Search Results - "Piccialli, Ilaria"

Exploring the Therapeutic Potential of Phytochemicals in Alzheimer's Disease: Focus on Polyphenols and Monoterpenes by Piccialli, Ilaria, Tedeschi, Valentina, Caputo, Lucia, D'Errico, Stefano, Ciccone, Roselia, De Feo, Vincenzo, Secondo, Agnese, Pannaccione, Anna

“…Alzheimer's disease (AD) is a chronic, complex neurodegenerative disorder mainly characterized by the irreversible loss of memory and cognitive functions…”
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Size-Based Effects of Anthropogenic Ultrafine Particles on Lysosomal TRPML1 Channel and Autophagy in Motoneuron-like Cells by Sapienza, Silvia, Tedeschi, Valentina, Apicella, Barbara, Palestra, Francesco, Russo, Carmela, Piccialli, Ilaria, Pannaccione, Anna, Loffredo, Stefania, Secondo, Agnese

“…Background: An emerging body of evidence indicates an association between anthropogenic particulate matter (PM) and neurodegeneration. Although the historical…”
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Nucleic Acids as Biotools at the Interface between Chemistry and Nanomedicine in the COVID-19 Era by Borbone, Nicola, Piccialli, Ilaria, Falanga, Andrea Patrizia, Piccialli, Vincenzo, Roviello, Giovanni N, Oliviero, Giorgia

“…The recent development of mRNA vaccines against the SARS-CoV-2 infection has turned the spotlight on the potential of nucleic acids as innovative prophylactic…”
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Exploring the Parallel G-Quadruplex Nucleic Acid World: A Spectroscopic and Computational Investigation on the Binding of the c-myc Oncogene NHE III1 Region by the Phytochemical Polydatin by Greco, Francesca, Musumeci, Domenica, Borbone, Nicola, Falanga, Andrea Patrizia, D'Errico, Stefano, Terracciano, Monica, Piccialli, Ilaria, Roviello, Giovanni Nicola, Oliviero, Giorgia

“…Trans-polydatin (tPD), the 3-β-D-glucoside of the well-known nutraceutical trans-resveratrol, is a natural polyphenol with documented anti-cancer,…”
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The 3-(3-oxoisoindolin-1-yl)pentane-2,4-dione (ISOAC1) as a new molecule able to inhibit Amyloid β aggregation and neurotoxicity by Piccialli, Ilaria, Greco, Francesca, Roviello, Giovanni, Sisalli, Maria Josè, Tedeschi, Valentina, di Mola, Antonia, Borbone, Nicola, Oliviero, Giorgia, De Feo, Vincenzo, Secondo, Agnese, Massa, Antonio, Pannaccione, Anna

“…Amyloid β 1–42 (Aβ1–42) protein aggregation is considered one of the main triggers of Alzheimer’s disease (AD). In this study, we examined the in vitro…”
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The new KV3.4 inhibitor BDS-I[1-8] as a potential pharmacological opportunity in Alzheimer's disease therapy by Piccialli, Ilaria, Ciccone, Roselia, Pannaccione, Anna

“…[...]since several works implicated K+ flux as a common trigger in regulating inflammasome formation, it is possible to speculate that the astrocytic…”
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The Antioxidant Activity of Limonene Counteracts Neurotoxicity Triggered byAβ1-42 Oligomers in Primary Cortical Neurons by Piccialli, Ilaria, Tedeschi, Valentina, Caputo, Lucia, Amato, Giuseppe, De Martino, Laura, De Feo, Vincenzo, Secondo, Agnese, Pannaccione, Anna

“…Many natural-derived compounds, including the essential oils from plants, are investigated to find new potential protective agents in several neurodegenerative…”
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Rebound effects of NCX3 pharmacological inhibition: A novel strategy to accelerate myelin formation in oligodendrocytes by Cammarota, Mariarosaria, de Rosa, Valeria, Pannaccione, Anna, Secondo, Agnese, Tedeschi, Valentina, Piccialli, Ilaria, Fiorino, Ferdinando, Severino, Beatrice, Annunziato, Lucio, Boscia, Francesca

“…The Na+/Ca2+ exchanger NCX3 is an important regulator of sodium and calcium homeostasis in oligodendrocyte lineage. To date, no information is available on the…”
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The Na+/Ca2+ Exchanger 3 Is Functionally Coupled With the NaV1.6 Voltage-Gated Channel and Promotes an Endoplasmic Reticulum Ca2+ Refilling in a Transgenic Model of Alzheimer’s Disease by Piccialli, Ilaria, Ciccone, Roselia, Secondo, Agnese, Boscia, Francesca, Tedeschi, Valentina, de Rosa, Valeria, Cepparulo, Pasquale, Annunziato, Lucio, Pannaccione, Anna

“…The remodelling of neuronal ionic homeostasis by altered channels and transporters is a critical feature of the Alzheimer’s disease (AD) pathogenesis…”
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The Anemonia sulcata Toxin BDS-I Protects Astrocytes Exposed to Aβ1–42 Oligomers by Restoring [Ca2+]i Transients and ER Ca2+ Signaling by Piccialli, Ilaria, Tedeschi, Valentina, Boscia, Francesca, Ciccone, Roselia, Casamassa, Antonella, de Rosa, Valeria, Grieco, Paolo, Secondo, Agnese, Pannaccione, Anna

“…Intracellular calcium concentration ([Ca2+]i) transients in astrocytes represent a highly plastic signaling pathway underlying the communication between…”
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Involvement of KV3.4 Channel in Parkinson’s Disease: A Key Player in the Control of Midbrain and Striatum Differential Vulnerability during Disease Progression? by Magliocca, Giorgia, Esposito, Emilia, Tufano, Michele, Piccialli, Ilaria, Rubino, Valentina, Tedeschi, Valentina, Sisalli, Maria Jose, Carriero, Flavia, Ruggiero, Giuseppina, Secondo, Agnese, Annunziato, Lucio, Scorziello, Antonella, Pannaccione, Anna

“…Parkinson’s disease (PD), the second most common neurodegenerative disease in the elderly, is characterized by selective loss of dopaminergic neurons and…”
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Increased KV2.1 Channel Clustering Underlies the Reduction of Delayed Rectifier K+ Currents in Hippocampal Neurons of the Tg2576 Alzheimer’s Disease Mouse by Piccialli, Ilaria, Sisalli, Maria José, de Rosa, Valeria, Boscia, Francesca, Tedeschi, Valentina, Secondo, Agnese, Pannaccione, Anna

“…Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by the progressive deterioration of cognitive functions. Cortical and hippocampal…”
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Synthesis and Pharmacological Evaluation of a Novel Peptide Based on Anemonia sulcata BDS-I Toxin as a New KV3.4 Inhibitor Exerting a Neuroprotective Effect Against Amyloid-β Peptide by Ciccone, Roselia, Piccialli, Ilaria, Grieco, Paolo, Merlino, Francesco, Annunziato, Lucio, Pannaccione, Anna

“…There is increasing evidence that the fast-inactivating potassium current I A , encoded by K V 3. 4 channels, plays an important role in Alzheimer's Disease…”
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Synthesis and Biological Evaluation of a New Structural Simplified Analogue of cADPR, a Calcium-Mobilizing Secondary Messenger Firstly Isolated from Sea Urchin Eggs by D'Errico, Stefano, Borbone, Nicola, Catalanotti, Bruno, Secondo, Agnese, Petrozziello, Tiziana, Piccialli, Ilaria, Pannaccione, Anna, Costantino, Valeria, Mayol, Luciano, Piccialli, Gennaro, Oliviero, Giorgia

“…Herein, we reported on the synthesis of cpIPP, which is a new structurally-reduced analogue of cyclic ADP-ribose (cADPR), a potent Ca -releasing secondary…”
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The Na+/Ca2+exchanger in Alzheimer’s disease by Pannaccione, Anna, Piccialli, Ilaria, Secondo, Agnese, Ciccone, Roselia, Molinaro, Pasquale, Boscia, Francesca, Annunziato, Lucio

“…Schematic representation of the role played by NCX at synaptic and neuronal level after Aβ exposure. [Display omitted] •Sodium/calcium exchangers (NCXs) play a…”
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Lavender and coriander essential oils and their main component linalool exert a protective effect against amyloid‐β neurotoxicity by Caputo, Lucia, Piccialli, Ilaria, Ciccone, Roselia, Caprariis, Paolo, Massa, Antonio, De Feo, Vincenzo, Pannaccione, Anna

“…Alzheimer's disease (AD) is a neurodegenerative disorder leading to cognitive deficits and cognitive decline. Since no cure or preventing therapy is currently…”
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Amyloid β-Induced Upregulation of Nav1.6 Underlies Neuronal Hyperactivity in Tg2576 Alzheimer’s Disease Mouse Model by Ciccone, Roselia, Franco, Cristina, Piccialli, Ilaria, Boscia, Francesca, Casamassa, Antonella, de Rosa, Valeria, Cepparulo, Pasquale, Cataldi, Mauro, Annunziato, Lucio, Pannaccione, Anna

“…Hyperexcitability and alterations in neuronal networks contribute to cognitive impairment in Alzheimer’s Disease (AD). Voltage-gated sodium channels (Na V ),…”
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Na+/Ca2+ exchanger isoform 1 (NCX1) and canonical transient receptor potential channel 6 (TRPC6) are recruited by STIM1 to mediate Store-Operated Calcium Entry in primary cortical neurons by Tedeschi, Valentina, Sisalli, Maria Josè, Pannaccione, Anna, Piccialli, Ilaria, Molinaro, Pasquale, Annunziato, Lucio, Secondo, Agnese

“…•Na+/Ca2+ exchanger 1 (NCX1) activity is modulated by STIM1 in cortical neurons•NCX1 is recruited by STIM1 to take part in neuronal SOCE•TRPC6 is recruited by…”
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Engineering an oncolytic adenoviral platform for precise delivery of antisense peptide nucleic acid to modulate PD-L1 overexpression in cancer cells by Falanga, Andrea Patrizia, Greco, Francesca, Terracciano, Monica, D’Errico, Stefano, Marzano, Maria, Feola, Sara, Sepe, Valentina, Fontana, Flavia, Piccialli, Ilaria, Cerullo, Vincenzo, Santos, Hélder A., Borbone, Nicola

“…The oncolytic adenovirus (OAds) is employed as carriers for delivering antisense peptide nucleic acid (PNA) aimed at modulating PD-L1 expression in cancer…”
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The new K V 3.4 inhibitor BDS-I[1-8] as a potential pharmacological opportunity in Alzheimer's disease therapy by Piccialli, Ilaria, Ciccone, Roselia, Pannaccione, Anna

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