Search Results - "Phillips, Emma C"

Physiological release of endogenous tau is stimulated by neuronal activity by Pooler, Amy M, Phillips, Emma C, Lau, Dawn H W, Noble, Wendy, Hanger, Diane P

“…Propagation of tau pathology is linked with progressive neurodegeneration, but the mechanism underlying trans‐synaptic spread of tau is unknown. We show that…”
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The physiological and pathological biophysics of phase separation and gelation of RNA binding proteins in amyotrophic lateral sclerosis and fronto-temporal lobar degeneration by St George-Hyslop, Peter, Lin, Julie Qiaojin, Miyashita, Akinori, Phillips, Emma C., Qamar, Seema, Randle, Suzanne J., Wang, GuoZhen

“…[Display omitted] •Some intrinsically disordered proteins undergo reversible phase separation/gelation.•Reversible phase separation/gelation underpins function…”
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Astrocytes and neuroinflammation in Alzheimer's disease by Phillips, Emma C, Croft, Cara L, Kurbatskaya, Ksenia, O'Neill, Michael J, Hutton, Michael L, Hanger, Diane P, Garwood, Claire J, Noble, Wendy

“…Increased production of amyloid β-peptide (Aβ) and altered processing of tau in Alzheimer's disease (AD) are associated with synaptic dysfunction, neuronal…”
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Staff education, regular sedation and analgesia quality feedback, and a sedation monitoring technology for improving sedation and analgesia quality for critically ill, mechanically ventilated patients: a cluster randomised trial by Walsh, Timothy S, Prof, Kydonaki, Kalliopi, PhD, Antonelli, Jean, BSc, Stephen, Jacqueline, PhD, Lee, Robert J, MSc, Everingham, Kirsty, PhD, Hanley, Janet, PhD, Phillips, Emma C, MBChB, Uutela, Kimmo, PhD, Peltola, Petra, BN, Cole, Stephen, FFICM, Quasim, Tara, MD, Ruddy, James, FFICM, McDougall, Marcia, FRCA, Davidson, Alan, FFICM, Rutherford, John, PhD, Richards, Jonathan, FFICM, Weir, Christopher J, Prof

“…Summary Background Optimal sedation of patients in intensive care units (ICUs) requires the avoidance of pain, agitation, and unnecessary deep sedation, but…”
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FUS Phase Separation Is Modulated by a Molecular Chaperone and Methylation of Arginine Cation-π Interactions by Qamar, Seema, Wang, GuoZhen, Randle, Suzanne J., Ruggeri, Francesco Simone, Varela, Juan A., Lin, Julie Qiaojin, Phillips, Emma C., Miyashita, Akinori, Williams, Declan, Ströhl, Florian, Meadows, William, Ferry, Rodylyn, Dardov, Victoria J., Tartaglia, Gian G., Farrer, Lindsay A., Kaminski Schierle, Gabriele S., Kaminski, Clemens F., Holt, Christine E., Fraser, Paul E., Schmitt-Ulms, Gerold, Klenerman, David, Knowles, Tuomas, Vendruscolo, Michele, St George-Hyslop, Peter

“…Reversible phase separation underpins the role of FUS in ribonucleoprotein granules and other membrane-free organelles and is, in part, driven by the…”
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Impact of Tigecycline on C. difficile Outcomes: Case Series and Propensity-Matched Retrospective Study by Phillips, Emma C, Warren, Cirle A, Ma, Jennie Z, Madden, Gregory R

“…This case series and propensity-matched cohort study on the use of tigecycline in Clostridioides difficile infection (CDI) evaluated the effect of tigecycline…”
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The Rubik's cube of doing and being: Factors influencing professional identity transition to the medical registrar by Kerins, Joanne, Phillips, Emma C., Smith, Samantha E., Tallentire, Victoria R.

“…Background Professional identity transitions, such as the transition to medical registrar, are challenging. How minoritised identities influence transitions…”
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Videolaryngoscopy use before and after the initial phases of the COVID-19 pandemic: The report of the VL-iCUE survey with responses from 96 countries by Wylie, Nia W, Durrant, Emma L, Phillips, Emma C, De Jong, Audrey, Schoettker, Patrick, Kawagoe, Izumi, de Pinho Martins, Márcio, Zapatero, Juliana, Graham, Catriona, McNarry, Alistair F

“…The potential benefit of videolaryngoscopy use in facilitating tracheal intubation has already been established, however its use was actively encouraged during…”
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Assessing Medical Students' Nontechnical Skills Using Immersive Simulation: What Are the Essential Components? by Phillips, Emma C., Smith, Samantha E., Hamilton, Ailsa L., Kerins, Joanne, Clarke, Benjamin, Tallentire, Victoria R.

“…INTRODUCTIONNontechnical skills (NTS) have been acknowledged to be important for medical students and can be linked to improved clinical performance. However,…”
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Upregulation of calpain activity precedes tau phosphorylation and loss of synaptic proteins in Alzheimer's disease brain by Kurbatskaya, Ksenia, Phillips, Emma C, Croft, Cara L, Dentoni, Giacomo, Hughes, Martina M, Wade, Matthew A, Al-Sarraj, Safa, Troakes, Claire, O'Neill, Michael J, Perez-Nievas, Beatriz G, Hanger, Diane P, Noble, Wendy

“…Alterations in calcium homeostasis are widely reported to contribute to synaptic degeneration and neuronal loss in Alzheimer's disease. Elevated cytosolic…”
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Membrane association and release of wild-type and pathological tau from organotypic brain slice cultures by Croft, Cara L, Wade, Matthew A, Kurbatskaya, Ksenia, Mastrandreas, Pavlina, Hughes, Martina M, Phillips, Emma C, Pooler, Amy M, Perkinton, Michael S, Hanger, Diane P, Noble, Wendy

“…The spatiotemporal transmission of pathological tau in the brain is characteristic of Alzheimer’s disease. Release of both soluble and abnormal tau species…”
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Novel Pathogenic C2 Variant Associated with Disseminated GBS Infection by Phillips, Emma C., Gupta, Monica, Li, Rung-Chi, Sohn, Julia K., Lawrence, Monica G.

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Critical residues involved in tau binding to fyn: implications for tau phosphorylation in Alzheimer's disease by Lau, Dawn H W, Hogseth, Marte, Phillips, Emma C, O'Neill, Michael J, Pooler, Amy M, Noble, Wendy, Hanger, Diane P

“…Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterised by neuropathological deposits of amyloid plaques and neurofibrillary tangles…”
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Intracellular and extracellular roles for tau in neurodegenerative disease by Hanger, Diane P, Lau, Dawn H W, Phillips, Emma C, Bondulich, Marie K, Guo, Tong, Woodward, Benjamin W, Pooler, Amy M, Noble, Wendy

“…Tau has a well-established role as a microtubule-associated protein, in which it stabilizes the neuronal cytoskeleton. This function of tau is influenced by…”
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Videolaryngoscopy utilisation: Facts and opinions by Wylie, Nia W, Phillips, Emma C, Harrington, Julia K, McNarry, Alistair F

“…AbstractBackgroundVideolaryngoscopy is used in routine and predicted difficult tracheal intubation. McGrath MAC videolaryngoscopes (VLs) are now widely…”
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ASTROCYTE ACTIVATION INFLUENCES THE DEVELOPMENT OF TAUOPATHY by Phillips, Emma C, Garwood, Claire J, Hanger, Diane P, Noble, Wendy

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Development and validation of the theatre team tool (TTT): A clinical debriefing tool for multidisciplinary theatre teams by Phillips, Emma C., Mellanby, Edward, Tallentire, Victoria R.

“…Clinical debriefing (CD) after unanticipated clinical events benefits staff, teams, patients and systems. Use of a structured tool may help overcome barriers…”
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697. Outcomes of Tigecycline Use for Clostridioides difficile Infection: A Case Series of 28 Patients by Phillips, Emma C, Warren, Cirle A, Madden, Gregory

“…Abstract Background Clostridioides difficile infection remains a highly morbid or lethal condition in an unacceptably large proportion of patients. To date,…”
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P1‐116: ASTROCYTE ACTIVATION INFLUENCES THE DEVELOPMENT OF TAUOPATHY by Phillips, Emma C., Garwood, Claire J., Hanger, Diane P., Noble, Wendy

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Novel Pathogenic C2 Variant Associated with Disseminated GBS Infection by Phillips, Emma C, Gupta, Monica, Li, Rung-Chi, Sohn, Julia K, Lawrence, Monica G

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