Search Results - "Piatkov, Konstantin I."

Neurodegeneration-Associated Protein Fragments as Short-Lived Substrates of the N-End Rule Pathway by Brower, Christopher S., Piatkov, Konstantin I., Varshavsky, Alexander

“…Protein aggregates are a common feature of neurodegenerative syndromes. Specific protein fragments were found to be aggregated in disorders including…”
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N-end rule pathway counteracts cell death by destroying proapoptotic protein fragments by Piatkov, Konstantin I, Brower, Christopher S, Varshavsky, Alexander

“…In the course of apoptosis, activated caspases cleave ∼500 to ∼1,000 different proteins in a mammalian cell. The dynamics of apoptosis involve a number of…”
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Calpain-generated natural protein fragments as short-lived substrates of the N-end rule pathway by Piatkov, Konstantin I, Oh, Jang-Hyun, Liu, Yuan, Varshavsky, Alexander

“…Calpains are Ca ²⁺-dependent intracellular proteases. We show here that calpain-generated natural C-terminal fragments of proteins that include G…”
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The Auto-Generated Fragment of the Usp1 Deubiquitylase Is a Physiological Substrate of the N-End Rule Pathway by Piatkov, Konstantin I., Colnaghi, Luca, Békés, Miklos, Varshavsky, Alexander, Huang, Tony T.

“…Deamidation of N-terminal Gln by the Ntaq1 NtQ-amidase is a part of the Arg/N-end rule pathway, a ubiquitin-dependent proteolytic system. Here we identify…”
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Glutamine-Specific N-Terminal Amidase, a Component of the N-End Rule Pathway by Wang, Haiqing, Piatkov, Konstantin I., Brower, Christopher S., Varshavsky, Alexander

“…Deamidation of N-terminal Gln by Nt Q-amidase, an N-terminal amidohydrolase, is a part of the N-end rule pathway of protein degradation. We detected the…”
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Formyl-methionine as a degradation signal at the N-termini of bacterial proteins by Piatkov, Konstantin I, Vu, Tri T M, Hwang, Cheol-Sang, Varshavsky, Alexander

“…In bacteria, all nascent proteins bear the pretranslationally formed N-terminal formyl-methionine (fMet) residue. The fMet residue is cotranslationally…”
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Liat1, an arginyltransferase-binding protein whose evolution among primates involved changes in the numbers of its 10-residue repeats by Brower, Christopher S., Rosen, Connor E., Jones, Richard H., Wadas, Brandon C., Piatkov, Konstantin I., Varshavsky, Alexander

“…The arginyltransferase Ate1 is a component of the N-end rule pathway, which recognizes proteins containing N-terminal degradation signals called N-degrons,…”
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Analyzing N-terminal Arginylation through the Use of Peptide Arrays and Degradation Assays by Wadas, Brandon, Piatkov, Konstantin I., Brower, Christopher S., Varshavsky, Alexander

“…Nα-terminal arginylation (Nt-arginylation) of proteins is mediated by the Ate1 arginyltransferase (R-transferase), a component of the Arg/N-end rule pathway…”
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Downregulation of the Arg/N-degron Pathway Sensitizes Cancer Cells to Chemotherapy In Vivo by Leboeuf, Dominique, Abakumova, Tatiana, Prikazchikova, Tatiana, Rhym, Luke, Anderson, Daniel G., Zatsepin, Timofei S., Piatkov, Konstantin I.

“…The N-degron pathway is an emerging target for anti-tumor therapies, because of its capacity to positively regulate many hallmarks of cancer, including…”
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Beta-amyloid induces apoptosis of neuronal cells by inhibition of the Arg/N-end rule pathway proteolytic activity by Kechko, Olga I, Petrushanko, Irina Yu, Brower, Christopher S, Adzhubei, Alexei A, Moskalev, Alexey A, Piatkov, Konstantin I, Mitkevich, Vladimir A, Makarov, Alexander A

“…Alzheimer's disease (AD) is accompanied by the dysfunction of intracellular protein homeostasis systems, in particular the ubiquitin-proteasome system (UPS)…”
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Calpain-generated natural protein fragments as short-lived substrates of the N-end rule pathway by Piatkov, Konstantin I., Oh, Jang-Hyun, Liu, Yuan, Varshavsky, Alexander

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The N-end rule pathway counteracts cell death by destroying proapoptotic protein fragments by Piatkov, Konstantin I., Brower, Christopher S., Varshavsky, Alexander

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Abstract 1841: TAK-500 is a clinical stage immune-cell directed antibody drug conjugate (iADC) inducing STING activation in CCR2-expressing intratumor myeloid cells and favorable immunomodulation by Schalper, Kurt A., Matsuda, Atsushi, Ganno-Sherwood, Michelle, Maldonado-Lopez, Angel E., Rosentrater, Emily, Porciuncula, Angelo, Zhang, Dong Mei, Christensen, Camilla L., Merrigan, Samantha A., Hatten, Tiquella, Lee, Hong Myung, Lee, Min Young, Dong, Linlin, Huang, Jian, Iartchouk, Natasha, Wang, Jianing, Xu, He, Yoneyama, Tomoki, Piatkov, Konstantin I., Harbison, Carole E., Parent, Alex, Lineberry, Neil, Abu-Yousif, Adnan O., Appleman, Vicky

“…Abstract Introduction: Myeloid cells are present in the tumor microenvironment (TME) of most human solid cancers, playing an essential role to influence local…”
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