Search Results - "Phillips Jr, George N."

Adaptive evolution of threonine deaminase in plant defense against insect herbivores by Gonzales-Vigil, Eliana, Bianchetti, Christopher M, Phillips, George N. Jr, Howe, Gregg A

“…Gene duplication is a major source of plant chemical diversity that mediates plant-herbivore interactions. There is little direct evidence, however, that novel…”
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Complete set of glycosyltransferase structures in the calicheamicin biosynthetic pathway reveals the origin of regiospecificity by Chang, Aram, Singh, Shanteri, Helmich, Kate E, Goff, Randal D, Bingman, Craig A, Thorson, Jon S, Phillips, George N., Jr

“…Glycosyltransferases are useful synthetic catalysts for generating natural products with sugar moieties. Although several natural product glycosyltransferase…”
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Structural consequences of effector protein complex formation in a diiron hydroxylase by Bailey, Lucas J, McCoy, Jason G, Phillips, George N. Jr, Fox, Brian G

“…Carboxylate-bridged diiron hydroxylases are multicomponent enzyme complexes responsible for the catabolism of a wide range of hydrocarbons and as such have…”
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Structural analysis of fish versus mammalian hemoglobins: Effect of the heme pocket environment on autooxidation and hemin loss by Aranda IV, Roman, Cai, He, Worley, Chad E., Levin, Elena J., Li, Rong, Olson, John S., Phillips Jr, George N., Richards, Mark P.

“…The underlying stereochemical mechanisms for the dramatic differences in autooxidation and hemin loss rates of fish versus mammalian hemoglobins (Hb) have been…”
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Drop-on-demand sample delivery for studying biocatalysts in action at X-ray free-electron lasers by Fuller, Franklin D, Gul, Sheraz, Chatterjee, Ruchira, Burgie, E Sethe, Young, Iris D, Lebrette, Hugo, Srinivas, Vivek, Brewster, Aaron S, Michels-Clark, Tara, Clinger, Jonathan A, Andi, Babak, Ibrahim, Mohamed, Pastor, Ernest, de Lichtenberg, Casper, Hussein, Rana, Pollock, Christopher J, Zhang, Miao, Stan, Claudiu A, Kroll, Thomas, Fransson, Thomas, Weninger, Clemens, Kubin, Markus, Aller, Pierre, Lassalle, Louise, Bräuer, Philipp, Miller, Mitchell D, Amin, Muhamed, Koroidov, Sergey, Roessler, Christian G, Allaire, Marc, Sierra, Raymond G, Docker, Peter T, Glownia, James M, Nelson, Silke, Koglin, Jason E, Zhu, Diling, Chollet, Matthieu, Song, Sanghoon, Lemke, Henrik, Liang, Mengning, Sokaras, Dimosthenis, Alonso-Mori, Roberto, Zouni, Athina, Messinger, Johannes, Bergmann, Uwe, Boal, Amie K, Bollinger, J Martin, Krebs, Carsten, Högbom, Martin, Phillips, George N, Vierstra, Richard D, Sauter, Nicholas K, Orville, Allen M, Kern, Jan, Yachandra, Vittal K, Yano, Junko

“…A robust acoustic droplet ejection–drop-on-tape method delivers samples to an X-ray free-electron laser source for combined serial femtosecond crystallography…”
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Structure of Human J-type Co-chaperone HscB Reveals a Tetracysteine Metal-binding Domain by Bitto, Eduard, Bingman, Craig A., Bittova, Lenka, Kondrashov, Dmitry A., Bannen, Ryan M., Fox, Brian G., Markley, John L., Phillips, George N.

“…Iron-sulfur proteins play indispensable roles in a broad range of biochemical processes. The biogenesis of iron-sulfur proteins is a complex process that has…”
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Structure and Function of a Dual Reductase–Dehydratase Enzyme System Involved in p‑Terphenyl Biosynthesis by Clinger, Jonathan A, Zhang, Yinan, Liu, Yang, Miller, Mitchell D, Hall, Ronnie E, Van Lanen, Steven G, Phillips Jr, George N, Thorson, Jon S, Elshahawi, Sherif I

“…We report the identification of the ter gene cluster responsible for the formation of the p-terphenyl derivatives terfestatins B and C and echoside B from the…”
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Prochlorococcus phage ferredoxin: structural characterization and electron transfer to cyanobacterial sulfite reductases by Campbell, Ian J., Olmos, Jose Luis, Xu, Weijun, Kahanda, Dimithree, Atkinson, Joshua T., Sparks, Othneil Noble, Miller, Mitchell D., Phillips, George N., Bennett, George N., Silberg, Jonathan J.

“…Marine cyanobacteria are infected by phages whose genomes encode ferredoxin (Fd) electron carriers. These Fds are thought to redirect the energy harvested from…”
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A deep learning solution for crystallographic structure determination by Pan, Tom, Jin, Shikai, Miller, Mitchell D, Kyrillidis, Anastasios, Phillips, Jr, George N

“…The general de novo solution of the crystallographic phase problem is difficult and only possible under certain conditions. This paper develops an initial…”
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Structural and evolutionary relationships of “AT-less” type I polyketide synthase ketosynthases by Lohman, Jeremy R., Ma, Ming, Osipiuk, Jerzy, Nocek, Boguslaw, Kim, Youngchang, Chang, Changsoo, Cuff, Marianne, Mack, Jamey, Bigelow, Lance, Li, Hui, Endres, Michael, Babnigg, Gyorgy, Joachimiak, Andrzej, Phillips, George N., Shen, Ben

“…Acyltransferase (AT)-less type I polyketide synthases (PKSs) break the type I PKS paradigm. They lack the integrated AT domains within their modules and…”
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Watching a Protein as It Functions with 150-ps Time-Resolved X-ray Crystallography by Schotte, Friedrich, Lim, Manho, Jackson, Timothy A., Smirnov, Aleksandr V., Soman, Jayashree, Olson, John S., Phillips, George N., Wulff, Michael, Anfinrud, Philip A.

“…We report picosecond time-resolved x-ray diffraction from the myoglobin (Mb) mutant in which$Leu^{29}$is replaced by Phe (L29F mutant). The frame-by-frame…”
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Crystal structure of the protein At3g01520, a eukaryotic universal stress protein-like protein from arabidopsis thaliana in complex with AMP by Kim, Do Jin, Bitto, Eduard, Bingman, Craig A., Kim, Hyun-Jung, Han, Byung Woo, Phillips Jr, George N.

“…ABSTRACT Members of the universal stress protein (USP) family are conserved in a phylogenetically diverse range of prokaryotes, fungi, protists, and plants and…”
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Structural basis for selective activation of ABA receptors by Cutler, Sean R, Phillips, George N, Volkman, Brian F, Peterson, Francis C, Burgie, E Sethe, Park, Sang-Youl, Jensen, Davin R, Weiner, Joshua J, Bingman, Craig A, Chang, Chia-En A

“…The synthetic ABA agonist pyrabactin helped identify the PYR/PYL family of ABA receptors. Now the selectivity of pyrabactin toward specific members of this…”
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Conformational dynamics of adenylate kinase in crystals by Kim, Junhyung, Moon, Sojin, Romo, Tod D., Yang, Yifei, Bae, Euiyoung, Phillips, George N.

“…Adenylate kinase is a ubiquitous enzyme in living systems and undergoes dramatic conformational changes during its catalytic cycle. For these reasons, it is…”
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Structural characterization of human Uch37 by Burgie, Sethe E., Bingman, Craig A., Soni, Ameet B., Phillips Jr, George N.

“…Uch37 is a de-ubiquitylating enzyme that is functionally linked with the 26S proteasome via Rpn13, and is essential for metazoan development. Here, we report…”
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The structure of flavin-dependent tryptophan 7-halogenase RebH by Bitto, Eduard, Huang, Yu, Bingman, Craig A., Singh, Shanteri, Thorson, Jon S., Phillips Jr, George N.

“…Enzyme catalyzed regio- and stereo-specific halogenations influence the biological activity of a diverse array of therapeutically important natural products,…”
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Crystal structure of SsfS6, the putative C-glycosyltransferase involved in SF2575 biosynthesis by Wang, Fengbin, Zhou, Maoquan, Singh, Shanteri, Yennamalli, Ragothaman M., Bingman, Craig A., Thorson, Jon S., Phillips Jr, George N.

“…ABSTRACT The molecule known as SF2575 from Streptomyces sp. is a tetracycline polyketide natural product that displays antitumor activity against murine…”
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X-ray structure of a soluble Rieske-type ferredoxin from Mus musculus by Levin, Elena J., Elsen, Nathaniel L., Seder, Kory D., McCoy, Jason G., Fox, Brian G., Phillips Jr, George N.

“…The 2.07 Å resolution X‐ray crystal structure of a soluble Rieske‐type ferredoxin from Mus musculus encoded by the gene Mm.266515 is reported. Although they…”
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Improving the efficiency of molecular replacement by utilizing a new iterative transform phasing algorithm by He, Hongxing, Fang, Hengrui, Miller, Mitchell D., Phillips Jr, George N., Su, Wu-Pei

“…An iterative transform method proposed previously for direct phasing of high‐solvent‐content protein crystals is employed for enhancing the…”
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Effectiveness and limitations of local structural entropy optimization in the thermal stabilization of mesophilic and thermophilic adenylate kinases by Moon, Sojin, Bannen, Ryan M., Rutkoski, Thomas J., Phillips Jr, George N., Bae, Euiyoung

“…ABSTRACT Local structural entropy (LSE) is a descriptor for the extent of conformational heterogeneity in short protein sequences that is computed from…”
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