Search Results - "Pichel, José G."

IGF1R acts as a cancer-promoting factor in the tumor microenvironment facilitating lung metastasis implantation and progression by Alfaro-Arnedo, Elvira, López, Icíar P., Piñeiro-Hermida, Sergio, Canalejo, Marta, Gotera, Carolina, Sola, Jesús Javier, Roncero, Alejandra, Peces-Barba, Germán, Ruíz-Martínez, Carlos, Pichel, José G.

“…Given the long-term ineffectiveness of current therapies and late-stage diagnoses, lung cancer is a leading cause of malignant diseases. Tumor progression is…”
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Luminescent Cycloplatinated Complexes with Biologically Relevant Phosphine Ligands: Optical and Cytotoxic Properties by Millán, Gonzalo, Giménez, Nora, Lara, Rebeca, Berenguer, Jesús R, Moreno, M. Teresa, Lalinde, Elena, Alfaro-Arnedo, Elvira, López, Icíar P, Piñeiro-Hermida, Sergio, Pichel, José G

“…Two series of neutral luminescent pentafluorophenyl cycloplatinated­(II) complexes [Pt­(C^N)­(C6F5)­L] [C^N = C-deprotonated 2-phenylpyridine (ppy; a),…”
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A new family of luminescent iridium complexes: synthesis, optical, and cytotoxic studies by Millán, Gonzalo, Nieddu, Mattia, López, Icíar P, Ezquerro, Cintia, Berenguer, Jesús R, Larráyoz, Ignacio M, Pichel, José G, Lalinde, Elena

“…By using , -dibutyl-2,2'-bipyridine-4,4'-dicarboxamide as a diimine ( ) and distinctive cyclometalated groups, this work reports a new family of cationic…”
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IGF1R deficiency attenuates acute inflammatory response in a bleomycin-induced lung injury mouse model by Piñeiro-Hermida, Sergio, López, Icíar P., Alfaro-Arnedo, Elvira, Torrens, Raquel, Iñiguez, María, Alvarez-Erviti, Lydia, Ruíz-Martínez, Carlos, Pichel, José G.

“…IGF1R (Insulin-like Growth Factor 1 Receptor) is a tyrosine kinase with pleiotropic cellular functions. IGF activity maintains human lung homeostasis and is…”
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A new family of luminescent [Pt(pbt) 2 (C 6 F 5 )L] n + ( n = 1, 0) complexes: synthesis, optical and cytotoxic studies by Gómez de Segura, David, Giménez, Nora, Rincón-Montón, David, Moreno, M Teresa, Pichel, José G, López, Icíar P, Lalinde, Elena

“…Given the widely recognized bioactivity of 2-arylbenzothiazoles against tumor cells, we have designed a new family of luminescent heteroleptic…”
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Investigation on Optical and Biological Properties of 2‐(4‐Dimethylaminophenyl)benzothiazole Based Cycloplatinated Complexes by Lara, Rebeca, Millán, Gonzalo, Moreno, M. Teresa, Lalinde, Elena, Alfaro‐Arnedo, Elvira, López, Icíar P., Larráyoz, Ignacio M., Pichel, José G.

“…The optical and biological properties of 2‐(4‐dimethylaminophenyl)benzothiazole cycloplatinated complexes featuring bioactive ligands ([{Pt(Me2N‐pbt)(C6F5)}L]…”
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Plasma fractalkine contributes to systemic myeloid diversity and PD‐L1/PD‐1 blockade in lung cancer by Bocanegra, Ana, Fernández‐Hinojal, Gonzalo, Ajona, Daniel, Blanco, Ester, Zuazo, Miren, Garnica, Maider, Chocarro, Luisa, Alfaro‐Arnedo, Elvira, Piñeiro‐Hermida, Sergio, Morente, Pilar, Fernández, Leticia, Remirez, Ana, Echaide, Miriam, Martinez‐Aguillo, Maite, Morilla, Idoia, Tavira, Beatriz, Roncero, Alejandra, Gotera, Carolina, Ventura, Alfonso, Recalde, Nerea, Pichel, José G, Lasarte, Juan José, Montuenga, Luis, Vera, Ruth, Pio, Ruben, Escors, David, Kochan, Grazyna

“…Recent studies highlight the importance of baseline functional immunity for immune checkpoint blockade therapies. High‐dimensional systemic immune profiling is…”
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Cigarette Smoke Directly Promotes Pulmonary Arterial Remodeling and Kv7.4 Channel Dysfunction by Sevilla-Montero, Javier, Labrousse-Arias, David, Fernández-Pérez, Cintia, Fernández-Blanco, Laura, Barreira, Bianca, Mondéjar-Parreño, Gema, Alfaro-Arnedo, Elvira, López, Icíar P, Pérez-Rial, Sandra, Peces-Barba, Germán, Pichel, José G, Peinado, Víctor Ivo, Cogolludo, Ángel, Calzada, María J

“…Cigarette smoke is considered the chief leading cause of chronic obstructive pulmonary disease (COPD). Its impact on the progressive deterioration of airways…”
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Characterization of the acute inflammatory profile and resolution of airway inflammation after Igf1r-gene targeting in a murine model of HDM-induced asthma by Piñeiro-Hermida, Sergio, Alfaro-Arnedo, Elvira, Gregory, Joshua A, Torrens, Raquel, Ruíz-Martínez, Carlos, Adner, Mikael, López, Icíar P, Pichel, José G

“…Asthma is a chronic inflammatory disease characterized by bronchial hyperresponsiveness, mucus overproduction and airway remodeling. Notably, we have recently…”
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IGF1R Deficiency Modulates Brain Signaling Pathways and Disturbs Mitochondria and Redox Homeostasis by Cardoso, Susana, López, Icíar P, Piñeiro-Hermida, Sergio, Pichel, José G, Moreira, Paula I

“…Insulin-like growth factor 1 receptor (IGF1R)-mediated signaling pathways modulate important neurophysiological aspects in the central nervous system,…”
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IGF1R is a mediator of sex-specific metabolism in mice: Effects of age and high-fat diet by Pérez-Matute, Patricia, López, Icíar P, Íñiguez, María, Recio-Fernández, Emma, Torrens, Raquel, Piñeiro-Hermida, Sergio, Alfaro-Arnedo, Elvira, Chau, Luong, Walz, Christina, Hoeflich, Andreas, Oteo, José A, Pichel, José G

“…We aimed to investigate the short and long-term metabolic consequences of IGF1R systemic gene deficiency in mice. mutant mice were used to suppress IGF1R…”
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IGF1R as a Potential Pharmacological Target in Allergic Asthma by Alfaro-Arnedo, Elvira, López, Icíar P, Piñeiro-Hermida, Sergio, Ucero, Álvaro C, González-Barcala, Francisco J, Salgado, Francisco J, Pichel, José G

“…Asthma is a chronic lung disease characterized by reversible airflow obstruction, airway hyperresponsiveness (AHR), mucus overproduction and inflammation…”
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Maraviroc ameliorates the increased adipose tissue macrophage recruitment induced by a high-fat diet in a mouse model of obesity by Pérez-Matute, Patricia, Pichel, José G, Iñiguez, María, Recio-Fernández, Emma, Pérez-Martínez, Laura, Torrens, Raquel, Blanco, José Ramón, Oteo, José Antonio

“…Any strategy designed to decrease the macrophage content in adipose tissue (AT) is of great value as a way to decrease inflammation in this fat depot and also…”
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Prominent release of lipoxygenase generated mediators in a murine house dust mite-induced asthma model by Kolmert, Johan, Piñeiro-Hermida, Sergio, Hamberg, Mats, Gregory, Joshua A., López, Icíar P., Fauland, Alexander, Wheelock, Craig E., Dahlén, Sven-Erik, Pichel, José G., Adner, Mikael

“…•In a murine C57BL/6 model HDM induced marked AHR and eosinophilic inflammation.•HDM exposure elevated 26 lipid mediators out of 112 measured.•5- and 12/15-LOX…”
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Correction: Alfaro-Arnedo et al. IGF1R as a Potential Pharmacological Target in Allergic Asthma. Biomedicines 2021, 9 , 912 by Alfaro-Arnedo, Elvira, López, Icíar P, Piñeiro-Hermida, Sergio, Ucero, Álvaro C, González-Barcala, Francisco J, Salgado, Francisco J, Pichel, José G

“…In the original article [...]…”
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Involvement of IGF Proteins in Severe Allergic Asthma: New Roles for Old Players by Vázquez-Mera, Sara, Pichel, José G., Salgado, Francisco Javier

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Benzothiazole‐Based Cycloplatinated Chromophores: Synthetic, Optical, and Biological Studies by Lalinde, Elena, Lara, Rebeca, López, Icíar P., Moreno, M. Teresa, Alfaro‐Arnedo, Elvira, Pichel, José G., Piñeiro‐Hermida, Sergio

“…Cycloplatinated complexes based on 2‐(4‐substituted)benzothiazole ligands of type [Pt(R‐PBT‐κC,N)Cl(L)] (PBT=2‐phenylbenzothiazole; R=Br (1), Me2N (2);…”
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Involvement of Igf1r in Bronchiolar Epithelial Regeneration: Role during Repair Kinetics after Selective Club Cell Ablation by López, Icíar P, Piñeiro-Hermida, Sergio, Pais, Rosete S, Torrens, Raquel, Hoeflich, Andreas, Pichel, José G

“…Regeneration of lung epithelium is vital for maintaining airway function and integrity. An imbalance between epithelial damage and repair is at the basis of…”
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Cochlear abnormalities in insulin-like growth factor-1 mouse mutants by Camarero, Guadalupe, Villar, M.Angeles, Contreras, Julio, Fernández-Moreno, Carmen, Pichel, José G., Avendaño, Carlos, Varela-Nieto, Isabel

“…Insulin-like growth factor 1 (IGF-1) modulates inner ear cell proliferation, differentiation and survival in culture. Its function in human hearing was first…”
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RNA microarray analysis in prenatal mouse cochlea reveals novel IGF-I target genes: implication of MEF2 and FOXM1 transcription factors by Sanchez-Calderon, Hortensia, Rodriguez-de la Rosa, Lourdes, Milo, Marta, Pichel, Jose G, Holley, Matthew, Varela-Nieto, Isabel

“…Insulin-like growth factor-I (IGF-I) provides pivotal cell survival and differentiation signals during inner ear development throughout evolution. Homozygous…”
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