Search Results - "Philp, Ashleigh M"

Long Intergenic Noncoding RNAs Mediate the Human Chondrocyte Inflammatory Response and Are Differentially Expressed in Osteoarthritis Cartilage by Pearson, Mark J., Philp, Ashleigh M., Heward, James A., Roux, Benoit T., Walsh, David A., Davis, Edward T., Lindsay, Mark A., Jones, Simon W.

“…Objective To identify long noncoding RNAs (lncRNAs), including long intergenic noncoding RNAs (lincRNAs), antisense RNAs, and pseudogenes, associated with the…”
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IL-6 secretion in osteoarthritis patients is mediated by chondrocyte-synovial fibroblast cross-talk and is enhanced by obesity by Pearson, Mark J., Herndler-Brandstetter, Dietmar, Tariq, Mohammad A., Nicholson, Thomas A., Philp, Ashleigh M., Smith, Hannah L., Davis, Edward T., Jones, Simon W., Lord, Janet M.

“…Increasing evidence suggests that inflammation plays a central role in driving joint pathology in certain patients with osteoarthritis (OA). Since many…”
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Mitochondrial uncoupler BAM15 reverses diet-induced obesity and insulin resistance in mice by Alexopoulos, Stephanie J., Chen, Sing-Young, Brandon, Amanda E., Salamoun, Joseph M., Byrne, Frances L., Garcia, Christopher J., Beretta, Martina, Olzomer, Ellen M., Shah, Divya P., Philp, Ashleigh M., Hargett, Stefan R., Lawrence, Robert T., Lee, Brendan, Sligar, James, Carrive, Pascal, Tucker, Simon P., Philp, Andrew, Lackner, Carolin, Turner, Nigel, Cooney, Gregory J., Santos, Webster L., Hoehn, Kyle L.

“…Obesity is a health problem affecting more than 40% of US adults and 13% of the global population. Anti-obesity treatments including diet, exercise, surgery…”
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eNAMPT Is Localised to Areas of Cartilage Damage in Patients with Hip Osteoarthritis and Promotes Cartilage Catabolism and Inflammation by Philp, Ashleigh M., Butterworth, Sam, Davis, Edward T., Jones, Simon W.

“…Obesity increases the risk of hip osteoarthritis (OA). Recent studies have shown that adipokine extracellular nicotinamide phosphoribosyltransferase (eNAMPT or…”
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Resistin promotes the abnormal Type I collagen phenotype of subchondral bone in obese patients with end stage hip osteoarthritis by Philp, Ashleigh M., Collier, Rebecca L., Grover, Liam M., Davis, Edward T., Jones, Simon W.

“…The purpose of this study was to determine the effect of adiposity on the architecture and composition of hip OA subchondral bone, and to examine the…”
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Metabolic remodeling of dystrophic skeletal muscle reveals biological roles for dystrophin and utrophin in adaptation and plasticity by Hardee, Justin P., Martins, Karen J.B., Miotto, Paula M., Ryall, James G., Gehrig, Stefan M., Reljic, Boris, Naim, Timur, Chung, Jin D., Trieu, Jen, Swiderski, Kristy, Philp, Ashleigh M., Philp, Andrew, Watt, Matthew J., Stroud, David A., Koopman, Rene, Steinberg, Gregory R., Lynch, Gordon S.

“…Preferential damage to fast, glycolytic myofibers is common in many muscle-wasting diseases, including Duchenne muscular dystrophy (DMD). Promoting an…”
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Kv2 Ion Channels Determine the Expression and Localization of the Associated AMIGO-1 Cell Adhesion Molecule in Adult Brain Neurons by Bishop, Hannah I, Cobb, Melanie M, Kirmiz, Michael, Parajuli, Laxmi K, Mandikian, Danielle, Philp, Ashleigh M, Melnik, Mikhail, Kuja-Panula, Juha, Rauvala, Heikki, Shigemoto, Ryuichi, Murray, Karl D, Trimmer, James S

“…Voltage-gated K (Kv) channels play important roles in regulating neuronal excitability. Kv channels comprise four principal α subunits, and transmembrane…”
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Subcellular Localization and Activity of TRPM4 in Medial Prefrontal Cortex Layer 2/3 by Riquelme, Denise, Silva, Ian, Philp, Ashleigh M, Huidobro-Toro, Juan P, Cerda, Oscar, Trimmer, James S, Leiva-Salcedo, Elias

“…TRPM4 is a Ca -activated non-selective cationic channel that conducts monovalent cations. TRPM4 has been proposed to contribute to burst firing and sustained…”
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Mitochondrial succinate dehydrogenase function is essential for sperm motility and male fertility by Woodhouse, Rachel M., Frolows, Natalya, Wang, Guoqiang, Hawdon, Azelle, Wong, Edmund Heng Kin, Dansereau, Linda C., Su, Yingying, Adair, Liam D., New, Elizabeth J., Philp, Ashleigh M., Tan, Wei Kang, Philp, Andrew, Ashe, Alyson

“…Mitochondrial health is crucial to sperm quality and male fertility, but the precise role of mitochondria in sperm function remains unclear. SDHA is a…”
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Therapeutic targets in lung tissue remodelling and fibrosis by Liu, Gang, Philp, Ashleigh M., Corte, Tamera, Travis, Mark A., Schilter, Heidi, Hansbro, Nicole G., Burns, Chris J., Eapen, Mathew S., Sohal, Sukhwinder S., Burgess, Janette K., Hansbro, Philip M.

“…Structural changes involving tissue remodelling and fibrosis are major features of many pulmonary diseases, including asthma, chronic obstructive pulmonary…”
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Developing anti-inflammatory therapeutics for patients with osteoarthritis by Philp, Ashleigh M, Davis, Edward T, Jones, Simon W

“…OA is the most common joint disorder in the world, but there are no approved therapeutics to prevent disease progression. Historically, OA has been considered…”
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The influence of aerobic exercise on mitochondrial quality control in skeletal muscle by Philp, Ashleigh M., Saner, Nicholas J., Lazarou, Michael, Ganley, Ian G., Philp, Andrew

“…Mitochondria are dynamic organelles, intricately designed to meet cellular energy requirements. To accommodate alterations in energy demand, mitochondria have…”
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The importance of mitochondrial quality control for maintaining skeletal muscle function across health span by Sligar, James, DeBruin, Danielle A, Saner, Nicholas J, Philp, Ashleigh M, Philp, Andrew

“…As the principal energy-producing organelles of the cell, mitochondria support numerous biological processes related to metabolism, growth, and regeneration in…”
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Nicotinamide riboside supplementation does not alter whole‐body or skeletal muscle metabolic responses to a single bout of endurance exercise by Stocks, Ben, Ashcroft, Stephen P., Joanisse, Sophie, Dansereau, Linda C., Koay, Yen Chin, Elhassan, Yasir S., Lavery, Gareth G., Quek, Lake‐Ee, O'Sullivan, John F., Philp, Ashleigh M., Wallis, Gareth A., Philp, Andrew

“…Key points Acute nicotinamide riboside (NR) supplementation does not alter substrate metabolism at rest, during or in recovery from endurance exercise. NR does…”
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A Perspective on “Hypoxia Resistance is an Inherent Phenotype of the Mouse Flexor Digitorum Brevis Skeletal Muscle” by Padilha, Camila, Philp, Ashleigh M

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Mitochondrial hydrogen sulfide supplementation improves health in the C. elegans Duchenne muscular dystrophy model by Ellwood, Rebecca A., Hewitt, Jennifer E., Torregrossa, Roberta, Philp, Ashleigh M., Hardee, Justin P., Hughes, Samantha, van de Klashorst, David, Gharahdaghi, Nima, Anupom, Taslim, Slade, Luke, Deane, Colleen S., Cooke, Michael, Etheridge, Timothy, Piasecki, Mathew, Antebi, Adam, Lynch, Gordon S., Philp, Andrew, Vanapalli, Siva A., Whiteman, Matthew, Szewczyk, Nathaniel J.

“…Duchenne muscular dystrophy (DMD) is an X-linked recessive disorder characterized by progressive muscle degeneration and weakness due to mutations in the…”
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Diet-induced vitamin D deficiency reduces skeletal muscle mitochondrial respiration by Ashcroft, Stephen P, Fletcher, Gareth, Philp, Ashleigh M, Jenkinson, Carl, Das, Shatarupa, Hansbro, Philip M, Atherton, Philip J, Philp, Andrew

“…Vitamin D deficiency is associated with symptoms of skeletal muscle myopathy including muscle weakness and fatigue. Recently, vitamin D-related metabolites…”
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Adverse roles of mast cell chymase-1 in COPD by Liu, Gang, Jarnicki, Andrew G., Paudel, Keshav R., Lu, Wenying, Wadhwa, Ridhima, Philp, Ashleigh M., Van Eeckhoutte, Hannelore, Marshall, Jacqueline E., Malyla, Vamshikrishna, Katsifis, Angelica, Fricker, Michael, Hansbro, Nicole G., Dua, Kamal, Kermani, Nazanin Z., Eapen, Mathew S., Tiotiu, Angelica, Chung, K. Fan, Caramori, Gaetano, Bracke, Ken, Adcock, Ian M., Sohal, Sukhwinder S., Wark, Peter A., Oliver, Brian G., Hansbro, Philip M.

“…Background COPD is the third leading cause of death worldwide. Cigarette smoke (CS)-induced chronic inflammation inducing airway remodelling, emphysema and…”
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Liver-selective imidazolopyrazine mitochondrial uncoupler SHD865 reverses adiposity and glucose intolerance in mice by Beretta, Martina, Dai, Yumin, Olzomer, Ellen M, Vancuylenburg, Calum S, Santiago-Rivera, José A, Philp, Ashleigh M, Hargett, Stefan R, Li, Keyong, Shah, Divya P, Chen, Sing-Young, Alexopoulos, Stephanie J, Li, Catherine, Harris, Thurl E, Lee, Brendan, Wathier, Michel, Cermak, Jennifer M, Tucker, Simon P, Turner, Nigel, Bayliss, Douglas A, Philp, Andrew, Byrne, Frances L, Santos, Webster L, Hoehn, Kyle L

“…Excess body fat is a risk factor for metabolic diseases and is a leading preventable cause of morbidity and mortality worldwide. There is a strong need to find…”
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The Effect of Vancomycin and Gentamicin Antibiotics on Human Osteoblast Proliferation, Metabolic Function, and Bone Mineralization by Philp, Ashleigh M., Raja, Saroop, Philp, Andrew, Newton Ede, Matthew P., Jones, Simon W.

“…The present study investigates the effect of vancomycin and gentamicin antibiotics on primary human osteoblasts. Osteoblasts were incubated with vancomycin,…”
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