Search Results - "Phillips, Jonathan E"

Inhaled Phosphodiesterase 4 (PDE4) Inhibitors for Inflammatory Respiratory Diseases by Phillips, Jonathan E

“…PDE4 inhibitors can suppress a variety of inflammatory cell functions that contribute to their anti-inflammatory actions in respiratory diseases like chronic…”
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The Hippo kinase cascade regulates a contractile cell behavior and cell density in a close unicellular relative of animals by Phillips, Jonathan E, Pan, Duojia

“…The genomes of close unicellular relatives of animals encode orthologs of many genes that regulate animal development. However, little is known about the…”
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Genome editing in the unicellular holozoan Capsaspora owczarzaki suggests a premetazoan role for the Hippo pathway in multicellular morphogenesis by Phillips, Jonathan E, Santos, Maribel, Konchwala, Mohammed, Xing, Chao, Pan, Duojia

“…Animal development is mediated by a surprisingly small set of canonical signaling pathways such as Wnt, Hedgehog, TGF-beta, Notch, and Hippo pathways. Although…”
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Bleomycin induces molecular changes directly relevant to idiopathic pulmonary fibrosis: a model for "active" disease by Peng, Ruoqi, Sridhar, Sriram, Tyagi, Gaurav, Phillips, Jonathan E, Garrido, Rosario, Harris, Paul, Burns, Lisa, Renteria, Lorena, Woods, John, Chen, Leena, Allard, John, Ravindran, Palanikumar, Bitter, Hans, Liang, Zhenmin, Hogaboam, Cory M, Kitson, Chris, Budd, David C, Fine, Jay S, Bauer, Carla M T, Stevenson, Christopher S

“…The preclinical model of bleomycin-induced lung fibrosis, used to investigate mechanisms related to idiopathic pulmonary fibrosis (IPF), has incorrectly…”
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secreted protein is an endogenous chemorepellant in Dictyostelium discoideum by Phillips, Jonathan E, Gomer, Richard H

“…Chemorepellants may play multiple roles in physiological and pathological processes. However, few endogenous chemorepellants have been identified, and how they…”
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Use of a Wearable Biosensor to Study Heart Rate Variability in Chronic Obstructive Pulmonary Disease and Its Relationship to Disease Severity by Park, Seon-Cheol, Saiphoklang, Narongkorn, Jung, Donghyun, Gomez, David, Phillips, Jonathan E, Dolezal, Brett A, Tashkin, Donald P, Barjaktarevic, Igor, Cooper, Christopher B

“…The purpose of this study was to explore the relationships between heart rate variability (HRV) and various phenotypic measures that relate to health and…”
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Assessment of Brd4 Inhibition in Idiopathic Pulmonary Fibrosis Lung Fibroblasts and in Vivo Models of Lung Fibrosis by Tang, Xiaoyan, Peng, Ruoqi, Phillips, Jonathan E, Deguzman, Jeremy, Ren, Yonglin, Apparsundaram, Subramanium, Luo, Qi, Bauer, Carla M, Fuentes, Maria E, DeMartino, Julie A, Tyagi, Gaurav, Garrido, Rosario, Hogaboam, Cory M, Denton, Christopher P, Holmes, Alan M, Kitson, Christopher, Stevenson, Christopher S, Budd, David C

“…Idiopathic pulmonary fibrosis (IPF) is a chronic lung disease of high unmet medical need. Although bromodomain (Brd) and extra terminal domain isoforms have…”
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Partial genetic suppression of a loss-of-function mutant of the neuronal ceroid lipofuscinosis-associated protease TPP1 in Dictyostelium discoideum by Phillips, Jonathan E, Gomer, Richard H

“…Neuronal ceroid lipofuscinosis (NCL) is the most common childhood-onset neurodegenerative disease. NCL is inevitably fatal, and there is currently no treatment…”
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The p21-activated kinase (PAK) family member PakD is required for chemorepulsion and proliferation inhibition by autocrine signals in Dictyostelium discoideum by Phillips, Jonathan E, Gomer, Richard H

“…In Dictyostelium discoideum, the secreted proteins AprA and CfaD function as reporters of cell density and regulate cell number by inhibiting proliferation at…”
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Assembling a Hippo: the evolutionary emergence of an animal developmental signaling pathway by Phillips, Jonathan E., Zheng, Yonggang, Pan, Duojia

“…Components of the Hippo kinase module are present in some unicellular organisms, and unicellular orthologs of the Hippo pathway kinase Warts have the…”
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A novel, orally active CXCR1/2 receptor antagonist, Sch527123, inhibits neutrophil recruitment, mucus production, and goblet cell hyperplasia in animal models of pulmonary inflammation by Chapman, Richard W, Minnicozzi, Michael, Celly, Chander S, Phillips, Jonathan E, Kung, Ted T, Hipkin, R William, Fan, Xuedong, Rindgen, Diane, Deno, Gregory, Bond, Richard, Gonsiorek, Waldemar, Billah, Motasim M, Fine, Jay S, Hey, John A

“…Sch527123 [2-hydroxy-N,N-dimethyl-3-[[2-[[1(R)-(5-methyl-2-furanyl)propyl]amino]-3,4-dioxo-1-cyclobuten-1-yl]amino]ben-zamide] is a potent, selective…”
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Antigen-induced mast cell expansion and bronchoconstriction in a mouse model of asthma by Li, Shannon, Aliyeva, Minara, Daphtary, Nirav, Martin, Rebecca A, Poynter, Matthew E, Kostin, Shannon F, van der Velden, Jos L, Hyman, Alexandra M, Stevenson, Christopher S, Phillips, Jonathan E, Lundblad, Lennart K A

“…Lung mastocytosis and antigen-induced bronchoconstriction are common features in allergic asthmatics. It is therefore important that animal models of asthma…”
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The ROCO Kinase QkgA Is Necessary for Proliferation Inhibition by Autocrine Signals in Dictyostelium discoideum by Phillips, Jonathan E, Gomer, Richard H

“…Classifications Services EC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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House dust mite models: Will they translate clinically as a superior model of asthma? by Phillips, Jonathan E., PhD, Peng, Ruoqi, MD, Harris, Paul, BS, Burns, Lisa, BS, Renteria, Lorena, Lundblad, Lennart K.A., PhD, Fine, Jay S., PhD, Bauer, Carla M.T., PhD, Stevenson, Christopher S., PhD

“…The data presented here significantly extend the current knowledge by demonstrating that HDM sensitization and challenge in mice induces a type I…”
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A Retinoblastoma Orthologue Is Required for the Sensing of a Chalone in Dictyostelium discoideum by Bakthavatsalam, Deenadayalan, White, Michael J V, Herlihy, Sarah E, Phillips, Jonathan E, Gomer, Richard H

“…Classifications Services EC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Association of bronchial disease on CT imaging and clinical definitions of chronic bronchitis in a single-center COPD phenotyping study by Fat, Marisa, Andersen, Tyler, Fazio, Jane C., Park, Seon Cheol, Abtin, Fereidoun, Buhr, Russell G., Phillips, Jonathan E., Belperio, John, Tashkin, Donald P., Cooper, Christopher B., Barjaktarevic, Igor

“…Chronic Bronchitis (CB) represents a phenotype of chronic obstructive pulmonary disease (COPD). While several definitions have been used for diagnosis, the…”
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Practical Considerations in Dose Extrapolation from Animals to Humans by Hickey, Anthony J, Maloney, Sara E, Kuehl, Phillip J, Phillips, Jonathan E, Wolff, Ronald K

“…Animal studies are an important component of drug product development and the regulatory review process since modern practices have been in place, for almost a…”
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Corrigendum to “Bleomycin induced lung fibrosis increases work of breathing in the mouse” [Pulm. Pharmacol.Therapeut. 25 (2012) 281-285] by Phillips, Jonathan E., Peng, Ruoqi, Burns, Lisa, Harris, Paul, Garrido, Rosario, Tyagi, Gaurav, Fine, Jay S., Stevenson, Christopher S.

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Functional similarities between the dictyostelium protein AprA and the human protein dipeptidyl‐peptidase IV by Herlihy, Sarah E., Tang, Yu, Phillips, Jonathan E., Gomer, Richard H.

“…Autocrine proliferation repressor protein A (AprA) is a protein secreted by Dictyostelium discoideum cells. Although there is very little sequence similarity…”
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Dry Powder and Nebulized Aerosol Inhalation of Pharmaceuticals Delivered to Mice Using a Nose-only Exposure System by Phillips, Jonathan E, Zhang, Xuxia, Johnston, James A

“…Obstructive respiratory diseases like asthma and chronic obstructive pulmonary disease (COPD) are currently treated by inhaled anti-inflammatory and…”
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