Search Results - "Pickens, Charles L"

Neurobiology of the incubation of drug craving by Pickens, Charles L, Airavaara, Mikko, Theberge, Florence, Fanous, Sanya, Hope, Bruce T, Shaham, Yavin

“…It was suggested in 1986 that cue-induced drug craving in cocaine addicts progressively increases over the first several weeks of abstinence and remains high…”
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Chronic alcohol produces neuroadaptations to prime dorsal striatal learning by DePoy, Lauren, Daut, Rachel, Brigman, Jonathan L., MacPherson, Kathryn, Crowley, Nicole, Gunduz-Cinar, Ozge, Pickens, Charles L., Cinar, Resat, Saksida, Lisa M., Kunos, George, Lovinger, David M., Bussey, Timothy J., Camp, Marguerite C., Holmes, Andrew

“…Drug addictions including alcoholism are characterized by degradation of executive control over behavior and increased compulsive drug seeking. These profound…”
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A Novel Multichoice Touchscreen Paradigm for Assessing Cognitive Flexibility in Mice by Piantadosi, Patrick T, Lieberman, Abby G, Pickens, Charles L, Bergstrom, Hadley C, Holmes, Andrew

“…Cognitive flexibility refers to various processes which enable behaviors to be modified on the basis of a change in the contingencies between stimuli or…”
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Dorsolateral Striatum Engagement Interferes with Early Discrimination Learning by Bergstrom, Hadley C., Lipkin, Anna M., Lieberman, Abby G., Pinard, Courtney R., Gunduz-Cinar, Ozge, Brockway, Emma T., Taylor, William W., Nonaka, Mio, Bukalo, Olena, Wills, Tiffany A., Rubio, F. Javier, Li, Xuan, Pickens, Charles L., Winder, Danny G., Holmes, Andrew

“…In current models, learning the relationship between environmental stimuli and the outcomes of actions involves both stimulus-driven and goal-directed systems,…”
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Neither Amphetamine nor Sub-Anesthetic Ketamine Treatment during Adolescence Impairs Devaluation in Rats Tested during Adulthood by Davis, Ian R, Fisher, Hayley, McLean, Caitlin, Murray, Jackson, Pickens, Charles L

“…Much of the existing animal literature on the devaluation task suggests that prior repeated exposure to drugs of abuse during adulthood can impair…”
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Role of Dorsal Medial Prefrontal Cortex Dopamine D1-Family Receptors in Relapse to High-Fat Food Seeking Induced by the Anxiogenic Drug Yohimbine by NAIR, Sunila G, NAVARRE, Brittany M, CIFANI, Carlo, PICKENS, Charles L, BOSSERT, Jennifer M, SHAHAM, Yavin

“…In humans, relapse to maladaptive eating habits during dieting is often provoked by stress. In rats, the anxiogenic drug yohimbine, which causes stress-like…”
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Different Roles for Orbitofrontal Cortex and Basolateral Amygdala in a Reinforcer Devaluation Task by Pickens, Charles L, Saddoris, Michael P, Setlow, Barry, Gallagher, Michela, Holland, Peter C, Schoenbaum, Geoffrey

“…The orbitofrontal cortex (OFC) and basolateral amygdala (BLA) are critical for using learned representations of outcomes to guide behavior. Neurophysiological…”
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Effects of the MCH1 receptor antagonist SNAP 94847 on high-fat food-reinforced operant responding and reinstatement of food seeking in rats by Nair, Sunila G., Adams-Deutsch, Tristan, Pickens, Charles L., Smith, Daniel G., Shaham, Yavin

“…Rationale and objectives The melanin-concentrating hormone 1 (MCH1) receptors play an important role in home-cage food consumption in rodents, but their role…”
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Orbitofrontal Lesions Impair Use of Cue-Outcome Associations in a Devaluation Task by Pickens, Charles L, Saddoris, Michael P, Gallagher, Michela, Holland, Peter C

“…The orbitofrontal cortex (OFC) has been implicated in the use of outcome expectancies to guide behavior. The present study used a devaluation task to examine…”
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Alcohol reward, dopamine depletion, and GDNF by Pickens, Charles L, Calu, Donna J

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Dose-dependent effects of alcohol injections on omission-contingency learning have an inverted-U pattern by Pickens, Charles L., Cook, Anna, Gaeddert, Brooke

“…•Repeated 1.75-g/kg/24-h alcohol injections impaired omission learning weeks later.•Repeated injections at a higher dose (3.5-g/kg/24-h) did not alter omission…”
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Pre-training naltrexone increases conditioned fear learning independent of adolescent alcohol consumption history by Pajser, Alisa, Fisher, Hayley, Pickens, Charles L.

“…•Pre-training naltrexone increased conditioned fear during training and test.•Pre-training LY2456302 (kappa opioid receptor antagonist) did not affect…”
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Pre-training inactivation of basolateral amygdala and mediodorsal thalamus, but not orbitofrontal cortex or prelimbic cortex, impairs devaluation in a multiple-response/multiple-reinforcer cued operant task by Fisher, Hayley, Pajser, Alisa, Pickens, Charles L.

“…•Pre-training basolateral amygdala inactivation impaired devaluation.•Pre-training mediodorsal thalamus inactivation impaired devaluation.•Pre-training…”
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Extended operant training increases infralimbic and prelimbic cortex Fos regardless of fear conditioning experience by Pajser, Alisa, Foster, Christian, Gaeddert, Brooke, Pickens, Charles L.

“…•Suppressed fear after extended fear training was replicated.•Medial prefrontal cortex Fos had no relationship with fear levels.•Extended lever training…”
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Voluntary alcohol access during adolescence/early adulthood, but not during adulthood, causes faster omission contingency learning by Pickens, Charles L., Kallenberger, Paige, Pajser, Alisa, Fisher, Hayley

“…•Adolescent/early adult alcohol access led to faster omission learning weeks later.•Adult alcohol access had no effect on omission learning weeks…”
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Individual differences in voluntary alcohol consumption are associated with conditioned fear in the fear incubation model by Pajser, Alisa, Limoges, Aaron, Long, Charday, Pickens, Charles L.

“…•Alcohol consumption in adolescence and adulthood did not affect conditioned fear.•In the adolescent alcohol group, high consumption was associated with lower…”
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Context-Induced Relapse to Alcohol Seeking After Punishment in a Rat Model by Marchant, Nathan J, Khuc, Thi N, Pickens, Charles L, Bonci, Antonello, Shaham, Yavin

“…Background Rat studies have demonstrated that exposure to environments associated with alcohol intake reinstates alcohol seeking after extinction of…”
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Impairments in expression of devaluation in a Pavlovian goal-tracking task, but not a free operant devaluation task, after fentanyl exposure in female rats by Pickens, Charles L, Hougham, Alyssa, Kim, Jihyeon, Wang, Chuhan, Leder, Jendaya, Line, Chelsea, McDaniel, Kathleen, Micek, Lydia, Miller, Jadyn, Powell, Kendall, Waren, Olivia, Brenneman, Ellie, Erdley, Brooke

“…In laboratory animals, there are numerous demonstrations that past exposure to drugs of abuse can lead to devaluation impairments weeks after the final drug…”
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Relationship of low doses of alcohol voluntarily consumed during adolescence and early adulthood with subsequent behavioral flexibility by Fisher, Hayley, Bright, Nicholas, Gallo, Mark, Pajser, Alisa, Pickens, Charles L

“…Previous alcohol use is associated with impaired decision-making and impulsivity in humans, but the relationship between alcohol use and…”
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An Unconditioned Stimulus Retrieval Extinction Procedure to Prevent the Return of Fear Memory by Liu, Jianfeng, Zhao, Liyan, Xue, Yanxue, Shi, Jie, Suo, Lin, Luo, Yixiao, Chai, Baisheng, Yang, Chang, Fang, Qin, Zhang, Yan, Bao, Yanping, Pickens, Charles L, Lu, Lin

“…Background Conditioned fear memories can be updated by extinction during reconsolidation, and this effect is specific to the reactivated conditioned stimulus…”
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