Search Results - "Picada, Jaqueline"
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Melatonin prevents oxidative stress, inflammatory activity, and DNA damage in cirrhotic rats
Published in World journal of gastroenterology : WJG (21-01-2022)“…Cirrhosis is an important health problem characterized by a significant change in liver parenchyma. In animals, this can be reproduced by an experimental model…”
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Simvastatin Reduces Hepatic Oxidative Stress and Endoplasmic Reticulum Stress in Nonalcoholic Steatohepatitis Experimental Model
Published in Oxidative medicine and cellular longevity (2019)“…Objective. In this study, we evaluated the efficacy of simvastatin in the treatment of nonalcoholic steatohepatitis induced by methionine and choline-deficient…”
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Evaluation of toxicity and mutagenicity of a synthetic effluent containing azo dye after Advanced Oxidation Process treatment
Published in Chemosphere (Oxford) (01-01-2021)“…Approximately 20% industrial water pollution comes from textile dyeing process, with Azo dyes being a major problem in this scenario and requiring new forms of…”
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Antinociceptive and genotoxic assessments of the antagonist TRPV1 receptor SB-366791 on morphine-induced tolerance in mice
Published in Naunyn-Schmiedeberg's archives of pharmacology (01-03-2020)“…Chronic pain is mainly treated with opioid analgesics such as morphine. However, the use of these substances can cause adverse effects, including dependence…”
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Nonclinical evaluation of IQG-607, an anti-tuberculosis candidate with potential use in combination drug therapy
Published in Regulatory toxicology and pharmacology (01-03-2020)“…New effective compounds to treat tuberculosis are urgently needed. IQG-607 is an orally active anti-tuberculosis drug candidate, with promising preliminary…”
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Photobiomodulation intervention improves oxidative, inflammatory, and morphological parameters of skeletal muscle in cirrhotic Wistar rats
Published in Lasers in medical science (01-04-2022)“…Photobiomodulation (PBM) might be an intervention method to mitigate sarcopenia in cirrhotic patients. Given the lack of research on this issue, the goal of…”
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Lupin protein concentrate as a novel functional food additive that can reduce colitis-induced inflammation and oxidative stress
Published in Nutrients (18-05-2022)“…© 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative…”
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Comparative toxicity of coal and coal ash: Assessing biological impacts and potential mechanisms through in vitro and in vivo testing
Published in Journal of trace elements in medicine and biology (01-01-2024)“…Coal and coal ash present inorganic elements associated with negative impacts on environment and human health. The objective of this study was to compare the…”
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Evaluation of lipolysis and toxicological parameters of low-level laser therapy at different wavelengths and doses in the abdominal subcutaneous tissue
Published in Lasers in medical science (01-03-2022)“…Investigate the effects of low-level lasers therapy (LLLT) aiming abdominal lipolysis. Female Wistar rats received applications of LLLT directly in the…”
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Gamma-Decanolactone Alters the Expression of GluN2B, A1 Receptors, and COX-2 and Reduces DNA Damage in the PTZ-Induced Seizure Model After Subchronic Treatment in Mice
Published in Neurochemical research (01-08-2021)“…Gamma-decanolactone (GD) has been shown to reduce epileptic behavior in different models, inflammatory decreasing, oxidative stress, and genotoxic parameters…”
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Quercetin Decreases Liver Damage in Mice with Non-Alcoholic Steatohepatitis
Published in Basic & clinical pharmacology & toxicology (01-06-2013)“…Non-alcoholic steatohepatitis (NASH) is a frequent condition in obese patients that may progress to end-stage liver disease. This study was designed to…”
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Chemical and toxicological effects of medicinal Baccharis trimera extract from coal burning area
Published in Chemosphere (Oxford) (01-03-2016)“…The entire process of power generation, extraction, processing and use of coal strongly impact water resources, soil, air quality and biota leads to changes in…”
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13
Rosmarinic acid as a protective agent against genotoxicity of ethanol in mice
Published in Food and chemical toxicology (01-05-2012)“…► Genotoxicity effect of ethanol in vivo. ► Rosmarinic acid significantly reduces DNA damage caused by ethanol in mice. ► Rosmarinic acid decrease the levels…”
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Melatonin Activates Endoplasmic Reticulum Stress and Apoptosis in Rats with Diethylnitrosamine-Induced Hepatocarcinogenesis
Published in PloS one (11-12-2015)“…Hepatocellular carcinoma (HCC) is one of the most lethal human cancers worldwide because of its high incidence, its metastatic potential and the low efficacy…”
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A 28‐day Sub‐acute Genotoxic and Behavioural Assessment of Garcinielliptone FC
Published in Basic & clinical pharmacology & toxicology (01-08-2018)“…Garcinielliptone FC (GFC) is a polyisoprenylated benzophenone isolated from Platonia insignis Mart (Clusiaceae) with promising anticonvulsant properties…”
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Biotoxicological Analyses of Trimeroside from Baccharis trimera Using a Battery of In Vitro Test Systems
Published in Oxidative medicine and cellular longevity (01-01-2018)“…The use in folk medicine of Baccharis trimera and recent studies on DNA damage by oxidative stress mechanisms have motivated this study. We investigated the…”
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Persistent Increased Frequency of Genomic Instability in Women Diagnosed with Breast Cancer: Before, during, and after Treatments
Published in Oxidative medicine and cellular longevity (01-01-2018)“…This study aimed to evaluate DNA damage in patients with breast cancer before treatment (background) and after chemotherapy (QT) and radiotherapy (RT)…”
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Toxicological profile of the Hymenaea courbaril stem bark hydroalcoholic extract using in vitro bioassays and an alternative in vivo Caenorhabditis elegans model
Published in Journal of Toxicology and Environmental Health, Part A (17-09-2023)“…Hymenaea genus has been used in folk medicine in Brazil, but few studies investigated its toxicity profile. Thus, the aim of this study was to determine…”
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Evaluation of acute and subacute toxicity and mutagenic activity of the aqueous extract of pecan shells [Carya illinoinensis (Wangenh.) K. Koch]
Published in Food and chemical toxicology (01-09-2013)“…•Pecan shells aqueous extract does not present oral acute and subacute toxicity.•The extract does not induce mutagenic effects in vitro and in vivo.•The lack…”
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In Vivo Genotoxicity Evaluation of an Artichoke (Cynara scolymus L.) Aqueous Extract
Published in Journal of food science (01-02-2013)“…The Cynara scolymus (artichoke) is widely consumed as tea or food and shows important therapeutic properties. However, few studies have assessed the possible…”
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