Management of brain metastasis from rectal cancer using whole‑brain radiation therapy followed by bevacizumab and chemotherapy: A case report

Management of brain metastasis from rectal cancer using whole‑brain radiation therapy followed by bevacizumab and chemotherapy: A case report

Brain metastases in colorectal cancer are uncommon, which has resulted in a shortage of data concerning their screening and management. Multiple therapeutic modalities with chemotherapy, chemoradiation and targeted therapy, including bevacizumab and cetuximab regimens, have shown promising results....

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Bibliographic Details
Published in:Oncology letters Vol. 26; no. 4; p. 1
Main Authors: Van Nguyen, Hung, Phung, Duong Thuy, Nguyen, Trung Thanh, Tran, Bach Trung, Mai, Kim Ngan Thi, Trinh, Huy Le
Format: Journal Article
Language:English
Published: Athens Spandidos Publications 01-10-2023
Spandidos Publications UK Ltd
D.A. Spandidos
Subjects:
Abdomen
Anorexia
Brain cancer
Brain research
Cancer
Cancer therapies
Care and treatment
Case Report
Case reports
Chemotherapy
Colorectal cancer
Edema
Health aspects
Lymphatic system
Magnetic resonance imaging
Medical prognosis
Metastasis
Mutation
Oncology
Patients
Radiation
Radiation therapy
Radiosurgery
Radiotherapy
Tomography
Toxicity
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Summary:Brain metastases in colorectal cancer are uncommon, which has resulted in a shortage of data concerning their screening and management. Multiple therapeutic modalities with chemotherapy, chemoradiation and targeted therapy, including bevacizumab and cetuximab regimens, have shown promising results. The present study describes the case of a 47-year-old male, diagnosed with T4N2M1 rectal cancer who underwent systemic therapy with modified FOLFOXIRI and cetuximab. The patient achieved a complete clinical response after 12 cycles. Following the discontinuation of cetuximab, the patient was given capecitabine as a maintenance therapy and subsequently developed brain metastasis. The patient received whole-brain radiation therapy (WBRT) followed by a bevacizumab plus FOLFIRI regimen. The patient showed a good response as revealed by cranial magnetic resonance imaging, with a reduction in lesion size and no sign of cerebral edema. In addition, the patient maintained a stable neurological condition for >10 months. These findings suggest that the early detection of brain metastases requires the close monitoring of neurological symptoms. In addition, WBRT followed by bevacizumab and chemotherapy is a potential management plan for brain metastasis from rectal cancer. Key words: case report, brain metastasis, rectal cancer, bevacizumab, whole-brain radiation therapy
ISSN:1792-1074
1792-1082
DOI:10.3892/ol.2023.14033