Search Results - "Pica, Natalie"

Toward a Universal Influenza Virus Vaccine: Prospects and Challenges by Pica, Natalie, Palese, Peter

“…Current influenza virus vaccines are annually reformulated to elicit protection by generating an immune response toward the virus strains that are predicted to…”
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Chimeric Hemagglutinin Influenza Virus Vaccine Constructs Elicit Broadly Protective Stalk-Specific Antibodies by Krammer, Florian, Pica, Natalie, Hai, Rong, Margine, Irina, Palese, Peter

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Environmental factors affecting the transmission of respiratory viruses by Pica, Natalie, Bouvier, Nicole M

“…► Respiratory viruses are spread from person to person via various modes of transmission, including direct and indirect contact, droplet spray, and aerosol. ►…”
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Noncompletion and nonpublication of trials studying rare diseases: A cross-sectional analysis by Rees, Chris A, Pica, Natalie, Monuteaux, Michael C, Bourgeois, Florence T

“…Rare diseases affect as many as 60 million people in the United States and Europe. However, most rare diseases lack effective therapies and are in critical…”
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NS1-Truncated Live Attenuated Virus Vaccine Provides Robust Protection to Aged Mice from Viral Challenge by PICA, Natalie, LANGLOIS, Ryan A, KRAMMER, Florian, MARGINE, Irina, PALESE, Peter

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Influenza Viruses Expressing Chimeric Hemagglutinins: Globular Head and Stalk Domains Derived from Different Subtypes by Hai, Rong, Krammer, Florian, Tan, Gene S, Pica, Natalie, Eggink, Dirk, Maamary, Jad, Margine, Irina, Albrecht, Randy A, Palese, Peter

“…The influenza virus hemagglutinin molecule possesses a globular head domain that mediates receptor binding and a stalk domain at the membrane-proximal region…”
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Hemagglutinin Stalk-Reactive Antibodies Are Boosted following Sequential Infection with Seasonal and Pandemic H1N1 Influenza Virus in Mice by KRAMMER, Florian, PICA, Natalie, RONG HAI, TAN, Gene S, PALESE, Peter

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Vaccination with a synthetic peptide from the influenza virus hemagglutinin provides protection against distinct viral subtypes by Wang, Taia T., Tan, Gene S., Hai, Rong, Pica, Natalie, Ngai, Lily, Ekiert, Damian C., Wilson, Ian A., García-Sastre, Adolfo, Moran, Thomas M., Palese, Peter

“…Current influenza virus vaccines protect mostly against homologous virus strains; thus, regular immunization with updated vaccine formulations is necessary to…”
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A carboxy-terminal trimerization domain stabilizes conformational epitopes on the stalk domain of soluble recombinant hemagglutinin substrates by Krammer, Florian, Margine, Irina, Tan, Gene S, Pica, Natalie, Krause, Jens C, Palese, Peter

“…Recently, a new class of broadly neutralizing anti-influenza virus antibodies that target the stalk domain of the viral hemagglutinin was discovered. As such,…”
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Broadly protective monoclonal antibodies against H3 influenza viruses following sequential immunization with different hemagglutinins by Wang, Taia T, Tan, Gene S, Hai, Rong, Pica, Natalie, Petersen, Erin, Moran, Thomas M, Palese, Peter

“…As targets of adaptive immunity, influenza viruses are characterized by the fluidity with which they respond to the selective pressure applied by neutralizing…”
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Hemagglutinin stalk antibodies elicited by the 2009 pandemic influenza virus as a mechanism for the extinction of seasonal H1N1 viruses by Pica, Natalie, Hai, Rong, Krammer, Florian, Wang, Taia T., Maamary, Jad, Eggink, Dirk, Tan, Gene S., Krause, Jens C., Moran, Thomas, Stein, Cheryl R., Banach, David, Wrammert, Jens, Belshe, Robert B., García-Sastre, Adolfo, Palese, Peter

“…After the emergence of pandemic influenza viruses in 1957, 1968, and 2009, existing seasonal viruses were observed to be replaced in the human population by…”
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Transmission of Influenza B Viruses in the Guinea Pig by PICA, Natalie, CHOU, Yi-Ying, BOUVIER, Nicole M, PALESE, Peter

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The M Segment of the 2009 New Pandemic H1N1 Influenza Virus Is Critical for Its High Transmission Efficiency in the Guinea Pig Model by CHOU, Yi-Ying, ALBRECHT, Randy A, PICA, Natalie, LOWEN, Anice C, RICHT, Jürgen A, GARCIA-SASTRE, Adolfo, PALESE, Peter, HAI, Rong

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Enhanced Mammalian Transmissibility of Seasonal Influenza A/H1N1 Viruses Encoding an Oseltamivir-Resistant Neuraminidase by BOUVIER, Nicole M, RAHMAT, Saad, PICA, Natalie

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The DBA.2 Mouse Is Susceptible to Disease following Infection with a Broad, but Limited, Range of Influenza A and B Viruses by Pica, Natalie, Iyer, Arun, Ramos, Irene, Bouvier, Nicole M, Fernandez-Sesma, Ana, García-Sastre, Adolfo, Lowen, Anice C, Palese, Peter, Steel, John

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Discontinuation and Nonpublication of Randomized Clinical Trials Conducted in Children by Pica, Natalie, Bourgeois, Florence

“…Trial discontinuation and nonpublication represent potential waste in research resources and lead to compromises in medical evidence. Pediatric trials may be…”
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Attenuated Influenza Virus Construct with Enhanced Hemagglutinin Protein Expression by MAAMARY, Jad, PICA, Natalie, BELICHA-VILLANUEVA, Alan, CHOU, Yi-Ying, KRAMMER, Florian, QINSHAN GAO, GARCIA-SASTRE, Adolfo, PALESE, Peter

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Ambient Temperature and Respiratory Virus Infection by PICA, Natalie, BOUVIER, Nicole M

“…Respiratory viruses are important pediatric pathogens with pronounced seasonal patterns of circulation. Various hypotheses have been put forth to explain the…”
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Closing the Brief Case: Safe To Go Back in the Water? Vibrio parahaemolyticus Wound Infection Associated with Brackish Water by Brennan-Krohn, Thea, Pica, Natalie, Sandora, Thomas J, McAdam, Alexander

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The Brief Case: Safe To Go Back in the Water? Vibrio parahaemolyticus Wound Infection Associated with Brackish Water by Brennan-Krohn, Thea, Pica, Natalie, Sandora, Thomas J, McAdam, Alexander

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