Search Results - "Piao, Xijun"

Discrete Assembly of Synthetic Peptide–DNA Triplex Structures from Polyvalent Melamine–Thymine Bifacial Recognition by Zeng, Yingying, Pratumyot, Yaowalak, Piao, Xijun, Bong, Dennis

“…We have designed a 21-residue α-peptide that simultaneously recognizes two decadeoxyoligothymidine (dT10) tracts to form triplexes with a peptide–DNA strand…”
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Double-stranded RNA reduction by chaotropic agents during in vitro transcription of messenger RNA by Piao, Xijun, Yadav, Vibha, Wang, Eddie, Chang, Wayne, Tau, Lanna, Lindenmuth, Benjamin E., Wang, Sharon X.

“…In-vitro-transcribed messenger RNA (mRNA) has recently shown increasing significance in the development of vaccines and therapeutics. Immunogenic…”
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Bifacial Peptide Nucleic Acid Directs Cooperative Folding and Assembly of Binary, Ternary, and Quaternary DNA Complexes by Piao, Xijun, Xia, Xin, Bong, Dennis

“…We report herein the structuring of single-stranded thymine-rich DNA sequences into peptide–DNA hairpin triplex structures via designed melamine–thymine…”
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Multiresponsive Switchable Diarylethene and Its Application in Bioimaging by Piao, Xijun, Zou, Ying, Wu, Junchen, Li, Chunyan, Yi, Tao

“…A multiresponsive fluorescent switch based on diarylethene and terpyridine units was developed. It exhibits effective switchable fluorescence which can be…”
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RNA Nanotechnology to Solubilize Hydrophobic Antitumor Drug for Targeted Delivery by Piao, Xijun, Yin, Hongran, Guo, Sijin, Wang, Hongzhi, Guo, Peixuan

“…Small‐molecule drugs are used extensively in clinics for cancer treatment; however, many antitumor chemical drugs dissolve poorly in aqueous solution. Their…”
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Supercoiled DNA percentage: A key in-process control of linear DNA template for mRNA drug substance manufacturing by Piao, Xijun, Tang, Yujie, Li, Xiuzhi, Zhang, Weicheng, Yang, Wei, Xu, Xining, Wang, Wenjing, Jiang, Jiajia, Xu, Jun, Hu, Kunkun, Xu, Meiling, Liu, Mengjie, Sun, Mengfei, Jin, Lin

“…The development of messenger RNA (mRNA) vaccines and therapeutics necessitates the production of high-quality in vitro-transcribed mRNA drug substance with…”
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Excited-State Dynamics of Melamine and Its Lysine Derivative Investigated by Femtosecond Transient Absorption Spectroscopy by Zhang, Yuyuan, Beckstead, Ashley A, Hu, Yuesong, Piao, Xijun, Bong, Dennis, Kohler, Bern

“…Melamine may have been an important prebiotic information carrier, but its excited-state dynamics, which determine its stability under UV radiation, have never…”
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Bifacial Peptide Nucleic Acid as an Allosteric Switch for Aptamer and Ribozyme Function by Xia, Xin, Piao, Xijun, Bong, Dennis

“…We demonstrate herein that bifacial peptide nucleic acid (bPNA) hybrid triplexes functionally substitute for duplex DNA or RNA. Structure–function loss in…”
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Methods for construction and characterization of simple or special multifunctional RNA nanoparticles based on the 3WJ of phi29 DNA packaging motor by Guo, Sijin, Piao, Xijun, Li, Hui, Guo, Peixuan

“…•The common methods and protocols for in vitro synthesis of RNA are summarized.•The basic methods for constructing and pRNA-3WJ nanoparticles are…”
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Assessment and comparison of thermal stability of phosphorothioate-DNA, DNA, RNA, 2'-F RNA, and LNA in the context of Phi29 pRNA 3WJ by Piao, Xijun, Wang, Hongzhi, Binzel, Daniel W, Guo, Peixuan

“…The question of whether RNA is more stable or unstable compared to DNA or other nucleic acids has long been a subject of extensive scrutiny and public…”
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Oxygen-enriched vacancy Co2MnO4 spinel catalyst activated peroxymonosulfate for degradation of phenol: Non-radical dominated reaction pathway by Yue, Lijuan, Hao, Liangyun, Zhang, Junkai, Piao, Xijun, Chen, Chunguang

“…Spinel is a desirable catalyst for active peroxymonosulfate (PMS) to degrade organic pollutants in complex water matrix. In this study, spinel-type Co2MnO4…”
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Site-Specific and Enzymatic Cross-Linking of sgRNA Enables Wavelength-Selectable Photoactivated Control of CRISPR Gene Editing by Zhang, Dongyang, Liu, Luping, Jin, Shuaijiang, Tota, Ember, Li, Zijie, Piao, Xijun, Zhang, Xuan, Fu, Xiang-Dong, Devaraj, Neal K

“…Chemical cross-linking enables rapid identification of RNA-protein and RNA-nucleic acid inter- and intramolecular interactions. However, no method exists to…”
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Multiplexed Photoactivation of mRNA with Single-Cell Resolution by Zhang, Dongyang, Jin, Shuaijiang, Piao, Xijun, Devaraj, Neal K

“…We demonstrate sequential optical activation of two types of mRNAs in the same mammalian cell through the sequential photocleavage of small molecule caging…”
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Multiplexed photo-activation of mRNA with single-cell resolution by Zhang, Dongyang, Jin, Shuaijiang, Piao, Xijun, Devaraj, Neal K.

“…We demonstrate sequential optical activation of two types of mRNAs in the same mammalian cell through the sequential photocleavage of small molecule caging…”
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Peptide Ligation and RNA Cleavage via an Abiotic Template Interface by Piao, Xijun, Xia, Xin, Mao, Jie, Bong, Dennis

“…We report herein DNA- and RNA-templated chemical transformation of bifacial peptide nucleic acid (bPNA) fragments directed by an abiotic triplex hybrid…”
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Site-specific and enzymatic cross-linking of sgRNA enables wavelength-selectable photo-activated control of CRISPR gene editing by Zhang, Dongyang, Liu, Luping, Jin, Shuaijiang, Tota, Ember, Li, Zijie, Piao, Xijun, Zhang, Xuan, Fu, Xiang-Dong, Devaraj, Neal K.

“…Chemical cross-linking enables rapid identification of RNA-protein and RNA-nucleic acid inter- and intramolecular interactions. However, no method exists to…”
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Bifacial PNA Complexation Inhibits Enzymatic Access to DNA and RNA by Xia, Xin, Piao, Xijun, Fredrick, Kurt, Bong, Dennis

“…Full stop: Herein we report the effective in vitro inhibition of transcription, reverse‐transcription and exonuclease function by formation of synthetic…”
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Bifacial PNA in Nucleic Acid Folding, Peptide Ligation and in vitro Selection by Piao, Xijun

“…This dissertation summarizes three research projects regarding the fundamental studies and applications of bifacial Peptide Nucleic Acid (bPNA)-nucleic acid…”
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Multispherical interactions and their effects on the Tibetan Plateau's earth system: a review of the recent researches by Yao, Tandong, Wu, Fuyuan, Ding, Lin, Sun, Jimin, Zhu, Liping, Piao, Shilong, Deng, Tao, Ni, Xijun, Zheng, Hongbo, Ouyang, Hua

“…Abstract The Tibetan Plateau (TP) is a regional Earth system showing very strong interactions among its lithosphere, hydrosphere, cryosphere, biosphere,…”
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