Search Results - "Phua, Cheryl Zi Jin"

Evolution of natural lifespan variation and molecular strategies of extended lifespan in yeast by Kaya, Alaattin, Phua, Cheryl Zi Jin, Lee, Mitchell, Wang, Lu, Tyshkovskiy, Alexander, Ma, Siming, Barre, Benjamin, Liu, Weiqiang, Harrison, Benjamin R, Zhao, Xiaqing, Zhou, Xuming, Wasko, Brian M, Bammler, Theo K, Promislow, Daniel El, Kaeberlein, Matt, Gladyshev, Vadim N

“…To understand the genetic basis and selective forces acting on longevity, it is useful to examine lifespan variation among closely related species, or…”
Get full text

Genomic landscape of lung adenocarcinoma in East Asians by Chen, Jianbin, Yang, Hechuan, Teo, Audrey Su Min, Amer, Lidyana Bte, Sherbaf, Faranak Ghazi, Tan, Chu Quan, Alvarez, Jacob Josiah Santiago, Lu, Bingxin, Lim, Jia Qi, Takano, Angela, Nahar, Rahul, Lee, Yin Yeng, Phua, Cheryl Zi Jin, Chua, Khi Pin, Suteja, Lisda, Chen, Pauline Jieqi, Chang, Mei Mei, Koh, Tina Puay Theng, Ong, Boon-Hean, Anantham, Devanand, Hsu, Anne Ann Ling, Gogna, Apoorva, Too, Chow Wei, Aung, Zaw Win, Lee, Yi Fei, Wang, Lanying, Lim, Tony Kiat Hon, Wilm, Andreas, Choi, Poh Sum, Ng, Poh Yong, Toh, Chee Keong, Lim, Wan-Teck, Ma, Siming, Lim, Bing, Liu, Jin, Tam, Wai Leong, Skanderup, Anders Jacobsen, Yeong, Joe Poh Sheng, Tan, Eng-Huat, Creasy, Caretha L., Tan, Daniel Shao Weng, Hillmer, Axel M., Zhai, Weiwei

“…Lung cancer is the world’s leading cause of cancer death and shows strong ancestry disparities. By sequencing and assembling a large genomic and transcriptomic…”
Get full text

p53-dependent crosstalk between DNA replication integrity and redox metabolism mediated through a NRF2-PARP1 axis by Elfar, Gamal Ahmed, Aning, Obed, Ngai, Tsz Wai, Yeo, Pearlyn, Chan, Joel Wai Kit, Sim, Shang Hong, Goh, Leonard, Yuan, Ju, Phua, Cheryl Zi Jin, Yeo, Joanna Zhen Zhen, Mak, Shi Ya, Goh, Brian Kim Poh, Chow, Pierce Kah-Hoe, Tam, Wai Leong, Ho, Ying Swan, Cheok, Chit Fang

“…Mechanisms underlying p53-mediated protection of the replicating genome remain elusive, despite the quintessential role of p53 in maintaining genomic…”
Get full text

A multimodal atlas of hepatocellular carcinoma reveals convergent evolutionary paths and ‘bad apple’ effect on clinical trajectory by Chen, Jianbin, Kaya, Neslihan Arife, Zhang, Ying, Kendarsari, Raden Indah, Sekar, Karthik, Lee Chong, Shay, Seshachalam, Veerabrahma Pratap, Ling, Wen Huan, Jin Phua, Cheryl Zi, Lai, Hannah, Yang, Hechuan, Lu, Bingxin, Lim, Jia Qi, Ma, Siming, Chew, Sin Chi, Chua, Khi Pin, Santiago Alvarez, Jacob Josiah, Wu, Lingyan, Ooi, London, Yaw-Fui Chung, Alexander, Cheow, Peng Chung, Kam, Juinn Huar, Wei-Chieh Kow, Alfred, Ganpathi, Iyer Shridhar, Bunchaliew, Chairat, Thammasiri, Jidapa, Koh, Peng Soon, Bee-Lan Ong, Diana, Lim, Jasmine, de Villa, Vanessa H., Dela Cruz, Rouchelle D., Loh, Tracy Jiezhen, Wan, Wei Keat, Leow, Wei Qiang, Yang, Yi, Liu, Jin, Skanderup, Anders Jacobsen, Pang, Yin Huei, Ting Soon, Gwyneth Shook, Madhavan, Krishnakumar, Kiat-Hon Lim, Tony, Bonney, Glenn, Goh, Brian K.P., Chew, Valerie, Dan, Yock Young, Toh, Han Chong, Sik-Yin Foo, Roger, Tam, Wai Leong, Zhai, Weiwei, Kah-Hoe Chow, Pierce

“…Hepatocellular carcinoma (HCC) is a highly fatal cancer characterized by high intra-tumor heterogeneity (ITH). A panoramic understanding of its tumor…”
Get full text

Domain-specific p53 mutants activate EGFR by distinct mechanisms exposing tissue-independent therapeutic vulnerabilities by Ho, Teresa Lai Fong, Lee, May Yin, Goh, Hui Chin, Ng, Germaine Yi Ning, Lee, Jane Jia Hui, Kannan, Srinivasaraghavan, Lim, Yan Ting, Zhao, Tianyun, Lim, Edwin Kok Hao, Phua, Cheryl Zi Jin, Lee, Yi Fei, Lim, Rebecca Yi Xuan, Ng, Perry Jun Hao, Yuan, Ju, Chan, Dedrick Kok Hong, Lieske, Bettina, Chong, Choon Seng, Lee, Kuok Chung, Lum, Jeffrey, Cheong, Wai Kit, Yeoh, Khay Guan, Tan, Ker Kan, Sobota, Radoslaw M., Verma, Chandra S., Lane, David P., Tam, Wai Leong, Venkitaraman, Ashok R.

“…Mis-sense mutations affecting TP53 promote carcinogenesis both by inactivating tumor suppression, and by conferring pro-carcinogenic activities. We report here…”
Get full text

Genetic perturbation of mitochondrial function reveals functional role for specific mitonuclear genes, metabolites, and pathways that regulate lifespan by Phua, Cheryl Zi Jin, Zhao, Xiaqing, Turcios-Hernandez, Lesly, McKernan, Morrigan, Abyadeh, Morteza, Ma, Siming, Promislow, Daniel, Kaeberlein, Matt, Kaya, Alaattin

“…Altered mitochondrial function is tightly linked to lifespan regulation, but underlying mechanisms remain unclear. Here, we report the chronological and…”
Get full text

PARP4 interacts with hnRNPM to regulate splicing during lung cancer progression by Lee, Yi Fei, Phua, Cheryl Zi Jin, Yuan, Ju, Zhang, Bin, Lee, May Yin, Kannan, Srinivasaraghavan, Chiu, Yui Hei Jasper, Koh, Casslynn Wei Qian, Yap, Choon Kong, Lim, Edwin Kok Hao, Chen, Jianbin, Lim, Yuhua, Lee, Jane Jia Hui, Skanderup, Anders Jacobsen, Wang, Zhenxun, Zhai, Weiwei, Tan, Nguan Soon, Verma, Chandra S, Tay, Yvonne, Tan, Daniel Shao Weng, Tam, Wai Leong

“…The identification of cancer driver genes from sequencing data has been crucial in deepening our understanding of tumor biology and expanding targeted therapy…”
Get full text

The effect of inhibition of receptor tyrosine kinase AXL on DNA damage response in ovarian cancer by Yeo, Xun Hui, Sundararajan, Vignesh, Wu, Zhengwei, Phua, Zi Jin Cheryl, Ho, Yin Ying, Peh, Kai Lay Esther, Chiu, Yi-Chia, Tan, Tuan Zea, Kappei, Dennis, Ho, Ying Swan, Tan, David Shao Peng, Tam, Wai Leong, Huang, Ruby Yun-Ju

“…AXL is a receptor tyrosine kinase that is often overexpressed in cancers. It contributes to pathophysiology in cancer progression and therapeutic resistance,…”
Get full text

Author Correction: The effect of inhibition of receptor tyrosine kinase AXL on DNA damage response in ovarian cancer by Yeo, Xun Hui, Sundararajan, Vignesh, Wu, Zhengwei, Phua, Zi Jin Cheryl, Ho, Yin Ying, Peh, Kai Lay Esther, Chiu, Yi-Chia, Tan, Tuan Zea, Kappei, Dennis, Ho, Ying Swan, Tan, David Shao Peng, Tam, Wai Leong, Huang, Ruby Yun-Ju

Get full text

Multimodal molecular landscape of response to Y90-resin microsphere radioembolization followed by nivolumab for advanced hepatocellular carcinoma by Kaya, Neslihan Arife, Tai, David, Lim, Xinru, Lim, Jia Qi, Lau, Mai Chan, Goh, Denise, Phua, Cheryl Zi Jin, Wee, Felicia Yu Ting, Joseph, Craig Ryan, Lim, Jeffrey Chun Tatt, Neo, Zhen Wei, Ye, Jiangfeng, Cheung, Lawrence, Lee, Joycelyn, Loke, Kelvin S H, Gogna, Apoorva, Yao, Fei, Lee, May Yin, Shuen, Timothy Wai Ho, Toh, Han Chong, Hilmer, Axel, Chan, Yun Shen, Lim, Tony Kiat-Hon, Tam, Wai Leong, Choo, Su Pin, Yeong, Joe, Zhai, Weiwei

“…Combination therapy with radioembolization (yttrium-90)-resin microspheres) followed by nivolumab has shown a promising response rate of 30.6% in a Phase II…”
Get full text

Genomic landscape of lung adenocarcinoma in East Asians by Chen, Jianbin, Yang, Hechuan, Teo, Audrey Su Min, Amer, Lidyana Bte, Sherbaf, Faranak Ghazi, Tan, Chu Quan, Alvarez, Jacob Josiah Santiago, Lu, Bingxin, Qi Lim, Jia, Takano, Angela, Nahar, Rahul, Lee, Yin Yeng, Phua, Cheryl Zi Jin, Chua, Khi Pin, Suteja, Lisda, Chen, Pauline Jieqi, Chang, Mei Mei, Koh, Tina Puay Theng, Ong, Boon-Hean, Anantham, Devanand, Hsu, Anne Ann Ling, Gogna, Apoorva, Wei, Chow, Aung, Zaw Win, Lee, Yi Fei, Wang, Lanying, Lim, Tony Kia Thon, Wilm, Andreas, Choi, Poh Sum, Ng, Poh Yong, Toh, Chee Keong, Lim, Wan-Teck, Ma, Siming, Lim, Bing, Liu, Jin, Tam, Wai Leong, Skanderup, Anders Jacobsen, Yeong, Joe Poh Sheng, Tan, Eng-Huat, Creasy, Caretha L, Tan, Daniel Shao Weng, Hillmer, Axel M, Zhai, Weiwei

“…Lung cancer is the world's leading cause of cancer death and shows strong ancestry disparities. By sequencing and assembling a large genomic and transcriptomic…”
Get full text