Search Results - "Phillips, Ryan S"

Putting the theory into 'burstlet theory' with a biophysical model of burstlets and bursts in the respiratory preBötzinger complex by Phillips, Ryan S, Rubin, Jonathan E

“…Inspiratory breathing rhythms arise from synchronized neuronal activity in a bilaterally distributed brainstem structure known as the preBötzinger complex…”
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Effects of persistent sodium current blockade in respiratory circuits depend on the pharmacological mechanism of action and network dynamics by Phillips, Ryan S, Rubin, Jonathan E

“…The mechanism(s) of action of most commonly used pharmacological blockers of voltage-gated ion channels are well understood; however, this knowledge is rarely…”
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The effects of chloride dynamics on substantia nigra pars reticulata responses to pallidal and striatal inputs by Phillips, Ryan S, Rosner, Ian, Gittis, Aryn H, Rubin, Jonathan E

“…As a rodent basal ganglia (BG) output nucleus, the substantia nigra pars reticulata (SNr) is well positioned to impact behavior. SNr neurons receive GABAergic…”
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Predictions and experimental tests of a new biophysical model of the mammalian respiratory oscillator by Phillips, Ryan S, Koizumi, Hidehiko, Molkov, Yaroslav I, Rubin, Jonathan E, Smith, Jeffrey C

“…Previously our computational modeling studies (Phillips et al., 2019) proposed that neuronal persistent sodium current (I NaP ) and calcium-activated…”
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Biophysical mechanisms in the mammalian respiratory oscillator re-examined with a new data-driven computational model by Phillips, Ryan S, John, Tibin T, Koizumi, Hidehiko, Molkov, Yaroslav I, Smith, Jeffrey C

“…An autorhythmic population of excitatory neurons in the brainstem pre-Bötzinger complex is a critical component of the mammalian respiratory oscillator. Two…”
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Interdependence of cellular and network properties in respiratory rhythm generation by Phillips, Ryan S, Baertsch, Nathan A

“…How breathing is generated by the preBötzinger complex (preBötC) remains divided between two ideological frameworks, and a persistent sodium current (I ) lies…”
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How neural networks walk and chew gum by Baertsch, Nathan A., Phillips, Ryan S.

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A novel mechanism for ramping bursts based on slow negative feedback in model respiratory neurons by John, Sushmita R, Phillips, Ryan S, Rubin, Jonathan E

“…Recordings from pre-Bötzinger complex neurons responsible for the inspiratory phase of the respiratory rhythm reveal a ramping burst pattern, starting around…”
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Occupational Stress in United Kingdom Audiologists by Phillips, Ryan S, Saunders, Gabrielle H

“…Occupational stress is known to have detrimental effects on health care professionals worldwide. This study aimed to address a research gap by investigating…”
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Dynamics of ramping bursts in a respiratory neuron model by Abdulla, Muhammad U., Phillips, Ryan S., Rubin, Jonathan E.

“…Intensive computational and theoretical work has led to the development of multiple mathematical models for bursting in respiratory neurons in the…”
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Inspiratory rhythm generation is stabilized by I h by Burgraff, Nicholas J, Phillips, Ryan S, Severs, Liza J, Bush, Nicholas E, Baertsch, Nathan A, Ramirez, Jan-Marino

“…Cellular and network properties must be capable of generating rhythmic activity that is both flexible and stable. This is particularly important for breathing,…”
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Inspiratory rhythm generation is stabilized by Ih by Burgraff, Nicholas J, Phillips, Ryan S, Severs, Liza J, Bush, Nicholas E, Baertsch, Nathan A, Ramirez, Jan-Marino

“…Cellular and network properties must be capable of generating rhythmic activity that is both flexible and stable. This is particularly important for breathing,…”
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Modeling Effects of Variable preBötzinger Complex Network Topology and Cellular Properties on Opioid-Induced Respiratory Depression and Recovery by Chou, Grant M, Bush, Nicholas E, Phillips, Ryan S, Baertsch, Nathan A, Harris, Kameron Decker

“…The preBötzinger complex (preBötC), located in the medulla, is the essential rhythm-generating neural network for breathing. The actions of opioids on this…”
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Pain-facilitating medullary neurons contribute to opioid-induced respiratory depression by Phillips, Ryan S, Cleary, Daniel R, Nalwalk, Julia W, Arttamangkul, Seksiri, Hough, Lindsay B, Heinricher, Mary M

“…Respiratory depression is a therapy-limiting side effect of opioid analgesics, yet our understanding of the brain circuits mediating this potentially lethal…”
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Transient Receptor Potential Channels TRPM4 and TRPC3 Critically Contribute to Respiratory Motor Pattern Formation but not Rhythmogenesis in Rodent Brainstem Circuits by Koizumi, Hidehiko, John, Tibin T, Chia, Justine X, Tariq, Mohammad F, Phillips, Ryan S, Mosher, Bryan, Chen, Yonghua, Thompson, Ryan, Zhang, Ruli, Koshiya, Naohiro, Smith, Jeffrey C

“…Transient receptor potential channel, TRPM4, the putative molecular substrate for Ca -activated nonselective cation current ( ), is hypothesized to generate…”
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A novel, non-invasive method of respiratory monitoring for use with stereotactic procedures by Cleary, Daniel R., Phillips, Ryan S., Wallisch, Michael, Heinricher, Mary M.

“…► VPT is a low-profile, non-invasive respiratory monitor used with a stereotaxic frame. ► VPT detects small fluctuations in pressure at the nares during…”
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Biophysical Mechanisms of Rhythm Generation in the Pre-Bötzinger Complex by Phillips, Ryan S

“…The pre-Bötzinger complex (pre-BötC) is an essential rhythmogenic brainstem nucleus located in the ventrolateral medulla. Rhythmic output from the pre-BötC is…”
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Dynamics of ramping bursts in a respiratory neuron model by Abdulla, Muhammad U, Phillips, Ryan S, Rubin, Jonathan E

“…Intensive computational and theoretical work has led to the development of mutliple mathematical models for bursting in respiratory neurons in the…”
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Measuring the Effectiveness of Photoresponsive Nanocomposite Coatings on Aircraft Windshields to Mitigate Laser Intensity by Phillips, Ryan S, Bilan, Hubert K., Widel, Zachary X., DeMik, Randal J., Brain, Samantha J., Moy, Matthew, Crowder, Charles, Harriman, Stanley L., O'Malley, James T., Burlas, Joseph E., Emmert, Steven F., Keleher, Jason J.

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Measuring the Effectiveness of Photoresponsive Nanocompsite Coatings on Aircraft Windshields to Mitigate Laser Intensity by Moy, Matthew, Bilan, Hubert K, Phillips, Ryan S, Burlas, Joseph E, Crowder, Charles, Brain, Samantha J, Widel, Zachary X, Keleher, Jason J, Emmert, Steven F, O'Malley, James T, DeMik, Randal J, Harriman, Stanley L

“…In 2004, pilots reported 46 laser illumination events to the Federal Aviation Administration (FAA), with the number increasing to approximately 3,600 in 2011…”
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