Search Results - "Pickering, Andrew"
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Acting with the World: Doing without Science
Published in E-cadernos CES (31-03-2023)“…In this paper I contrast two systematically different patterns of acting in the world via the concepts of enframing and poiesis. Enframing is the usual stance…”
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Cause or casualty: The role of mitochondrial DNA in aging and age-associated disease
Published in Biochimica et biophysica acta. Molecular basis of disease (01-02-2019)“…The mitochondrial genome (mtDNA) represents a tiny fraction of the whole genome, comprising just 16.6 kilobases encoding 37 genes involved in oxidative…”
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Ideological polarization and government debt
Published in International tax and public finance (01-08-2022)“…Models of strategic debt predict that public debt increases with polarization, measured by the ideological distance between the government and its likely…”
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The immunoproteasome, the 20S proteasome and the PA28αβ proteasome regulator are oxidative-stress-adaptive proteolytic complexes
Published in Biochemical journal (15-12-2010)“…Oxidized cytoplasmic and nuclear proteins are normally degraded by the proteasome, but accumulate with age and disease. We demonstrate the importance of…”
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5
HSP70 mediates dissociation and reassociation of the 26S proteasome during adaptation to oxidative stress
Published in Free radical biology & medicine (01-10-2011)“…We report an entirely new role for the HSP70 chaperone in dissociating 26S proteasome complexes (into free 20S proteasomes and bound 19S regulators),…”
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Differential roles of proteasome and immunoproteasome regulators Pa28αβ, Pa28γ and Pa200 in the degradation of oxidized proteins
Published in Archives of biochemistry and biophysics (15-07-2012)“…► Pa28αβ and Pa28γ enhance selective degradation of oxidized proteins by 20S proteasome. ► Pa28αβ enhances selective degradation of oxidized proteins by the…”
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Lifespan of mice and primates correlates with immunoproteasome expression
Published in The Journal of clinical investigation (01-05-2015)“…There is large variation in lifespan among different species, and there is evidence that modulation of proteasome function may contribute to longevity…”
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Degradation of damaged proteins: the main function of the 20S proteasome
Published in Progress in molecular biology and translational science (2012)“…Cellular proteins are exposed to oxidative modification and other forms of damage through oxidative stress and disease, and as a consequence of aging. This…”
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The proteasome: A key modulator of nervous system function, brain aging, and neurodegenerative disease
Published in Frontiers in cell and developmental biology (13-04-2023)“…The proteasome is a large multi-subunit protease responsible for the degradation and removal of oxidized, misfolded, and polyubiquitinated proteins. The…”
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Nrf2-dependent Induction of Proteasome and Pa28αβ Regulator Are Required for Adaptation to Oxidative Stress
Published in The Journal of biological chemistry (23-03-2012)“…The ability to adapt to acute oxidative stress (e.g. H2O2, peroxynitrite, menadione, and paraquat) through transient alterations in gene expression is an…”
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Oxidative stress adaptation with acute, chronic, and repeated stress
Published in Free radical biology & medicine (01-02-2013)“…Oxidative stress adaptation, or hormesis, is an important mechanism by which cells and organisms respond to, and cope with, environmental and physiological…”
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Inverse Electron-Demand Diels-Alder Methylcellulose Hydrogels Enable the Co-delivery of Chondroitinase ABC and Neural Progenitor Cells
Published in Biomacromolecules (08-06-2020)“…A hydrogel that can deliver both proteins and cells enables the local microenvironment of transplanted cells to be manipulated with a single injection. Toward…”
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IDEOLOGY AND THE GROWTH OF GOVERNMENT
Published in The review of economics and statistics (01-08-2011)“…We analyze the impact of ideology on the size of government. In a simple model, the government sets redistribution and provision of public services according…”
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Early-adulthood spike in protein translation drives aging via juvenile hormone/germline signaling
Published in Nature communications (18-08-2023)“…Protein translation (PT) declines with age in invertebrates, rodents, and humans. It has been assumed that elevated PT at young ages is beneficial to health…”
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15
Inequality and the composition of taxes
Published in International tax and public finance (01-08-2018)“…This paper analyses the political economics of the composition of taxes. Taxes may be levied on income, or on expenditure, with the median voter pivotal in the…”
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Layer-by-Layer Polymer Functionalization Improves Nanoparticle Penetration and Glioblastoma Targeting in the Brain
Published in ACS nano (12-12-2023)“…Glioblastoma is characterized by diffuse infiltration into surrounding healthy brain tissues, which makes it challenging to treat. Complete surgical resection…”
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The Economic Consequences of Political Donation Limits
Published in Economica (London) (01-07-2018)“…The economic consequences of limits on political donations depend on the degree of political competition. Donors, who are ideologically aligned with…”
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Local delivery of stabilized chondroitinase ABC degrades chondroitin sulfate proteoglycans in stroke-injured rat brains
Published in Journal of controlled release (10-03-2019)“…Central nervous system (CNS) injuries, such as stroke and spinal cord injuries, result in the formation of a proteoglycan-rich glial scar, which acts as a…”
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Subsyndromes and symptom clusters: Multilevel factor analysis of behavioral and psychological symptoms of dementia with intensive longitudinal data
Published in Alzheimer's & dementia (01-10-2024)“…INTRODUCTION Behavioral and psychological symptoms in dementia (BPSD) are dynamic phenomena with a high amount of intraindividual variability. We applied a…”
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Protein translation paradox: Implications in translational regulation of aging
Published in Frontiers in cell and developmental biology (13-01-2023)“…Protein translation is an essential cellular process playing key roles in growth and development. Protein translation declines over the course of age in…”
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