Search Results - "Phillips, Rodney"

Duration of HIV-1 viral suppression on cessation of antiretroviral therapy in primary infection correlates with time on therapy by Stöhr, Wolfgang, Fidler, Sarah, McClure, Myra, Weber, Jonathan, Cooper, David, Ramjee, Gita, Kaleebu, Pontiano, Tambussi, Giuseppe, Schechter, Mauro, Babiker, Abdel, Phillips, Rodney E, Porter, Kholoud, Frater, John

“…A minority of HIV-1 positive individuals treated with antiretroviral therapy (ART) in primary HIV-1 infection (PHI) maintain viral suppression on stopping…”
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Low copy target detection by Droplet Digital PCR through application of a novel open access bioinformatic pipeline, ‘definetherain’ by Jones, Mathew, Williams, James, Gärtner, Kathleen, Phillips, Rodney, Hurst, Jacob, Frater, John

“…•The requirement for protocol adaptation from qPCR to ddPCR is characterised.•A potential loss of sensitivity for ddPCR at low target numbers is reported.•A…”
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Early and nonreversible decrease of CD161++/MAIT cells in HIV infection by Cosgrove, Cormac, Ussher, James E., Rauch, Andri, Gärtner, Kathleen, Kurioka, Ayako, Hühn, Michael H., Adelmann, Krista, Kang, Yu-Hoi, Fergusson, Joannah R., Simmonds, Peter, Goulder, Philip, Hansen, Ted H., Fox, Julie, Günthard, Huldrych F., Khanna, Nina, Powrie, Fiona, Steel, Alan, Gazzard, Brian, Phillips, Rodney E., Frater, John, Uhlig, Holm, Klenerman, Paul

“…HIV infection is associated with immune dysfunction, perturbation of immune-cell subsets and opportunistic infections. CD161++CD8+ T cells are a…”
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Immunological biomarkers predict HIV-1 viral rebound after treatment interruption by Hurst, Jacob, Hoffmann, Matthias, Pace, Matthew, Williams, James P., Thornhill, John, Hamlyn, Elizabeth, Meyerowitz, Jodi, Willberg, Chris, Koelsch, Kersten K., Robinson, Nicola, Brown, Helen, Fisher, Martin, Kinloch, Sabine, Cooper, David A., Schechter, Mauro, Tambussi, Giuseppe, Fidler, Sarah, Babiker, Abdel, Weber, Jonathan, Kelleher, Anthony D., Phillips, Rodney E., Frater, John

“…Treatment of HIV-1 infection with antiretroviral therapy (ART) in the weeks following transmission may induce a state of ‘post-treatment control’ (PTC) in some…”
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HIV-1 DNA predicts disease progression and post-treatment virological control by Williams, James P, Hurst, Jacob, Stöhr, Wolfgang, Robinson, Nicola, Brown, Helen, Fisher, Martin, Kinloch, Sabine, Cooper, David, Schechter, Mauro, Tambussi, Giuseppe, Fidler, Sarah, Carrington, Mary, Babiker, Abdel, Weber, Jonathan, Koelsch, Kersten K, Kelleher, Anthony D, Phillips, Rodney E, Frater, John

“…In HIV-1 infection, a population of latently infected cells facilitates viral persistence despite antiretroviral therapy (ART). With the aim of identifying…”
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TLR signaling in human antigen‐presenting cells regulates MR1‐dependent activation of MAIT cells by Ussher, James E., Wilgenburg, Bonnie, Hannaway, Rachel F., Ruustal, Kerstin, Phalora, Prabhjeet, Kurioka, Ayako, Hansen, Ted H., Willberg, Christian B., Phillips, Rodney E., Klenerman, Paul

“…Mucosal‐associated invariant T (MAIT) cells are an abundant innate‐like T lymphocyte population that are enriched in liver and mucosal tissues. They are…”
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Exhaustion of Activated CD8 T Cells Predicts Disease Progression in Primary HIV-1 Infection by Hoffmann, Matthias, Pantazis, Nikos, Martin, Genevieve E, Hickling, Stephen, Hurst, Jacob, Meyerowitz, Jodi, Willberg, Christian B, Robinson, Nicola, Brown, Helen, Fisher, Martin, Kinloch, Sabine, Babiker, Abdel, Weber, Jonathan, Nwokolo, Nneka, Fox, Julie, Fidler, Sarah, Phillips, Rodney, Frater, John

“…The rate at which HIV-1 infected individuals progress to AIDS is highly variable and impacted by T cell immunity. CD8 T cell inhibitory molecules are…”
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Structured observations reveal slow HIV-1 CTL escape by Roberts, Hannah E, Hurst, Jacob, Robinson, Nicola, Brown, Helen, Flanagan, Peter, Vass, Laura, Fidler, Sarah, Weber, Jonathan, Babiker, Abdel, Phillips, Rodney E, McLean, Angela R, Frater, John

“…The existence of viral variants that escape from the selection pressures imposed by cytotoxic T-lymphocytes (CTLs) in HIV-1 infection is well documented, but…”
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Adaptation of HIV-1 to human leukocyte antigen class I by Kawashima, Yuka, Pfafferott, Katja, Frater, John, Matthews, Philippa, Payne, Rebecca, Addo, Marylyn, Gatanaga, Hiroyuki, Fujiwara, Mamoru, Hachiya, Atsuko, Koizumi, Hirokazu, Kuse, Nozomi, Oka, Shinichi, Duda, Anna, Prendergast, Andrew, Crawford, Hayley, Leslie, Alasdair, Brumme, Zabrina, Brumme, Chanson, Allen, Todd, Brander, Christian, Kaslow, Richard, Tang, James, Hunter, Eric, Allen, Susan, Mulenga, Joseph, Branch, Songee, Roach, Tim, John, Mina, Mallal, Simon, Ogwu, Anthony, Shapiro, Roger, Prado, Julia G., Fidler, Sarah, Weber, Jonathan, Pybus, Oliver G., Klenerman, Paul, Ndung’u, Thumbi, Phillips, Rodney, Heckerman, David, Harrigan, P. Richard, Walker, Bruce D., Takiguchi, Masafumi, Goulder, Philip

“…HIV a moving target In order to determine whether HIV is adapting to the human leukocyte antigen (HLA) alleles, such as HLA-B * 57, B * 57 and B * 51, that…”
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Modelling the evolution and spread of HIV immune escape mutants by Fryer, Helen R, Frater, John, Duda, Anna, Roberts, Mick G, Phillips, Rodney E, McLean, Angela R

“…During infection with human immunodeficiency virus (HIV), immune pressure from cytotoxic T-lymphocytes (CTLs) selects for viral mutants that confer escape from…”
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Human Immunodeficiency Virus Infection Impairs Th1 and Th17 Mycobacterium tuberculosis–Specific T-Cell Responses by Murray, Lyle W, Satti, Iman, Meyerowitz, Jodi, Jones, Matthew, Willberg, Christian B, Ussher, James E, Goedhals, Dominique, Hurst, Jacob, Phillips, Rodney E, McShane, Helen, Vuuren, Cloete van, Frater, John

“…HIV infection is associated with a complex pattern of Mycobacterium tuberculosis–specific T-cell impairment. In South African participants, we report an…”
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LLT1 and CD161 Expression in Human Germinal Centers Promotes B Cell Activation and CXCR4 Downregulation by Llibre, Alba, López-Macías, Constantino, Marafioti, Teresa, Mehta, Hema, Partridge, Amy, Kanzig, Carina, Rivellese, Felice, Galson, Jacob D, Walker, Lucy J, Milne, Paul, Phillips, Rodney E, Kelly, Dominic F, Freeman, Gordon J, El Shikh, Mohey Eldin, Klenerman, Paul, Willberg, Christian B

“…Germinal centers (GCs) are microanatomical structures critical for the development of high-affinity Abs and B cell memory. They are organized into two zones,…”
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Control of HIV-1 immune escape by CD8 T cells expressing enhanced T-cell receptor by Jakobsen, Bent K, Riley, James L, Varela-Rohena, Angel, Molloy, Peter E, Dunn, Steven M, Li, Yi, Suhoski, Megan M, Carroll, Richard G, Milicic, Anita, Mahon, Tara, Sutton, Deborah H, Laugel, Bruno, Moysey, Ruth, Cameron, Brian J, Vuidepot, Annelise, Purbhoo, Marco A, Cole, David K, Phillips, Rodney E, June, Carl H, Sewell, Andrew K

“…In HIV research, new types of reagents are needed to target infected cells and overcome HIV's ability to vary its HLA-I-restricted antigens and escape from…”
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Beating Atomic Swords into Immunological Ploughshares by Frater, John, Hurst, Jacob, Phillips, Rodney E.

“…Deliberate redirection of T cell responses to human immunodeficiency virus-1 might enhance immunity and thus aid viral containment. Dahirel et al. (2011)…”
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HIV-1-specific CD4+ responses in primary HIV-1 infection predict disease progression by FRATER, John, EWINGS, Fiona, HURST, Jacob, BROWN, Helen, ROBINSON, Nicola, FIDLER, Sarah, BABIKER, Abdel, WEBER, Jonathan, PORTER, Kholoud, PHILLIPS, Rodney E

“…Immune factors determining clinical progression following HIV-1 infection remain unclear. The SPARTAC trial randomized 366 participants in primary HIV…”
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Mapping the drivers of within-host pathogen evolution using massive data sets by Palmer, Duncan S., Turner, Isaac, Fidler, Sarah, Frater, John, Goedhals, Dominique, Goulder, Philip, Huang, Kuan-Hsiang Gary, Oxenius, Annette, Phillips, Rodney, Shapiro, Roger, Vuuren, Cloete van, McLean, Angela R., McVean, Gil

“…Differences among hosts, resulting from genetic variation in the immune system or heterogeneity in drug treatment, can impact within-host pathogen evolution…”
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Memory Inflation: Continuous Accumulation of Antiviral CD8+ T Cells Over Time by Karrer, Urs, Sierro, Sophie, Wagner, Markus, Oxenius, Annette, Hengel, Hartmut, Koszinowski, Ulrich H, Phillips, Rodney E, Klenerman, Paul

“…CD8+ T lymphocytes play an important role in the control of intracellular pathogens during both acute and persistent infections. This is particularly true in…”
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Efficacious Early Antiviral Activity of HIV Gag- and Pol-Specific HLA-B2705-Restricted CD8+ T Cells by PAYNE, Rebecca P, KLØVERPRIS, Henrik, LUZZI, Graz, EDWARDS, Anne, PHILLIPS, Rodney, PRADO, Julia G, GOULDER, Philip J. R, SACHA, Jonah B, BRUMME, Zabrina, BRUMME, Chanson, BUUS, Søren, SIMS, Stuart, HICKLING, Stephen, RIDDELL, Lynn, FABIAN CHEN

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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CD161 expression on hepatitis C virus–specific CD8+ T cells suggests a distinct pathway of T cell differentiation by Northfield, John W., Kasprowicz, Victoria, Lucas, Michaela, Kersting, Nadine, Bengsh, Bertram, Kim, Arthur, Phillips, Rodney E., Walker, Bruce D., Thimme, Robert, Lauer, Georg, Klenerman, Paul

“…Hepatitis C virus (HCV) causes chronic infection accompanied by a high risk of liver failure and hepatocellular carcinoma. CD8+ T cell responses are important…”
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B-cell depletion reveals a role for antibodies in the control of chronic HIV-1 infection by Klenerman, Paul, Huang, Kuan-Hsiang G, Bonsall, David, Katzourakis, Aris, Thomson, Emma C, Fidler, Sarah J, Main, Janice, Muir, David, Weber, Jonathan N, Frater, Alexander J, Phillips, Rodney E, Pybus, Oliver G, Goulder, Philip J.R, McClure, Myra O, Cooke, Graham S

“…HIV can be partially contained by host immunity and understanding the basis of this may inform vaccine design. The importance of B-cell function in long-term…”
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