Search Results - "Pickard, M R"

GAS5, a non-protein-coding RNA, controls apoptosis and is downregulated in breast cancer by Mourtada-Maarabouni, M, Pickard, M R, Hedge, V L, Farzaneh, F, Williams, G T

“…Effective control of both cell survival and cell proliferation is critical to the prevention of oncogenesis and to successful cancer therapy. Using functional…”
Get full text

Synthesis and biological evaluation of 3-(4-chlorophenyl)-4-substituted pyrazole derivatives by Horrocks, P, Pickard, M R, Parekh, H H, Patel, S P, Pathak, Ravindra B

“…3-(4-Chlorophenyl)-4-substituted pyrazole derivatives were synthesised and tested for their in vitro antifungal activity. Some compounds showed very good…”
Get more information

Long non-coding RNA GAS5 regulates apoptosis in prostate cancer cell lines by Pickard, M.R., Mourtada-Maarabouni, M., Williams, G.T.

“…While the role of small non-coding RNAs, such as miRNAs, in apoptosis control is well established, long non-coding RNAs (lncRNAs) have received less attention…”
Get full text

Influence of maternal hyperthyroidism in the rat on the expression of neuronal and astrocytic cytoskeletal proteins in fetal brain by Evans, IM, Pickard, MR, Sinha, AK, Leonard, AJ, Sampson, DC, Ekins, RP

“…Maternal hypothyroidism during pregnancy impairs brain function in human and rat offspring, but little is known regarding the influence of maternal…”
Get full text

Maternal hypothyroidism in the rat influences placental and liver glycogen stores: fetal growth retardation near term is unrelated to maternal and placental glucose metabolic compromise by Pickard, MR, Leonard, AJ, Ogilvie, LM, Edwards, PR, Evans, IM, Sinha, AK, Ekins, RP

“…Maternal hypothyroidism impairs fetal growth in the rat, but the mechanisms by which this occurs are unknown. Since the fetus derives its glucose supply from…”
Get full text

Maternal hypothyroxinemia disrupts neurotransmitter metabolic enzymes in developing brain by Evans, IM, Sinha, AK, Pickard, MR, Edwards, PR, Leonard, AJ, Ekins, RP

“…Maternal thyroid status influences early brain development and, consequently, cognitive and motor function in humans and rats. The biochemical targets of…”
Get full text

Maternal thyroid status regulates the expression of neuronal and astrocytic cytoskeletal proteins in the fetal brain by Sampson, D, Pickard, MR, Sinha, AK, Evans, IM, Leonard, AJ, Ekins, RP

“…Maternal thyroid hormone (TH) crosses the placenta and is postulated to regulate fetal brain development. However, TH-dependent stages of fetal brain…”
Get full text

Maternal hypothyroxinemia influences glucose transporter expression in fetal brain and placenta by Pickard, MR, Sinha, AK, Ogilvie, LM, Leonard, AJ, Edwards, PR, Ekins, RP

“…The influence of maternal hypothyroxinemia on the expression of the glucose transporters, GLUT1 and GLUT3, in rat fetal brain and placenta was investigated…”
Get full text

Thyroid Hormone Receptor Expression in Rat Placenta by Leonard, A.J., Evans, I.M., Pickard, M.R., Bandopadhyay, R., Sinha, A.K., Ekins, R.P.

“…The expression of c- erbAα and -β encoded thyroid hormone receptors (TR) was investigated in rat placenta between 16 and 21 days of gestation (dg), and in…”
Get full text

Hypothyroidism in the adult rat causes brain region-specific biochemical dysfunction by Ahmed, M T, Sinha, A K, Pickard, M R, Kim, K D, Ekins, R P

“…The influence of hypothyroidism in the adult rat on brain biochemistry was investigated. Hypothyroidism was induced in 6-month-old male rats by partial…”
Get more information

Neonatal lamb vigour is improved by feeding docosahexaenoic acid in the form of algal biomass during late gestation by Pickard, R. M., Beard, A. P., Seal, C. J., Edwards, S. A.

“…To determine whether feeding a sustainable, algal source of docosahexaenoic acid (DHA) to sheep during late pregnancy would improve neonatal lamb vigour, 48…”
Get full text

The influence of the maternal thyroid hormone environment during pregnancy on the ontogenesis of brain and placental ornithine decarboxylase activity in the rat by Pickard, M R, Sinha, A K, Ogilvie, L, Ekins, R P

“…The influence of maternal hypothyroxinaemia on early brain and placental development was examined in a partially thyroidectomized (parathyroid-spared; TX) rat…”
Get more information

Phospholipids in synaptic function by Hawthorne, J N, Pickard, M R

Get more information

Effect of maternal hypothyroxinaemia in the rat on brain biochemistry in adult progeny by Hadjzadeh, M, Sinha, A K, Pickard, M R, Ekins, R P

“…The effects of maternal hypothyroxinaemia during pregnancy on subsequent brain biochemistry in progeny was studied. Normal and partially thyroidectomized rat…”
Get more information

The effect of 3,5,3'-triiodothyronine on leucine uptake and incorporation into protein in cultured neurons and subcellular fractions of rat central nervous system by Pickard, M R, Sinha, A K, Gullo, D, Patel, N, Hubank, M, Ekins, R P

“…Previous studies have shown that nuclear thyroid hormone receptors in rat brain are preferentially localized within neurons. These cells also synthesize…”
Get more information

Perturbation of thyroid hormone homeostasis in the adult and brain function by Sinha, A K, Pickard, M R, Kim, K D, Ahmed, M T, al Yatama, F, Evans, I M, Elkins, R P

“…Although a critical role of thyroid hormones in mammalian brain development is well established and extensively documented, the adult CNS is often thought to…”
Get more information

Transport of thyroid hormones to target tissues by Ekins, R P, Sinha, A K, Pickard, M R, Evans, I M, al Yatama, F

“…Endemic iodine deficiency is associated with maternal hypothyroxinemia and a relatively high incidence of neurological disorders in the offspring. The previous…”
Get more information

Robust uptake of magnetic nanoparticles (MNPs) by central nervous system (CNS) microglia: implications for particle uptake in mixed neural cell populations by Pickard, Mark R, Chari, Divya M

“…Magnetic nanoparticles (MNPs) are important contrast agents used to monitor a range of neuropathological processes; microglial cells significantly contribute…”
Get full text

Ligand-binding properties of a muscarinic acetylcholine receptor from torpedo electric organ by Strange, P.G., Dowdall, M.J., Golds, P.R., Pickard, M.R.

Get full text

Magnetic nanoparticle labeling of astrocytes derived for neural transplantation by Pickard, Mark R, Jenkins, Stuart I, Koller, Chris J, Furness, David N, Chari, Divya M

“…Astrocytes are a major transplant cell population to promote neural repair in a range of pathological conditions. In this context, the development of robust…”
Get more information