Search Results - "Piccirillo, C. A."

Mechanisms of human FoxP3+ Treg cell development and function in health and disease by Attias, M., Al‐Aubodah, T., Piccirillo, C. A.

“…Summary Regulatory T (Treg) cells represent an essential component of peripheral tolerance. Given their potently immunosuppressive functions that is…”
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TGF-β1 modulates Foxp3 expression and regulatory activity in distinct CD4+ T cell subsets by Pyzik, M., Piccirillo, C. A.

“…Although forkhead box p3 (Foxp3) expression is restricted to naturally occurring CD4+ regulatory T cells (TREG), little is known about the various signals that…”
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Mechanisms of human FoxP3 + T reg cell development and function in health and disease by Attias, M, Al-Aubodah, T, Piccirillo, C A

“…Regulatory T (T ) cells represent an essential component of peripheral tolerance. Given their potently immunosuppressive functions that is orchestrated by the…”
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Intravenous immunoglobulin attenuates airway hyperresponsiveness in a murine model of allergic asthma by Kaufman, G. N., Massoud, A. H., Audusseau, S., Banville-Langelier, A.-A., Wang, Y., Guay, J., Garellek, J. A., Mourad, W., Piccirillo, C. A., McCusker, C., Mazer, B. D.

“…Summary Background Intravenous immunoglobulin (IVIG) has potent anti‐inflammatory and immune‐modulating properties. IVIG has been utilized as a steroid‐sparing…”
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Regulatory T cells: exploring mechanisms for future therapies by Piccirillo, C. A.

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Functional evaluation of the role of C‐type lectin domain family 16A at the chromosome 16p13 locus by Zouk, H., D'Hennezel, E., Du, X., Ounissi‐Benkalha, H., Piccirillo, C. A., Polychronakos, C.

“…Summary The type 1 diabetes‐associated 16p13 locus contains the CLEC16A gene. Its preferential immune cell expression suggests involvement in autoimmunity…”
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An ENU-induced splicing mutation reveals a role for Unc93b1 in early immune cell activation following influenza A H1N1 infection by Lafferty, E I, Flaczyk, A, Angers, I, Homer, R, d'Hennezel, E, Malo, D, Piccirillo, C A, Vidal, S M, Qureshi, S T

“…Genetic and immunological analysis of host–pathogen interactions can reveal fundamental mechanisms of susceptibility and resistance to infection. Modeling…”
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The Inhibitory Effects of Transforming Growth Factor-Beta-1 (TGF-β1) in Autoimmune Diseases by Prud'homme, Gérald J, Piccirillo, Ciriaco A

“…The importance of transforming growth factor-beta-1 (TGF-β1) in immunoregulation and tolerance has been increasingly recognized. It is now proposed that there…”
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Control of Type 1 Autoimmune Diabetes by Naturally Occurring CD4+CD25+ Regulatory T Lymphocytes in Neonatal NOD Mice by PICCIRILLO, C. A., TRITT, M., SGOUROUDIS, E., ALBANESE, A., PYZIK, M., HAY, V.

“…: Nonobese diabetic (NOD) mice serve as a model of spontaneous type 1 diabetes (T1D), a T cell‐mediated autoimmune disease leading to the destruction of…”
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S-adenosylmethionine blocks tumorigenesis and with immune checkpoint inhibitor enhances anti-cancer efficacy against BRAF mutant and wildtype melanomas by Mehdi, A., Attias, M., Arakelian, A., Szyf, M., Piccirillo, C.A., Rabbani, S.A.

“…Despite marked success in treatment with immune checkpoint inhibitor (CPI), only a third of patients are responsive. Thus, melanoma still has one of the…”
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Prevention of experimental allergic encephalomyelitis by intramuscular gene transfer with cytokine-encoding plasmid vectors by Piccirillo, C A, Prud'homme, G J

“…Antiinflammatory cytokines such as transforming growth factor beta1 (TGF-beta1) and interleukin 4 (IL-4) can protect from autoimmune diseases. To study the…”
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Cutting Edge: Control of CD8+ T Cell Activation by CD4+CD25+ Immunoregulatory Cells by Piccirillo, Ciriaco A, Shevach, Ethan M

“…CD4(+)CD25(+) regulatory T cells inhibit organ-specific autoimmune diseases induced by CD4(+)CD25(-) T cells and are potent suppressors of CD4(+)CD25(-) T cell…”
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Control of T-cell activation by CD4+ CD25+ suppressor T cells by Shevach, Ethan M., McHugh, Rebecca S., Piccirillo, Ciriaco A., Thornton, Angela M.

“…Depletion of the minor (∼10%) subpopulation of CD4+ T cells that co‐expresses CD25 (interleukin (IL)‐2 receptor α‐chain) by thymectomy of neonates on the third…”
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Transfer of cell membrane components via trogocytosis occurs in CD4+Foxp3+CD25+ regulatory T-cell contact-dependent suppression by Bahcheli, D., Hay, V., Nadeau, J. L., Piccirillo, C. A.

“…A key component of the immune system is its ability to establish and maintain peripheral tolerance. Naturally occurring CD4+CD25+Foxp3+ regulatory T (nTreg)…”
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Immune modulation by plasmid DNA-mediated cytokine gene transfer by Piccirillo, Ciriaco A, Prud'homme, Gérald J

“…Autoimmune diseases frequently develop as a result of an abnormal activation of autoreactive T cells, excessive production of proinflammatory cytokines,…”
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Translational control of immune responses: from transcripts to translatomes by Piccirillo, Ciriaco A, Bjur, Eva, Topisirovic, Ivan, Sonenberg, Nahum, Larsson, Ola

“…Translation of mRNA is controlled by a whole host of tightly regulated processes. In this Focus Review, Piccirillo et al . describe how translational skewing…”
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TGF-beta1 modulates Foxp3 expression and regulatory activity in distinct CD4+ T cell subsets by Pyzik, M, Piccirillo, C A

“…Although forkhead box p3 (Foxp3) expression is restricted to naturally occurring CD4(+) regulatory T cells (T(REG)), little is known about the various signals…”
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Naturally-occurring CD4 +CD25 + immunoregulatory T cells: central players in the arena of peripheral tolerance by Piccirillo, Ciriaco A, Shevach, Ethan M

“…Self/non-self discrimination is a complex process that involves maintaining tolerance to autoantigens while preserving the potential to generate an effective…”
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CD4 + CD25 + regulatory T cells control Leishmania major persistence and immunity by Belkaid, Yasmine, Piccirillo, Ciriaco A, Mendez, Susana, Shevach, Ethan M, Sacks, David L

“…The long-term persistence of pathogens in a host that is also able to maintain strong resistance to reinfection, referred to as concomitant immunity, is a…”
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Inhibiting the MNK1/2-eIF4E axis impairs melanoma phenotype switching and potentiates antitumor immune responses by Huang, Fan, Gonçalves, Christophe, Bartish, Margarita, Rémy-Sarrazin, Joelle, Issa, Mark E, Cordeiro, Brendan, Guo, Qianyu, Emond, Audrey, Attias, Mikhael, Yang, William, Plourde, Dany, Su, Jie, Gimeno, Marina Godoy, Zhan, Yao, Galán, Alba, Rzymski, Tomasz, Mazan, Milena, Masiejczyk, Magdalena, Faber, Jacek, Khoury, Elie, Benoit, Alexandre, Gagnon, Natascha, Dankort, David, Journe, Fabrice, Ghanem, Ghanem E, Krawczyk, Connie M, Saragovi, H Uri, Piccirillo, Ciriaco A, Sonenberg, Nahum, Topisirovic, Ivan, Rudd, Christopher E, Miller, Jr, Wilson H, Del Rincón, Sonia V

“…Melanomas commonly undergo a phenotype switch, from a proliferative to an invasive state. Such tumor cell plasticity contributes to immunotherapy resistance;…”
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