Search Results - "Physiological reviews"

The Microbiota-Gut-Brain Axis by Cryan, John F, O'Riordan, Kenneth J, Cowan, Caitlin S M, Sandhu, Kiran V, Bastiaanssen, Thomaz F S, Boehme, Marcus, Codagnone, Martin G, Cussotto, Sofia, Fulling, Christine, Golubeva, Anna V, Guzzetta, Katherine E, Jaggar, Minal, Long-Smith, Caitriona M, Lyte, Joshua M, Martin, Jason A, Molinero-Perez, Alicia, Moloney, Gerard, Morelli, Emanuela, Morillas, Enrique, O'Connor, Rory, Cruz-Pereira, Joana S, Peterson, Veronica L, Rea, Kieran, Ritz, Nathaniel L, Sherwin, Eoin, Spichak, Simon, Teichman, Emily M, van de Wouw, Marcel, Ventura-Silva, Ana Paula, Wallace-Fitzsimons, Shauna E, Hyland, Niall, Clarke, Gerard, Dinan, Timothy G

“…The importance of the gut-brain axis in maintaining homeostasis has long been appreciated. However, the past 15 yr have seen the emergence of the microbiota…”
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Neuropathic Pain: From Mechanisms to Treatment by Finnerup, Nanna Brix, Kuner, Rohini, Jensen, Troels Staehelin

“…Neuropathic pain caused by a lesion or disease of the somatosensory nervous system is a common chronic pain condition with major impact on quality of life…”
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Diversity and Biology of Cancer-Associated Fibroblasts by Biffi, Giulia, Tuveson, David A

“…Efforts to develop anti-cancer therapies have largely focused on targeting the epithelial compartment, despite the presence of non-neoplastic stromal…”
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Wound Healing: A Cellular Perspective by Rodrigues, Melanie, Kosaric, Nina, Bonham, Clark A, Gurtner, Geoffrey C

“…Wound healing is one of the most complex processes in the human body. It involves the spatial and temporal synchronization of a variety of cell types with…”
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Mechanisms of Insulin Action and Insulin Resistance by Petersen, Max C, Shulman, Gerald I

“…The 1921 discovery of insulin was a Big Bang from which a vast and expanding universe of research into insulin action and resistance has issued. In the…”
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Blood-Brain Barrier: From Physiology to Disease and Back by Sweeney, Melanie D, Zhao, Zhen, Montagne, Axel, Nelson, Amy R, Zlokovic, Berislav V

“…The blood-brain barrier (BBB) prevents neurotoxic plasma components, blood cells, and pathogens from entering the brain. At the same time, the BBB regulates…”
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The Sleep-Immune Crosstalk in Health and Disease by Besedovsky, Luciana, Lange, Tanja, Haack, Monika

“…Sleep and immunity are bidirectionally linked. Immune system activation alters sleep, and sleep in turn affects the innate and adaptive arm of our body's…”
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Free Fatty Acid Receptors in Health and Disease by Kimura, Ikuo, Ichimura, Atsuhiko, Ohue-Kitano, Ryuji, Igarashi, Miki

“…Fatty acids are metabolized and synthesized as energy substrates during biological responses. Long- and medium-chain fatty acids derived mainly from dietary…”
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The KEAP1-NRF2 System: a Thiol-Based Sensor-Effector Apparatus for Maintaining Redox Homeostasis by Yamamoto, Masayuki, Kensler, Thomas W, Motohashi, Hozumi

“…The Kelch-like ECH-associated protein 1-NF-E2-related factor 2 (KEAP1-NRF2) system forms the major node of cellular and organismal defense against oxidative…”
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Sarcopenia: Aging-Related Loss of Muscle Mass and Function by Larsson, Lars, Degens, Hans, Li, Meishan, Salviati, Leonardo, Lee, Young Il, Thompson, Wesley, Kirkland, James L, Sandri, Marco

“…Sarcopenia is a loss of muscle mass and function in the elderly that reduces mobility, diminishes quality of life, and can lead to fall-related injuries, which…”
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Cellular Senescence: Aging, Cancer, and Injury by Calcinotto, Arianna, Kohli, Jaskaren, Zagato, Elena, Pellegrini, Laura, Demaria, Marco, Alimonti, Andrea

“…Cellular senescence is a permanent state of cell cycle arrest that occurs in proliferating cells subjected to different stresses. Senescence is, therefore, a…”
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Fundamental Mechanisms of Regulated Cell Death and Implications for Heart Disease by Del Re, Dominic P, Amgalan, Dulguun, Linkermann, Andreas, Liu, Qinghang, Kitsis, Richard N

“…Twelve regulated cell death programs have been described. We review in detail the basic biology of nine including death receptor-mediated apoptosis, death…”
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Regulation and metabolic functions of mTORC1 and mTORC2 by Szwed, Angelia, Kim, Eugene, Jacinto, Estela

“…Cells metabolize nutrients for biosynthetic and bioenergetic needs to fuel growth and proliferation. The uptake of nutrients from the environment and their…”
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Pregnancy and COVID-19 by Wastnedge, Elizabeth A N, Reynolds, Rebecca M, van Boeckel, Sara R, Stock, Sarah J, Denison, Fiona C, Maybin, Jacqueline A, Critchley, Hilary O D

“…There are many unknowns for pregnant women during the coronavirus disease 2019 (COVID-19) pandemic. Clinical experience of pregnancies complicated with…”
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Metabolomics for Investigating Physiological and Pathophysiological Processes by Wishart, David S

“…Metabolomics uses advanced analytical chemistry techniques to enable the high-throughput characterization of metabolites from cells, organs, tissues, or…”
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The Neutrophil's Role During Health and Disease by Liew, Pei Xiong, Kubes, Paul

“…Neutrophils have always been considered as uncomplicated front-line troopers of the innate immune system equipped with limited proinflammatory duties. Yet…”
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Physiology of Astroglia by Verkhratsky, Alexei, Nedergaard, Maiken

“…Astrocytes are neural cells of ectodermal, neuroepithelial origin that provide for homeostasis and defense of the central nervous system (CNS). Astrocytes are…”
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Angiotensin II Signal Transduction: An Update on Mechanisms of Physiology and Pathophysiology by Forrester, Steven J, Booz, George W, Sigmund, Curt D, Coffman, Thomas M, Kawai, Tatsuo, Rizzo, Victor, Scalia, Rosario, Eguchi, Satoru

“…The renin-angiotensin-aldosterone system plays crucial roles in cardiovascular physiology and pathophysiology. However, many of the signaling mechanisms have…”
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Neuronal Cell Death by Fricker, Michael, Tolkovsky, Aviva M, Borutaite, Vilmante, Coleman, Michael, Brown, Guy C

“…Neuronal cell death occurs extensively during development and pathology, where it is especially important because of the limited capacity of adult neurons to…”
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The ACE2/Angiotensin-(1-7)/MAS Axis of the Renin-Angiotensin System: Focus on Angiotensin-(1-7) by Santos, Robson Augusto Souza, Sampaio, Walkyria Oliveira, Alzamora, Andreia C, Motta-Santos, Daisy, Alenina, Natalia, Bader, Michael, Campagnole-Santos, Maria Jose

“…The renin-angiotensin system (RAS) is a key player in the control of the cardiovascular system and hydroelectrolyte balance, with an influence on organs and…”
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