Search Results - "Phoenix, Kathryn"

Therapeutic metformin/AMPK activation promotes the angiogenic phenotype in the ERα negative MDA-MB-435 breast cancer model by Phoenix, Kathryn N, Vumbaca, Frank, Claffey, Kevin P

“…Metformin, a first line treatment for type 2 diabetes, has been implicated as a potential anti-neoplastic agent for breast cancers as well as other cancers…”
Get full text

PLCβ2 Promotes VEGF-Induced Vascular Permeability by Phoenix, Kathryn N., Yue, Zhichao, Yue, Lixia, Cronin, Chunxia G., Liang, Bruce T., Hoeppner, Luke H., Claffey, Kevin P.

“…BACKGROUNDRegulation of vascular permeability is critical to maintaining tissue metabolic homeostasis. VEGF (vascular endothelial growth factor) is a key…”
Get full text

Dietary energy availability affects primary and metastatic breast cancer and metformin efficacy by Phoenix, Kathryn N, Vumbaca, Frank, Fox, Melissa M, Evans, Rebecca, Claffey, Kevin P

“…Dietary energy restriction has been shown to repress both mammary tumorigenesis and aggressive mammary tumor growth in animal studies. Metformin, a caloric…”
Get full text

Double-Stranded RNA-Binding Protein Regulates Vascular Endothelial Growth Factor mRNA Stability, Translation, and Breast Cancer Angiogenesis by Vumbaca, Frank, Phoenix, Kathryn N., Rodriguez-Pinto, Daniel, Han, David K., Claffey, Kevin P.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Patient-derived heavy chain antibody targets cell surface HSP90 on breast tumors by Devarakonda, Charan V, Kita, Daniel, Phoenix, Kathryn N, Claffey, Kevin P

“…Monoclonal antibodies have been used to effectively treat various tumors. We previously established a unique strategy to identify tumor specific antibodies by…”
Get full text

Regulation of Ovarian Cancer Cell Viability and Sensitivity to Cisplatin by Progesterone Receptor Membrane Component-1 by Peluso, John J., Liu, Xiufang, Saunders, M. Melinda, Claffey, Kevin P., Phoenix, Kathryn

“…Context: Progesterone (P4) influences ovarian cancer cells by an unknown mechanism. Objective: The objective was to determine whether P4 acts through…”
Get full text

AMP-Activated Protein Kinase α 2 Isoform Suppression in Primary Breast Cancer Alters AMPK Growth Control and Apoptotic Signaling by Fox, Melissa M, Phoenix, Kathryn N, Kopsiaftis, Stavros G, Claffey, Kevin P

“…Adenosine monophosphate-activated protein kinase (AMPK) is a metabolic regulator that promotes energy conservation and restoration when cells are exposed to…”
Get full text

Revealing the role of phospholipase Cβ3 in the regulation of VEGF-induced vascular permeability by Hoeppner, Luke H., Phoenix, Kathryn N., Clark, Karl J., Bhattacharya, Resham, Gong, Xun, Sciuto, Tracey E., Vohra, Pawan, Suresh, Sandip, Bhattacharya, Santanu, Dvorak, Ann M., Ekker, Stephen C., Dvorak, Harold F., Claffey, Kevin P., Mukhopadhyay, Debabrata

“…VEGF induces vascular permeability (VP) in ischemic diseases and cancer, leading to many pathophysiological consequences. The molecular mechanisms by which…”
Get full text

AMPKα2 Suppresses Murine Embryonic Fibroblast Transformation and Tumorigenesis by Phoenix, Kathryn N, Devarakonda, Charan V, Fox, Melissa M, Stevens, Laura E, Claffey, Kevin P

“…AMP-activated kinase (AMPK) is a key metabolic sensor and stress signaling kinase. AMPK activity is known to suppress anabolic processes such as protein and…”
Get full text

Identification of novel tumor antigens with patient-derived immune-selected antibodies by Rodriguez-Pinto, Daniel, Sparkowski, Jason, Keough, Martin P., Phoenix, Kathryn N., Vumbaca, Frank, Han, David K., Gundelfinger, Eckart D., Beesley, Philip, Claffey, Kevin P.

“…The identification of tumor antigens capable of eliciting an immune response in vivo may be an effective method to identify therapeutic cancer targets. We have…”
Get full text

Systemically Administered Anti-uPAR Antibody Plasma and Lung ELF Pharmacokinetics Characterized by Minimal Lung PBPK Model by Sharma, Sharad, Leonard, Antony, Phoenix, Kathryn, Chang, Hsueh Yuan, Wang, Jun, Hansel, Steven

“…Antibody-based therapeutics have recently gained keen attention for the treatment of pulmonary indications. However, systemically administered antibody…”
Get full text

Phospholipase Cβ2 Promotes Vascular Endothelial Growth Factor Induced Vascular Permeability by Phoenix, Kathryn N., Yue, Zhichao, Yue, Lixia, Cronin, Chunxia G., Liang, Bruce T., Hoeppner, Luke H., Claffey, Kevin P.

Get full text

PLC (Phospholipase C) β2 Promotes VEGF (Vascular Endothelial Growth Factor)–Induced Vascular Permeability by Phoenix, Kathryn N., Yue, Zhichao, Yue, Lixia, Cronin, Chunxia G., Liang, Bruce T., Hoeppner, Luke H., Claffey, Kevin P.

Get full text

Descriptive analysis of tumor cells with stem like phenotypes in metastatic and benign adrenal tumors by Jensen, Todd, Vadasz, Stephanie, Phoenix, Kathryn, Claffey, Kevin, Parikh, Nehal, Finck, Christine

“…Abstract Background Neuroblastoma (NB) comprises 7% of all childhood cancers. Here we report a descriptive analysis of key cellular markers that have…”
Get full text

Abstract 1138: AMPK promotes survival of breast cancer cells by modulating metabolic stress by Sullivan, Katie L., Kopsiaftis, Stavros, Phoenix, Kathryn N., Fox, Melissa M., Claffey, Kevin P.

“…Breast cancer cells can respond to microenvironmental stressors by becoming dormant, that is inhibiting cell proliferation until the environment becomes…”
Get full text

Abstract 4209: AMPK suppression in bladder tumorigenesis by Kopsiaftis, Stavros, Phoenix, Kathryn N., Sullivan, Katie L., Taylor, John A., Claffey, Kevin P.

“…Bladder cancer is the fifth most diagnosed cancer in the US. In 2013 there were approximately 72,570 newly diagnosed cases and 15,210 deaths attributing to…”
Get full text

Abstract 2661: Patient-derived breast cancer targeting heavy chain antibodies by Devarakonda, Charan Kumar V., Kita, Daniel, Phoenix, Kathryn N., Magee, Dewey M., Claffey, Kevin P.

“…The emergence of tumor-targeting antibodies such as Trastuzumab, Rituximab and anti-CD47 antibody has highlighted the significant role of antibodies for…”
Get full text

Abstract 1092: AMPK alpha 2 promotes tumor cell survival in models of breast cancer dormancy by Sullivan, Katie L., Phoenix, Kathryn N., Fox, Melissa M., Kopsiaftis, Stavros, Claffey, Kevin P.

“…Breast cancer can recur after standard of care treatment, even after many years. As a result, there is a need to identify new ways to treat metastatic…”
Get full text

Abstract 310: Role of AMPKalpha isoforms in bladder tumorigenesis by Kopsiaftis, Stavros, Phoenix, Kathryn N., Sullivan, Katie L., Hegde, Poornima, Taylor, John A., Claffey, Kevin P.

“…Bladder cancer is the fifth most diagnosed cancer and currently is one of the most expensive cancers to treat due to lifelong surveillance. Bladder cancer is…”
Get full text

mARC1 in MASLD: Modulation of lipid accumulation in human hepatocytes and adipocytes by Jones, Amanda K, Bajrami, Besnik, Campbell, Morgan K, Erzurumluoglu, Abdullah Mesut, Guo, Qiusha, Chen, Hongxing, Zhang, Xiaomei, Zeveleva, Svetlana, Kvaskoff, David, Brunner, Andreas-David, Muller, Stefanie, Gathey, Vasudha, Dave, Rajvee M, Tanner, James W, Rixen, Sophia, Struwe, Michel A, Phoenix, Kathryn, Klumph, Kaitlyn J, Robinson, Heather, Veyel, Daniel, Muller, Annkatrin, Noyvert, Boris, Bartholdy, Boris Alexander, Steixner-Kumar, Agnes A, Stutzki, Jan, Drichel, Dmitriy, Omland, Steffen, Sheehan, Ryan, Hill, Jon, Bretschneider, Tom, Gottschling, Dirk, Scheidig, Axel J, Clement, Bernd, Giera, Martin, Ding, Zhihao, Broadwater, John, Warren, Curtis R

“…Mutations in the gene MTARC1 (mitochondrial amidoxime-reducing component 1) protect carriers from metabolic dysfunction-associated steatohepatitis (MASH) and…”
Get full text