Search Results - "Phipps, Krista M."

IL-17A is essential for cell activation and inflammatory gene circuits in subjects with psoriasis by Krueger, James G., MD, Fretzin, Scott, MD, Suárez-Fariñas, Mayte, PhD, Haslett, Patrick A., MB, BS, Phipps, Krista M, Cameron, Gregory S., PhD, McColm, Juliet, MD, Katcherian, Artemis, Cueto, Inna, White, Traci, Banerjee, Subhashis, MD, Hoffman, Robert W., DO

“…Background In subjects with psoriasis, inflammation and epidermal hyperplasia are thought to be controlled by T cell–derived cytokines. Evidence suggests that…”
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Small interfering RNA molecules as potential anti-human rhinovirus agents: in vitro potency, specificity, and mechanism by Phipps, Krista M., Martinez, Alejandro, Lu, Jin, Heinz, Beverly A., Zhao, Genshi

“…RNA silencing or interference (RNAi) is a sequence-specific, post-transcriptional process of mRNA degradation. The degradation of target gene mRNA can be…”
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An adenine-to-guanine nucleotide change in the IRES SL-IV domain of picornavirus/hepatitis C chimeric viruses leads to a nonviable phenotype by McKnight, Kevin L, Sandefur, Stephanie, Phipps, Krista M, Heinz, Beverly A

“…The inability for the internal ribosomal entry site (IRES) of hepatitis C virus (HCV) to be readily studied in the context of viral replication has been…”
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Single and multiple ascending dose studies in healthy volunteers to assess the safety and PK of LY3372689, an inhibitor of the O‐GlcNAcase (OGA) enzyme by Lowe, Stephen L, Goldsmith, Paul, Phipps, Krista M, Kevin, Donnelly B, Biglan, Kevin, Mancini, Michele, Nuthall, Hugh Norman, Mergott, Dustin J., Kielbasa, William

“…Background LY3372689, an OGA enzyme inhibitor, is being developed as a potential treatment for tauopathies, including Alzheimer’s disease. OGA inhibition is…”
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Brain target occupancy of LY3372689, an inhibitor of the O‐GlcNAcase (OGA) enzyme, following administration of single and multiple doses to healthy volunteers by Kielbasa, William, Shcherbinin, Sergey, Goldsmith, Paul, Phipps, Krista M, Biglan, Kevin, Mancini, Michele, Russell, David, Constantinescu, Cristian, Gunn, Roger N, Nuthall, Hugh Norman, Mergott, Dustin J., Lowe, Stephen L, Collins, Emily C

“…Background LY3372689, an O‐GlcNAcase (OGA) enzyme inhibitor, is being developed as a potential treatment of tauopathies, including Alzheimer’s disease. OGA…”
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Brain target occupancy of LY3372689, an inhibitor of the O‐GlcNAcase (OGA) enzyme: Translation from rat to human: Neuroimaging / evaluating treatments by Shcherbinin, Sergey, Kielbasa, William, Dubois, Susan, Lowe, Stephen L, Phipps, Krista M, Tseng, James, Kevin, Donnelly B, Natanegara, Fanni, Warner, Susan, Dreyfus, Nicolas, Lindsay‐Scott, Peter, Hawk, Mai Khanh, McDonald, Nicholas, Zhang, Xiaoyu, Gilmore, Julie A, Biglan, Kevin, Mergott, Dustin J, Russell, David, Gunn, Roger N, Constantinescu, Cristian, Nuthall, Hugh Norman, Collins, Emily C

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A single ascending dose study in healthy volunteers to assess the safety and PK of LY3372689, an inhibitor of O‐GlcNAcase (OGA) enzyme by Kielbasa, William, Phipps, Krista M, Tseng, James, Natanegara, Fanni, Cheng, Eden, Monk, Scott A., Bundgaard, Christoffer, Kevin, Donnelly B., Nuthall, Hugh Norman, McDonald, Nicholas, Lindsay‐Scott, Peter, Dreyfus, Nicolas, Hawk, Mai Khanh, Warner, Susan, Biglan, Kevin, Gilmore, Julie A., Zhang, Xiaoyu, Mergott, Dustin J., Lowe, Stephen L.

“…Background LY3372689, an O‐GlcNAcase (OGA) enzyme inhibitor, is being developed as a potential treatment for tauopathies, including Alzheimer’s disease. OGA…”
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Brain target occupancy of LY3372689, an inhibitor of the O‐GlcNAcase (OGA) enzyme: Translation from rat to human by Shcherbinin, Sergey, Kielbasa, William, Dubois, Susan, Lowe, Stephen L, Phipps, Krista M, Tseng, James, Kevin, Donnelly B, Natanegara, Fanni, Warner, Susan, Dreyfus, Nicolas, Lindsay‐Scott, Peter, Hawk, Mai Khanh, McDonald, Nicholas, Zhang, Xiaoyu, Gilmore, Julie A, Biglan, Kevin, Mergott, Dustin J, Russell, David, Gunn, Roger N, Constantinescu, Cristian, Nuthall, Hugh Norman, Collins, Emily C

“…Background LY3372689, an O‐GlcNAcase (OGA) enzyme inhibitor, is being developed as a potential treatment of tauopathies, including Alzheimer’s disease. OGA…”
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A single ascending dose study in healthy volunteers to assess the safety and PK of LY3372689, an inhibitor of O‐GlcNAcase (OGA) enzyme: Human/Human trials: Anti‐tau by Kielbasa, William, Phipps, Krista M, Tseng, James, Natanegara, Fanni, Cheng, Eden, Monk, Scott A., Bundgaard, Christoffer, Kevin, Donnelly B., Nuthall, Hugh Norman, McDonald, Nicholas, Lindsay‐Scott, Peter, Dreyfus, Nicolas, Hawk, Mai Khanh, Warner, Susan, Biglan, Kevin, Gilmore, Julie A., Zhang, Xiaoyu, Mergott, Dustin J., Lowe, Stephen L.

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IL-17A is Essential for Cell Activation and Inflammatory Gene Circuits in Psoriasis by Krueger, James G., Fretzin, Scott, Suárez-Fariñas, Mayte, Haslett, Patrick A., Phipps, Krista M., Cameron, Gregory S., McColm, Juliet, Katcherian, Artemis, Cueto, Inna, White, Traci, Banerjee, Subhashis, Hoffman, Robert W.

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