Search Results - "Pich, E. Merlo"

Ketamine enhances structural plasticity in mouse mesencephalic and human iPSC-derived dopaminergic neurons via AMPAR-driven BDNF and mTOR signaling by Cavalleri, L, Merlo Pich, E, Millan, M J, Chiamulera, C, Kunath, T, Spano, P F, Collo, G

“…Among neurobiological mechanisms underlying antidepressant properties of ketamine, structural remodeling of prefrontal and hippocampal neurons has been…”
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A New Population-Enrichment Strategy to Improve Efficiency of Placebo-Controlled Clinical Trials of Antidepressant Drugs by Merlo‐Pich, E, Alexander, R C, Fava, M, Gomeni, R

“…The rate‐limiting factor in the discovery of novel antidepressants is the inefficient methodology of traditional multicenter randomized clinical trials (RCTs)…”
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Neural response to the observable self in social anxiety disorder by Pujol, J, Giménez, M, Ortiz, H, Soriano-Mas, C, López-Solà, M, Farré, M, Deus, J, Merlo-Pich, E, Harrison, B J, Cardoner, N, Navinés, R, Martín-Santos, R

“…Distorted images of the observable self are considered crucial in the development and maintenance of social anxiety. We generated an experimental situation in…”
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Model-Based Approach and Signal Detection Theory to Evaluate the Performance of Recruitment Centers in Clinical Trials With Antidepressant Drugs by Merlo‐Pich, E, Gomeni, R

“…The objective of this study was to characterize the performance of each recruitment center in multicenter clinical trials and to provide criteria to…”
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Response to "Clinical Trials of Antidepressants: 'Enrichment Strategies'" and "The Placebo Response Is Part of Good Medicine" by Merlo‐Pich, E, Alexander, RC, Fava, M, Gomeni, R

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Microarray analysis of cultured human brain aggregates following cortisol exposure: Implications for cellular functions relevant to mood disorders by Salaria, S., Chana, G., Caldara, F., Feltrin, E., Altieri, M., Faggioni, F., Domenici, E., Merlo-Pich, E., Everall, I.P.

“…Increased cortisol levels in humans are often observed in patients suffering from mood disorders. In this study human fetal brain aggregates were exposed to…”
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Time-dependent induction of anxiogenic-like effects after central infusion of urocortin or corticotropin-releasing factor in the rat by SPINA, M. G, MERLO-PICH, E, AKWA, Y, BALDUCCI, C, BASSO, A. M, ZORRILLA, E. P, BRITTON, K. T, RIVIER, J, VALE, W. W, KOOB, G. F

“…Corticotropin-releasing factor (CRF) and urocortin (Ucn) belong to the CRF-related family, share a high degree of structural homology and bind to CRF…”
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Pharmacokinetics and time-course of D2 receptor occupancy induced by atypical antipsychotics in stabilized schizophrenic patients by Catafau, AM, Penengo, MM, Nucci, G., Bullich, S., Corripio, I., Parellada, E., García-Ribera, C., Gomeni, R., Merlo-Pich, E.

“…The 123I-IBZM SPECT measured D2 receptor occupancy (D2RO) in chronically dosed, stabilized schizophrenic patients and its relationship with antipsychotic (AP)…”
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Apolipoprotein E Expression by Neurons Surviving Excitotoxic Stress by Boschert, U., Merlo-Pich, E., Higgins, Guy, Roses, A.D., Catsicas, S.

“…In the adult brain, apolipoprotein E (apoE) mRNA is thought to be expressed by nonneuronal cells. Yet, when a brain damage has occurred, the protein is found…”
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rKv1.2 overexpression in the central medial thalamic area decreases caffeine‐induced arousal by Cazzin, C., Piccoli, L., Massagrande, M., Garbati, N., Michielin, F., Knaus, H.‐G., Ring, C. J. A., Morrison, A. D., Merlo‐Pich, E., Rovo, Z., Astori, S., Lüthi, A., Corti, C., Corsi, M.

“…The voltage‐gated potassium channel Kv1.2 belongs to the shaker‐related family and has recently been implicated in the control of sleep profile on the basis of…”
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Highly controlled gene expression using combinations of a tissue-specific promoter, recombinant adenovirus and a tetracycline-regulatable transcription factor by GHERSA, P, PESCINI GOBERT, R, SATTONNET-ROCHE, P, RICHARDS, C. A, MERLO PICH, E, HOOFT VAN HUIJSDUIJNEN, R

“…Controllable gene expression is a desirable feature both in gene therapy protocols and for the study of gene function in animals and plants. We have exploited…”
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Cloning OF P2X5 and P2X6 receptors and the distribution and properties of an extended family of ATP-gated ion channels by Collo, G, North, RA, Kawashima, E, Merlo-Pich, E, Neidhart, S, Surprenant, A, Buell, G

“…Two new P2X receptor cDNAs (P2X5 and P2X6) were isolated and expressed. All six proteins are 36-48 percent identical and seem to have two transmembrane…”
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Appetite-suppressing effects on urocortin, a CRF-related neuropeptide by Spina, Mariarosa, Merlo-Pich, Emilio, Raymond K. W. Chan, Basso, Ana Maria, Rivier, Jean, Vale, Wylie, Koob, George F.

“…The neuropeptide corticotropin-releasing factor (CRF) is well known to act on the central nervous system in ways that mimic stress and result in decreases in…”
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Molecular mechanisms of the positive reinforcing effect of nicotine by Merlo Pich, E, Chiamulera, C, Carboni, L

“…Animal models of nicotine dependence are fundamental experimental tools for the understanding of the neurobiological and molecular processes underlying smoking…”
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Neuroimaging as endpoints in clinical trials: Are we there yet? Perspective from the first Provence workshop by Valenzuela, M, Bartrés-Faz, D, Beg, F, Fornito, A, Merlo-Pich, E, Müller, U, Öngür, D, Toga, A W, Yücel, M

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Distribution of the messenger RNA for the small conductance calcium-activated potassium channel SK3 in the adult rat brain and correlation with immunoreactivity by Tacconi, S., Carletti, R., Bunnemann, B., Plumpton, C., Merlo Pich, E., Terstappen, G.C.

“…Small conductance calcium-activated potassium channels are voltage independent potassium channels which modulate the firing patterns of neurons by activating…”
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S54 USE OF PRECLINICAL DRUG PROFILE IN CLINICAL SETTINGS FOR NOVEL COMPOUNDS IN DEPRESSION by Merlo Pich, E, Corsi, M

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Corticotropin-releasing factor (CRF) antagonist [D-Phe12,Nle21,38,C alpha MeLeu37]CRF attenuates the acute actions of the highly potent cannabinoid receptor agonist HU-210 on defensive-withdrawal behavior in rats by Rodríguez de Fonseca, F, Rubio, P, Menzaghi, F, Merlo-Pich, E, Rivier, J, Koob, G F, Navarro, M

“…The present study evaluated the modulatory role of central corticotropin-releasing factor (CRF) systems in the mediation of the effects of acute exposure to…”
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S.26.04 The role of the D3 dopamine receptor in stimulant dependence: studies in humans with pharmacological fMRI by Ersche, K.D, Craig, K.J, Shabbir, S, Abbott, S, Müller, U, Suckling, J, Sahakian, B.J, Merlo-Pich, E, Bullmore, E.T, Robbins, T.W

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Learning impairment in transgenic mice with central overexpression of corticotropin-releasing factor by Heinrichs, S.C, Stenzel-Poore, M.P, Gold, L.H, Battenberg, E, Bloom, F.E, Koob, G.F, Vale, W.W, Merlo Pich, E

“…The present studies were designed to test the learning and memory capacities of transgenic mice with central overexpression of corticotropin-releasing factor…”
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