Search Results - "Phipps, R. J."

Novel insights into actions of bisphosphonates on bone: Differences in interactions with hydroxyapatite by Nancollas, G.H., Tang, R., Phipps, R.J., Henneman, Z., Gulde, S., Wu, W., Mangood, A., Russell, R.G.G., Ebetino, F.H.

“…Bisphosphonates are now the most widely used drugs for diseases associated with increased bone resorption, such as osteoporosis. Although bisphosphonates act…”
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Differences between bisphosphonates in binding affinities for hydroxyapatite by Lawson, M. A., Xia, Z., Barnett, B. L., Triffitt, J. T., Phipps, R. J., Dunford, J. E., Locklin, R. M., Ebetino, F. H., Russell, R. G. G.

“…Bisphosphonates (BPs) inhibit bone resorption and are widely used for the treatment of bone diseases, including osteoporosis. BPs are also being studied for…”
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Strontium ranelate does not stimulate bone formation in ovariectomized rats by Fuchs, R. K., Allen, M. R., Condon, K. W., Reinwald, S., Miller, L. M., McClenathan, D., Keck, B., Phipps, R. J., Burr, D. B.

“…Introduction Strontium ranelate (SrR) is suggested to function as a dual-acting agent in the treatment of postmenopausal osteoporosis with anti-resorptive and…”
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Long-term risedronate treatment normalizes mineralization and continues to preserve trabecular architecture: Sequential triple biopsy studies with micro-computed tomography by Borah, B., Dufresne, T.E., Ritman, E.L., Jorgensen, S.M., Liu, S., Chmielewski, P.A., Phipps, R.J., Zhou, Xiaojie, Sibonga, J.D., Turner, R.T.

“…The objective of the study was to assess the time course of changes in bone mineralization and architecture using sequential triple biopsies from women with…”
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Nitrogen-containing bisphosphonates induce apoptosis of Caco-2 cells in vitro by inhibiting the mevalonate pathway: a model of bisphosphonate-induced gastrointestinal toxicity by Suri, S, Mönkkönen, J, Taskinen, M, Pesonen, J, Blank, M.A, Phipps, R.J, Rogers, M.J

“…Bisphosphonates have become an important addition to the pharmacological armamentarium against postmenopausal osteoporosis. One of the major side effects of…”
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Treatment with risedronate or alendronate prevents hind-limb immobilization-induced loss of bone density and strength in adult female rats by Mosekilde, Li, Thomsen, J.S, Mackey, M.S, Phipps, R.J

“…Immobilization leads to rapid loss of bone mass and mechanical competence, and long-term immobilization or repeated periods of short-term immobilization can…”
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Effects of risedronate, alendronate, and etidronate on the viability and activity of rat bone marrow stromal cells in vitro by Still, K, Phipps, R J, Scutt, A

“…The effects of risedronate, alendronate, and etidronate were assessed in calcifying fibroblastic colony-forming unit (CFU-f) cultures of rat bone marrow cells…”
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Nonclinical model for assessing gastric effects of bisphosphonates by BLANK, M. A, EMS, B. L, GIBSON, G. W, MYERS, W. R, BERMAN, S. K, PHIPPS, R. J, SMITH, P. N

“…Gastrointestinal intolerance has been associated with amino bisphosphonate therapy in the clinic. The objective of this study was to develop a model for…”
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Inhibition of Protein Prenylation by Bisphosphonates Causes Sustained Activation of Rac, Cdc42, and Rho GTPases by Dunford, James E, Rogers, Michael J, Ebetino, Frank H, Phipps, Roger J, Coxon, Fraser P

“…N‐BPs, which inhibit bone resorption by preventing prenylation of small GTPases, unexpectedly cause the accumulation of GTP‐bound, unprenylated Rho family…”
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The effect of risedronate on bone mineralization as measured by micro-computed tomography with synchrotron radiation: Correlation to histomorphometric indices of turnover by Borah, Babul, Ritman, Erik L., Dufresne, Thomas E., Jorgensen, Steven M., Liu, Sheng, Sacha, Jarek, Phipps, Roger J., Turner, Russell T.

“…The primary goal of our study was to determine changes in bone mineralization in postmenopausal osteoporotic women treated for 3 years with risedronate or…”
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Effect of Risedronate on Osteocyte Viability and Bone Turnover in Paired Iliac Bone Biopsies from Early Postmenopausal Women by Qiu, S., Phipps, R. J., Ebetino, F. H., Palnitkar, S., Sudhaker Rao, D.

“…It is unclear whether standard clinical doses of risedronate affect osteocyte viability. This study examined osteocyte viability and bone remodeling rate in…”
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Tissue Distribution of Newer Anticonvulsant Drugs in Postmortem Cases by Levine, Barry, Phipps, Rebecca Jufer, Naso, Clare, Fahie, Kisha, Fowler, David

“…Levetiracetam, hydroxycarbazepine (the primary product of oxcarbazepine use), and topiramate were quantified using the acid/neutral drug screening procedure…”
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Risedronate Preserves Trabecular Architecture and Increases Bone Strength in Vertebra of Ovariectomized Minipigs as Measured by Three‐Dimensional Microcomputed Tomography by Borah, Babul, Dufresne, Thomas E., Chmielewski, Paula A., Gross, Gary J., Prenger, Marla C., Phipps, Roger J.

“…Risedronate reduces the risk of new vertebral fractures up to 70% within 1 year of treatment in patients with osteoporosis. Both increases in bone mass and…”
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Calculating clinically relevant drug doses to use in animal studies by Fuchs, R. K., Allen, M. R., Condon, K. W., Reinwald, S., Miller, L. M., McClenathan, D., Keck, B., Phipps, R. J., Burr, D. B.

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Effect of risedronate on bone mass, remodelling and biomechanical strength in orchidectomized rats by Díaz-Curiel, M, de la Piedra, C, Romero, F I, Montero, M, Gómez, S, Lefort, M, Carrascal, M T, Phipps, R J

“…The ability of risedronate to prevent and/or treat orchidectomy-induced osteoporosis in male rats was studied. Ninety-five 10-week-old male Wistar rats were…”
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Bisphosphonates and gastrointestinal damage by Blank, M A, Gibson, G W, Phipps, R J, Smith, P N

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Effects of 0.5 ppm ozone on glycoprotein secretion, ion and water fluxes in sheep trachea by Phipps, R J, Denas, S M, Sielczak, M W, Wanner, A

“…We studied the effects of ozone (O3) exposure on airway mucus secretion. Sheep were exposed in vivo to 0.5 ppm O3, 4 h/day for 2 days (acute, n = 6), 6 wks…”
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Control of mucus secretion and ion transport in airways by Nadel, J A, Davis, B, Phipps, R J

“…The output of secretions from the airway submucosal glands is regulated by vagal efferent nerves. Stimulation of cough receptors increases mucus output…”
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Effect of ozone on the postnatal development of lamb mucociliary apparatus by Mariassy, A T, Abraham, W M, Phipps, R J, Sielczak, M W, Wanner, A

“…We determined whether exposure to O3 early in the postnatal period impairs the normal development of the mucociliary apparatus in lambs and whether such…”
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The effects of irritation at various levels of the airway upon tracheal mucus secretion in the cat by Phipps, R J, Richardson, P S

“…1. Sulphated glycoprotein output from the trachea, isolated in situ, has been measured in anaesthetized cats by a radio-isotopic method. The effects of…”
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