Search Results - "Philo, John"

SEDNTERP: a calculation and database utility to aid interpretation of analytical ultracentrifugation and light scattering data by Philo, John S.

“…Proper interpretation of analytical ultracentrifugation (AUC) data for purified proteins requires ancillary information and calculations to account for factors…”
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A critical review of methods for size characterization of non-particulate protein aggregates by Philo, John S

“…Although size exclusion chromatography (SEC) has been, and will continue to be, the primary analytical tool for characterization of the content and size…”
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Mechanisms of protein aggregation by Philo, John S, Arakawa, Tsutomu

“…Aggregation or reversible self-association of protein therapeutics can arise through a number of different mechanisms. Five common aggregation mechanisms are…”
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Improved methods for fitting sedimentation coefficient distributions derived by time-derivative techniques by Philo, John S.

“…Time-derivative approaches to analyzing sedimentation velocity data have proven to be highly successful and have now been used routinely for more than a…”
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Is any measurement method optimal for all aggregate sizes and types? by Philo, John S

“…Protein-based pharmaceuticals exhibit a wide range of aggregation phenomena, making it virtually impossible to find any one analytical method that works well…”
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The Glucagon-Like Peptide 2 Analog Teduglutide Reversibly Associates to Form Pentamers by Philo, John S, Sydor, Wasyl, Arakawa, Tsutomu

“…Glucagon-like peptide 1 and 2 and their analog peptide therapeutics are known to reversibly associate to form oligomers. Here we report the association…”
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The critical role of mobile phase composition in size exclusion chromatography of protein pharmaceuticals by Arakawa, Tsutomu, Ejima, Daisuke, Li, Tiansheng, Philo, John S

“…Size exclusion chromatography (SEC) is the most widely used method for aggregation analysis of pharmaceutical proteins. However SEC analysis has a number of…”
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Elizabeth I’s Translation of Tacitus: Lambeth Palace Library, MS 683 by Philo, John-Mark

“…Abstract Preserved at Lambeth Palace Library is a manuscript translation of Tacitus’s Annales, completed in the late sixteenth century. The translation was…”
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Henry Savile's Tacitus in Italy by Philo, John‐Mark

“…This article examines the Italian afterlife of Henry Savile's Tacitus. Approximately four years before his execution, Henry Cuffe (1562/3–1601), classical…”
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English and Scottish Scholars at the Library of Gian Vincenzo Pinelli (1565–1601) by Philo, John-Mark

“…Throughout the second half of the sixteenth century, the scholar and collector Gian Vincenzo Pinelli (1535–1601) welcomed poets, mathematicians, antiquarians,…”
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Effects of acid exposure on the conformation, stability, and aggregation of monoclonal antibodies by Ejima, Daisuke, Tsumoto, Kouhei, Fukada, Harumi, Yumioka, Ryosuke, Nagase, Kazuo, Arakawa, Tsutomu, Philo, John S.

“…Exposure of antibodies to low pH is often unavoidable for purification and viral clearance. The conformation and stability of two humanized monoclonal…”
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Structure, signaling mechanism and regulation of the natriuretic peptide receptor guanylate cyclase by Misono, Kunio S, Philo, John S, Arakawa, Tsutomu, Ogata, Craig M, Qiu, Yue, Ogawa, Haruo, Young, Howard S

“…Atrial natriuretic peptide (ANP) and the homologous B-type natriuretic peptide are cardiac hormones that dilate blood vessels and stimulate natriuresis and…”
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Limiting the sedimentation coefficient for sedimentation velocity data analysis: Partial boundary modeling and g( s ∗) approaches revisited by Philo, John S.

“…Brown and coworkers (Eur. Biophys. J. 38 (2009) 1079–1099) introduced partial boundary modeling (PBM) to simplify sedimentation velocity data analysis by…”
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Synthesis and Biological Evaluation of a Library of Sulfonamide Analogs of Memantine to Target Glioblastoma by Philo, John E., Caudle, Jenna D., Moussa, Reema N., Kampmeyer, Patrick M., Hasin, Tasfia R., Seo, David K., Sheaff, Robert J., Lamar, Angus A.

“…A library of 34 lipophilic sulfonamides based upon the memantine core has been synthesized to identify potential drug candidates to cross the blood‐brain…”
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Injector-coupled transverse instabilities in a multi-element premixed combustor by Philo, John J, Gejji, Rohan M, Slabaugh, Carson D

“…Combustion instabilities in a high-pressure, multi-element combustor are studied in order to understand the relationship between the chamber and injector…”
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Tudor Humanists, London Printers, and the Status of Women: The Struggle over Livy in the Querelle des Femmes by PHILO, JOHN-MARK

“…This essay discusses a novel contribution to the Renaissance debate over women. In 1551, William Thomas translated a brief but significant moment from Livy’s…”
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SHAKESPEARE'S "MACBETH" AND LIVY'S LEGENDARY ROME by PHILO, JOHN-MARK

“…Livy's History of Rome exerts a strong but insufficiently explored influence on Shakespeare's Macbeth. The Macbeth narrative as Shakespeare received it already…”
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Role of Arginine in Protein Refolding, Solubilization, and Purification by Tsumoto, Kouhei, Umetsu, Mitsuo, Kumagai, Izumi, Ejima, Daisuke, Philo, John S., Arakawa, Tsutomu

“…Recombinant proteins are often expressed in the form of insoluble inclusion bodies in bacteria. To facilitate refolding of recombinant proteins obtained from…”
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The leucine-rich amelogenin protein (LRAP) is primarily monomeric and unstructured in physiological solution by Tarasevich, Barbara J., Philo, John S., Maluf, Nasib Karl, Krueger, Susan, Buchko, Garry W., Lin, Genyao, Shaw, Wendy J.

“…Amelogenin proteins are critical to the formation of enamel in teeth and may have roles in controlling growth and regulating microstructures of the intricately…”
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Elution of antibodies from a Protein-A column by aqueous arginine solutions by Arakawa, Tsutomu, Philo, John S, Tsumoto, Kouhei, Yumioka, Ryosuke, Ejima, Daisuke

“…Acidic pH is commonly used to elute antibodies from Protein-A affinity column, although low pH may result in aggregation of the proteins. As an alternative,…”
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