Search Results - "Pichon, Claire E. Le"

Single nucleus RNA-sequencing defines unexpected diversity of cholinergic neuron types in the adult mouse spinal cord by Alkaslasi, Mor R., Piccus, Zoe E., Hareendran, Sangeetha, Silberberg, Hanna, Chen, Li, Zhang, Yajun, Petros, Timothy J., Le Pichon, Claire E.

“…In vertebrates, motor control relies on cholinergic neurons in the spinal cord that have been extensively studied over the past hundred years, yet the full…”
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The Role of PIEZO2 in Human Mechanosensation by Chesler, Alexander T, Szczot, Marcin, Bharucha-Goebel, Diana, Čeko, Marta, Donkervoort, Sandra, Laubacher, Claire, Hayes, Leslie H, Alter, Katharine, Zampieri, Cristiane, Stanley, Christopher, Innes, A. Micheil, Mah, Jean K, Grosmann, Carla M, Bradley, Nathaniel, Nguyen, David, Foley, A. Reghan, Le Pichon, Claire E, Bönnemann, Carsten G

“…Inactivating variants in PIEZO2, which encodes a stretch-gated ion channel, impair touch perception and proprioception. Visual cues partially compensate for…”
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The functional and anatomical dissection of somatosensory subpopulations using mouse genetics by Le Pichon, Claire E, Chesler, Alexander T

“…The word somatosensation comes from joining the Greek word for body (soma) with a word for perception (sensation). Somatosensory neurons comprise the largest…”
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Stereotyped transcriptomic transformation of somatosensory neurons in response to injury by Nguyen, Minh Q, Le Pichon, Claire E, Ryba, Nicholas

“…In mice, spared nerve injury replicates symptoms of human neuropathic pain and induces upregulation of many genes in somatosensory neurons. Here we used single…”
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Dual leucine zipper kinase is required for mechanical allodynia and microgliosis after nerve injury by Wlaschin, Josette J, Gluski, Jacob M, Nguyen, Eileen, Silberberg, Hanna, Thompson, James H, Chesler, Alexander T, Le Pichon, Claire E

“…Neuropathic pain resulting from nerve injury can become persistent and difficult to treat but the molecular signaling responsible for its development remains…”
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Why sex matters by Wlaschin, Josette J, Hareendran, Sangeetha, Le Pichon, Claire E

“…The immune mechanisms underlying hypersensitivity to pain after nerve injury are different in male and female mice…”
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Author Correction: A harmonized atlas of mouse spinal cord cell types and their spatial organization by Russ, Daniel E., Cross, Ryan B. Patterson, Li, Li, Koch, Stephanie C., Matson, Kaya J. E., Yadav, Archana, Alkaslasi, Mor R., Lee, Dylan I., Le Pichon, Claire E., Menon, Vilas, Levine, Ariel J.

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A harmonized atlas of mouse spinal cord cell types and their spatial organization by Russ, Daniel E., Cross, Ryan B. Patterson, Li, Li, Koch, Stephanie C., Matson, Kaya J. E., Yadav, Archana, Alkaslasi, Mor R., Lee, Dylan I., Le Pichon, Claire E., Menon, Vilas, Levine, Ariel J.

“…Single-cell RNA sequencing data can unveil the molecular diversity of cell types. Cell type atlases of the mouse spinal cord have been published in recent…”
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Cell-Type-Specific Splicing of Piezo2 Regulates Mechanotransduction by Szczot, Marcin, Pogorzala, Leah A., Solinski, Hans Jürgen, Young, Lynn, Yee, Philina, Le Pichon, Claire E., Chesler, Alexander T., Hoon, Mark A.

“…Piezo2 is a mechanically activated ion channel required for touch discrimination, vibration detection, and proprioception. Here, we discovered that Piezo2 is…”
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Ventral arkypallidal neurons inhibit accumbal firing to promote reward consumption by Vachez, Yvan M., Tooley, Jessica R., Abiraman, Kavitha, Matikainen-Ankney, Bridget, Casey, Eric, Earnest, Tom, Ramos, Leana M., Silberberg, Hanna, Godynyuk, Elizabeth, Uddin, Olivia, Marconi, Lauren, Le Pichon, Claire E., Creed, Meaghan C.

“…The nucleus accumbens shell (NAcSh) and the ventral pallidum (VP) are critical for reward processing, although the question of how coordinated activity within…”
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Specialized Mechanosensory Nociceptors Mediating Rapid Responses to Hair Pull by Ghitani, Nima, Barik, Arnab, Szczot, Marcin, Thompson, James H., Li, Chia, Le Pichon, Claire E., Krashes, Michael J., Chesler, Alexander T.

“…The somatosensory system provides animals with the ability to detect, distinguish, and respond to diverse thermal, mechanical, and irritating stimuli. While…”
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Local production of reactive oxygen species drives vincristine-induced axon degeneration by Gomez-Deza, Jorge, Slavutsky, Anastasia L., Nebiyou, Matthew, Le Pichon, Claire E.

“…Neurological side effects arising from chemotherapy, such as severe pain and cognitive impairment, are a major concern for cancer patients. These major side…”
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Selective gene expression by postnatal electroporation during olfactory interneuron neurogenesis by Chesler, Alexander T, Le Pichon, Claire E, Brann, Jessica H, Araneda, Ricardo C, Zou, Dong-Jing, Firestein, Stuart

“…Neurogenesis persists in the olfactory system throughout life. The mechanisms of how new neurons are generated, how they integrate into circuits, and their…”
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Antibody-Mediated Targeting of Tau In Vivo Does Not Require Effector Function and Microglial Engagement by Lee, Seung-Hye, Le Pichon, Claire E., Adolfsson, Oskar, Gafner, Valérie, Pihlgren, Maria, Lin, Han, Solanoy, Hilda, Brendza, Robert, Ngu, Hai, Foreman, Oded, Chan, Ruby, Ernst, James A., DiCara, Danielle, Hotzel, Isidro, Srinivasan, Karpagam, Hansen, David V., Atwal, Jasvinder, Lu, Yanmei, Bumbaca, Daniela, Pfeifer, Andrea, Watts, Ryan J., Muhs, Andreas, Scearce-Levie, Kimberly, Ayalon, Gai

“…The spread of tau pathology correlates with cognitive decline in Alzheimer’s disease. In vitro, tau antibodies can block cell-to-cell tau spreading. Although…”
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Discovery of Highly Potent, Selective, and Brain-Penetrant Aminopyrazole Leucine-Rich Repeat Kinase 2 (LRRK2) Small Molecule Inhibitors by Estrada, Anthony A, Chan, Bryan K, Baker-Glenn, Charles, Beresford, Alan, Burdick, Daniel J, Chambers, Mark, Chen, Huifen, Dominguez, Sara L, Dotson, Jennafer, Drummond, Jason, Flagella, Michael, Fuji, Reina, Gill, Andrew, Halladay, Jason, Harris, Seth F, Heffron, Timothy P, Kleinheinz, Tracy, Lee, Donna W, Pichon, Claire E. Le, Liu, Xingrong, Lyssikatos, Joseph P, Medhurst, Andrew D, Moffat, John G, Nash, Kevin, Scearce-Levie, Kimberly, Sheng, Zejuan, Shore, Daniel G, Wong, Susan, Zhang, Shuo, Zhang, Xiaolin, Zhu, Haitao, Sweeney, Zachary K

“…Leucine-rich repeat kinase 2 (LRRK2) has drawn significant interest in the neuroscience research community because it is one of the most compelling targets for…”
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Author Correction: A harmonized atlas of mouse spinal cord cell types and their spatial organization by Russ, Daniel E., Cross, Ryan B. Patterson, Li, Li, Koch, Stephanie C., Matson, Kaya J. E., Yadav, Archana, Alkaslasi, Mor R., Lee, Dylan I., Le Pichon, Claire E., Menon, Vilas, Levine, Ariel J.

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Relative contribution of TARPs γ-2 and γ-7 to cerebellar excitatory synaptic transmission and motor behavior by Yamazaki, Maya, Le Pichon, Claire E., Jackson, Alexander C., Cerpas, Manuel, Sakimura, Kenji, Scearce-Levie, Kimberly, Nicoll, Roger A.

“…Transmembrane AMPA receptor regulatory proteins (TARPs) play an essential role in excitatory synaptic transmission throughout the central nervous system (CNS)…”
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EGFR inhibitor erlotinib delays disease progression but does not extend survival in the SOD1 mouse model of ALS by Le Pichon, Claire E, Dominguez, Sara L, Solanoy, Hilda, Ngu, Hai, Lewin-Koh, Nicholas, Chen, Mark, Eastham-Anderson, Jeffrey, Watts, Ryan, Scearce-Levie, Kimberly

“…Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease that causes progressive paralysis due to motor neuron death. Several lines of…”
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Olfactory behavior and physiology are disrupted in prion protein knockout mice by Le Pichon, Claire E, Valley, Matthew T, Polymenidou, Magdalini, Chesler, Alexander T, Sagdullaev, Botir T, Aguzzi, Adriano, Firestein, Stuart

“…The normal physiological function of the prion protein PrP C remains unknown. Here, the authors report that PrP knockout mice show altered behavior in two…”
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G protein/cAMP signal cascade is required for axonal convergence into olfactory glomeruli by Chesler, Alexander T, Zou, Dong-Jing, Le Pichon, Claire E, Peterlin, Zita A, Matthews, Glennis A, Pei, Xin, Miller, Michael C, Firestein, Stuart

“…The mammalian odorant receptors (ORs) comprise a large family of G protein-coupled receptors that are critical determinants of both the odorant response…”
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