

“…Pathological examinations, using a panel of tau and other antibodies, were performed on the brains from 55 consecutively acquired cases of frontotemporal lobar…”
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Genetic associations between cathepsin D exon 2 C→T polymorphism and Alzheimer’s disease, and pathological correlations with genotype by Davidson, Y, Gibbons, L, Pritchard, A, Hardicre, J, Wren, J, Tian, J, Shi, J, Stopford, C, Julien, C, Thompson, J, Payton, A, Thaker, U, Hayes, A J, Iwatsubo, T, Pickering-Brown, S M, Pendleton, N, Horan, M A, Burns, A, Purandare, N, Lendon, C L, Neary, D, Snowden, J S, Mann, D M A

“…Genetic variations represent major risk factors for Alzheimer’s disease (AD). While familial early onset AD is associated with mutations in the amyloid…”
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Association between apolipoprotein E e4 allele and arteriosclerosis, cerebral amyloid angiopathy, and cerebral white matter damage in Alzheimer’s disease by Tian, J, Shi, J, Bailey, K, Lendon, C L, Pickering-Brown, S M, Mann, D M A

“…Objective: To investigate the association between white matter damage, as evidenced by myelin loss (ML), the extent of cerebral amyloid angiopathy (CAA), or…”
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The apolipoprotein E ε4 allele selectively increases the risk of frontotemporal lobar degeneration in males by Srinivasan, R, Davidson, Y, Gibbons, L, Payton, A, Richardson, A M T, Varma, A, Julien, C, Stopford, C, Thompson, J, Horan, M A, Pendleton, N, Pickering-Brown, S M, Neary, D, Snowden, J S, Mann, D M A

“…Objective: To determine whether polymorphic variations in the apolipoprotein E gene (APOE) are associated with increased risk of frontotemporal lobar…”
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A polymorphic variation in the interleukin 1A gene increases brain microglial cell activity in Alzheimer’s disease by Hayes, A, Green, E K, Pritchard, A, Harris, J M, Zhang, Y, Lambert, J C, Chartier-Harlin, M C, Pickering-Brown, S M, Lendon, C L, Mann, D M A

“…Objective: To investigate the impact of possession of the −889 C/T polymorphism of the interleukin 1A gene (IL-1A) and the −511 C/T polymorphism of the…”
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Frequency of tau mutations in three series of non-Alzheimer's degenerative dementia by Houlden, H., Baker, M., Adamson, J., Grover, A., Waring, S., Dickson, D., Lynch, T., Boeve, B., Petersen, R. C., Pickering-Brown, S., Owen, F., Neary, D., Craufurd, D., Snowden, J., Mann, D., Hutton, M.

“…Splice‐site and missense mutations have been identified in tau associated with frontotemporal dementia with parkinsonism linked to chromosome 17. In this study…”
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Pathological relationships between microglial cell activity and tau and amyloid β protein in patients with Alzheimer's disease by Hayes, A., Thaker, U., Iwatsubo, T., Pickering-Brown, S.M., Mann, D.M.A.

“…The extent of microglial cell activation (microglial cell load) was estimated by image analysis of ferritin-immunostained sections of frontal cortex from 72…”
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Comparison of extent of tau pathology in patients with frontotemporal dementia with Parkinsonism linked to chromosome 17 (FTDP-17), frontotemporal lobar degeneration with Pick bodies and early onset Alzheimer's disease by Shiarli, A.-M., Jennings, R., Shi, J., Bailey, K., Davidson, Y., Tian, J., Bigio, E. H., Ghetti, B., Murrell, J. R., Delisle, M. B., Mirra, S., Crain, B., Zolo, P., Arima, K., Iseki, E., Murayama, S., Kretzschmar, H., Neumann, M., Lippa, C., Halliday, G., MacKenzie, J., Khan, N., Ravid, R., Dickson, D., Wszolek, Z., Iwatsubo, T., Pickering-Brown, S. M., Mann, D. M. A.

“…In order to gain insight into the pathogenesis of frontotemporal lobar degeneration (FTLD), the mean tau load in frontal cortex was compared in 34 patients…”
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A polymorphism in the angiotensin 1-converting enzyme gene is associated with damage to cerebral cortical white matter in Alzheimer's disease by Tian, J, Shi, J, Bailey, K, Harris, J.M, Pritchard, A, Lambert, J.-C, Chartier-Harlin, M.-C, Pickering-Brown, S.M, Lendon, C.L, Mann, D.M.A

“…The impact of the insertion (I)/deletion (D) (I/D) polymorphism in the angiotensin 1-converting enzyme (ACE) gene on the extent of white matter myelin loss…”
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The angiotensin 1-converting enzyme insertion (I)/deletion (D) polymorphism does not influence the extent of amyloid or tau pathology in patients with sporadic Alzheimer's disease by Lendon, C.L, Thaker, U, Harris, J.M, McDonagh, A.M, Lambert, J.-C, Chartier-Harlin, M.-C, Iwatsubo, T, Pickering-Brown, S.M, Mann, D.M.A

“…An insertion (I)/deletion (D) polymorphism in the angiotensin 1-converting enzyme (ACE) gene has, in some studies, been associated with increased risk for…”
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Amyloid β protein deposition in patients with frontotemporal lobar degeneration: relationship to age and apolipoprotein E genotype by Mann, D.M.A, McDonagh, A.M, Pickering-Brown, S.M, Kowa, H, Iwatsubo, T

“…Amyloid β protein (Aβ) deposition was investigated in the frontal cortex of 54 autopsy cases of frontotemporal lobar degeneration (FTLD) using methenamine…”
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Tau load is associated with apolipoprotein E genotype and the amount of amyloid β protein, Aβ40, in sporadic and familial Alzheimer's disease by Thaker, U., McDonagh, A. M., Iwatsubo, T., Lendon, C. L., Pickering-Brown, S. M., A. Mann, D. M.

“…U. Thaker, A. M. McDonagh, T. Iwatsubo, C. L. Lendon, S. M. Pickering‐Brown and D. M. A. Mann (2003) Neuropathology and Applied Neurobiology 29, 35–44 
Tau…”
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