Search Results - "Pichler, Andrea C"

The Road Less Taken: Less Appreciated Pathways for Manipulating CD8 + T Cell Exhaustion by Pichler, Andrea C, Cannons, Jennifer L, Schwartzberg, Pamela L

“…Exhausted CD8 T (Tex) cells are a distinct cell population that arise during persistent antigen exposure in the context of chronic infections and cancers…”
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Eomes-Dependent Loss of the Co-activating Receptor CD226 Restrains CD8+ T Cell Anti-tumor Functions and Limits the Efficacy of Cancer Immunotherapy by Weulersse, Marianne, Asrir, Assia, Pichler, Andrea C., Lemaitre, Lea, Braun, Matthias, Carrié, Nadège, Joubert, Marie-Véronique, Le Moine, Marie, Do Souto, Laura, Gaud, Guillaume, Das, Indrajit, Brauns, Elisa, Scarlata, Clara M., Morandi, Elena, Sundarrajan, Ashmitha, Cuisinier, Marine, Buisson, Laure, Maheo, Sabrina, Kassem, Sahar, Agesta, Arantxa, Pérès, Michaël, Verhoeyen, Els, Martinez, Alejandra, Mazieres, Julien, Dupré, Loïc, Gossye, Thomas, Pancaldi, Vera, Guillerey, Camille, Ayyoub, Maha, Dejean, Anne S., Saoudi, Abdelhadi, Goriely, Stanislas, Avet-Loiseau, Hervé, Bald, Tobias, Smyth, Mark J., Martinet, Ludovic

“…CD8+ T cells within the tumor microenvironment (TME) are exposed to various signals that ultimately determine functional outcomes. Here, we examined the role…”
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TCR-independent CD137 (4-1BB) signaling promotes CD8+-exhausted T cell proliferation and terminal differentiation by Pichler, Andrea C., Carrié, Nadège, Cuisinier, Marine, Ghazali, Samira, Voisin, Alison, Axisa, Pierre-Paul, Tosolini, Marie, Mazzotti, Céline, Golec, Dominic P., Maheo, Sabrina, do Souto, Laura, Ekren, Rüçhan, Blanquart, Eve, Lemaitre, Lea, Feliu, Virginie, Joubert, Marie-Véronique, Cannons, Jennifer L., Guillerey, Camille, Avet-Loiseau, Hervé, Watts, Tania H., Salomon, Benoit L., Joffre, Olivier, Grinberg-Bleyer, Yenkel, Schwarzberg, Pamela L., Lucca, Liliana E., Martinet, Ludovic

“…CD137 (4-1BB)-activating receptor represents a promising cancer immunotherapeutic target. Yet, the cellular program driven by CD137 and its role in cancer…”
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Chemotherapy followed by anti-CD137 mAb immunotherapy improves disease control in a mouse myeloma model by Guillerey, Camille, Nakamura, Kyohei, Pichler, Andrea C, Barkauskas, Deborah, Krumeich, Sophie, Stannard, Kimberley, Miles, Kim, Harjunpää, Heidi, Yu, Yuan, Casey, Mika, Doban, Alina I, Lazar, Mircea, Hartel, Gunter, Smith, David, Vuckovic, Slavica, Teng, Michele Wl, Bergsagel, P Leif, Chesi, Marta, Hill, Geoffrey R, Martinet, Ludovic, Smyth, Mark J

“…Immunotherapy holds promise for multiple myeloma (MM) patients but little is known about how MM-induced immunosuppression influences response to therapy. Here,…”
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PI3Kδ: a key driver of effector differentiation under conditions of T cell exhaustion by Pichler, Andrea C, Cannons, Jennifer L, Golec, Dominic P, Reilley, Julie, McGavern, Dorian B, Schwartzberg, Pamela L

“…In chronic infection and cancer, prolonged antigen exposure drives a state of T cell hyporesponsiveness, called exhaustion. A small subset of TCF1 +progenitor…”
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PI3Kdelta coordinates transcriptional, epigenetic and metabolic changes to promote effector CD8 T cells differentiation by Cannons, Jennifer Leigh, Pichler, Andrea C, Villarino, Alejandro, Kapnick, Senta, Shih, Han-Yu, Uzel, Gulbu, Su, Helen, McGuire, Peter, O'Shea, John J, McGavern, Dorian B, Schwartzberg, Pamela

“…Activated PI3K-delta syndrome (APDS) is a primary immunodeficiency caused by heterozygous activating mutations of PIK3CD, resulting in dysregulated immunity,…”
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