Search Results - "Piccotti, J R"

Are Th2 helper T lymphocytes beneficial, deleterious, or irrelevant in promoting allograft survival? by PICCOTTI, J. R, CHAN, S. Y, VANBUSKIRK, A. M, EICHWALD, E. J, BISHOP, D. K

“…It is widely accepted that Th1 helper T lymphocytes (HTL) initiate allograft rejection by promoting the development of alloantigen-specific cytotoxic T…”
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IL-12 antagonism induces T helper 2 responses, yet exacerbates cardiac allograft rejection. Evidence against a dominant protective role for T helper 2 cytokines in alloimmunity by Piccotti, JR, Chan, SY, Goodman, RE, Magram, J, Eichwald, EJ, Bishop, DK

“…IL-12 promotes Th1 development and inhibits the generation of Th2 by inducing IFN-gamma production. In several experimental models, Th2 are preferentially…”
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Cytokine regulation of chronic cardiac allograft rejection : Evidence against a role for TH1 in the disease process by PICCOTTI, J. R, KEWANG LI, CHAN, S. Y, EICHWALD, E. J, BISHOP, D. K

“…Transient depletion of CD4+ T cells in cardiac allograft recipients prolongs allograft survival; however, grafts exhibit signs of chronic rejection…”
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Effect of cocaine administration on concanavalin A-stimulated T-lymphocyte proliferation in rats by Piccotti, J R, Bricker, J D

“…There is a high prevalence of cocaine abuse among Americans. There is an increasing concern over the rise of infectious diseases among individuals in this drug…”
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Alloantigen-Reactive Th1 Development in IL-12-Deficient Mice by Piccotti, Joseph R, Li, Kewang, Chan, Sherri Y, Ferrante, Jessica, Magram, Jeanne, Eichwald, Ernst J, Bishop, D. Keith

“…IL-12p70, a 70- to 75-kDa heterodimer consisting of disulfide-bonded 35-kDa (p35) and 40-kDa (p40) subunits, enhances Th1 development primarily by its ability…”
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Differential effects of IL-12 receptor blockade with IL-12 p40 homodimer on the induction of CD4+ and CD8+ IFN-gamma-producing cells by Piccotti, J R, Chan, S Y, Li, K, Eichwald, E J, Bishop, D K

“…The role of IL-12 role in regulating Th1/Th2 balance is attributed in part to the ability of this cytokine to induce IFNgamma production by NK and Th1 cells,…”
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Induction of Apoptosis by Cationic Amphiphilic Drugs Amiodarone and Imipramine by Piccotti, J R, LaGattuta, MS, Knight, SA, Gonzales, A J, Bleavins, M R

“…Phospholipidosis is the excessive accumulation of intracellular phospholipids in cell lysosomes. Drugs that induce this disease often share common…”
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Tissue-specific consequences of the anti-adenoviral immune response: implications for cardiac transplants by Bishop, D. Keith, Chan, Sherri Y, Li, Kewang, Piccotti, Joseph R, Louie, Marisa C, Judge, Thomas A, Turka, Laurence A, Eichwald, Ernst J

“…The immune response to adenoviral vectors can induce inflammation and loss of transgene expression in transfected tissues. This would limit the use of…”
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Interleukin-12 (IL-12)-driven alloimmune responses in vitro and in vivo: Requirement for beta 1 subunit of the IL-12 receptor by Piccotti, J R, Li, K, Chan, SY, Eichwald, E J, Bishop, D K

“…Interleukin-12 (IL-12) mediates its biologic activities via binding high-affinity receptors on T and natural killer cells. Although emphasis has been placed on…”
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Interleukin-12 (IL-12)-driven alloimmune responses in vitro and in vivo : Requirement for β1 subunit of the IL-12 receptor by PICCOTTI, J. R, KEWANG LI, CHAN, S. Y, EICHWALD, E. J, BISHOP, D. K

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Interleukin-12 (IL-12)-driven alloimmune responses in vitro and in vivo: requirement for beta1 subunit of the IL-12 receptor by Piccotti, J R, Li, K, Chan, S Y, Eichwald, E J, Bishop, D K

“…Interleukin-12 (IL-12) mediates its biologic activities via binding high-affinity receptors on T and natural killer cells. Although emphasis has been placed on…”
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Differential effects of IL-12 receptor blockade with IL-12 p40 homodimer on the induction of CD4 super(+) and CD8 super(+) IFN- gamma -producing cells by Piccotti, J R, Chan, SY, Li, Kewang, Eichwald, E J, Bishop, D K

“…The role of IL-12 role in regulating Th1/Th2 balance is attributed in part to the ability of this cytokine to induce IFN gamma production by NK and Th1 cells,…”
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IL-2 antagonism induces T helper 2 responses, yet exacerbates cardiac allograft rejection. Evidence against a dominant protective role for T helper 2 cytokines in alloimmunity by Piccotti, J R, Chan, SY, Goodman, R E, Magram, J, Eichwald, E J, Bishop, D K

“…IL-12 promotes Th1 development and inhibits the generation of Th2 by inducing IFN- gamma production. In several experimental models, Th2 are preferentially…”
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Genetic vaccination-induced immune responses to the human immunodeficiency virus protein Rev: emergence of the interleukin 2-producing helper T lymphocyte by Chan, S Y, Louie, M C, Piccotti, J R, Iyer, G, Ling, X, Yang, Z Y, Nabel, G J, Bishop, D K

“…Rev M10 is a trans-dominant negative inhibitor of HIV replication. Hence, stable transduction of CD4+ T cells with Rev M10 represents a novel gene therapy…”
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Suppression of splenic T lymphocyte proliferation by acute cocaine administration by Piccotti, Joseph R, Brissette-Storkus, Cindy S, Chambers, William H, Bricker, J.Douglas

“…We have recently demonstrated that cocaine administration has a limited effect on mitogen-stimulated T lymphocyte proliferation. The present study investigated…”
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Regulation of Cardiac Allograft Rejection by T Lymphocytes by DeBruyne, Lisa A, Piccotti, Joseph R, Bishop, D.Keith

“…Cardiac allograft rejection is diagnosed by routine, surveillance endomyocardial biopsy (EMB). EMB is an invasive and expensive procedure that detects ongoing,…”
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