Search Results - "Picard, Daniel"

Involvement of CXCL1/CXCR2 During Microglia Activation Following Inflammation-Sensitized Hypoxic-Ischemic Brain Injury in Neonatal Rats by Serdar, Meray, Kempe, Karina, Herrmann, Ralf, Picard, Daniel, Remke, Marc, Herz, Josephine, Bendix, Ivo, Felderhoff-Müser, Ursula, Sabir, Hemmen

“…Background: Microglia are key mediators of inflammation during perinatal brain injury. As shown experimentally after inflammation-sensitized hypoxic ischemic…”
Get full text

Recommendations for POCUS Curriculum in Canadian Undergraduate Medical Education: Consensus from the Inaugural Seguin Canadian POCUS Education Conference by Weill, Sacha, Picard, Daniel Armand, Kim, Daniel J, Woo, Michael Y

“…Point of care ultrasound (POCUS) in Canadian undergraduate medical education (UGME) is limited. To address this paucity, the inaugural Seguin Canadian POCUS…”
Get full text

Molecular subgroups of atypical teratoid rhabdoid tumours in children: an integrated genomic and clinicopathological analysis by Torchia, Jonathon, MSc, Picard, Daniel, MSc, Lafay-Cousin, Lucie, MD, Hawkins, Cynthia E, PhD, Kim, Seung-Ki, MD, Letourneau, Louis, BSc, Ra, Young-Shin, Prof, Ho, King Ching, MSc, Chan, Tiffany Sin Yu, PhD, Sin-Chan, Patrick, MSc, Dunham, Christopher P, MD, Yip, Stephen, FRCPC, Ng, Ho-keung, MD, Lu, Jian-Qiang, FRCPC, Albrecht, Steffen, MD, Pimentel, José, PhD, Chan, Jennifer A, MD, Somers, Gino R, MBBS, Zielenska, Maria, PhD, Faria, Claudia C, PhD, Roque, Lucia, PhD, Baskin, Berivan, PhD, Birks, Diane, MS, Foreman, Nick, Prof, Strother, Douglas, MD, Klekner, Almos, PhD, Garami, Miklos, PhD, Hauser, Peter, PhD, Hortobágyi, Tibor, PhD, Bognár, Laszló, PhD, Wilson, Beverly, MD, Hukin, Juliette, FRCPC, Carret, Anne-Sophie, MD, Van Meter, Timothy E, PhD, Nakamura, Hideo, MD, Toledano, Helen, MD, Fried, Iris, MD, Fults, Daniel, MD, Wataya, Takafumi, PhD, Fryer, Chris, FRCPC, Eisenstat, David D, MD, Scheineman, Katrin, Prof, Johnston, Donna, MD, Michaud, Jean, MD, Zelcer, Shayna, MD, Hammond, Robert, MD, Ramsay, David A, MBChB, Fleming, Adam J, MD, Lulla, Rishi R, MD, Fangusaro, Jason R, MD, Sirachainan, Nongnuch, MD, Larbcharoensub, Noppadol, MD, Hongeng, Suradej, MD, Barakzai, Muhammad Abrar, MD, Montpetit, Alexandre, PhD, Stephens, Derek, MSc, Grundy, Richard G, FRCPCH, Schüller, Ulrich, MD, Nicolaides, Theodore, MD, Tihan, Tarik, PhD, Phillips, Joanna, PhD, Taylor, Michael D, PhD, Rutka, James T, MD, Dirks, Peter, PhD, Bader, Gary D, PhD, Warmuth-Metz, Monika, Prof, Rutkowski, Stefan, Prof, Pietsch, Torsten, Prof, Judkins, Alexander R, MD, Jabado, Nada, PhD, Bouffet, Eric, Prof, Huang, Annie, Dr

“…Summary Background Rhabdoid brain tumours, also called atypical teratoid rhabdoid tumours, are lethal childhood cancers with characteristic genetic alterations…”
Get full text

Proteogenomic profiling uncovers differential therapeutic vulnerabilities between TCF3::PBX1 and TCF3::HLF translocated B-cell acute lymphoblastic leukemia by Blumel, Lena, Bernardi, Flavia, Picard, Daniel, Diaz, Jacob Torrejon, Jepsen, Vera H, Hasselmann, Rebecca, Schliehe-Diecks, Julian, Bartl, Jasmin, Qin, Nan, Bornhauser, Beat, Bhatia, Sanil, Marovka, Blerim, Marsaud, Veronique, Dingli, Florent, Loew, Damarys, Stanulla, Martin, Bourqin, Jean-Pierre, Borkhardt, Arndt, Remke, Marc, Ayrault, Olivier, Fischer, Ute

Get full text

Frequent Amplification of a chr19q13.41 MicroRNA Polycistron in Aggressive Primitive Neuroectodermal Brain Tumors by Li, Meihua, Lee, Kyle F., Lu, Yuntao, Clarke, Ian, Shih, David, Eberhart, Charles, Collins, V. Peter, Van Meter, Tim, Picard, Daniel, Zhou, Limei, Boutros, Paul C., Modena, Piergiorgio, Liang, Muh-Lii, Scherer, Steve W., Bouffet, Eric, Rutka, James T., Pomeroy, Scott L., Lau, Ching C., Taylor, Michael D., Gajjar, Amar, Dirks, Peter B., Hawkins, Cynthia E., Huang, Annie

“…We discovered a high-level amplicon involving the chr19q13.41 microRNA (miRNA) cluster (C19MC) in 11/45 (∼25%) primary CNS-PNET, which results in striking…”
Get full text

YBX1 Indirectly Targets Heterochromatin-Repressed Inflammatory Response-Related Apoptosis Genes through Regulating CBX5 mRNA by Kloetgen, Andreas, Duggimpudi, Sujitha, Schuschel, Konstantin, Hezaveh, Kebria, Picard, Daniel, Schaal, Heiner, Remke, Marc, Klusmann, Jan-Henning, Borkhardt, Arndt, McHardy, Alice C, Hoell, Jessica I

“…Medulloblastomas arise from undifferentiated precursor cells in the cerebellum and account for about 20% of all solid brain tumors during childhood; standard…”
Get full text

Unleashing T cell anti-tumor immunity: new potential for 5-Nonloxytryptamine as an agent mediating MHC-I upregulation in tumors by Stachura, PaweÅ, Liu, Wei, Xu, Haifeng C, Wlodarczyk, Agnès, Stencel, Olivia, Pandey, Piyush, Vogt, Melina, Bhatia, Sanil, Picard, Daniel, Remke, Marc, Lang, Karl S, Häussinger, Dieter, Homey, Bernhard, Lang, Philipp A, Borkhardt, Arndt, Pandyra, Aleksandra A

“…Abstract Background New therapies are urgently needed in melanoma, particularly in late-stage patients not responsive to immunotherapies and kinase inhibitors…”
Get full text

Characterization of an RNA binding protein interactome reveals a context-specific post-transcriptional landscape of MYC-amplified medulloblastoma by Kameda-Smith, Michelle M., Zhu, Helen, Luo, En-Ching, Suk, Yujin, Xella, Agata, Yee, Brian, Chokshi, Chirayu, Xing, Sansi, Tan, Frederick, Fox, Raymond G., Adile, Ashley A., Bakhshinyan, David, Brown, Kevin, Gwynne, William D., Subapanditha, Minomi, Miletic, Petar, Picard, Daniel, Burns, Ian, Moffat, Jason, Paruch, Kamil, Fleming, Adam, Hope, Kristin, Provias, John P., Remke, Marc, Lu, Yu, Reya, Tannishtha, Venugopal, Chitra, Reimand, Jüri, Wechsler-Reya, Robert J., Yeo, Gene W., Singh, Sheila K.

“…Pediatric medulloblastoma (MB) is the most common solid malignant brain neoplasm, with Group 3 (G3) MB representing the most aggressive subgroup. MYC…”
Get full text

Co-targeting HSP90 alpha and CDK7 overcomes resistance against HSP90 inhibitors in BCR-ABL1+ leukemia cells by Vogt, Melina, Dienstbier, Niklas, Schliehe-Diecks, Julian, Scharov, Katerina, Tu, Jia-Wey, Gebing, Philip, Hogenkamp, Julian, Bilen, Berna-Selin, Furlan, Silke, Picard, Daniel, Remke, Marc, Yasin, Layal, Bickel, David, Kalia, Munishikha, Iacoangeli, Alfredo, Lenz, Thomas, Stühler, Kai, Pandyra, Aleksandra A., Hauer, Julia, Fischer, Ute, Wagener, Rabea, Borkhardt, Arndt, Bhatia, Sanil

“…HSP90 has emerged as an appealing anti-cancer target. However, HSP90 inhibitors (HSP90i) are characterized by limited clinical utility, primarily due to the…”
Get full text

The homeobox transcription factor HB9 induces senescence and blocks differentiation in hematopoietic stem and progenitor cells by Ingenhag, Deborah, Reister, Sven, Auer, Franziska, Bhatia, Sanil, Wildenhain, Sarah, Picard, Daniel, Remke, Marc, Hoell, Jessica I, Kloetgen, Andreas, Sohn, Dennis, Jänicke, Reiner U, Koegler, Gesine, Borkhardt, Arndt, Hauer, Julia

“…The homeobox gene encodes for the transcription factor HB9, which is essential for pancreatic as well as motor neuronal development. Beside its physiological…”
Get full text

Author Correction: Characterization of an RNA binding protein interactome reveals a context-specific post-transcriptional landscape of MYC-amplified medulloblastoma by Kameda-Smith, Michelle M., Zhu, Helen, Luo, En-Ching, Suk, Yujin, Xella, Agata, Yee, Brian, Chokshi, Chirayu, Xing, Sansi, Tan, Frederick, Fox, Raymond G., Adile, Ashley A., Bakhshinyan, David, Brown, Kevin, Gwynne, William D., Subapanditha, Minomi, Miletic, Petar, Picard, Daniel, Burns, Ian, Moffat, Jason, Paruch, Kamil, Fleming, Adam, Hope, Kristin, Provias, John P., Remke, Marc, Lu, Yu, Reya, Tannishtha, Venugopal, Chitra, Reimand, Jüri, Wechsler-Reya, Robert J., Yeo, Gene W., Singh, Sheila K.

Get full text

Primary cilia contribute to the aggressiveness of atypical teratoid/rhabdoid tumors by Blümel, Lena, Qin, Nan, Berlandi, Johannes, Paisana, Eunice, Cascão, Rita, Custódia, Carlos, Pauck, David, Picard, Daniel, Langini, Maike, Stühler, Kai, Meyer, Frauke-Dorothee, Göbbels, Sarah, Malzkorn, Bastian, Liebau, Max C., Barata, João T., Jeibmann, Astrid, Kerl, Kornelius, Erkek, Serap, Kool, Marcel, Pfister, Stefan M., Johann, Pascal D., Frühwald, Michael C., Borkhardt, Arndt, Reifenberger, Guido, Faria, Claudia C., Fischer, Ute, Hasselblatt, Martin, Bartl, Jasmin, Remke, Marc

“…Atypical teratoid/rhabdoid tumor (AT/RT) is a highly malignant brain tumor in infants that is characterized by loss of nuclear expression of SMARCB1 or SMARCA4…”
Get full text

MEK Inhibitors Reverse Growth of Embryonal Brain Tumors Derived from Oligoneural Precursor Cells by Modzelewska, Katarzyna, Boer, Elena F., Mosbruger, Timothy L., Picard, Daniel, Anderson, Daniela, Miles, Rodney R., Kroll, Mitchell, Oslund, William, Pysher, Theodore J., Schiffman, Joshua D., Jensen, Randy, Jette, Cicely A., Huang, Annie, Stewart, Rodney A.

“…Malignant brain tumors are the leading cause of cancer-related deaths in children. Primitive neuroectodermal tumors of the CNS (CNS-PNETs) are particularly…”
Get full text

A Sexually Dimorphic Role for STAT3 in Sonic Hedgehog Medulloblastoma by White, Christine L, Jayasekara, W Samantha N, Picard, Daniel, Chen, Jasmine, Watkins, D Neil, Cain, Jason E, Remke, Marc, Gough, Daniel J

“…Medulloblastoma is the most common malignant brain tumor in children and represents 20% of all pediatric central nervous system neoplasms. While advances in…”
Get full text

Optical Genome Mapping Identifies Novel Recurrent Structural Alterations in Childhood ETV6::RUNX1+ and High Hyperdiploid Acute Lymphoblastic Leukemia by Brandes, Danielle, Yasin, Layal, Nebral, Karin, Ebler, Jana, Schinnerl, Dagmar, Picard, Daniel, Bergmann, Anke K., Alam, Jubayer, Köhrer, Stefan, Haas, Oskar A., Attarbaschi, Andishe, Marschall, Tobias, Stanulla, Martin, Borkhardt, Arndt, Brozou, Triantafyllia, Fischer, Ute, Wagener, Rabea

“…The mutational landscape of B‐cell precursor acute lymphoblastic leukemia (BCP‐ALL), the most common pediatric cancer, is not fully described partially because…”
Get full text

The Second Oncogenic Hit Determines the Cell Fate of ETV6-RUNX1 Positive Leukemia by Rodríguez-Hernández, Guillermo, Casado-García, Ana, Isidro-Hernández, Marta, Picard, Daniel, Raboso-Gallego, Javier, Alemán-Arteaga, Silvia, Orfao, Alberto, Blanco, Oscar, Riesco, Susana, Prieto-Matos, Pablo, García Criado, Francisco Javier, García Cenador, María Begoña, Hock, Hanno, Enver, Tariq, Sanchez-Garcia, Isidro, Vicente-Dueñas, Carolina

“…ETV6-RUNX1 is almost exclusively associated with childhood B-cell acute lymphoblastic leukemia (B-ALL), but the consequences of ETV6-RUNX1 expression on cell…”
Get full text

Eukaryotic translation initiation factor 4E binding protein 1 (EIF4EBP1) expression in glioblastoma is driven by ETS1- and MYBL2-dependent transcriptional activation by Hauffe, Laura, Picard, Daniel, Musa, Julian, Remke, Marc, Grünewald, Thomas G. P., Rotblat, Barak, Reifenberger, Guido, Leprivier, Gabriel

“…Eukaryotic translation initiation factor 4E binding protein 1 ( EIF4EBP1 ) encodes the 4EBP1 protein, a negative regulator of mRNA translation and a substrate…”
Get full text

1403-C 5-Nonyloxytryptamine reveals novel approach for MHC-I upregulation in tumors by Stachura, Pawel, Liu, Wei, Xu, Haifeng, Wlodarczyk, Agnes, Stencel, Olivia, Pandey, Piyush, Vogt, Melina, Bhatia, Sanil, Picard, Daniel, Remke, Marc, Lang, Karl, Häussinger, Dieter, Homey, Bernhard, Lang, Philipp A, Borkhardt, Arndt, Pandyra, Aleksandra A

“…BackgroundMelanoma is categorized as an immunologically ‘cold’ tumor due to its unresponsiveness to immunotherapies. Efforts to enhance the immune response…”
Get full text

Resolving inherited and de novo germline predisposing sequence variants by means of whole exome trio analyses in childhood hematological malignancies by Brozou, Triantafyllia, Yasin, Layal, Brandes, Danielle, Picard, Daniel, Walter, Carolin, Varghese, Julian, Dugas, Martin, Fischer, Ute, Borkhardt, Arndt, Haas, Oskar A

“…Molecular screening tools have significantly eased the assessment of potential germline susceptibility factors that may underlie the development of pediatric…”
Get full text

Silencing of Thrombospondin-1 Is Critical for Myc-Induced Metastatic Phenotypes in Medulloblastoma by LIMEIZHOU, PICARD, Daniel, DER, Sandy D, HUANG, Annie, RA, Young-Shin, MEIHUALI, NORTHCOTT, Paul A, YAQI HU, STEARNS, Duncan, HAWKINS, Cynthia, TAYLOR, Michael D, RUTKA, James

“…Mechanisms by which c-Myc (Myc) amplification confers aggressive medulloblastoma phenotypes are poorly defined. Here, we show using orthotopic models that high…”
Get full text