Search Results - "Pickering, Alex"

Mutagenesis of a Conserved Glutamate Reveals the Contribution of Electrostatic Energy to Adenosylcobalamin Co–C Bond Homolysis in Ornithine 4,5-Aminomutase and Methylmalonyl-CoA Mutase by Makins, Caitlyn, Pickering, Alex V, Mariani, Chloe, Wolthers, Kirsten R

“…Binding of substrate to ornithine 4,5-aminomutase (OAM) and methylmalonyl-CoA mutase (MCM) leads to the formation of an electrostatic interaction between a…”
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Cross-modal representation alignment of molecular structure and perturbation-induced transcriptional profiles by Finlayson, Samuel G, McDermott, Matthew B A, Pickering, Alex V, Lipnick, Scott L, Kohane, Isaac S

“…Modeling the relationship between chemical structure and molecular activity is a key goal in drug development. Many benchmark tasks have been proposed for…”
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Proceedings from the 2nd Next Gen Therapies for Systemic Juvenile Idiopathic Arthritis and Macrophage Activation Syndrome symposium held on October 3-4, 2019 by Canna, Scott W., Schulert, Grant S., de Jesus, Adriana, Pickering, Alex, Brunner, Hermine, Gadina, Massimo, Levine, Stewart, Goldbach-Mansky, Raphaela, Boutelle, Jonathan, Sinha, Rashmi, DeBenedetti, Fabrizio, Grom, Alexei, Gottlieb, Beth, Yeung, Rae, Riskalla, Mona, Prahalad, Sampath, Alehashemi, Sara, Chandrakasan, Shan, Vastert, Bas, Kimura, Yuki, Carlson, Anna, Schumacher, Emily, Minerva, Regina, Pierce, Jonathan, Pierce, Kate, Martinez, Zulayka, Cupp, Kari, Bush, Leah, Costello, Wendy, DelGaizo, Vincent

“…Abstract For reasons poorly understood, and despite the availability of biological medications blocking IL-1 and IL-6 that have markedly improved overall…”
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Distinct Gene Expression Signatures Characterize Strong Clinical Responders Versus Nonresponders to Canakinumab in Children With Systemic Juvenile Idiopathic Arthritis by Verweyen, Emely L., Pickering, Alex, Grom, Alexei A., Schulert, Grant S.

“…Objective Canakinumab is a human anti–interleukin‐1β (anti–IL‐1β) blocking agent that effectively neutralizes IL‐1β–mediated signaling for treatment of…”
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Transcriptional Profiling of Tofacitinib Treatment in Juvenile Idiopathic Arthritis: Implications for Treatment Response Prediction by Eloseily, Esraa, Pickering, Alex, Dhakal, Sanjeev, Ruperto, Nicolino, Brunner, Hermine I., Grom, Alexi A., Thornton, Sherry

“…Objectives To assess changes in gene expression following tofacitinib treatment and investigate transcription patterns as potential predictors of treatment…”
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Distinct gene expression signatures characterize strong clinical responders vs non-responders to Canakinumab in children with sJIA by Verweyen, Emely L, Pickering, Alex, Grom, Alexei A, Schulert, Grant S

“…Canakinumab is a human anti-IL-1β blocking agent that effectively neutralizes IL-1β mediated signaling for treatment of systemic juvenile idiopathic arthritis…”
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Recombinant Interleukin‐1 Receptor Antagonist Is an Effective First‐Line Treatment Strategy in New‐Onset Systemic Juvenile Idiopathic Arthritis, Irrespective of HLA‐DRB1 Background and IL1RN Variants by Erkens, Remco G. A., Calis, Jorg J. A., Verwoerd, Anouk, De Roock, Sytze, Ter Haar, Nienke M., Den Engelsman, Gerda, Van der Veken, Lars T., Ernst, Robert F., Van Deutekom, Hanneke W. M., Pickering, Alex, Scholman, Rianne C., Jansen, Marc H. A., Swart, Joost F., Sinha, Rashmi, Roth, Johannes, Schulert, Grant S., Grom, Alexei A., Van Loosdregt, Jorg, Vastert, Sebastiaan J.

“…Objective Human leukocyte antigen (HLA)‐DRB1*15:01 has been recently associated with interstitial lung disease (LD), eosinophilia, and drug reactions in…”
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Disease Course, Treatments, and Outcomes of Children With Systemic Juvenile Idiopathic Arthritis–Associated Lung Disease by Huang, Yannan, Sompii‐Montgomery, Laura, Patti, Jessica, Pickering, Alex, Yasin, Shima, Do, Thuy, Baker, Elizabeth, Gao, Denny, Abdul‐Aziz, Rabheh, Behrens, Edward M., Canna, Scott, Clark, Matthew, Co, Dominic O., Collins, Kathleen P., Eberhard, Barbara, Friedman, Monica, Graham, Thomas B., Hahn, Timothy, Hersh, Aimee O., Hobday, Patricia, Holland, Michael J., Huggins, Jennifer, Lu, Pai‐Yue, Mannion, Melissa L., Manos, Cynthia K., Neely, Jessica, Onel, Karen, Orandi, Amir B., Ramirez, Andrea, Reinhardt, Adam, Riskalla, Mona, Santiago, Laisa, Stoll, Matthew L., Ting, Tracy, Grom, Alexei A., Towe, Christopher, Schulert, Grant S.

“…Objective Systemic juvenile idiopathic arthritis–associated lung disease (SJIA‐LD) is a life‐threatening disease complication. Key questions remain regarding…”
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Induced Pluripotent Stem Cells from Nonhuman Primates by Mishra, Anuja, Qiu, Zhifang, Farnsworth, Steven L, Hemmi, Jacob J, Li, Miao, Pickering, Alexander V, Hornsby, Peter J

“…Induced pluripotent stem cells from nonhuman primates (NHPs) have unique roles in cell biology and regenerative medicine. Because of the relatedness of NHPs to…”
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Proceedings from the 2 nd Next Gen Therapies for Systemic Juvenile Idiopathic Arthritis and Macrophage Activation Syndrome symposium held on October 3-4, 2019 by Canna, Scott W, Schulert, Grant S, de Jesus, Adriana, Pickering, Alex, Brunner, Hermine, Gadina, Massimo, Levine, Stewart, Goldbach-Mansky, Raphaela, Boutelle, Jonathan, Sinha, Rashmi, DeBenedetti, Fabrizio, Grom, Alexei

“…For reasons poorly understood, and despite the availability of biological medications blocking IL-1 and IL-6 that have markedly improved overall disease…”
Get full text

Cross-modal representation alignment of molecular structure and perturbation-induced transcriptional profiles by Finlayson, Samuel G, McDermott, Matthew B. A, Pickering, Alex V, Lipnick, Scott L, Kohane, Isaac S

“…Modeling the relationship between chemical structure and molecular activity is a key goal in drug development. Many benchmark tasks have been proposed for…”
Get full text

Arming the next general with materials enthusiasm by PICKERING, Alex

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