Search Results - "Phillips, John w."

Cohort Profile: the Health and Retirement Study (HRS) by Sonnega, Amanda, Faul, Jessica D, Ofstedal, Mary Beth, Langa, Kenneth M, Phillips, John WR, Weir, David R

“…The Health and Retirement Study (HRS) is a nationally representative longitudinal survey of more than 37 000 individuals over age 50 in 23 000 households in…”
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The Allen Mouse Brain Common Coordinate Framework: A 3D Reference Atlas by Wang, Quanxin, Ding, Song-Lin, Li, Yang, Royall, Josh, Feng, David, Lesnar, Phil, Graddis, Nile, Naeemi, Maitham, Facer, Benjamin, Ho, Anh, Dolbeare, Tim, Blanchard, Brandon, Dee, Nick, Wakeman, Wayne, Hirokawa, Karla E., Szafer, Aaron, Sunkin, Susan M., Oh, Seung Wook, Bernard, Amy, Phillips, John W., Hawrylycz, Michael, Koch, Christof, Zeng, Hongkui, Harris, Julie A., Ng, Lydia

“…Recent large-scale collaborations are generating major surveys of cell types and connections in the mouse brain, collecting large amounts of data across…”
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Hierarchical organization of cortical and thalamic connectivity by Harris, Julie A., Mihalas, Stefan, Hirokawa, Karla E., Whitesell, Jennifer D., Choi, Hannah, Bernard, Amy, Bohn, Phillip, Caldejon, Shiella, Casal, Linzy, Cho, Andrew, Feiner, Aaron, Feng, David, Gaudreault, Nathalie, Gerfen, Charles R., Graddis, Nile, Groblewski, Peter A., Henry, Alex M., Ho, Anh, Howard, Robert, Knox, Joseph E., Kuan, Leonard, Kuang, Xiuli, Lecoq, Jerome, Lesnar, Phil, Li, Yaoyao, Luviano, Jennifer, McConoughey, Stephen, Mortrud, Marty T., Naeemi, Maitham, Ng, Lydia, Oh, Seung Wook, Ouellette, Benjamin, Shen, Elise, Sorensen, Staci A., Wakeman, Wayne, Wang, Quanxin, Wang, Yun, Williford, Ali, Phillips, John W., Jones, Allan R., Koch, Christof, Zeng, Hongkui

“…The mammalian cortex is a laminar structure containing many areas and cell types that are densely interconnected in complex ways, and for which generalizable…”
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Single-nucleus and single-cell transcriptomes compared in matched cortical cell types by Bakken, Trygve E, Hodge, Rebecca D, Miller, Jeremy A, Yao, Zizhen, Nguyen, Thuc Nghi, Aevermann, Brian, Barkan, Eliza, Bertagnolli, Darren, Casper, Tamara, Dee, Nick, Garren, Emma, Goldy, Jeff, Graybuck, Lucas T, Kroll, Matthew, Lasken, Roger S, Lathia, Kanan, Parry, Sheana, Rimorin, Christine, Scheuermann, Richard H, Schork, Nicholas J, Shehata, Soraya I, Tieu, Michael, Phillips, John W, Bernard, Amy, Smith, Kimberly A, Zeng, Hongkui, Lein, Ed S, Tasic, Bosiljka

“…Transcriptomic profiling of complex tissues by single-nucleus RNA-sequencing (snRNA-seq) affords some advantages over single-cell RNA-sequencing (scRNA-seq)…”
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Prostate epithelial cell of origin determines cancer differentiation state in an organoid transformation assay by Park, Jung Wook, Lee, John K., Phillips, John W., Huang, Patrick, Cheng, Donghui, Huang, Jiaoti, Witte, Owen N.

“…The cell of origin for prostate cancer remains a subject of debate. Genetically engineered mouse models have demonstrated that both basal and luminal cells can…”
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A Single-Cell Roadmap of Lineage Bifurcation in Human ESC Models of Embryonic Brain Development by Yao, Zizhen, Mich, John K., Ku, Sherman, Menon, Vilas, Krostag, Anne-Rachel, Martinez, Refugio A., Furchtgott, Leon, Mulholland, Heather, Bort, Susan, Fuqua, Margaret A., Gregor, Ben W., Hodge, Rebecca D., Jayabalu, Anu, May, Ryan C., Melton, Samuel, Nelson, Angelique M., Ngo, N. Kiet, Shapovalova, Nadiya V., Shehata, Soraya I., Smith, Michael W., Tait, Leah J., Thompson, Carol L., Thomsen, Elliot R., Ye, Chaoyang, Glass, Ian A., Kaykas, Ajamete, Yao, Shuyuan, Phillips, John W., Grimley, Joshua S., Levi, Boaz P., Wang, Yanling, Ramanathan, Sharad

“…During human brain development, multiple signaling pathways generate diverse cell types with varied regional identities. Here, we integrate single-cell RNA…”
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Distinct Transcriptomic Cell Types and Neural Circuits of the Subiculum and Prosubiculum along the Dorsal-Ventral Axis by Ding, Song-Lin, Yao, Zizhen, Hirokawa, Karla E., Nguyen, Thuc Nghi, Graybuck, Lucas T., Fong, Olivia, Bohn, Phillip, Ngo, Kiet, Smith, Kimberly A., Koch, Christof, Phillips, John W., Lein, Ed S., Harris, Julie A., Tasic, Bosiljka, Zeng, Hongkui

“…Subicular regions play important roles in spatial processing and many cognitive functions, and these are mainly attributed to the subiculum (Sub) rather than…”
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Tumor Repression of VCaP Xenografts by a Pyrrole-Imidazole Polyamide by Hargrove, Amanda E, Martinez, Thomas F, Hare, Alissa A, Kurmis, Alexis A, Phillips, John W, Sud, Sudha, Pienta, Kenneth J, Dervan, Peter B

“…Pyrrole-imidazole (Py-Im) polyamides are high affinity DNA-binding small molecules that can inhibit protein-DNA interactions. In VCaP cells, a human prostate…”
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National Institutes of Health social and behavioral research in response to the SARS-CoV2 Pandemic by Riley, William T, Borja, Susan E, Hooper, Monica Webb, Lei, Ming, Spotts, Erica L, Phillips, John W R, Gordon, Joshua A, Hodes, Richard J, Lauer, Michael S, Schwetz, Tara A, Perez-Stable, Eliseo

“…Abstract The COVID-19 pandemic has been mitigated primarily using social and behavioral intervention strategies, and these strategies have social and economic…”
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Discovering Modes of Action for Therapeutic Compounds Using a Genome-Wide Screen of Yeast Heterozygotes by Lum, Pek Yee, Armour, Christopher D., Stepaniants, Sergey B., Cavet, Guy, Wolf, Maria K., Butler, J.Scott, Hinshaw, Jerald C., Garnier, Philippe, Prestwich, Glenn D., Leonardson, Amy, Garrett-Engele, Philip, Rush, Christopher M., Bard, Martin, Schimmack, Greg, Phillips, John W., Roberts, Christopher J., Shoemaker, Daniel D.

“…Modern medicine faces the challenge of developing safer and more effective therapies to treat human diseases. Many drugs currently in use were discovered…”
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Single-dose pharmacokinetic and toxicity analysis of pyrrole–imidazole polyamides in mice by Synold, Timothy W., Xi, Bixin, Wu, Jun, Yen, Yun, Li, Benjamin C., Yang, Fei, Phillips, John W., Nickols, Nicholas G., Dervan, Peter B.

“…Purpose Pyrrole–imidazole (Py-Im) polyamides are programmable, sequence-specific DNA minor groove–binding ligands. Previous work in cell culture has shown that…”
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Isolation, structure elucidation and antibacterial activity of a new tetramic acid, ascosetin by Ondeyka, John G, Smith, Scott K, Zink, Deborah L, Vicente, Francisca, Basilio, Angela, Bills, Gerald F, Polishook, Jon D, Garlisi, Charles, Mcguinness, Debra, Smith, Elizabeth, Qiu, Hongchen, Gill, Charles J, Donald, Robert GK, Phillips, John W, Goetz, Michael A, Singh, Sheo B

“…The ever-increasing bacterial resistance to clinical antibiotics is making many drugs ineffective and creating significant treatment gaps. This can be only…”
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Isolation, Structure Elucidation, and Biological Activity of Altersolanol P Using Staphylococcus aureus Fitness Test Based Genome-Wide Screening by Ondeyka, John, Buevich, Alexei V, Williamson, R. Thomas, Zink, Deborah L, Polishook, Jon D, Occi, James, Vicente, Francisca, Basilio, Angela, Bills, Gerald F, Donald, Robert G. K, Phillips, John W, Goetz, Michael A, Singh, Sheo B

“…Bacteria continue to evade existing antibiotics by acquiring resistance by various mechanisms, leading to loss of antibiotic effectiveness. To avoid an…”
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Conserved cell types with divergent features in human versus mouse cortex by Hodge, Rebecca D., Bakken, Trygve E., Miller, Jeremy A., Smith, Kimberly A., Barkan, Eliza R., Graybuck, Lucas T., Close, Jennie L., Long, Brian, Johansen, Nelson, Penn, Osnat, Yao, Zizhen, Eggermont, Jeroen, Höllt, Thomas, Levi, Boaz P., Shehata, Soraya I., Aevermann, Brian, Beller, Allison, Bertagnolli, Darren, Brouner, Krissy, Casper, Tamara, Cobbs, Charles, Dalley, Rachel, Dee, Nick, Ding, Song-Lin, Ellenbogen, Richard G., Fong, Olivia, Garren, Emma, Goldy, Jeff, Gwinn, Ryder P., Hirschstein, Daniel, Keene, C. Dirk, Keshk, Mohamed, Ko, Andrew L., Lathia, Kanan, Mahfouz, Ahmed, Maltzer, Zoe, McGraw, Medea, Nguyen, Thuc Nghi, Nyhus, Julie, Ojemann, Jeffrey G., Oldre, Aaron, Parry, Sheana, Reynolds, Shannon, Rimorin, Christine, Shapovalova, Nadiya V., Somasundaram, Saroja, Szafer, Aaron, Thomsen, Elliot R., Tieu, Michael, Quon, Gerald, Scheuermann, Richard H., Yuste, Rafael, Sunkin, Susan M., Lelieveldt, Boudewijn, Feng, David, Ng, Lydia, Bernard, Amy, Hawrylycz, Michael, Phillips, John W., Tasic, Bosiljka, Zeng, Hongkui, Jones, Allan R., Koch, Christof, Lein, Ed S.

“…Elucidating the cellular architecture of the human cerebral cortex is central to understanding our cognitive abilities and susceptibility to disease. Here we…”
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N-Myc Drives Neuroendocrine Prostate Cancer Initiated from Human Prostate Epithelial Cells by Lee, John K., Phillips, John W., Smith, Bryan A., Park, Jung Wook, Stoyanova, Tanya, McCaffrey, Erin F., Baertsch, Robert, Sokolov, Artem, Meyerowitz, Justin G., Mathis, Colleen, Cheng, Donghui, Stuart, Joshua M., Shokat, Kevan M., Gustafson, W. Clay, Huang, Jiaoti, Witte, Owen N.

“…MYCN amplification and overexpression are common in neuroendocrine prostate cancer (NEPC). However, the impact of aberrant N-Myc expression in prostate…”
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A mesoscale connectome of the mouse brain by Oh, Seung Wook, Harris, Julie A., Ng, Lydia, Winslow, Brent, Cain, Nicholas, Mihalas, Stefan, Wang, Quanxin, Lau, Chris, Kuan, Leonard, Henry, Alex M., Mortrud, Marty T., Ouellette, Benjamin, Nguyen, Thuc Nghi, Sorensen, Staci A., Slaughterbeck, Clifford R., Wakeman, Wayne, Li, Yang, Feng, David, Ho, Anh, Nicholas, Eric, Hirokawa, Karla E., Bohn, Phillip, Joines, Kevin M., Peng, Hanchuan, Hawrylycz, Michael J., Phillips, John W., Hohmann, John G., Wohnoutka, Paul, Gerfen, Charles R., Koch, Christof, Bernard, Amy, Dang, Chinh, Jones, Allan R., Zeng, Hongkui

“…Comprehensive knowledge of the brain’s wiring diagram is fundamental for understanding how the nervous system processes information at both local and global…”
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Completion of a programmable DNA-binding small molecule library by Hsu, Carey F., Phillips, John W., Trauger, John W., Farkas, Michelle E., Belitsky, Jason M., Heckel, Alexander, Olenyuk, Bogdan Z., Puckett, James W., Wang, Clay C.C., Dervan, Peter B.

“…Hairpin pyrrole-imidazole (Py-Im) polyamides are programmable oligomers that bind the DNA minor groove in a sequence-specific manner with affinities comparable…”
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A large-scale standardized physiological survey reveals functional organization of the mouse visual cortex by de Vries, Saskia E. J., Lecoq, Jerome A., Buice, Michael A., Groblewski, Peter A., Ocker, Gabriel K., Oliver, Michael, Feng, David, Cain, Nicholas, Ledochowitsch, Peter, Millman, Daniel, Roll, Kate, Garrett, Marina, Keenan, Tom, Kuan, Leonard, Mihalas, Stefan, Olsen, Shawn, Thompson, Carol, Wakeman, Wayne, Waters, Jack, Williams, Derric, Barber, Chris, Berbesque, Nathan, Blanchard, Brandon, Bowles, Nicholas, Caldejon, Shiella D., Casal, Linzy, Cho, Andrew, Cross, Sissy, Dang, Chinh, Dolbeare, Tim, Edwards, Melise, Galbraith, John, Gaudreault, Nathalie, Gilbert, Terri L., Griffin, Fiona, Hargrave, Perry, Howard, Robert, Huang, Lawrence, Jewell, Sean, Keller, Nika, Knoblich, Ulf, Larkin, Josh D., Larsen, Rachael, Lau, Chris, Lee, Eric, Lee, Felix, Leon, Arielle, Li, Lu, Long, Fuhui, Luviano, Jennifer, Mace, Kyla, Nguyen, Thuyanh, Perkins, Jed, Robertson, Miranda, Seid, Sam, Shea-Brown, Eric, Shi, Jianghong, Sjoquist, Nathan, Slaughterbeck, Cliff, Sullivan, David, Valenza, Ryan, White, Casey, Williford, Ali, Witten, Daniela M., Zhuang, Jun, Zeng, Hongkui, Farrell, Colin, Ng, Lydia, Bernard, Amy, Phillips, John W., Reid, R. Clay, Koch, Christof

“…To understand how the brain processes sensory information to guide behavior, we must know how stimulus representations are transformed throughout the visual…”
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The RNA-binding proteins hnRNP H and F regulate splicing of a MYC-dependent HRAS exon in prostate cancer cells by Chen, Xinyuan, Yang, Harry Taegyun, Zhang, Beatrice, Phillips, John W, Cheng, Donghui, Rigo, Frank, Witte, Owen N, Xing, Yi, Black, Douglas L

“…The MYC proto-oncogene contributes to the pathogenesis of more than half of human cancers. Malignant transformation by MYC transcriptionally up-regulates the…”
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Pathway-guided analysis identifies Myc-dependent alternative pre-mRNA splicing in aggressive prostate cancers by Phillips, John W., Pan, Yang, Tsai, Brandon L., Xie, Zhijie, Demirdjian, Levon, Xiao, Wen, Yang, Harry T., Zhang, Yida, Lin, Chia Ho, Cheng, Donghui, Hu, Qiang, Liu, Song, Black, Douglas L., Witte, Owen N., Xing, Yi

“…We sought to define the landscape of alternative pre-mRNA splicing in prostate cancers and the relationship of exon choice to known cancer driver alterations…”
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