Search Results - "Piazza, Aurèle"

Homologous Recombination and the Formation of Complex Genomic Rearrangements by Piazza, Aurèle, Heyer, Wolf-Dietrich

“…The maintenance of genome integrity involves multiple independent DNA damage avoidance and repair mechanisms. However, the origin and pathways of the focal…”
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Multi-invasions Are Recombination Byproducts that Induce Chromosomal Rearrangements by Piazza, Aurèle, Wright, William Douglass, Heyer, Wolf-Dietrich

“…Inaccurate repair of broken chromosomes generates structural variants that can fuel evolution and inflict pathology. We describe a novel rearrangement…”
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Recombination-mediated genome rearrangements by Savocco, Jérôme, Piazza, Aurèle

“…[Display omitted] Homologous recombination (HR) is a universal DNA double-strand break (DSB) repair pathway that uses an intact DNA molecule as a template…”
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Moving forward one step back at a time: reversibility during homologous recombination by Piazza, Aurèle, Heyer, Wolf-Dietrich

“…DNA double-strand breaks are genotoxic lesions whose repair can be templated off an intact DNA duplex through the conserved homologous recombination (HR)…”
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Cohesin regulates homology search during recombinational DNA repair by Piazza, Aurèle, Bordelet, Hélène, Dumont, Agnès, Thierry, Agnès, Savocco, Jérôme, Girard, Fabien, Koszul, Romain

“…Homologous recombination repairs DNA double-strand breaks (DSB) using an intact dsDNA molecule as a template. It entails a homology search step, carried out…”
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Dynamic Processing of Displacement Loops during Recombinational DNA Repair by Piazza, Aurèle, Shah, Shanaya Shital, Wright, William Douglass, Gore, Steven K., Koszul, Romain, Heyer, Wolf-Dietrich

“…Displacement loops (D-loops) are pivotal intermediates of homologous recombination (HR), a universal DNA double strand break (DSB) repair pathway. We developed…”
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Multi‐Invasion‐Induced Rearrangements as a Pathway for Physiological and Pathological Recombination by Piazza, Aurèle, Heyer, Wolf‐Dietrich

“…Cells mitigate the detrimental consequences of DNA damage on genome stability by attempting high fidelity repair. Homologous recombination templates DNA…”
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Short loop length and high thermal stability determine genomic instability induced by G-quadruplex-forming minisatellites by Piazza, Aurèle, Adrian, Michael, Samazan, Frédéric, Heddi, Brahim, Hamon, Florian, Serero, Alexandre, Lopes, Judith, Teulade-Fichou, Marie-Paule, Phan, Anh Tuân, Nicolas, Alain

“…G‐quadruplexes (G4) are polymorphic four‐stranded structures formed by certain G‐rich nucleic acids, with various biological roles. However, structural…”
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Neuroinvasion and anosmia are independent phenomena upon infection with SARS-CoV-2 and its variants by de Melo, Guilherme Dias, Perraud, Victoire, Alvarez, Flavio, Vieites-Prado, Alba, Kim, Seonhee, Kergoat, Lauriane, Coleon, Anthony, Trüeb, Bettina Salome, Tichit, Magali, Piazza, Aurèle, Thierry, Agnès, Hardy, David, Wolff, Nicolas, Munier, Sandie, Koszul, Romain, Simon-Lorière, Etienne, Thiel, Volker, Lecuit, Marc, Lledo, Pierre-Marie, Renier, Nicolas, Larrous, Florence, Bourhy, Hervé

“…Anosmia was identified as a hallmark of COVID-19 early in the pandemic, however, with the emergence of variants of concern, the clinical profile induced by…”
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Mechanism of homology search expansion during recombinational DNA break repair in Saccharomyces cerevisiae by Dumont, Agnès, Mendiboure, Nicolas, Savocco, Jérôme, Anani, Loqmen, Moreau, Pierrick, Thierry, Agnès, Modolo, Laurent, Jost, Daniel, Piazza, Aurèle

“…Homology search is a central step of DNA double-strand break (DSB) repair by homologous recombination (HR). How it operates in cells remains elusive. We…”
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The yeast Pif1 helicase prevents genomic instability caused by G-quadruplex-forming CEB1 sequences in vivo by Ribeyre, Cyril, Lopes, Judith, Boulé, Jean-Baptiste, Piazza, Aurèle, Guédin, Aurore, Zakian, Virginia A, Mergny, Jean-Louis, Nicolas, Alain

“…In budding yeast, the Pif1 DNA helicase is involved in the maintenance of both nuclear and mitochondrial genomes, but its role in these processes is still…”
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G-quadruplex-induced instability during leading-strand replication by Lopes, Judith, Piazza, Aurèle, Bermejo, Rodrigo, Kriegsman, Barry, Colosio, Arianna, Teulade-Fichou, Marie-Paule, Foiani, Marco, Nicolas, Alain

“…G‐quadruplexes are four‐stranded nucleic acid structures whose biological functions remain poorly understood. In the yeast S. cerevisia e, we report that…”
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Delineation of two multi-invasion-induced rearrangement pathways that differently affect genome stability by Reitz, Diedre, Djeghmoum, Yasmina, Watson, Ruth A, Rajput, Pallavi, Argueso, Juan Lucas, Heyer, Wolf-Dietrich, Piazza, Aurèle

“…Punctuated bursts of structural genomic variations (SVs) have been described in various organisms, but their etiology remains incompletely understood…”
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Characterizing meiotic chromosomes' structure and pairing using a designer sequence optimized for Hi‐C by Muller, Héloïse, Scolari, Vittore F, Agier, Nicolas, Piazza, Aurèle, Thierry, Agnès, Mercy, Guillaume, Descorps‐Declere, Stéphane, Lazar‐Stefanita, Luciana, Espeli, Olivier, Llorente, Bertrand, Fischer, Gilles, Mozziconacci, Julien, Koszul, Romain

“…In chromosome conformation capture experiments (Hi‐C), the accuracy with which contacts are detected varies due to the uneven distribution of restriction sites…”
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Non-Canonical G-quadruplexes cause the hCEB1 minisatellite instability in Saccharomyces cerevisiae by Piazza, Aurèle, Cui, Xiaojie, Adrian, Michael, Samazan, Frédéric, Heddi, Brahim, Phan, Anh-Tuan, Nicolas, Alain G

“…G-quadruplexes (G4) are polymorphic four-stranded structures formed by certain G-rich nucleic acids in vitro, but the sequence and structural features…”
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Detection of Homologous Recombination Intermediates via Proximity Ligation and Quantitative PCR in Saccharomyces cerevisiae by Reitz, Diedre, Savocco, Jérôme, Piazza, Aurèle, Heyer, Wolf-Dietrich

“…DNA damage, including DNA double-stranded breaks and inter-strand cross-links, incurred during the S and G2 phases of the cell cycle can be repaired by…”
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Stimulation of gross chromosomal rearrangements by the human CEB1 and CEB25 minisatellites in Saccharomyces cerevisiae depends on G-quadruplexes or Cdc13 by Piazza, Aurèle, Serero, Alexandre, Boulé, Jean-Baptiste, Legoix-Né, Patricia, Lopes, Judith, Nicolas, Alain

“…Genomes contain tandem repeats that are at risk of internal rearrangements and a threat to genome integrity. Here, we investigated the behavior of the human…”
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Saccharomyces cerevisiae Mus81-Mms4 prevents accelerated senescence in telomerase-deficient cells by Schwartz, Erin K, Hung, Shih-Hsun, Meyer, Damon, Piazza, Aurèle, Yan, Kevin, Fu, Becky Xu Hua, Heyer, Wolf-Dietrich

“…Alternative lengthening of telomeres (ALT) in human cells is a conserved process that is often activated in telomerase-deficient human cancers. This process…”
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Genetic instability triggered by G-quadruplex interacting Phen-DC compounds in Saccharomyces cerevisiae by Piazza, Aurèle, Boulé, Jean-Baptiste, Lopes, Judith, Mingo, Katie, Largy, Eric, Teulade-Fichou, Marie-Paule, Nicolas, Alain

“…G-quadruplexes are nucleic acid secondary structures for which many biological roles have been proposed but whose existence in vivo has remained elusive. To…”
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Author Correction: Neuroinvasion and anosmia are independent phenomena upon infection with SARS-CoV-2 and its variants by de Melo, Guilherme Dias, Perraud, Victoire, Alvarez, Flavio, Vieites-Prado, Alba, Kim, Seonhee, Kergoat, Lauriane, Coleon, Anthony, Trüeb, Bettina Salome, Tichit, Magali, Piazza, Aurèle, Thierry, Agnès, Hardy, David, Wolff, Nicolas, Munier, Sandie, Koszul, Romain, Simon-Lorière, Etienne, Thiel, Volker, Lecuit, Marc, Lledo, Pierre-Marie, Renier, Nicolas, Larrous, Florence, Bourhy, Hervé

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