Search Results - "Pickering, M"

Recent advances in recreation ecology and the implications of different relationships between recreation use and ecological impacts by Monz, Christopher A, Pickering, Catherine M, Hadwen, Wade L

“…Recreation ecology - the study of the environmental consequences of outdoor recreation/nature-based tourism activities and their effective management - is an…”
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The immunoproteasome, the 20S proteasome and the PA28αβ proteasome regulator are oxidative-stress-adaptive proteolytic complexes by Pickering, Andrew M, Koop, Alison L, Teoh, Cheryl Y, Ermak, Gennady, Grune, Tilman, Davies, Kelvin J A

“…Oxidized cytoplasmic and nuclear proteins are normally degraded by the proteasome, but accumulate with age and disease. We demonstrate the importance of…”
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Questions asked and answered in pilot and feasibility randomized controlled trials by Shanyinde, Milensu, Pickering, Ruth M, Weatherall, Mark

“…In the last decade several authors have reviewed the features of pilot and feasibility studies and advised on the issues that should be addressed within them…”
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From barriers to limits to climate change adaptation: path dependency and the speed of change by Barnett, Jon, Evans, Louisa S., Gross, Catherine, Kiem, Anthony S., Kingsford, Richard T., Palutikof, Jean P., Pickering, Catherine M., Smithers, Scott G.

“…Research on the barriers and limits to climate change adaptation identifies many factors, but describes few processes whereby adaptation is constrained or may…”
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Tourist vehicle as a selective mechanism for plant dispersal: Evidence from a national park in the eastern Himalaya by Yang, Mingyu, Pickering, Catherine M., Xu, Lei, Lin, Xin

“…It is increasingly recognised that human vehicle may act as a vector to spread species, but research remains sparse to examine vehicle-mediated spread to…”
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The proteasome: A key modulator of nervous system function, brain aging, and neurodegenerative disease by Davidson, Kanisa, Pickering, Andrew M

“…The proteasome is a large multi-subunit protease responsible for the degradation and removal of oxidized, misfolded, and polyubiquitinated proteins. The…”
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Nrf2-dependent Induction of Proteasome and Pa28αβ Regulator Are Required for Adaptation to Oxidative Stress by Pickering, Andrew M., Linder, Robert A., Zhang, Hongqiao, Forman, Henry J., Davies, Kelvin J.A.

“…The ability to adapt to acute oxidative stress (e.g. H2O2, peroxynitrite, menadione, and paraquat) through transient alterations in gene expression is an…”
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miR-17 and miR-20a temper an E2F1-induced G1 checkpoint to regulate cell cycle progression by Pickering, M T, Stadler, B M, Kowalik, T F

“…The stringent regulation of cell cycle progression helps to maintain genetic stability in cells. MicroRNAs (miRNAs) are critical regulators of gene expression…”
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Everolimus versus sunitinib for patients with metastatic non-clear cell renal cell carcinoma (ASPEN): a multicentre, open-label, randomised phase 2 trial by Armstrong, Andrew J, Dr, Halabi, Susan, Prof, Eisen, Tim, Prof, Broderick, Samuel, MS, Stadler, Walter M, Prof, Jones, Robert J, Prof, Garcia, Jorge A, MD, Vaishampayan, Ulka N, Prof, Picus, Joel, Prof, Hawkins, Robert E, Prof, Hainsworth, John D, Prof, Kollmannsberger, Christian K, Prof, Logan, Theodore F, Prof, Puzanov, Igor, MD, Pickering, Lisa M, MD, Ryan, Christopher W, MD, Protheroe, Andrew, MD, Lusk, Christine M, MPH, Oberg, Sadie, BS, George, Daniel J, Prof

“…Summary Background Non-clear cell renal cell carcinomas are histologically and genetically diverse kidney cancers with variable prognoses, and their optimum…”
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Translational Mini-Review Series on Complement Factor H: Renal diseases associated with complement factor H: novel insights from humans and animals by Pickering, M.C, Cook, H.T

“…Factor H is the major regulatory protein of the alternative pathway of complement activation. Abnormalities in factor H have been associated with renal…”
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Differential roles of proteasome and immunoproteasome regulators Pa28αβ, Pa28γ and Pa200 in the degradation of oxidized proteins by Pickering, Andrew M., Davies, Kelvin J.A.

“…► Pa28αβ and Pa28γ enhance selective degradation of oxidized proteins by 20S proteasome. ► Pa28αβ enhances selective degradation of oxidized proteins by the…”
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Early-adulthood spike in protein translation drives aging via juvenile hormone/germline signaling by Kim, Harper S., Parker, Danitra J., Hardiman, Madison M., Munkácsy, Erin, Jiang, Nisi, Rogers, Aric N., Bai, Yidong, Brent, Colin, Mobley, James A., Austad, Steven N., Pickering, Andrew M.

“…Protein translation (PT) declines with age in invertebrates, rodents, and humans. It has been assumed that elevated PT at young ages is beneficial to health…”
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The implications of structured 5′ untranslated regions on translation and disease by Pickering, Becky M, Willis, Anne E

“…Translational control is a key step in eukaryotic gene expression. The majority of translational control occurs at the level of initiation, thus implicating…”
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Degradation of damaged proteins: the main function of the 20S proteasome by Pickering, Andrew M, Davies, Kelvin J A

“…Cellular proteins are exposed to oxidative modification and other forms of damage through oxidative stress and disease, and as a consequence of aging. This…”
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LANFEX: A Field and Modeling Study to Improve Our Understanding and Forecasting of Radiation Fog by Price, J. D., Lane, S., Boutle, I. A., Smith, D. K. E., Bergot, T., Lac, C., Duconge, L., McGregor, J., Kerr-Munslow, A., Pickering, M., Clark, R.

“…Fog is a high-impact weather phenomenon affecting human activity, including aviation, transport, and health. Its prediction is a longstanding issue for weather…”
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Protein translation paradox: Implications in translational regulation of aging by Kim, Harper S, Pickering, Andrew M

“…Protein translation is an essential cellular process playing key roles in growth and development. Protein translation declines over the course of age in…”
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Hospital nurse staffing and staff-patient interactions: an observational study by Bridges, Jackie, Griffiths, Peter, Oliver, Emily, Pickering, Ruth M

“…Existing evidence indicates that reducing nurse staffing and/or skill mix adversely affects care quality. Nursing shortages may lead managers to dilute nursing…”
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A meta-analysis of six prospective studies of falling in Parkinson's disease by Pickering, Ruth M., Grimbergen, Yvette A.M., Rigney, Una, Ashburn, Ann, Mazibrada, Gordon, Wood, Brian, Gray, Peggy, Kerr, Graham, Bloem, Bastiaan R.

“…Recurrent falls are a disabling feature of Parkinson's disease (PD). We have estimated the incidence of falling over a prospective 3 month follow‐up from a…”
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Expression of C9orf72-related dipeptides impairs motor function in a vertebrate model by Swaminathan, Amrutha, Bouffard, Marilou, Liao, Meijiang, Ryan, Sarah, Callister, Janis Bennion, Pickering-Brown, Stuart M, Armstrong, Gary Alan Barclay, Drapeau, Pierre

“…Abstract Large expansions of hexanucleotide GGGGCC (G4C2) repeats (hundreds to thousands) in the first intron of the chromosome 9 open reading frame 72…”
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Particle sizing calibration with refractive index correction for light scattering optical particle counters and impacts upon PCASP and CDP data collected during the Fennec campaign by Rosenberg, P. D, Dean, A. R, Williams, P. I, Dorsey, J. R, Minikin, A, Pickering, M. A, Petzold, A

“…Optical particle counters (OPCs) are used regularly for atmospheric research, measuring particle scattering cross sections to generate particle size…”
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