Search Results - "Piaggio, Eliane"

Effects of interleukin-2 in immunostimulation and immunosuppression by Pol, Jonathan G, Caudana, Pamela, Paillet, Juliette, Piaggio, Eliane, Kroemer, Guido

“…Historically, interleukin-2 (IL-2) was first described as an immunostimulatory factor that supports the expansion of activated effector T cells. A layer of…”
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Humanized Mice for the Study of Immuno-Oncology by De La Rochere, Philippe, Guil-Luna, Silvia, Decaudin, Didier, Azar, Georges, Sidhu, Sukhvinder S., Piaggio, Eliane

“…Immunotherapy is revolutionizing cancer treatment; however, complete responses are achieved in only a small fraction of patients and tumor types. Thus, there…”
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Tumor invasion in draining lymph nodes is associated with Treg accumulation in breast cancer patients by Núñez, Nicolas Gonzalo, Tosello Boari, Jimena, Ramos, Rodrigo Nalio, Richer, Wilfrid, Cagnard, Nicolas, Anderfuhren, Cyrill Dimitri, Niborski, Leticia Laura, Bigot, Jeremy, Meseure, Didier, De La Rochere, Philippe, Milder, Maud, Viel, Sophie, Loirat, Delphine, Pérol, Louis, Vincent-Salomon, Anne, Sastre-Garau, Xavier, Burkhard, Becher, Sedlik, Christine, Lantz, Olivier, Amigorena, Sebastian, Piaggio, Eliane

“…Tumor-draining lymph node (TDLN) invasion by metastatic cells in breast cancer correlates with poor prognosis and is associated with local immunosuppression,…”
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CD39 Expression Defines Cell Exhaustion in Tumor-Infiltrating CD8 + T Cells by Canale, Fernando P, Ramello, María C, Núñez, Nicolás, Araujo Furlan, Cintia L, Bossio, Sabrina N, Gorosito Serrán, Melisa, Tosello Boari, Jimena, Del Castillo, Andrés, Ledesma, Marta, Sedlik, Christine, Piaggio, Eliane, Gruppi, Adriana, Acosta Rodríguez, Eva A, Montes, Carolina L

“…The ability of CD8 T lymphocytes to eliminate tumors is limited by their ability to engender an immunosuppressive microenvironment. Here we describe a subset…”
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Peptide–TLR-7/8a conjugate vaccines chemically programmed for nanoparticle self-assembly enhance CD8 T-cell immunity to tumor antigens by Lynn, Geoffrey M., Sedlik, Christine, Baharom, Faezzah, Zhu, Yaling, Ramirez-Valdez, Ramiro A., Coble, Vincent L., Tobin, Kennedy, Nichols, Sarah R., Itzkowitz, Yaakov, Zaidi, Neeha, Gammon, Joshua M., Blobel, Nicolas J., Denizeau, Jordan, de la Rochere, Philippe, Francica, Brian J., Decker, Brennan, Maciejewski, Mateusz, Cheung, Justin, Yamane, Hidehiro, Smelkinson, Margery G., Francica, Joseph R., Laga, Richard, Bernstock, Joshua D., Seymour, Leonard W., Drake, Charles G., Jewell, Christopher M., Lantz, Olivier, Piaggio, Eliane, Ishizuka, Andrew S., Seder, Robert A.

“…Personalized cancer vaccines targeting patient-specific neoantigens are a promising cancer treatment modality; however, neoantigen physicochemical variability…”
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Efficient oral vaccination by bioengineering virus-like particles with protozoan surface proteins by Serradell, Marianela C., Rupil, Lucía L., Martino, Román A., Prucca, César G., Carranza, Pedro G., Saura, Alicia, Fernández, Elmer A., Gargantini, Pablo R., Tenaglia, Albano H., Petiti, Juan P., Tonelli, Renata R., Reinoso-Vizcaino, Nicolás, Echenique, José, Berod, Luciana, Piaggio, Eliane, Bellier, Bertrand, Sparwasser, Tim, Klatzmann, David, Luján, Hugo D.

“…Intestinal and free-living protozoa, such as Giardia lamblia , express a dense coat of variant-specific surface proteins (VSPs) on trophozoites that protects…”
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Prognostic value of intratumoral Fusobacterium nucleatum and association with immune-related gene expression in oral squamous cell carcinoma patients by Neuzillet, Cindy, Marchais, Manon, Vacher, Sophie, Hilmi, Marc, Schnitzler, Anne, Meseure, Didier, Leclere, Renaud, Lecerf, Charlotte, Dubot, Coraline, Jeannot, Emmanuelle, Klijanienko, Jerzy, Mariani, Odette, Calugaru, Valentin, Hoffmann, Caroline, Lesnik, Maria, Badois, Nathalie, Borcoman, Edith, Piaggio, Eliane, Kamal, Maud, Le Tourneau, Christophe, Bieche, Ivan

“…Changes in the oral microbiome, particularly Fusobacterium nucleatum , are associated with oral squamous cell carcinoma (OSCC). F. nucleatum has been reported…”
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Tumor Necrosis Factor α and Regulatory T Cells in Oncoimmunology by Salomon, Benoît L, Leclerc, Mathieu, Tosello, Jimena, Ronin, Emilie, Piaggio, Eliane, Cohen, José L

“…Tumor necrosis factor α (TNF) is a potent pro-inflammatory cytokine that has deleterious effect in some autoimmune diseases, which led to the use of anti-TNF…”
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Central Role of Defective Interleukin-2 Production in the Triggering of Islet Autoimmune Destruction by Tang, Qizhi, Adams, Jason Y., Penaranda, Cristina, Melli, Kristin, Piaggio, Eliane, Sgouroudis, Evridiki, Piccirillo, Ciriaco A., Salomon, Benoit L., Bluestone, Jeffrey A.

“…The dynamics of CD4 + effector T cells (Teff cells) and CD4 +Foxp3 + regulatory T cells (Treg cells) during diabetes progression in nonobese diabetic mice was…”
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Induction of anergic or regulatory tumor-specific CD4+ T cells in the tumor-draining lymph node by Alonso, Ruby, Flament, Héloïse, Lemoine, Sébastien, Sedlik, Christine, Bottasso, Emanuel, Péguillet, Isabel, Prémel, Virginie, Denizeau, Jordan, Salou, Marion, Darbois, Aurélie, Núñez, Nicolás Gonzalo, Salomon, Benoit, Gross, David, Piaggio, Eliane, Lantz, Olivier

“…CD4 + T cell antitumor responses have mostly been studied in transplanted tumors expressing secreted model antigens (Ags), while most mutated proteins in human…”
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Treg-targeted IL-2/anti-IL-2 complex controls graft- versus -host disease and supports anti-tumor effect in allogeneic hematopoietic stem cell transplantation by Thiolat, Allan, Pilon, Caroline, Caudana, Pamela, Moatti, Audrey, To, Nhu Hanh, Sedlik, Christine, Leclerc, Mathieu, Maury, Sébastien, Piaggio, Eliane, Cohen, José L

“…Modulating an immune response in opposite directions represents the holy grail in allogeneic hematopoietic stem cell transplantation (allo-HSCT) to avoid…”
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CD8+T cell responsiveness to anti-PD-1 is epigenetically regulated by Suv39h1 in melanomas by Niborski, Leticia Laura, Gueguen, Paul, Ye, Mengliang, Thiolat, Allan, Ramos, Rodrigo Nalio, Caudana, Pamela, Denizeau, Jordan, Colombeau, Ludovic, Rodriguez, Raphaël, Goudot, Christel, Luccarini, Jean-Michel, Soudé, Anne, Bournique, Bruno, Broqua, Pierre, Pace, Luigia, Baulande, Sylvain, Sedlik, Christine, Quivy, Jean-Pierre, Almouzni, Geneviève, Cohen, José L., Zueva, Elina, Waterfall, Joshua J., Amigorena, Sebastian, Piaggio, Eliane

“…Tumor-infiltrating CD8 + T cells progressively lose functionality and fail to reject tumors. The underlying mechanism and re-programing induced by checkpoint…”
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CD74 supports accumulation and function of regulatory T cells in tumors by Bonnin, Elisa, Rodrigo Riestra, Maria, Marziali, Federico, Mena Osuna, Rafael, Denizeau, Jordan, Maurin, Mathieu, Saez, Juan Jose, Jouve, Mabel, Bonté, Pierre-Emmanuel, Richer, Wilfrid, Nevo, Fabien, Lemoine, Sebastien, Girard, Nicolas, Lefevre, Marine, Borcoman, Edith, Vincent-Salomon, Anne, Baulande, Sylvain, Moreau, Helene D., Sedlik, Christine, Hivroz, Claire, Lennon-Duménil, Ana-Maria, Tosello Boari, Jimena, Piaggio, Eliane

“…Regulatory T cells (Tregs) are plastic cells playing a pivotal role in the maintenance of immune homeostasis. Tregs actively adapt to the microenvironment…”
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Inhibition of PI3K pathway increases immune infiltrate in muscle-invasive bladder cancer by Borcoman, Edith, De La Rochere, Philippe, Richer, Wilfrid, Vacher, Sophie, Chemlali, Walid, Krucker, Clémentine, Sirab, Nanour, Radvanyi, Francois, Allory, Yves, Pignot, Géraldine, Barry de Longchamps, Nicolas, Damotte, Diane, Meseure, Didier, Sedlik, Christine, Bieche, Ivan, Piaggio, Eliane

“…Although immune checkpoint inhibitors have shown improvement in survival in comparison to chemotherapy in urothelial bladder cancer, many patients still fail…”
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Author Correction: CBX3 antagonizes IFNγ/STAT1/PD-L1 axis to modulate colon inflammation and CRC chemosensitivity by Xiang, Yao, Mata-Garrido, Jorge, Fu, Yuanji, Desterke, Christophe, Batsché, Eric, Hamaï, Ahmed, Sedlik, Christine, Sereme, Youssouf, Skurnik, David, Jalil, Abdelali, Onifarasoaniaina, Rachel, Frapy, Eric, Beche, Jean-Christophe, Alao, Razack, Piaggio, Eliane, Arbibe, Laurence, Chang, Yunhua

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CBX3 antagonizes IFNγ/STAT1/PD-L1 axis to modulate colon inflammation and CRC chemosensitivity by Xiang, Yao, Mata-Garrido, Jorge, Fu, Yuanji, Desterke, Christophe, Batsché, Eric, Hamaï, Ahmed, Sedlik, Christine, Sereme, Youssouf, Skurnik, David, Jalil, Abdelali, Onifarasoaniaina, Rachel, Frapy, Eric, Beche, Jean-Christophe, Alao, Razack, Piaggio, Eliane, Arbibe, Laurence, Chang, Yunhua

“…As an important immune stimulator and modulator, IFNγ is crucial for gut homeostasis and its dysregulation links to diverse colon pathologies, such as colitis…”
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Imaging and multi-omics datasets converge to define different neural progenitor origins for ATRT-SHH subgroups by Lobón-Iglesias, María-Jesús, Andrianteranagna, Mamy, Han, Zhi-Yan, Chauvin, Céline, Masliah-Planchon, Julien, Manriquez, Valeria, Tauziede-Espariat, Arnault, Turczynski, Sandrina, Bouarich-Bourimi, Rachida, Frah, Magali, Dufour, Christelle, Blauwblomme, Thomas, Cardoen, Liesbeth, Pierron, Gaelle, Maillot, Laetitia, Guillemot, Delphine, Reynaud, Stéphanie, Bourneix, Christine, Pouponnot, Célio, Surdez, Didier, Bohec, Mylene, Baulande, Sylvain, Delattre, Olivier, Piaggio, Eliane, Ayrault, Olivier, Waterfall, Joshua J., Servant, Nicolas, Beccaria, Kevin, Dangouloff-Ros, Volodia, Bourdeaut, Franck

“…Atypical teratoid rhabdoid tumors (ATRT) are divided into MYC, TYR and SHH subgroups, suggesting diverse lineages of origin. Here, we investigate the imaging…”
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Acyl-coenzyme a binding protein (ACBP) - a risk factor for cancer diagnosis and an inhibitor of immunosurveillance by Montégut, Léa, Liu, Peng, Zhao, Liwei, Pérez-Lanzón, María, Chen, Hui, Mao, Misha, Zhang, Shuai, Derosa, Lisa, Naour, Julie Le, Lambertucci, Flavia, Mingoia, Silvia, Nogueira-Recalde, Uxía, Mena-Osuna, Rafael, Herranz-Montoya, Irene, Djouder, Nabil, Baulande, Sylvain, Pan, Hui, Joseph, Adrien, Messaoudene, Meriem, Routy, Bertrand, Fidelle, Marine, Ahmed, Tarek Ben, Caron, Olivier, Busson, Pierre, Boulate, David, Deschasaux-Tanguy, Mélanie, Arnault, Nathalie, Pol, Jonathan G, Piaggio, Eliane, Touvier, Mathilde, Zitvogel, Laurence, Delaloge, Suzette, Martins, Isabelle, Kroemer, Guido

“…The plasma concentrations of acyl coenzyme A binding protein (ACBP, also known as diazepam-binding inhibitor, DBI, or 'endozepine') increase with age and…”
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Innate lymphoid cells: NK and cytotoxic ILC3 subsets infiltrate metastatic breast cancer lymph nodes by Rethacker, Louise, Boy, Maxime, Bisio, Valeria, Roussin, France, Denizeau, Jordan, Vincent-Salomon, Anne, Borcoman, Edith, Sedlik, Christine, Piaggio, Eliane, Toubert, Antoine, Dulphy, Nicolas, Caignard, Anne

“…Innate lymphoid cells (ILCs) - which include cytotoxic Natural Killer (NK) cells and helper-type ILC - are important regulators of tissue immune homeostasis,…”
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Inhibition of the JAK/STAT Signaling Pathway in Regulatory T Cells Reveals a Very Dynamic Regulation of Foxp3 Expression by Goldstein, Jérémie D, Burlion, Aude, Zaragoza, Bruno, Sendeyo, Kélhia, Polansky, Julia K, Huehn, Jochen, Piaggio, Eliane, Salomon, Benoit L, Marodon, Gilles

“…The IL-2/JAK3/STAT-5 signaling pathway is involved on the initiation and maintenance of the transcription factor Foxp3 in regulatory T cells (Treg) and has…”
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