Search Results - "Pickar, D"

Schizophrenia is Associated with Elevated Amphetamine-Induced Synaptic Dopamine Concentrations: Evidence from a Novel Positron Emission Tomography Method by Breier, A., T.-P. Su, Saunders, R., Carson, R. E., Kolachana, B. S., De Bartolomeis, A., Weinberger, D. R., Weisenfeld, N., Malhotra, A. K., Eckelman, W. C., Pickar, D.

“…A major line of evidence that supports the hypothesis of dopamine overactivity in schizophrenia is the psychomimetic potential of agents such as amphetamine…”
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Prospects for pharmacotherapy of schizophrenia by Pickar, D

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Neuroendocrine and behavioral effects of high-dose anabolic steroid administration in male normal volunteers by Daly, R.C., Su, T.-P., Schmidt, P.J., Pagliaro, M., Pickar, D., Rubinow, D.R.

“…Objective: Despite widespread abuse of anabolic-androgenic steroids (AAS), the endocrine effects of supraphysiologic doses of these compounds remain unclear…”
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A functional serotonin transporter (5-HTT) polymorphism is associated with psychosis in neuroleptic-free schizophrenics by MALHOTRA, A. K, GOLDMAN, D, MAZZANTI, C, CLIFTON, A, BREIER, A, PICKAR, D

“…The neurotransmitter serotonin has been implicated in the pathophysiology of psychosis. The serotonin transporter (5-HTT) plays a critical role in regulation…”
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The D2 receptor : love it and leave it by PICKAR, D

“…Occupancy of the D2 receptor has been a foundation for the mechanism of antipsychotic action for over two decades. The introduction of atypical antipsychotics…”
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The effect of clozapine on cognition and psychiatric symptoms in patients with schizophrenia by Goldberg, T E, Greenberg, R D, Griffin, S J, Gold, J M, Kleinman, J E, Pickar, D, Schulz, S C, Weinberger, D R

“…Psychiatric symptoms and cognition were assessed in 13 patients with schizophrenia, one patient with schizoaffective disorder, and one patient with psychosis…”
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The dopamine D3 receptor (DRD3) Ser9Gly polymorphism and schizophrenia : a haplotype relative risk study and association with clozapine response by MALHOTRA, A. K, GOLDMAN, D, BUCHANAN, R. W, ROONEY, W, CLIFTON, A, KOSMIDIS, M. H, BREIER, A, PICKAR, D

“…Several lines of evidence suggest that the dopamine D3 receptor is involved in the pathophysiology of schizophrenia. The D3 receptor gene (DRD3) contains a…”
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Apolipoprotein E epsilon 4 and clinical phenotype in schizophrenia by Pickar, D, Malhotra, A K, Rooney, W, Breier, A, Goldman, D

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Is the mechanism of prefrontal hypofunction in depression the same as in schizophrenia? Regional cerebral blood flow during cognitive activation by Berman, K F, Doran, A R, Pickar, D, Weinberger, D R

“…To test the hypothesis that depressed and schizophrenic patients have a common pathophysiological mechanism for hypofunction of the prefrontal cortex…”
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Expressed emotion. Trait or state? by Schreiber, J L, Breier, A, Pickar, D

“…This exploratory study addresses the question of whether expressed emotion (EE) is a response characteristic of the parent (trait) or a parental response to…”
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Neuroleptic Effects on Autonomic Activity in Schizophrenia: Between-Group and Within-Subject Paradigms and Comparisons With Controls by Zahn, Theodore P., Pickar, David, van Kammen, Daniel P.

“…Effects of fluphenazine on electrodermal activity (EDA) and heart rate (HR) were studied in patients with schizophrenia and normal control subjects during rest…”
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Perspectives on a Time-Dependent Model of Neuroleptic Action by Pickar, David

“…The best support for the hypothesized involvement of central nervous system dopamine systems in the pathophysiology of schizophrenia is the association between…”
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Controllable and uncontrollable stress in humans: alterations in mood and neuroendocrine and psychophysiological function by Breier, A, Albus, M, Pickar, D, Zahn, T P, Wolkowitz, O M, Paul, S M

“…The authors exposed 10 healthy human volunteers to the stress of loud (100 dB) noise under controllable and uncontrollable conditions on two separate days…”
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14 Does rehabilitation after traumatic brain injury have to be so complicated? by Allanson, J, Seeley, H M, Psaila, K, Bateman, A, Gardner, A, Pickar, J D, Hutchinson, P J

“…Historical benchmarking to determine the rehabilitation pathways of Neurotrauma clinic attendees in a PCT where there is no community head injury service…”
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CSF corticotropin-releasing hormone in depressed patients and normal control subjects by Roy, A, Pickar, D, Paul, S, Doran, A, Chrousos, G P, Gold, P W

“…The authors studied CSF corticotropin-releasing hormone (CRH) and plasma cortisol in 22 depressed patients and 18 normal control subjects. CRH levels were…”
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Predictors of clozapine response in schizophrenia by PICKAR, D, OWEN, R. R, LITMAN, R. E, HSIAO, J. K, TUNG-PING SU

“…The introduction of the atypical neuroleptic, clozapine, has had widespread influence not only on the treatment of the seriously mentally ill patient, but also…”
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Cerebral structural pathology in schizophrenia: evidence for a selective prefrontal cortical defect by Shelton, R C, Karson, C N, Doran, A R, Pickar, D, Bigelow, L B, Weinberger, D R

“…To replicate earlier findings of central and cortical cerebral structural abnormalities and to further examine specific prefrontal cortical irregularities in…”
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Informed Consent in Schizophrenia Research by Pinals, Debra A., Malhotra, Anil K., Breier, Alan

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Neuroleptic responsivity of negative and positive symptoms in schizophrenia by Breier, A, Wolkowitz, O M, Doran, A R, Roy, A, Boronow, J, Hommer, D W, Pickar, D

“…The authors prospectively examined the effects of double-blind, placebo-controlled neuroleptic withdrawal and administration on ratings of negative and…”
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Plasma homovanillic acid and other predictors of clozapine response by Pickar, D

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